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Q6NY77

- HOGA1_DANRE

UniProt

Q6NY77 - HOGA1_DANRE

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Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

zgc:77082

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei165 – 1651Involved in proton transfer during cleavageBy similarity
Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei219 – 2191Substrate; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB

GO - Biological processi

  1. glyoxylate catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name:
Probable KHG-aldolase
Gene namesi
ORF Names:zgc:77082
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-2242. hoga1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 3243024-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273348Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6NY77.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000021126.

Structurei

3D structure databases

ProteinModelPortaliQ6NY77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 752Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DapA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0329.
GeneTreeiENSGT00530000063604.
HOVERGENiHBG081405.
InParanoidiQ6NY77.
KOiK18123.
OMAiLADHENI.
OrthoDBiEOG7H4DTV.
PhylomeDBiQ6NY77.
TreeFamiTF324600.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NY77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAHRSFSLL CRRSAVTSWR SQSHTAGKRL DISGIYPPIA TPFTEPEDVD
60 70 80 90 100
YQKLDDNIRK YGRLPFRGLV VQGSNGEYPY LTAEERVEVV KRVKQALPKD
110 120 130 140 150
KLVMAGSGCE STRATIQMSQ RMADAGADCV LVVTPCFYRG RMDSRALINH
160 170 180 190 200
YSKVADSCSV PVVLYSVPAN TGLDLPVDAV IQLSKHPNIV GLKDSGGDIT
210 220 230 240 250
RIALMVQKTR SQDFQVLAGS AGFLMAAYAV GAVGGVCALA NVLGQQVCEL
260 270 280 290 300
AQLCVSGRWD EAKELQYRLI EPNTAVTRGF GVPALKLAMD WFGYHGGICR
310 320
SPLQPLSKAD LEALRGKFSS NGWL
Length:324
Mass (Da):35,307
Last modified:July 5, 2004 - v1
Checksum:iC2D821D59F046031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066708 mRNA. Translation: AAH66708.1.
RefSeqiNP_998035.1. NM_212870.1.
UniGeneiDr.25699.

Genome annotation databases

EnsembliENSDART00000025820; ENSDARP00000021126; ENSDARG00000018944.
GeneIDi405806.
KEGGidre:405806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066708 mRNA. Translation: AAH66708.1 .
RefSeqi NP_998035.1. NM_212870.1.
UniGenei Dr.25699.

3D structure databases

ProteinModelPortali Q6NY77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000021126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000025820 ; ENSDARP00000021126 ; ENSDARG00000018944 .
GeneIDi 405806.
KEGGi dre:405806.

Organism-specific databases

CTDi 112817.
ZFINi ZDB-GENE-040426-2242. hoga1.

Phylogenomic databases

eggNOGi COG0329.
GeneTreei ENSGT00530000063604.
HOVERGENi HBG081405.
InParanoidi Q6NY77.
KOi K18123.
OMAi LADHENI.
OrthoDBi EOG7H4DTV.
PhylomeDBi Q6NY77.
TreeFami TF324600.

Miscellaneous databases

NextBioi 20817771.
PROi Q6NY77.

Gene expression databases

Bgeei Q6NY77.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
PROSITEi PS00666. DHDPS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiHOGA1_DANRE
AccessioniPrimary (citable) accession number: Q6NY77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3