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Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

spred2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
Gene namesi
Name:spred2
ORF Names:zgc:77284
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2342 spred2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769131 – 413Sprouty-related, EVH1 domain-containing protein 2Add BLAST413

Proteomic databases

PaxDbiQ6NYK3
PRIDEiQ6NYK3

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000045291

Structurei

3D structure databases

ProteinModelPortaliQ6NYK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122WH1PROSITE-ProRule annotationAdd BLAST118
Domaini195 – 248KBDPROSITE-ProRule annotationAdd BLAST54
Domaini303 – 411SPRPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

eggNOGiENOG410IQ21 Eukaryota
ENOG410Y62R LUCA
HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ6NYK3
KOiK04703
PhylomeDBiQ6NYK3

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEETHPNDD SYIVRVKAVV MTRDDSSGGW LAQEGGGLSR VGVCKVMPAE
60 70 80 90 100
LTGRSDFLIH GERLKDKQVI LECFVRKDLI YTKATPTFHH WKVDNKKCGL
110 120 130 140 150
TFQSPADARA FDRGVRKALE DLTEGSTTSS STLQNEAELG DDDVFTTATD
160 170 180 190 200
SSSNSSQKKD HSTQLVATST FYEPHPHRCI LQYRPPERYT LDQKFSRNLF
210 220 230 240 250
PFEDEEIVRI NPRERWMITG YEDYRYAAVP DKFIQPEDSD SYVQISKNDP
260 270 280 290 300
VKHDYTYPYV PSPDFTQCDL KRPCGGGSTV VSTQPRAFIL KGKRRKEDGE
310 320 330 340 350
RSRCVYCRDM FNHEENRRGQ CHDAPDPIRT CIHRVSFMWC ADSMLYHCMS
360 370 380 390 400
DPEGDYSDPC SCDTSEERFC LRWTALLGLA MLAPCLCCYP PLHGCHRCGV
410
ACGCCGGKHK AVG
Length:413
Mass (Da):46,830
Last modified:July 5, 2004 - v1
Checksum:i489E71676A1D73E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066561 mRNA Translation: AAH66561.1
RefSeqiNP_998399.1, NM_213234.1
UniGeneiDr.33129

Genome annotation databases

GeneIDi793290
KEGGidre:793290

Similar proteinsi

Entry informationi

Entry nameiSPRE2_DANRE
AccessioniPrimary (citable) accession number: Q6NYK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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