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Q6NY77

- HOGA1_DANRE

UniProt

Q6NY77 - HOGA1_DANRE

Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

zgc:77082

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

    Enzyme regulationi

    Inhibited by divalent cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei165 – 1651Involved in proton transfer during cleavageBy similarity
    Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
    Binding sitei195 – 1951SubstrateBy similarity
    Binding sitei219 – 2191Substrate; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB

    GO - Biological processi

    1. glyoxylate catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Probable 2-keto-4-hydroxyglutarate aldolase
    Short name:
    Probable KHG-aldolase
    Gene namesi
    ORF Names:zgc:77082
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 22

    Organism-specific databases

    ZFINiZDB-GENE-040426-2242. hoga1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 3243024-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273348Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ6NY77.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000021126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NY77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 752Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0329.
    GeneTreeiENSGT00530000063604.
    HOVERGENiHBG081405.
    InParanoidiQ6NY77.
    KOiK18123.
    OMAiLADHENI.
    OrthoDBiEOG7H4DTV.
    PhylomeDBiQ6NY77.
    TreeFamiTF324600.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.
    PROSITEiPS00666. DHDPS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6NY77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAHRSFSLL CRRSAVTSWR SQSHTAGKRL DISGIYPPIA TPFTEPEDVD    50
    YQKLDDNIRK YGRLPFRGLV VQGSNGEYPY LTAEERVEVV KRVKQALPKD 100
    KLVMAGSGCE STRATIQMSQ RMADAGADCV LVVTPCFYRG RMDSRALINH 150
    YSKVADSCSV PVVLYSVPAN TGLDLPVDAV IQLSKHPNIV GLKDSGGDIT 200
    RIALMVQKTR SQDFQVLAGS AGFLMAAYAV GAVGGVCALA NVLGQQVCEL 250
    AQLCVSGRWD EAKELQYRLI EPNTAVTRGF GVPALKLAMD WFGYHGGICR 300
    SPLQPLSKAD LEALRGKFSS NGWL 324
    Length:324
    Mass (Da):35,307
    Last modified:July 5, 2004 - v1
    Checksum:iC2D821D59F046031
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066708 mRNA. Translation: AAH66708.1.
    RefSeqiNP_998035.1. NM_212870.1.
    UniGeneiDr.25699.

    Genome annotation databases

    EnsembliENSDART00000025820; ENSDARP00000021126; ENSDARG00000018944.
    GeneIDi405806.
    KEGGidre:405806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066708 mRNA. Translation: AAH66708.1 .
    RefSeqi NP_998035.1. NM_212870.1.
    UniGenei Dr.25699.

    3D structure databases

    ProteinModelPortali Q6NY77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000021126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000025820 ; ENSDARP00000021126 ; ENSDARG00000018944 .
    GeneIDi 405806.
    KEGGi dre:405806.

    Organism-specific databases

    CTDi 112817.
    ZFINi ZDB-GENE-040426-2242. hoga1.

    Phylogenomic databases

    eggNOGi COG0329.
    GeneTreei ENSGT00530000063604.
    HOVERGENi HBG081405.
    InParanoidi Q6NY77.
    KOi K18123.
    OMAi LADHENI.
    OrthoDBi EOG7H4DTV.
    PhylomeDBi Q6NY77.
    TreeFami TF324600.

    Miscellaneous databases

    NextBioi 20817771.
    PROi Q6NY77.

    Gene expression databases

    Bgeei Q6NY77.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    PROSITEi PS00666. DHDPS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHOGA1_DANRE
    AccessioniPrimary (citable) accession number: Q6NY77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3