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Protein

DNA-directed RNA polymerase III subunit RPC7

Gene

Polr3g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC7
Short name:
RNA polymerase III subunit C7
Alternative name(s):
DNA-directed RNA polymerase III subunit G
Gene namesi
Name:Polr3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914736. Polr3g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223DNA-directed RNA polymerase III subunit RPC7PRO_0000073979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei134 – 1341PhosphothreonineBy similarity
Modified residuei158 – 1581PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXY9.
MaxQBiQ6NXY9.
PaxDbiQ6NXY9.
PeptideAtlasiQ6NXY9.
PRIDEiQ6NXY9.

PTM databases

iPTMnetiQ6NXY9.
PhosphoSiteiQ6NXY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035834.
CleanExiMM_POLR3G.
ExpressionAtlasiQ6NXY9. baseline and differential.
GenevisibleiQ6NXY9. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035289.

Structurei

3D structure databases

ProteinModelPortaliQ6NXY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKHU. Eukaryota.
ENOG4112311. LUCA.
GeneTreeiENSGT00390000002422.
HOGENOMiHOG000293249.
HOVERGENiHBG054922.
InParanoidiQ6NXY9.
KOiK03024.
OMAiCKKAGPK.
OrthoDBiEOG091G0TN0.
PhylomeDBiQ6NXY9.
TreeFamiTF103052.

Family and domain databases

InterProiIPR024661. RNA_pol_III_Rpc31.
[Graphical view]
PANTHERiPTHR15367. PTHR15367. 1 hit.
PfamiPF11705. RNA_pol_3_Rpc31. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNKGRGRA AYTFNIEAVG FSRGEKLPDV VLKPPPLFPD TDYKPVPLKT
60 70 80 90 100
GEDEDYMLAL KQELRETVKR LPYFIEPPEE KQDDIERYSK RYMKVYKEEW
110 120 130 140 150
VPDWRRLPRE MMPRKKCKKG DPKSKPSKAA AKATSLINSA DVLKTIEELE
160 170 180 190 200
KRGEGERSDE ENEEKEGSKE KDKDDEEDGE EDAEQEDYDE EEQEEENDYI
210 220
NSYFDNGDDF GVDSDDNMDE ATY
Length:223
Mass (Da):25,947
Last modified:July 5, 2004 - v1
Checksum:iAFC5A5305ABEF9F0
GO
Isoform 2 (identifier: Q6NXY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-160: DDIERYSKRY...KRGEGERSDE → GTHARQALPE...TLCLPFVIQY
     161-223: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,236
Checksum:i0A9D40E3C0A3172D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 16078DDIER…ERSDE → GTHARQALPEAGSSVFTEGA VDAGTCDHVTQPITQLEKTL LTRIVRKEKHLYFIVLFFFF FFLQLTHNTLCLPFVIQY in isoform 2. 1 PublicationVSP_012672Add
BLAST
Alternative sequencei161 – 22363Missing in isoform 2. 1 PublicationVSP_012673Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030063 mRNA. Translation: AAH30063.1.
BC066818 mRNA. Translation: AAH66818.1.
AK010126 mRNA. Translation: BAB26717.3.
CCDSiCCDS36738.1. [Q6NXY9-1]
RefSeqiNP_001074645.1. NM_001081176.1. [Q6NXY9-1]
UniGeneiMm.279781.

Genome annotation databases

EnsembliENSMUST00000048993; ENSMUSP00000035289; ENSMUSG00000035834. [Q6NXY9-1]
ENSMUST00000161920; ENSMUSP00000125054; ENSMUSG00000035834. [Q6NXY9-2]
GeneIDi67486.
KEGGimmu:67486.
UCSCiuc007rhx.1. mouse. [Q6NXY9-1]
uc007rhz.1. mouse. [Q6NXY9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030063 mRNA. Translation: AAH30063.1.
BC066818 mRNA. Translation: AAH66818.1.
AK010126 mRNA. Translation: BAB26717.3.
CCDSiCCDS36738.1. [Q6NXY9-1]
RefSeqiNP_001074645.1. NM_001081176.1. [Q6NXY9-1]
UniGeneiMm.279781.

3D structure databases

ProteinModelPortaliQ6NXY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035289.

PTM databases

iPTMnetiQ6NXY9.
PhosphoSiteiQ6NXY9.

Proteomic databases

EPDiQ6NXY9.
MaxQBiQ6NXY9.
PaxDbiQ6NXY9.
PeptideAtlasiQ6NXY9.
PRIDEiQ6NXY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048993; ENSMUSP00000035289; ENSMUSG00000035834. [Q6NXY9-1]
ENSMUST00000161920; ENSMUSP00000125054; ENSMUSG00000035834. [Q6NXY9-2]
GeneIDi67486.
KEGGimmu:67486.
UCSCiuc007rhx.1. mouse. [Q6NXY9-1]
uc007rhz.1. mouse. [Q6NXY9-2]

Organism-specific databases

CTDi10622.
MGIiMGI:1914736. Polr3g.

Phylogenomic databases

eggNOGiENOG410IKHU. Eukaryota.
ENOG4112311. LUCA.
GeneTreeiENSGT00390000002422.
HOGENOMiHOG000293249.
HOVERGENiHBG054922.
InParanoidiQ6NXY9.
KOiK03024.
OMAiCKKAGPK.
OrthoDBiEOG091G0TN0.
PhylomeDBiQ6NXY9.
TreeFamiTF103052.

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiPolr3g. mouse.
PROiQ6NXY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035834.
CleanExiMM_POLR3G.
ExpressionAtlasiQ6NXY9. baseline and differential.
GenevisibleiQ6NXY9. MM.

Family and domain databases

InterProiIPR024661. RNA_pol_III_Rpc31.
[Graphical view]
PANTHERiPTHR15367. PTHR15367. 1 hit.
PfamiPF11705. RNA_pol_3_Rpc31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPC7_MOUSE
AccessioniPrimary (citable) accession number: Q6NXY9
Secondary accession number(s): Q8K0W5, Q9CV05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.