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Protein

Purine nucleoside phosphorylase

Gene

pnp5a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37PhosphateUniRule annotation1
Binding sitei68PhosphateUniRule annotation1
Binding sitei120Phosphate; via amide nitrogenUniRule annotation1
Binding sitei205Purine nucleosideUniRule annotation1
Binding sitei224PhosphateUniRule annotation1
Binding sitei247Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-6798695 Neutrophil degranulation
R-DRE-74217 Purine salvage
R-DRE-74259 Purine catabolism
UniPathwayiUPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:pnp5aImported
Synonyms:npImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-2553 pnp5a

Expressioni

Gene expression databases

BgeeiENSDARG00000078619

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093456

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 283PNP_UDP_1InterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Phosphate bindingUniRule annotation3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 278Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
GeneTreeiENSGT00550000074740
HOGENOMiHOG000045183
HOVERGENiHBG002460
KOiK03783
OMAiDQVAFNY
OrthoDBiEOG091G0GEE
TreeFamiTF300049

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NYG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPESNTGYS FEDCQATADW LLSQTAVRPL VGIVCGSGLG GLADALKDQV
60 70 80 90 100
AFNYRDIPNF PQSTVHGHAG RLVFGTLKGR PCVCMQGRFH LYEGYPIQKI
110 120 130 140 150
TMPMRIFKML GVETVILTNA AGGLNQDYKV GDIMIIKDHL NMPGFAGNNP
160 170 180 190 200
LAGHNDERFG VRFPCMSDAY DRELQQMALD VGSELGFSDF LREGVYCVLG
210 220 230 240 250
GPSFETIAEC RMLHKLGADA VGMSTVHEVI VARHCGMRVF ALSLITNKAV
260 270 280 290
MDYDSEEKAN HEEVLQTGKQ RAEQLERLVS TIITRLEHNN NYA
Length:293
Mass (Da):32,371
Last modified:July 5, 2004 - v1
Checksum:iAB574BE87501863E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU464117 Genomic DNA No translation available.
BC066610 mRNA Translation: AAH66610.1
RefSeqiNP_998476.1, NM_213311.2
UniGeneiDr.105888

Genome annotation databases

EnsembliENSDART00000102681; ENSDARP00000093456; ENSDARG00000078619
GeneIDi791647
KEGGidre:791647

Similar proteinsi

Entry informationi

Entry nameiQ6NYG0_DANRE
AccessioniPrimary (citable) accession number: Q6NYG0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health