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Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

spred2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

GO - Biological processi

  1. multicellular organismal development Source: InterPro
  2. regulation of signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
Gene namesi
Name:spred2
ORF Names:zgc:77284
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2342. spred2b.

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Sprouty-related, EVH1 domain-containing protein 2PRO_0000076913Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Ras.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NYK3.
SMRiQ6NYK3. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 122118WH1PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 24854KBDPROSITE-ProRule annotationAdd
BLAST
Domaini303 – 411109SPRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KBD domain.PROSITE-ProRule annotation
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
Contains 1 WH1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG277322.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ6NYK3.
KOiK04703.
PhylomeDBiQ6NYK3.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NYK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEETHPNDD SYIVRVKAVV MTRDDSSGGW LAQEGGGLSR VGVCKVMPAE
60 70 80 90 100
LTGRSDFLIH GERLKDKQVI LECFVRKDLI YTKATPTFHH WKVDNKKCGL
110 120 130 140 150
TFQSPADARA FDRGVRKALE DLTEGSTTSS STLQNEAELG DDDVFTTATD
160 170 180 190 200
SSSNSSQKKD HSTQLVATST FYEPHPHRCI LQYRPPERYT LDQKFSRNLF
210 220 230 240 250
PFEDEEIVRI NPRERWMITG YEDYRYAAVP DKFIQPEDSD SYVQISKNDP
260 270 280 290 300
VKHDYTYPYV PSPDFTQCDL KRPCGGGSTV VSTQPRAFIL KGKRRKEDGE
310 320 330 340 350
RSRCVYCRDM FNHEENRRGQ CHDAPDPIRT CIHRVSFMWC ADSMLYHCMS
360 370 380 390 400
DPEGDYSDPC SCDTSEERFC LRWTALLGLA MLAPCLCCYP PLHGCHRCGV
410
ACGCCGGKHK AVG
Length:413
Mass (Da):46,830
Last modified:July 5, 2004 - v1
Checksum:i489E71676A1D73E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066561 mRNA. Translation: AAH66561.1.
RefSeqiNP_998399.1. NM_213234.1.
UniGeneiDr.33129.

Genome annotation databases

GeneIDi793290.
KEGGidre:793290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066561 mRNA. Translation: AAH66561.1.
RefSeqiNP_998399.1. NM_213234.1.
UniGeneiDr.33129.

3D structure databases

ProteinModelPortaliQ6NYK3.
SMRiQ6NYK3. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi793290.
KEGGidre:793290.

Organism-specific databases

CTDi793290.
ZFINiZDB-GENE-040426-2342. spred2b.

Phylogenomic databases

eggNOGiNOG277322.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ6NYK3.
KOiK04703.
PhylomeDBiQ6NYK3.

Miscellaneous databases

NextBioi20931386.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSPRE2_DANRE
AccessioniPrimary (citable) accession number: Q6NYK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.