Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch-like protein 21

Gene

klhl21

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 21
Gene namesi
Name:klhl21
ORF Names:zgc:76933
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040426-2627. klhl21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003966321 – 613Kelch-like protein 21Add BLAST613

Proteomic databases

PaxDbiQ6NYM1.

Expressioni

Gene expression databases

BgeeiENSDARG00000039255.
ExpressionAtlasiQ6NYM1. differential.

Interactioni

Subunit structurei

Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121765.

Structurei

3D structure databases

ProteinModelPortaliQ6NYM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 105BTBPROSITE-ProRule annotationAdd BLAST68
Domaini140 – 242BACKAdd BLAST103
Repeati289 – 337Kelch 1Add BLAST49
Repeati338 – 384Kelch 2Add BLAST47
Repeati386 – 424Kelch 3Add BLAST39
Repeati426 – 472Kelch 4Add BLAST47
Repeati474 – 514Kelch 5Add BLAST41
Repeati515 – 562Kelch 6Add BLAST48

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ6NYM1.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiQ6NYM1.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NYM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPVLQTQP SMLPFFDTAH AVNLLRGIHE LRAERKFFDV TLCAEGKEFH
60 70 80 90 100
CHRTVLAAAS MYFRAMFAGT LRESVMDRVV LHEVSAELLG LLVDFCYTGR
110 120 130 140 150
VTVTHDNVDL LLKTADLFQF PSVKEACCAF LEQRLDVSNC LEIQDFAEAY
160 170 180 190 200
ACRELAASAR RFVLKNIVEL AKSMDFERLS WKRLLEFVSD DGLCVDKEET
210 220 230 240 250
AYQIAVRWVK ADLQHRLHYW PELLQQVRLP FVRRFYLLAH VESDPLVYLS
260 270 280 290 300
PACLRLVSEA RSFQSYEYDR HDRPGHRMRP RPSTGLAEIL VVVGGCDQDC
310 320 330 340 350
DELVTVDCYN PQTGQWRYLA EFPDHLGGGY SIAALGNDIY VTGGSDGSRL
360 370 380 390 400
YDCVWRYNSS VNEWTEVSPM LKAREYHSSC VLKGQLYVVG SDSTERYDHT
410 420 430 440 450
IDCWEALPPM PHPMDNCSTT ACRGRLYAIG SLTGEDTMAI QCYDAESNRW
460 470 480 490 500
SLLNSGELPP WSFAPKSVTL NGLIYFVRDD SAEVDVYNPQ KNEWDKISPM
510 520 530 540 550
TQVHVGGSVS ALGGRLYVSG GYDNTFELSD VVEVYDPSSR SWSPAGRLPQ
560 570 580 590 600
PTFWHGSVSI FRQFMPLVQS TFEPIDIPEA NAIHLHRHHR NQALHNHNNN
610
VNQNHNQEVN QVH
Length:613
Mass (Da):69,737
Last modified:July 5, 2004 - v1
Checksum:iD83AFF765D17BC0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066537 mRNA. Translation: AAH66537.1.
BC155818 mRNA. Translation: AAI55819.1.
RefSeqiNP_001307336.1. NM_001320407.1.
XP_005162217.1. XM_005162160.3.
UniGeneiDr.85564.

Genome annotation databases

EnsembliENSDART00000057357; ENSDARP00000057356; ENSDARG00000039255.
ENSDART00000137486; ENSDARP00000121765; ENSDARG00000039255.
ENSDART00000140335; ENSDARP00000115156; ENSDARG00000039255.
ENSDART00000170172; ENSDARP00000138211; ENSDARG00000039255.
GeneIDi404613.
KEGGidre:404613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066537 mRNA. Translation: AAH66537.1.
BC155818 mRNA. Translation: AAI55819.1.
RefSeqiNP_001307336.1. NM_001320407.1.
XP_005162217.1. XM_005162160.3.
UniGeneiDr.85564.

3D structure databases

ProteinModelPortaliQ6NYM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121765.

Proteomic databases

PaxDbiQ6NYM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000057357; ENSDARP00000057356; ENSDARG00000039255.
ENSDART00000137486; ENSDARP00000121765; ENSDARG00000039255.
ENSDART00000140335; ENSDARP00000115156; ENSDARG00000039255.
ENSDART00000170172; ENSDARP00000138211; ENSDARG00000039255.
GeneIDi404613.
KEGGidre:404613.

Organism-specific databases

CTDi9903.
ZFINiZDB-GENE-040426-2627. klhl21.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ6NYM1.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiQ6NYM1.
TreeFamiTF329218.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ6NYM1.

Gene expression databases

BgeeiENSDARG00000039255.
ExpressionAtlasiQ6NYM1. differential.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH21_DANRE
AccessioniPrimary (citable) accession number: Q6NYM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.