Q6NYB7 (RAB1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-1A

Gene names

Name:	Rab1A
Synonyms:	Rab1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity.
Subunit structure	May interact with YIPF5 By similarity.
Subcellular location	Golgi apparatus. Endoplasmic reticulum.
Tissue specificity	Expressed in flagella of epididymal sperm. Ref.3
Post-translational modification	Phosphorylated by CDK1 kinase during mitosis By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Lipoprotein Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from direct assay PubMed 15728249. Source: MGI Rab protein signal transduction Inferred by curator PubMed 8807639. Source: RGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from direct assay PubMed 8807639. Source: RGD endoplasmic reticulum membrane Inferred from direct assay PubMed 8807639. Source: RGD neuronal cell body Inferred from direct assay PubMed 8573789. Source: RGD
Molecular_function	GTP binding Inferred from direct assay PubMed 8807639. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 205	204	Ras-related protein Rab-1A		PRO_0000121059
Regions
	Nucleotide binding	18 – 26	9	GTP By similarity
	Nucleotide binding	66 – 70	5	GTP By similarity
	Nucleotide binding	124 – 127	4	GTP By similarity
	Nucleotide binding	154 – 156	3	GTP By similarity
	Motif	40 – 48	9	Effector region By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	194	1	Phosphoserine; by CDK1 By similarity
	Lipidation	204	1	S-geranylgeranyl cysteine By similarity
	Lipidation	205	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	158 – 159	2	AT → EK in AAA42006. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6NYB7 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B2A8F4E3B0FB17D6	FASTA	205	22,678
	10 20 30 40 50 60 MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI 70 80 90 100 110 120 KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL 130 140 150 160 170 180 LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN VEQSFMTMAA EIKKRMGPGA 190 200 TAGGAEKSNV KIQSTPVKQS GGGCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library." Touchot N., Chardin P., Tavitian A. Proc. Natl. Acad. Sci. U.S.A. 84:8210-8214(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	"Identification of novel immunodominant epididymal sperm proteins using combinatorial approach." Khan S.A., Suryawanshi A.R., Ranpura S.A., Jadhav S.V., Khole V.V. Reproduction 138:81-93(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02998 mRNA. Translation: AAA42006.1. BC066662 mRNA. Translation: AAH66662.1.
IPI	IPI00421897.
PIR	TVRTYP. A39963.
RefSeq	NP_112352.2. NM_031090.2.
UniGene	Rn.106743.
3D structure databases
ProteinModelPortal	Q6NYB7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6NYB7. 1 interaction.
PTM databases
PhosphoSite	Q6NYB7.
Proteomic databases
PaxDb	Q6NYB7.
PRIDE	Q6NYB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	81754.
KEGG	rno:81754.
UCSC	RGD:619736. rat.
Organism-specific databases
CTD	5861.
RGD	619736. Rab1.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
KO	K07874.
Gene expression databases
ArrayExpress	Q6NYB7.
Genevestigator	Q6NYB7.
GermOnline	ENSRNOG00000004992. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20817273.

Entry information

Entry name

RAB1A_RAT

Accession

Primary (citable) accession number: Q6NYB7
Secondary accession number(s): P05711

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program