Q6NY19 (KANK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
KN motif and ankyrin repeat domain-containing protein 3

Alternative name(s):
Ankyrin repeat domain-containing protein 47

Gene names

Name:	KANK3
Synonyms:	ANKRD47

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	840 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the control of cytoskeleton formation by regulating actin polymerization. Ref.3
Tissue specificity	Strongly expressed in breast, liver, lung, skeletal muscle and kidney. Ref.3
Sequence similarities	Contains 5 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NY19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NY19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     795-840: AGVQRHNLSSLQPPPPRFKKFSCLSLPSSWDYNSCEPSRLAQLTIF → SESPPGSQTATPGEGECGDNGENPQVQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 840	840	KN motif and ankyrin repeat domain-containing protein 3		PRO_0000244582
Regions
	Repeat	622 – 652	31	ANK 1
	Repeat	656 – 690	35	ANK 2
	Repeat	695 – 724	30	ANK 3
	Repeat	728 – 758	31	ANK 4
	Repeat	762 – 795	34	ANK 5
	Coiled coil	181 – 230	50	Potential
	Coiled coil	367 – 404	38	Potential
	Compositional bias	479 – 482	4	Poly-Ser
	Compositional bias	807 – 810	4	Poly-Pro
Natural variations
	Alternative sequence	795 – 840	46	AGVQR…QLTIF → SESPPGSQTATPGEGECGDN GENPQVQ in isoform 2.		VSP_019607
	Natural variant	288	1	D → Y. Ref.1 Corresponds to variant rs890850 [ dbSNP | Ensembl ].		VAR_026909
	Natural variant	359	1	R → H. Corresponds to variant rs890853 [ dbSNP | Ensembl ].		VAR_026910
	Natural variant	485	1	A → T. Ref.1 Corresponds to variant rs2913955 [ dbSNP | Ensembl ].		VAR_026911

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4F917006B1B0FB66	FASTA	840	88,425
	10 20 30 40 50 60 MAKFALNQNL PDLGGPRLCP VPAAGGARSP SSPYSVETPY GFHLDLDFLK YIEELERGPA 70 80 90 100 110 120 ARRAPGPPTS RRPRAPRPGL AGARSPGAWT SSESLASDDG GAPGILSQGA PSGLLMQPLS 130 140 150 160 170 180 PRAPVRNPRV EHTLRETSRR LELAQTHERA PSPGRGVPRS PRGSGRSSPA PNLAPASPGP 190 200 210 220 230 240 AQLQLVREQM AAALRRLREL EDQARTLPEL QEQVRALRAE KARLLAGRAQ PEPDGEAETR 250 260 270 280 290 300 PDKLAQLRRL TERLATSERG GRARASPRAD SPDGLAAGRS EGALQVLDGE VGSLDGTPQT 310 320 330 340 350 360 REVAAEAVPE TREAGAQAVP ETREAGVEAA PETVEADAWV TEALLGLPAA AERELELLRA 370 380 390 400 410 420 SLEHQRGVSE LLRGRLRELE EAREAAEEAA AGARAQLREA TTQTPWSCAE KAAQTESPAE 430 440 450 460 470 480 APSLTQESSP GSMDGDRAVA PAGILKSIMK KRDGTPGAQP SSGPKSLQFV GVLNGEYESS 490 500 510 520 530 540 SSEDASDSDG DSENGGAEPP GSSSGSGDDS GGGSDSGTPG PPSGGDIRDP EPEAEAEPQQ 550 560 570 580 590 600 VAQGRCELSP RLREACVALQ RQLSRPRGVA SDGGAVRLVA QEWFRVSSQR RSQAEPVARM 610 620 630 640 650 660 LEGVRRLGPE LLAHVVNLAD GNGNTALHYS VSHGNLAIAS LLLDTGACEV NRQNRAGYSA 670 680 690 700 710 720 LMLAALTSVR QEEEDMAVVQ RLFCMGDVNA KASQTGQTAL MLAISHGRQD MVATLLACGA 730 740 750 760 770 780 DVNAQDADGA TALMCASEYG RLDTVRLLLT QPGCDPAILD NEGTSALAIA LEAEQDEVAA 790 800 810 820 830 840 LLHAHLSSGQ PDTQAGVQRH NLSSLQPPPP RFKKFSCLSL PSSWDYNSCE PSRLAQLTIF
	Isoform 2 [UniParc]. Checksum: 66CCB7F5B1B251F5	FASTA	821	85,893
	10 20 30 40 50 60 MAKFALNQNL PDLGGPRLCP VPAAGGARSP SSPYSVETPY GFHLDLDFLK YIEELERGPA 70 80 90 100 110 120 ARRAPGPPTS RRPRAPRPGL AGARSPGAWT SSESLASDDG GAPGILSQGA PSGLLMQPLS 130 140 150 160 170 180 PRAPVRNPRV EHTLRETSRR LELAQTHERA PSPGRGVPRS PRGSGRSSPA PNLAPASPGP 190 200 210 220 230 240 AQLQLVREQM AAALRRLREL EDQARTLPEL QEQVRALRAE KARLLAGRAQ PEPDGEAETR 250 260 270 280 290 300 PDKLAQLRRL TERLATSERG GRARASPRAD SPDGLAAGRS EGALQVLDGE VGSLDGTPQT 310 320 330 340 350 360 REVAAEAVPE TREAGAQAVP ETREAGVEAA PETVEADAWV TEALLGLPAA AERELELLRA 370 380 390 400 410 420 SLEHQRGVSE LLRGRLRELE EAREAAEEAA AGARAQLREA TTQTPWSCAE KAAQTESPAE 430 440 450 460 470 480 APSLTQESSP GSMDGDRAVA PAGILKSIMK KRDGTPGAQP SSGPKSLQFV GVLNGEYESS 490 500 510 520 530 540 SSEDASDSDG DSENGGAEPP GSSSGSGDDS GGGSDSGTPG PPSGGDIRDP EPEAEAEPQQ 550 560 570 580 590 600 VAQGRCELSP RLREACVALQ RQLSRPRGVA SDGGAVRLVA QEWFRVSSQR RSQAEPVARM 610 620 630 640 650 660 LEGVRRLGPE LLAHVVNLAD GNGNTALHYS VSHGNLAIAS LLLDTGACEV NRQNRAGYSA 670 680 690 700 710 720 LMLAALTSVR QEEEDMAVVQ RLFCMGDVNA KASQTGQTAL MLAISHGRQD MVATLLACGA 730 740 750 760 770 780 DVNAQDADGA TALMCASEYG RLDTVRLLLT QPGCDPAILD NEGTSALAIA LEAEQDEVAA 790 800 810 820 LLHAHLSSGQ PDTQSESPPG SQTATPGEGE CGDNGENPQV Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-288 AND THR-485. Tissue: Mammary gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Placenta.
[3]	"Kank proteins: a new family of ankyrin-repeat domain-containing proteins." Zhu Y., Kakinuma N., Wang Y., Kiyama R. Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128815 mRNA. Translation: BAC87620.1. BC035849 mRNA. Translation: AAH35849.1. BC066124 mRNA. Translation: AAH66124.1. BC066775 mRNA. Translation: AAH66775.1.
IPI	IPI00394818. IPI00744564.
RefSeq	NP_940873.2. NM_198471.2.
UniGene	Hs.322473.
3D structure databases
ProteinModelPortal	Q6NY19.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6NY19. 1 interaction.
PTM databases
PhosphoSite	Q6NY19.
Polymorphism databases
DMDM	74749039.
Proteomic databases
PaxDb	Q6NY19.
PRIDE	Q6NY19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330915; ENSP00000328923; ENSG00000186994. ENST00000593649; ENSP00000470728; ENSG00000186994.
GeneID	256949.
KEGG	hsa:256949.
UCSC	uc010dwa.3. human.
Organism-specific databases
CTD	256949.
GeneCards	GC19M008387.
HGNC	HGNC:24796. KANK3.
HPA	HPA051153.
MIM	614611. gene.
neXtProt	NX_Q6NY19.
PharmGKB	PA162392612.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000060328.
HOVERGEN	HBG101217.
InParanoid	Q6NY19.
OMA	NPRVEHT.
Gene expression databases
Bgee	Q6NY19.
CleanEx	HS_KANK3.
Genevestigator	Q6NY19.
GermOnline	ENSG00000186994. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR021939. KN_motif. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF12075. KN_motif. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	256949.
NextBio	92881.
SOURCE	Search...

Entry information

Entry name

KANK3_HUMAN

Accession

Primary (citable) accession number: Q6NY19
Secondary accession number(s): Q6NZI1, Q6ZQR3, Q8IUV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.