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Q6NYK3 (SPRE2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sprouty-related, EVH1 domain-containing protein 2

Short name=Spred-2
Gene names
Name:spred2
ORF Names:zgc:77284
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Subunit structure

Interacts with Ras By similarity.

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Phosphorylated on tyrosine By similarity.

Sequence similarities

Contains 1 KBD domain.

Contains 1 SPR (sprouty) domain.

Contains 1 WH1 domain.

Ontologies

Keywords
   Cellular componentMembrane
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: InterPro

regulation of signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Sprouty-related, EVH1 domain-containing protein 2
PRO_0000076913

Regions

Domain5 – 122118WH1
Domain195 – 24854KBD
Domain303 – 411109SPR

Sequences

Sequence LengthMass (Da)Tools
Q6NYK3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 489E71676A1D73E4

FASTA41346,830
        10         20         30         40         50         60 
MIEETHPNDD SYIVRVKAVV MTRDDSSGGW LAQEGGGLSR VGVCKVMPAE LTGRSDFLIH 

        70         80         90        100        110        120 
GERLKDKQVI LECFVRKDLI YTKATPTFHH WKVDNKKCGL TFQSPADARA FDRGVRKALE 

       130        140        150        160        170        180 
DLTEGSTTSS STLQNEAELG DDDVFTTATD SSSNSSQKKD HSTQLVATST FYEPHPHRCI 

       190        200        210        220        230        240 
LQYRPPERYT LDQKFSRNLF PFEDEEIVRI NPRERWMITG YEDYRYAAVP DKFIQPEDSD 

       250        260        270        280        290        300 
SYVQISKNDP VKHDYTYPYV PSPDFTQCDL KRPCGGGSTV VSTQPRAFIL KGKRRKEDGE 

       310        320        330        340        350        360 
RSRCVYCRDM FNHEENRRGQ CHDAPDPIRT CIHRVSFMWC ADSMLYHCMS DPEGDYSDPC 

       370        380        390        400        410 
SCDTSEERFC LRWTALLGLA MLAPCLCCYP PLHGCHRCGV ACGCCGGKHK AVG 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC066561 mRNA. Translation: AAH66561.1.
RefSeqNP_998399.1. NM_213234.1.
UniGeneDr.33129.

3D structure databases

ProteinModelPortalQ6NYK3.
SMRQ6NYK3. Positions 1-124.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID793290.
KEGGdre:793290.

Organism-specific databases

CTD793290.
ZFINZDB-GENE-040426-2342. spred2b.

Phylogenomic databases

eggNOGNOG277322.
HOGENOMHOG000220886.
HOVERGENHBG057556.
InParanoidQ6NYK3.
KOK04703.
PhylomeDBQ6NYK3.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20931386.

Entry information

Entry nameSPRE2_DANRE
AccessionPrimary (citable) accession number: Q6NYK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families