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Protein

Kelch-like protein 21

Gene

klhl21

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-8951664 Neddylation
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 21
Gene namesi
Name:klhl21
ORF Names:zgc:76933
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040426-2627 klhl21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003966321 – 613Kelch-like protein 21Add BLAST613

Proteomic databases

PaxDbiQ6NYM1
PRIDEiQ6NYM1

Expressioni

Gene expression databases

BgeeiENSDARG00000039255
ExpressionAtlasiQ6NYM1 baseline

Interactioni

Subunit structurei

Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121765

Structurei

3D structure databases

ProteinModelPortaliQ6NYM1
SMRiQ6NYM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 105BTBPROSITE-ProRule annotationAdd BLAST68
Domaini140 – 242BACKAdd BLAST103
Repeati289 – 337Kelch 1Add BLAST49
Repeati338 – 384Kelch 2Add BLAST47
Repeati386 – 424Kelch 3Add BLAST39
Repeati426 – 472Kelch 4Add BLAST47
Repeati474 – 514Kelch 5Add BLAST41
Repeati515 – 562Kelch 6Add BLAST48

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000261671
HOVERGENiHBG101644
InParanoidiQ6NYM1
KOiK10458
OMAiRFYLLAH
OrthoDBiEOG091G0380
PhylomeDBiQ6NYM1
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NYM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPVLQTQP SMLPFFDTAH AVNLLRGIHE LRAERKFFDV TLCAEGKEFH
60 70 80 90 100
CHRTVLAAAS MYFRAMFAGT LRESVMDRVV LHEVSAELLG LLVDFCYTGR
110 120 130 140 150
VTVTHDNVDL LLKTADLFQF PSVKEACCAF LEQRLDVSNC LEIQDFAEAY
160 170 180 190 200
ACRELAASAR RFVLKNIVEL AKSMDFERLS WKRLLEFVSD DGLCVDKEET
210 220 230 240 250
AYQIAVRWVK ADLQHRLHYW PELLQQVRLP FVRRFYLLAH VESDPLVYLS
260 270 280 290 300
PACLRLVSEA RSFQSYEYDR HDRPGHRMRP RPSTGLAEIL VVVGGCDQDC
310 320 330 340 350
DELVTVDCYN PQTGQWRYLA EFPDHLGGGY SIAALGNDIY VTGGSDGSRL
360 370 380 390 400
YDCVWRYNSS VNEWTEVSPM LKAREYHSSC VLKGQLYVVG SDSTERYDHT
410 420 430 440 450
IDCWEALPPM PHPMDNCSTT ACRGRLYAIG SLTGEDTMAI QCYDAESNRW
460 470 480 490 500
SLLNSGELPP WSFAPKSVTL NGLIYFVRDD SAEVDVYNPQ KNEWDKISPM
510 520 530 540 550
TQVHVGGSVS ALGGRLYVSG GYDNTFELSD VVEVYDPSSR SWSPAGRLPQ
560 570 580 590 600
PTFWHGSVSI FRQFMPLVQS TFEPIDIPEA NAIHLHRHHR NQALHNHNNN
610
VNQNHNQEVN QVH
Length:613
Mass (Da):69,737
Last modified:July 5, 2004 - v1
Checksum:iD83AFF765D17BC0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066537 mRNA Translation: AAH66537.1
BC155818 mRNA Translation: AAI55819.1
RefSeqiNP_001307336.1, NM_001320407.1
XP_005162217.1, XM_005162160.3
UniGeneiDr.85564

Genome annotation databases

EnsembliENSDART00000057357; ENSDARP00000057356; ENSDARG00000039255
ENSDART00000137486; ENSDARP00000121765; ENSDARG00000039255
ENSDART00000140335; ENSDARP00000115156; ENSDARG00000039255
ENSDART00000170172; ENSDARP00000138211; ENSDARG00000039255
GeneIDi404613
KEGGidre:404613

Similar proteinsi

Entry informationi

Entry nameiKLH21_DANRE
AccessioniPrimary (citable) accession number: Q6NYM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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