Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6NY77 (HOGA1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

EC=4.1.3.16
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name=Probable KHG-aldolase
Gene names
ORF Names:zgc:77082
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulation

Inhibited by divalent cations By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the DapA family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function4-hydroxy-2-oxoglutarate aldolase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion Potential
Chain23 – 3243024-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000273348

Regions

Region74 – 752Substrate binding By similarity

Sites

Active site1931Schiff-base intermediate with substrate By similarity
Binding site1951Substrate By similarity
Binding site2191Substrate; via carbonyl oxygen By similarity
Site1651Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NY77 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C2D821D59F046031

FASTA32435,307
        10         20         30         40         50         60 
MFAHRSFSLL CRRSAVTSWR SQSHTAGKRL DISGIYPPIA TPFTEPEDVD YQKLDDNIRK 

        70         80         90        100        110        120 
YGRLPFRGLV VQGSNGEYPY LTAEERVEVV KRVKQALPKD KLVMAGSGCE STRATIQMSQ 

       130        140        150        160        170        180 
RMADAGADCV LVVTPCFYRG RMDSRALINH YSKVADSCSV PVVLYSVPAN TGLDLPVDAV 

       190        200        210        220        230        240 
IQLSKHPNIV GLKDSGGDIT RIALMVQKTR SQDFQVLAGS AGFLMAAYAV GAVGGVCALA 

       250        260        270        280        290        300 
NVLGQQVCEL AQLCVSGRWD EAKELQYRLI EPNTAVTRGF GVPALKLAMD WFGYHGGICR 

       310        320 
SPLQPLSKAD LEALRGKFSS NGWL 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC066708 mRNA. Translation: AAH66708.1.
RefSeqNP_998035.1. NM_212870.1.
UniGeneDr.25699.

3D structure databases

ProteinModelPortalQ6NY77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000021126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000025820; ENSDARP00000021126; ENSDARG00000018944.
GeneID405806.
KEGGdre:405806.

Organism-specific databases

CTD112817.
ZFINZDB-GENE-040426-2242. hoga1.

Phylogenomic databases

eggNOGCOG0329.
GeneTreeENSGT00530000063604.
HOVERGENHBG081405.
InParanoidQ6NY77.
OMATHKEHMR.
OrthoDBEOG7H4DTV.
PhylomeDBQ6NY77.
TreeFamTF324600.

Gene expression databases

BgeeQ6NY77.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view]
PANTHERPTHR12128. PTHR12128. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
PROSITEPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817771.
PROQ6NY77.

Entry information

Entry nameHOGA1_DANRE
AccessionPrimary (citable) accession number: Q6NY77
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families