Q6NXT6 (TAPT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane anterior posterior transformation protein 1 homolog

Alternative name(s):
Cytomegalovirus partial fusion receptor

Gene names

Name:	TAPT1
Synonyms:	CMVFR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development By similarity. In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TAPT1 family.
Sequence caution	The sequence AAF28308.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Traceable author statement Ref.4. Source: UniProtKB
Molecular function	growth hormone-releasing hormone receptor activity Traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NXT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NXT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     551-567: KDLLEIDRFTICGNRID → SVLLCQSGLPEC

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 567	566	Transmembrane anterior posterior transformation protein 1 homolog		PRO_0000328872
Regions
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	157 – 179	23	Helical; Potential
	Transmembrane	236 – 256	21	Helical; Potential
	Transmembrane	403 – 423	21	Helical; Potential
	Transmembrane	432 – 452	21	Helical; Potential
	Compositional bias	3 – 39	37	Gly-rich
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.5
Natural variations
	Alternative sequence	551 – 567	17	KDLLE…GNRID → SVLLCQSGLPEC in isoform 2.		VSP_032842
	Natural variant	465	1	E → K. Corresponds to variant rs35606284 [ dbSNP | Ensembl ].		VAR_042568
	Natural variant	522	1	N → S. Corresponds to variant rs16893137 [ dbSNP | Ensembl ].		VAR_042569
Experimental info
	Sequence conflict	30	1	E → D in BAC11022. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2EAB6EF6A7A40E71	FASTA	567	64,260
	10 20 30 40 50 60 MAGVGDAAAP GEGGGGGVDG PQRDGRGEAE QPGGSGGQGP PPAPQLTETL GFYESDRRRE 70 80 90 100 110 120 RRRGRTELSL LRFLSAELTR GYFLEHNEAK YTERRERVYT CLRIPRELEK LMVFGIFLCL 130 140 150 160 170 180 DAFLYVFTLL PLRVFLALFR LLTLPCYGLR DRRLLQPAQV CDILKGVILV ICYFMMHYVD 190 200 210 220 230 240 YSMMYHLIRG QSVIKLYIIY NMLEVADRLF SSFGQDILDA LYWTATEPKE RKRAHIGVIP 250 260 270 280 290 300 HFFMAVLYVF LHAILIMVQA TTLNVAFNSH NKSLLTIMMS NNFVEIKGSV FKKFEKNNLF 310 320 330 340 350 360 QMSNSDIKER FTNYVLLLIV CLRNMEQFSW NPDHLWVLFP DVCMVIASEI AVDIVKHAFI 370 380 390 400 410 420 TKFNDITADV YSEYRASLAF DLVSSRQKNA YTDYSDSVAR RMGFIPLPLA VLLIRVVTSS 430 440 450 460 470 480 IKVQGILSYA CVILFYFGLI SLKVLNSIVL LGKSCQYVKE AKMEEKLSNP PATCTPGKPS 490 500 510 520 530 540 SKSQNKCKPS QGLSTEENLS ASITKQPIHQ KENIIPLLVT SNSDQFLTTP DGDEKDITQD 550 560 NSELKHRSSK KDLLEIDRFT ICGNRID
	Isoform 2 [UniParc]. Checksum: FA05217C534697E3	FASTA	562	63,487
	10 20 30 40 50 60 MAGVGDAAAP GEGGGGGVDG PQRDGRGEAE QPGGSGGQGP PPAPQLTETL GFYESDRRRE 70 80 90 100 110 120 RRRGRTELSL LRFLSAELTR GYFLEHNEAK YTERRERVYT CLRIPRELEK LMVFGIFLCL 130 140 150 160 170 180 DAFLYVFTLL PLRVFLALFR LLTLPCYGLR DRRLLQPAQV CDILKGVILV ICYFMMHYVD 190 200 210 220 230 240 YSMMYHLIRG QSVIKLYIIY NMLEVADRLF SSFGQDILDA LYWTATEPKE RKRAHIGVIP 250 260 270 280 290 300 HFFMAVLYVF LHAILIMVQA TTLNVAFNSH NKSLLTIMMS NNFVEIKGSV FKKFEKNNLF 310 320 330 340 350 360 QMSNSDIKER FTNYVLLLIV CLRNMEQFSW NPDHLWVLFP DVCMVIASEI AVDIVKHAFI 370 380 390 400 410 420 TKFNDITADV YSEYRASLAF DLVSSRQKNA YTDYSDSVAR RMGFIPLPLA VLLIRVVTSS 430 440 450 460 470 480 IKVQGILSYA CVILFYFGLI SLKVLNSIVL LGKSCQYVKE AKMEEKLSNP PATCTPGKPS 490 500 510 520 530 540 SKSQNKCKPS QGLSTEENLS ASITKQPIHQ KENIIPLLVT SNSDQFLTTP DGDEKDITQD 550 560 NSELKHRSSK SVLLCQSGLP EC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH." Baldwin B.R., Zhang C.-O., Keay S. J. Gen. Virol. 81:27-35(2000) [PubMed: 10640539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-205, POSSIBLE FUNCTION FOR FUSION WITH HCMV. Tissue: Lung.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074494 mRNA. Translation: BAC11022.1. CH471069 Genomic DNA. Translation: EAW92754.1. BC066899 mRNA. Translation: AAH66899.1. AF189251 mRNA. Translation: AAF28308.1. Frameshift.
RefSeq	NP_699196.2. NM_153365.2.
UniGene	Hs.479223.
3D structure databases
ProteinModelPortal	Q6NXT6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6NXT6.
PTM databases
PhosphoSite	Q6NXT6.
Polymorphism databases
DMDM	74737002.
Proteomic databases
PRIDE	Q6NXT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000405303; ENSP00000385347; ENSG00000169762.
GeneID	202018.
KEGG	hsa:202018.
UCSC	uc010ied.1. human.
Organism-specific databases
CTD	202018.
GeneCards	GC04M016162.
H-InvDB	HIX0031376.
HGNC	HGNC:26887. TAPT1.
MIM	612758. gene.
neXtProt	NX_Q6NXT6.
PharmGKB	PA162405167.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17077.
GeneTree	ENSGT00390000010628.
HOGENOM	HBG444221.
HOVERGEN	HBG108546.
InParanoid	Q6NXT6.
OMA	TLGFYES.
OrthoDB	EOG4WM4TM.
PhylomeDB	Q6NXT6.
Gene expression databases
ArrayExpress	Q6NXT6.
Bgee	Q6NXT6.
CleanEx	HS_TAPT1.
Genevestigator	Q6NXT6.
Family and domain databases
InterPro	IPR008010. Membrane_Tatp1/CMV_rcpt. [Graphical view]
PANTHER	PTHR13317. DUF747_CMV_rcpt. 1 hit.
Pfam	PF05346. DUF747. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	90227.
SOURCE	Search...

Entry information

Entry name

TAPT1_HUMAN

Accession

Primary (citable) accession number: Q6NXT6
Secondary accession number(s): Q8N2S3, Q9NZK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.