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Q6NYK3

- SPRE2_DANRE

UniProt

Q6NYK3 - SPRE2_DANRE

Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

spred2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

    GO - Biological processi

    1. multicellular organismal development Source: InterPro
    2. regulation of signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 2
    Short name:
    Spred-2
    Gene namesi
    Name:spred2
    ORF Names:zgc:77284
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-2342. spred2b.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Sprouty-related, EVH1 domain-containing protein 2PRO_0000076913Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Ras.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NYK3.
    SMRiQ6NYK3. Positions 1-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 122118WH1PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 24854KBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 411109SPRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 KBD domain.PROSITE-ProRule annotation
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG277322.
    HOGENOMiHOG000220886.
    HOVERGENiHBG057556.
    InParanoidiQ6NYK3.
    KOiK04703.
    PhylomeDBiQ6NYK3.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NYK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEETHPNDD SYIVRVKAVV MTRDDSSGGW LAQEGGGLSR VGVCKVMPAE    50
    LTGRSDFLIH GERLKDKQVI LECFVRKDLI YTKATPTFHH WKVDNKKCGL 100
    TFQSPADARA FDRGVRKALE DLTEGSTTSS STLQNEAELG DDDVFTTATD 150
    SSSNSSQKKD HSTQLVATST FYEPHPHRCI LQYRPPERYT LDQKFSRNLF 200
    PFEDEEIVRI NPRERWMITG YEDYRYAAVP DKFIQPEDSD SYVQISKNDP 250
    VKHDYTYPYV PSPDFTQCDL KRPCGGGSTV VSTQPRAFIL KGKRRKEDGE 300
    RSRCVYCRDM FNHEENRRGQ CHDAPDPIRT CIHRVSFMWC ADSMLYHCMS 350
    DPEGDYSDPC SCDTSEERFC LRWTALLGLA MLAPCLCCYP PLHGCHRCGV 400
    ACGCCGGKHK AVG 413
    Length:413
    Mass (Da):46,830
    Last modified:July 5, 2004 - v1
    Checksum:i489E71676A1D73E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066561 mRNA. Translation: AAH66561.1.
    RefSeqiNP_998399.1. NM_213234.1.
    UniGeneiDr.33129.

    Genome annotation databases

    GeneIDi793290.
    KEGGidre:793290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066561 mRNA. Translation: AAH66561.1 .
    RefSeqi NP_998399.1. NM_213234.1.
    UniGenei Dr.33129.

    3D structure databases

    ProteinModelPortali Q6NYK3.
    SMRi Q6NYK3. Positions 1-124.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 793290.
    KEGGi dre:793290.

    Organism-specific databases

    CTDi 793290.
    ZFINi ZDB-GENE-040426-2342. spred2b.

    Phylogenomic databases

    eggNOGi NOG277322.
    HOGENOMi HOG000220886.
    HOVERGENi HBG057556.
    InParanoidi Q6NYK3.
    KOi K04703.
    PhylomeDBi Q6NYK3.

    Miscellaneous databases

    NextBioi 20931386.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSPRE2_DANRE
    AccessioniPrimary (citable) accession number: Q6NYK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3