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Protein
Submitted name:

Heat shock cognate 71 kDa protein

Gene

hspa8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processStress responseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-3371453 Regulation of HSF1-mediated heat shock response
R-DRE-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DRE-3371568 Attenuation phase
R-DRE-3371571 HSF1-dependent transactivation
R-DRE-432720 Lysosome Vesicle Biogenesis
R-DRE-432722 Golgi Associated Vesicle Biogenesis
R-DRE-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DRE-6798695 Neutrophil degranulation
R-DRE-72163 mRNA Splicing - Major Pathway
R-DRE-8856828 Clathrin-mediated endocytosis
R-DRE-8876725 Protein methylation
R-DRE-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock cognate 71 kDa proteinImported
Submitted name:
Heat shock protein 8Imported
Gene namesi
Name:hspa8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-990415-92 hspa8

Expressioni

Gene expression databases

BgeeiENSDARG00000068992
ExpressionAtlasiA0A0R4IVB0 baseline

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
HOVERGENiHBG051845
KOiK03283
OMAiAYTKNQD
OrthoDBiEOG091G03SF
TreeFamiTF105042

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NYR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD GVVQSDMKHW PFNVINDNSR
110 120 130 140 150
PKVQVEYKGE SKSFYPEEIS SMVLTKMKEI AEAYLGKTVS NAVITVPAYF
160 170 180 190 200
NDSQRQATKD AGTISGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL
210 220 230 240 250
GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FITEFKRKHK
260 270 280 290 300
KDISDNKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
310 320 330 340 350
RFEELNADLF RGTLDPVEKA LRDAKMDKAQ IHDIVLVGGS TRIPKIQKLL
360 370 380 390 400
QDYFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS
410 420 430 440 450
LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGIMNVSA VDKSTGKENK
510 520 530 540 550
ITITNDKGRL SKEDIERMVQ EAEKYKAEDD VQRDKVSAKN GLESYAFNMK
560 570 580 590 600
STVEDEKLKG KISDEDKQKI LDKCNEVIGW LDKNQTAERE EFEHQQKELE
610 620 630 640
KVCNPIITKL YQSAGGMPGG MPEGMPGGFP GAGAAPGGGS SGPTIEEVD
Length:649
Mass (Da):71,180
Last modified:July 5, 2004 - v1
Checksum:i18454BE693C838A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX120005 Genomic DNA No translation available.
BX276087 Genomic DNA No translation available.
BC063228 mRNA Translation: AAH63228.1
BC066491 mRNA Translation: AAH66491.1
BC154755 mRNA Translation: AAI54756.1
RefSeqiNP_001103873.1, NM_001110403.1
UniGeneiDr.75087

Genome annotation databases

EnsembliENSDART00000099994; ENSDARP00000090766; ENSDARG00000068992
ENSDART00000168898; ENSDARP00000141099; ENSDARG00000068992
ENSDART00000183657; ENSDARP00000145203; ENSDARG00000114726
GeneIDi573376
KEGGidre:573376

Similar proteinsi

Entry informationi

Entry nameiQ6NYR4_DANRE
AccessioniPrimary (citable) accession number: Q6NYR4
Secondary accession number(s): A0A0R4IVB0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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