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Protein

Ras-related protein Rab-1A

Gene

Rab1A

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in anterograde melanosome transport (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi36 – 43GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: RGD

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • autophagy Source: UniProtKB
  • cell migration Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • endocytosis Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: MGI
  • growth hormone secretion Source: UniProtKB
  • interleukin-8 secretion Source: UniProtKB
  • Rab protein signal transduction Source: RGD
  • vesicle transport along microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy, ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-1A
Gene namesi
Name:Rab1A
Synonyms:Rab1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi619736. Rab1.

Subcellular locationi

  • Golgi apparatus By similarity
  • Endoplasmic reticulum By similarity
  • Early endosome 1 Publication
  • Cytoplasmcytosol By similarity
  • Membrane By similarity
  • Melanosome By similarity

  • Note: Alternates between membrane-associated and cytosolic forms.By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • early endosome Source: UniProtKB
  • endoplasmic reticulum membrane Source: RGD
  • Golgi membrane Source: RGD
  • melanosome Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210592 – 205Ras-related protein Rab-1AAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei79O-(2-cholinephosphoryl)serineBy similarity1
Modified residuei194Phosphoserine; by CDK1By similarity1
Lipidationi204S-geranylgeranyl cysteineBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiQ6NYB7.

PTM databases

iPTMnetiQ6NYB7.
PhosphoSitePlusiQ6NYB7.

Expressioni

Tissue specificityi

Expressed in flagella of epididymal sperm.1 Publication

Gene expression databases

ExpressionAtlasiQ6NYB7. baseline and differential.
GenevisibleiQ6NYB7. RN.

Interactioni

Subunit structurei

May interact with YIPF5. Interacts with GDI1; this promotes dissociation from membranes. Interacts with C9orf72 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249626. 2 interactors.
IntActiQ6NYB7. 1 interactor.
MINTiMINT-4576596.

Structurei

3D structure databases

ProteinModelPortaliQ6NYB7.
SMRiQ6NYB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6NYB7.
KOiK07874.
PhylomeDBiQ6NYB7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NYB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI
60 70 80 90 100
RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN
110 120 130 140 150
NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF
160 170 180 190 200
LETSAKNATN VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS

GGGCC
Length:205
Mass (Da):22,678
Last modified:January 23, 2007 - v3
Checksum:iB2A8F4E3B0FB17D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158 – 159AT → EK in AAA42006 (PubMed:3317403).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02998 mRNA. Translation: AAA42006.1.
BC066662 mRNA. Translation: AAH66662.1.
PIRiA39963. TVRTYP.
RefSeqiNP_112352.2. NM_031090.2.
UniGeneiRn.106743.

Genome annotation databases

EnsembliENSRNOT00000084481; ENSRNOP00000073493; ENSRNOG00000004992.
GeneIDi81754.
KEGGirno:81754.
UCSCiRGD:619736. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02998 mRNA. Translation: AAA42006.1.
BC066662 mRNA. Translation: AAH66662.1.
PIRiA39963. TVRTYP.
RefSeqiNP_112352.2. NM_031090.2.
UniGeneiRn.106743.

3D structure databases

ProteinModelPortaliQ6NYB7.
SMRiQ6NYB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249626. 2 interactors.
IntActiQ6NYB7. 1 interactor.
MINTiMINT-4576596.

PTM databases

iPTMnetiQ6NYB7.
PhosphoSitePlusiQ6NYB7.

Proteomic databases

PRIDEiQ6NYB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084481; ENSRNOP00000073493; ENSRNOG00000004992.
GeneIDi81754.
KEGGirno:81754.
UCSCiRGD:619736. rat.

Organism-specific databases

CTDi5861.
RGDi619736. Rab1.

Phylogenomic databases

GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6NYB7.
KOiK07874.
PhylomeDBiQ6NYB7.

Enzyme and pathway databases

ReactomeiR-RNO-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiQ6NYB7.

Gene expression databases

ExpressionAtlasiQ6NYB7. baseline and differential.
GenevisibleiQ6NYB7. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB1A_RAT
AccessioniPrimary (citable) accession number: Q6NYB7
Secondary accession number(s): P05711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.