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Q6NYN7

- S22A6_DANRE

UniProt

Q6NYN7 - S22A6_DANRE

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Protein

Solute carrier family 22 member 6

Gene

slc22a6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity).By similarity

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 6
Alternative name(s):
Organic anion transporter 1
Renal organic anion transporter 1
Short name:
ROAT1
Gene namesi
Name:slc22a6
Synonyms:oat
ORF Names:zgc:77073
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2249. slc22a6l.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Solute carrier family 22 member 6PRO_0000324173Add
BLAST

Post-translational modificationi

Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072353.

Structurei

3D structure databases

ProteinModelPortaliQ6NYN7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini37 – 143107ExtracellularSequence AnalysisAdd
BLAST
Topological domaini165 – 1706CytoplasmicSequence Analysis
Topological domaini192 – 20110ExtracellularSequence Analysis
Topological domaini223 – 2286CytoplasmicSequence Analysis
Topological domaini250 – 2567ExtracellularSequence Analysis
Topological domaini278 – 34568CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini367 – 3748ExtracellularSequence Analysis
Topological domaini396 – 40611CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini428 – 4336ExtracellularSequence Analysis
Topological domaini455 – 46511CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini487 – 4915ExtracellularSequence Analysis
Topological domaini513 – 56048CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Transmembranei492 – 51221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

Multiple cysteine residues are necessary for proper targeting to the plasma membrane.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6NYN7.
KOiK08203.
PhylomeDBiQ6NYN7.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NYN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFSDLLEQV GSTGRFQVLH VTLLSMPILM MASHNLLQNF VAAVPPHHCQ
60 70 80 90 100
PHANLSMSST DAVDVLRATV PLGLNGKLER CKRYTTPQWQ ILSLNTSESL
110 120 130 140 150
WDESMAETET QSCEDGWFYN MTEMSSTIIT EWDLVCDYRA LKQMSQTTYM
160 170 180 190 200
GGVLVGAIVF GGLSDRFGRR VLLLISNLMM AIGGTCVAFS TSFTMFCVFR
210 220 230 240 250
VCCGMALSGL VLNSFSLIVE WIPTRVRTVV GTGTGYCYTT GQLILAAVAY
260 270 280 290 300
CIRDWRWLTL AVSLPFYVSF LYSWWFLESA RWLVLTKNPE QAVKNLKTVA
310 320 330 340 350
RINGRSAEGD KIDLEMLQES MKKEMACSKG SYSALDLLRT STMRTITICL
360 370 380 390 400
SAVWFSTSFA YYGLSMDLQK FGVSIYLIQI IFGAVDIPAK IIVTICMSML
410 420 430 440 450
GRRPSQCGAL VLAGIMILIN LLVPSDLQML RTSLAVIGKG CLAASFNCCY
460 470 480 490 500
LYAGELYPTV IRQSGMGWVS MMARFGAMVA PMVLLLGDDY PWIPGFIYGG
510 520 530 540 550
APIVSGIFAF FLPETLSQPL PDTIQDIDDR GLARTNSKRL PEKLDLAMKD
560
PSCVLLKESV
Length:560
Mass (Da):61,972
Last modified:July 5, 2004 - v1
Checksum:i14D3F32AB9771D45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC066519 mRNA. Translation: AAH66519.1.
RefSeqiNP_996960.1. NM_207077.1.
UniGeneiDr.107265.

Genome annotation databases

GeneIDi404609.
KEGGidre:404609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC066519 mRNA. Translation: AAH66519.1 .
RefSeqi NP_996960.1. NM_207077.1.
UniGenei Dr.107265.

3D structure databases

ProteinModelPortali Q6NYN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000072353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404609.
KEGGi dre:404609.

Organism-specific databases

CTDi 4942.
ZFINi ZDB-GENE-040426-2249. slc22a6l.

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q6NYN7.
KOi K08203.
PhylomeDBi Q6NYN7.

Miscellaneous databases

NextBioi 20817677.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS22A6_DANRE
AccessioniPrimary (citable) accession number: Q6NYN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3