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Protein

DNA-directed RNA polymerase III subunit RPC7

Gene

Polr3g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC7
Short name:
RNA polymerase III subunit C7
Alternative name(s):
DNA-directed RNA polymerase III subunit G
Gene namesi
Name:Polr3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914736 Polr3g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739791 – 223DNA-directed RNA polymerase III subunit RPC7Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134PhosphothreonineBy similarity1
Modified residuei158PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXY9
PaxDbiQ6NXY9
PeptideAtlasiQ6NXY9
PRIDEiQ6NXY9

PTM databases

iPTMnetiQ6NXY9
PhosphoSitePlusiQ6NXY9

Expressioni

Tissue specificityi

Expressed at low levels in the liver.1 Publication

Developmental stagei

Not detectable in unfertilized oocytes. First detected in zygotes and the 2-cell stage embryos. Expressed until at least the early blastocyst stage.1 Publication

Gene expression databases

BgeeiENSMUSG00000035834
CleanExiMM_POLR3G
GenevisibleiQ6NXY9 MM

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Directly interacts with POLR3C/RPC62. Also found a trimeric complex with POLR3C and POLR3GL.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035289

Structurei

3D structure databases

ProteinModelPortaliQ6NXY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKHU Eukaryota
ENOG4112311 LUCA
GeneTreeiENSGT00390000002422
HOGENOMiHOG000293249
HOVERGENiHBG054922
InParanoidiQ6NXY9
KOiK03024
OMAiEWIPDWR
OrthoDBiEOG091G0TN0
PhylomeDBiQ6NXY9
TreeFamiTF103052

Family and domain databases

InterProiView protein in InterPro
IPR024661 RNA_pol_III_Rpc31
PANTHERiPTHR15367 PTHR15367, 1 hit
PfamiView protein in Pfam
PF11705 RNA_pol_3_Rpc31, 1 hit
PIRSFiPIRSF000777 RNA_polIII_C31, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNKGRGRA AYTFNIEAVG FSRGEKLPDV VLKPPPLFPD TDYKPVPLKT
60 70 80 90 100
GEDEDYMLAL KQELRETVKR LPYFIEPPEE KQDDIERYSK RYMKVYKEEW
110 120 130 140 150
VPDWRRLPRE MMPRKKCKKG DPKSKPSKAA AKATSLINSA DVLKTIEELE
160 170 180 190 200
KRGEGERSDE ENEEKEGSKE KDKDDEEDGE EDAEQEDYDE EEQEEENDYI
210 220
NSYFDNGDDF GVDSDDNMDE ATY
Length:223
Mass (Da):25,947
Last modified:July 5, 2004 - v1
Checksum:iAFC5A5305ABEF9F0
GO
Isoform 2 (identifier: Q6NXY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-160: DDIERYSKRY...KRGEGERSDE → GTHARQALPE...TLCLPFVIQY
     161-223: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,236
Checksum:i0A9D40E3C0A3172D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01267283 – 160DDIER…ERSDE → GTHARQALPEAGSSVFTEGA VDAGTCDHVTQPITQLEKTL LTRIVRKEKHLYFIVLFFFF FFLQLTHNTLCLPFVIQY in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_012673161 – 223Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030063 mRNA Translation: AAH30063.1
BC066818 mRNA Translation: AAH66818.1
AK010126 mRNA Translation: BAB26717.3
CCDSiCCDS36738.1 [Q6NXY9-1]
RefSeqiNP_001074645.1, NM_001081176.1 [Q6NXY9-1]
UniGeneiMm.279781

Genome annotation databases

EnsembliENSMUST00000048993; ENSMUSP00000035289; ENSMUSG00000035834 [Q6NXY9-1]
ENSMUST00000161920; ENSMUSP00000125054; ENSMUSG00000035834 [Q6NXY9-2]
GeneIDi67486
KEGGimmu:67486
UCSCiuc007rhx.1 mouse [Q6NXY9-1]
uc007rhz.1 mouse [Q6NXY9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPC7_MOUSE
AccessioniPrimary (citable) accession number: Q6NXY9
Secondary accession number(s): Q8K0W5, Q9CV05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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