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Protein

Purine nucleoside phosphorylase

Gene

pnp5a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37PhosphateUniRule annotation1
Binding sitei68PhosphateUniRule annotation1
Binding sitei120Phosphate; via amide nitrogenUniRule annotation1
Binding sitei205Purine nucleosideUniRule annotation1
Binding sitei224PhosphateUniRule annotation1
Binding sitei247Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-74217. Purine salvage.
R-DRE-74259. Purine catabolism.
UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:pnp5aImported
Synonyms:npImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-2553. pnp5a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000078619.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093456.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 283PNP_UDP_1InterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984. Eukaryota.
COG0005. LUCA.
GeneTreeiENSGT00550000074740.
HOGENOMiHOG000045183.
HOVERGENiHBG002460.
KOiK03783.
OMAiHEEVMAV.
OrthoDBiEOG091G0GEE.
TreeFamiTF300049.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NYG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPESNTGYS FEDCQATADW LLSQTAVRPL VGIVCGSGLG GLADALKDQV
60 70 80 90 100
AFNYRDIPNF PQSTVHGHAG RLVFGTLKGR PCVCMQGRFH LYEGYPIQKI
110 120 130 140 150
TMPMRIFKML GVETVILTNA AGGLNQDYKV GDIMIIKDHL NMPGFAGNNP
160 170 180 190 200
LAGHNDERFG VRFPCMSDAY DRELQQMALD VGSELGFSDF LREGVYCVLG
210 220 230 240 250
GPSFETIAEC RMLHKLGADA VGMSTVHEVI VARHCGMRVF ALSLITNKAV
260 270 280 290
MDYDSEEKAN HEEVLQTGKQ RAEQLERLVS TIITRLEHNN NYA
Length:293
Mass (Da):32,371
Last modified:July 5, 2004 - v1
Checksum:iAB574BE87501863E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU464117 Genomic DNA. No translation available.
BC066610 mRNA. Translation: AAH66610.1.
RefSeqiNP_998476.1. NM_213311.2.
UniGeneiDr.105888.

Genome annotation databases

EnsembliENSDART00000102681; ENSDARP00000093456; ENSDARG00000078619.
GeneIDi791647.
KEGGidre:791647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU464117 Genomic DNA. No translation available.
BC066610 mRNA. Translation: AAH66610.1.
RefSeqiNP_998476.1. NM_213311.2.
UniGeneiDr.105888.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000102681; ENSDARP00000093456; ENSDARG00000078619.
GeneIDi791647.
KEGGidre:791647.

Organism-specific databases

CTDi791647.
ZFINiZDB-GENE-040426-2553. pnp5a.

Phylogenomic databases

eggNOGiKOG3984. Eukaryota.
COG0005. LUCA.
GeneTreeiENSGT00550000074740.
HOGENOMiHOG000045183.
HOVERGENiHBG002460.
KOiK03783.
OMAiHEEVMAV.
OrthoDBiEOG091G0GEE.
TreeFamiTF300049.

Enzyme and pathway databases

UniPathwayiUPA00606.
ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-74217. Purine salvage.
R-DRE-74259. Purine catabolism.

Gene expression databases

BgeeiENSDARG00000078619.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6NYG0_DANRE
AccessioniPrimary (citable) accession number: Q6NYG0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.