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Q6NYN7

- S22A6_DANRE

UniProt

Q6NYN7 - S22A6_DANRE

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Protein
Solute carrier family 22 member 6
Gene
slc22a6, oat, zgc:77073
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate By similarity.

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 6
    Alternative name(s):
    Organic anion transporter 1
    Renal organic anion transporter 1
    Short name:
    ROAT1
    Gene namesi
    Name:slc22a6
    Synonyms:oat
    ORF Names:zgc:77073
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-2249. slc22a6l.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei16 – 3621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini37 – 143107Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei144 – 16421Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini165 – 1706Cytoplasmic Reviewed prediction
    Transmembranei171 – 19121Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini192 – 20110Extracellular Reviewed prediction
    Transmembranei202 – 22221Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini223 – 2286Cytoplasmic Reviewed prediction
    Transmembranei229 – 24921Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini250 – 2567Extracellular Reviewed prediction
    Transmembranei257 – 27721Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini278 – 34568Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei346 – 36621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini367 – 3748Extracellular Reviewed prediction
    Transmembranei375 – 39521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini396 – 40611Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei407 – 42721Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini428 – 4336Extracellular Reviewed prediction
    Transmembranei434 – 45421Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini455 – 46511Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei466 – 48621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini487 – 4915Extracellular Reviewed prediction
    Transmembranei492 – 51221Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini513 – 56048Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Solute carrier family 22 member 6
    PRO_0000324173Add
    BLAST

    Post-translational modificationi

    Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane By similarity.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000072353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NYN7.

    Family & Domainsi

    Domaini

    Multiple cysteine residues are necessary for proper targeting to the plasma membrane By similarity.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ6NYN7.
    KOiK08203.
    PhylomeDBiQ6NYN7.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NYN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFSDLLEQV GSTGRFQVLH VTLLSMPILM MASHNLLQNF VAAVPPHHCQ    50
    PHANLSMSST DAVDVLRATV PLGLNGKLER CKRYTTPQWQ ILSLNTSESL 100
    WDESMAETET QSCEDGWFYN MTEMSSTIIT EWDLVCDYRA LKQMSQTTYM 150
    GGVLVGAIVF GGLSDRFGRR VLLLISNLMM AIGGTCVAFS TSFTMFCVFR 200
    VCCGMALSGL VLNSFSLIVE WIPTRVRTVV GTGTGYCYTT GQLILAAVAY 250
    CIRDWRWLTL AVSLPFYVSF LYSWWFLESA RWLVLTKNPE QAVKNLKTVA 300
    RINGRSAEGD KIDLEMLQES MKKEMACSKG SYSALDLLRT STMRTITICL 350
    SAVWFSTSFA YYGLSMDLQK FGVSIYLIQI IFGAVDIPAK IIVTICMSML 400
    GRRPSQCGAL VLAGIMILIN LLVPSDLQML RTSLAVIGKG CLAASFNCCY 450
    LYAGELYPTV IRQSGMGWVS MMARFGAMVA PMVLLLGDDY PWIPGFIYGG 500
    APIVSGIFAF FLPETLSQPL PDTIQDIDDR GLARTNSKRL PEKLDLAMKD 550
    PSCVLLKESV 560
    Length:560
    Mass (Da):61,972
    Last modified:July 5, 2004 - v1
    Checksum:i14D3F32AB9771D45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066519 mRNA. Translation: AAH66519.1.
    RefSeqiNP_996960.1. NM_207077.1.
    UniGeneiDr.107265.

    Genome annotation databases

    GeneIDi404609.
    KEGGidre:404609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066519 mRNA. Translation: AAH66519.1 .
    RefSeqi NP_996960.1. NM_207077.1.
    UniGenei Dr.107265.

    3D structure databases

    ProteinModelPortali Q6NYN7.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000072353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 404609.
    KEGGi dre:404609.

    Organism-specific databases

    CTDi 4942.
    ZFINi ZDB-GENE-040426-2249. slc22a6l.

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q6NYN7.
    KOi K08203.
    PhylomeDBi Q6NYN7.

    Miscellaneous databases

    NextBioi 20817677.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiS22A6_DANRE
    AccessioniPrimary (citable) accession number: Q6NYN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 5, 2004
    Last modified: April 16, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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