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Protein

Protein RCC2 homolog

Gene

rcc2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for completion of mitosis and cytokinesis.By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • neural crest cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2500257. Resolution of Sister Chromatid Cohesion.
R-DRE-5663220. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RCC2 homolog
Gene namesi
Name:rcc2
ORF Names:zgc:77115
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040426-2213. rcc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066541 – 495Protein RCC2 homologAdd BLAST495

Proteomic databases

PaxDbiQ6NYE2.
PRIDEiQ6NYE2.

Expressioni

Gene expression databases

BgeeiENSDARG00000011510.
ExpressionAtlasiQ6NYE2. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004838.

Structurei

3D structure databases

ProteinModelPortaliQ6NYE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 138RCC1 1Add BLAST63
Repeati141 – 192RCC1 2Add BLAST52
Repeati194 – 244RCC1 3Add BLAST51
Repeati246 – 320RCC1 4Add BLAST75
Repeati321 – 374RCC1 5Add BLAST54
Repeati376 – 420RCC1 6Add BLAST45
Repeati421 – 474RCC1 7Add BLAST54

Sequence similaritiesi

Contains 7 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1427. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOGENOMiHOG000232061.
HOVERGENiHBG080538.
InParanoidiQ6NYE2.
OMAiFWGVTNT.
OrthoDBiEOG091G07AD.
PhylomeDBiQ6NYE2.
TreeFamiTF101168.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NYE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKKVTDVS GNGGLKRKRG GGKKKEREFS SDDEFDDYEQ ENTKKPGKPA
60 70 80 90 100
AKAGLQPVTV ADDVKEKIKL EVPKVKGQLL IFGATNWDLI GRKEVPKQQA
110 120 130 140 150
AFRNLGQNLW GPHRYGCLSD VQVSCVVSGP CAAHSLIITT EGKLWSWGRN
160 170 180 190 200
DKGQLGHGDT KRLEAPKLIE GLGEEVIVAA ACGRNHTLAL TENGTVYTFG
210 220 230 240 250
ENKLGQLGQG NQTDAVLSPA TIQYNGQPIV KVACGAEFSM IVDCKGNLYS
260 270 280 290 300
FGCPEYGQLG HNSDGKFIAR AQRIEFDCEL IPRRVAIFIE KTKDGQVLPV
310 320 330 340 350
PNVVARDVAC GANHTLVLDS QKRVFSWGFG GYGRLGHAEQ KDEMVPRLVK
360 370 380 390 400
LFDFPGRGAT QIYCGYQCSF ALSEMGGLFF WGVTNTSRES TMYPKAVQDL
410 420 430 440 450
CGWKIRSLAC GKSSIIVAAD DSTISWGPSP TFGELGYGDN KPKSSTTAQE
460 470 480 490
VKTLDGVYSE QVVMGYSHSL VIARQDTEQE KEKLKKLPEY NPRTL
Length:495
Mass (Da):54,152
Last modified:July 5, 2004 - v1
Checksum:i8AC9A686AA071074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066628 mRNA. Translation: AAH66628.1.
RefSeqiNP_998341.1. NM_213176.1.
XP_005162219.1. XM_005162162.3.
XP_017209027.1. XM_017353538.1.
UniGeneiDr.828.

Genome annotation databases

EnsembliENSDART00000010647; ENSDARP00000004838; ENSDARG00000011510.
ENSDART00000170713; ENSDARP00000141590; ENSDARG00000011510.
GeneIDi406455.
KEGGidre:406455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066628 mRNA. Translation: AAH66628.1.
RefSeqiNP_998341.1. NM_213176.1.
XP_005162219.1. XM_005162162.3.
XP_017209027.1. XM_017353538.1.
UniGeneiDr.828.

3D structure databases

ProteinModelPortaliQ6NYE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004838.

Proteomic databases

PaxDbiQ6NYE2.
PRIDEiQ6NYE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010647; ENSDARP00000004838; ENSDARG00000011510.
ENSDART00000170713; ENSDARP00000141590; ENSDARG00000011510.
GeneIDi406455.
KEGGidre:406455.

Organism-specific databases

CTDi55920.
ZFINiZDB-GENE-040426-2213. rcc2.

Phylogenomic databases

eggNOGiKOG1427. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOGENOMiHOG000232061.
HOVERGENiHBG080538.
InParanoidiQ6NYE2.
OMAiFWGVTNT.
OrthoDBiEOG091G07AD.
PhylomeDBiQ6NYE2.
TreeFamiTF101168.

Enzyme and pathway databases

ReactomeiR-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2500257. Resolution of Sister Chromatid Cohesion.
R-DRE-5663220. RHO GTPases Activate Formins.

Miscellaneous databases

PROiQ6NYE2.

Gene expression databases

BgeeiENSDARG00000011510.
ExpressionAtlasiQ6NYE2. differential.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 4 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCC2_DANRE
AccessioniPrimary (citable) accession number: Q6NYE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.