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Protein

Transmembrane anterior posterior transformation protein 1 homolog

Gene

TAPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.By similarity

GO - Molecular functioni

  • growth hormone-releasing hormone receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane anterior posterior transformation protein 1 homolog
Alternative name(s):
Cytomegalovirus partial fusion receptor
Gene namesi
Name:TAPT1
Synonyms:CMVFR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26887. TAPT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17923HelicalSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405167.

Polymorphism and mutation databases

BioMutaiTAPT1.
DMDMi74737002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 567566Transmembrane anterior posterior transformation protein 1 homologPRO_0000328872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei523 – 5231PhosphoserineCombined sources
Modified residuei529 – 5291PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NXT6.
MaxQBiQ6NXT6.
PaxDbiQ6NXT6.
PRIDEiQ6NXT6.

PTM databases

iPTMnetiQ6NXT6.
PhosphoSiteiQ6NXT6.
SwissPalmiQ6NXT6.

Expressioni

Gene expression databases

BgeeiQ6NXT6.
CleanExiHS_TAPT1.
ExpressionAtlasiQ6NXT6. baseline and differential.
GenevisibleiQ6NXT6. HS.

Organism-specific databases

HPAiHPA042567.

Interactioni

Protein-protein interaction databases

BioGridi128412. 6 interactions.
IntActiQ6NXT6. 2 interactions.
STRINGi9606.ENSP00000385347.

Structurei

3D structure databases

ProteinModelPortaliQ6NXT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 3937Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the TAPT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2490. Eukaryota.
ENOG410XT6F. LUCA.
GeneTreeiENSGT00390000010628.
HOGENOMiHOG000154508.
HOVERGENiHBG108546.
InParanoidiQ6NXT6.
OMAiTCTPGKP.
OrthoDBiEOG7KWSH3.
PhylomeDBiQ6NXT6.
TreeFamiTF105962.

Family and domain databases

InterProiIPR008010. Tatp1.
[Graphical view]
PANTHERiPTHR13317. PTHR13317. 1 hit.
PfamiPF05346. DUF747. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVGDAAAP GEGGGGGVDG PQRDGRGEAE QPGGSGGQGP PPAPQLTETL
60 70 80 90 100
GFYESDRRRE RRRGRTELSL LRFLSAELTR GYFLEHNEAK YTERRERVYT
110 120 130 140 150
CLRIPRELEK LMVFGIFLCL DAFLYVFTLL PLRVFLALFR LLTLPCYGLR
160 170 180 190 200
DRRLLQPAQV CDILKGVILV ICYFMMHYVD YSMMYHLIRG QSVIKLYIIY
210 220 230 240 250
NMLEVADRLF SSFGQDILDA LYWTATEPKE RKRAHIGVIP HFFMAVLYVF
260 270 280 290 300
LHAILIMVQA TTLNVAFNSH NKSLLTIMMS NNFVEIKGSV FKKFEKNNLF
310 320 330 340 350
QMSNSDIKER FTNYVLLLIV CLRNMEQFSW NPDHLWVLFP DVCMVIASEI
360 370 380 390 400
AVDIVKHAFI TKFNDITADV YSEYRASLAF DLVSSRQKNA YTDYSDSVAR
410 420 430 440 450
RMGFIPLPLA VLLIRVVTSS IKVQGILSYA CVILFYFGLI SLKVLNSIVL
460 470 480 490 500
LGKSCQYVKE AKMEEKLSNP PATCTPGKPS SKSQNKCKPS QGLSTEENLS
510 520 530 540 550
ASITKQPIHQ KENIIPLLVT SNSDQFLTTP DGDEKDITQD NSELKHRSSK
560
KDLLEIDRFT ICGNRID
Length:567
Mass (Da):64,260
Last modified:July 5, 2004 - v1
Checksum:i2EAB6EF6A7A40E71
GO
Isoform 2 (identifier: Q6NXT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-567: KDLLEIDRFTICGNRID → SVLLCQSGLPEC

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):63,487
Checksum:iFA05217C534697E3
GO

Sequence cautioni

The sequence AAF28308.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301E → D in BAC11022 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti465 – 4651E → K.
Corresponds to variant rs35606284 [ dbSNP | Ensembl ].
VAR_042568
Natural varianti522 – 5221N → S.
Corresponds to variant rs16893137 [ dbSNP | Ensembl ].
VAR_042569

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei551 – 56717KDLLE…GNRID → SVLLCQSGLPEC in isoform 2. 1 PublicationVSP_032842Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074494 mRNA. Translation: BAC11022.1.
CH471069 Genomic DNA. Translation: EAW92754.1.
BC066899 mRNA. Translation: AAH66899.1.
AF189251 mRNA. Translation: AAF28308.1. Frameshift.
CCDSiCCDS47030.1. [Q6NXT6-1]
RefSeqiNP_699196.2. NM_153365.2. [Q6NXT6-1]
UniGeneiHs.479223.

Genome annotation databases

EnsembliENST00000405303; ENSP00000385347; ENSG00000169762. [Q6NXT6-1]
GeneIDi202018.
KEGGihsa:202018.
UCSCiuc010ied.2. human. [Q6NXT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074494 mRNA. Translation: BAC11022.1.
CH471069 Genomic DNA. Translation: EAW92754.1.
BC066899 mRNA. Translation: AAH66899.1.
AF189251 mRNA. Translation: AAF28308.1. Frameshift.
CCDSiCCDS47030.1. [Q6NXT6-1]
RefSeqiNP_699196.2. NM_153365.2. [Q6NXT6-1]
UniGeneiHs.479223.

3D structure databases

ProteinModelPortaliQ6NXT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128412. 6 interactions.
IntActiQ6NXT6. 2 interactions.
STRINGi9606.ENSP00000385347.

PTM databases

iPTMnetiQ6NXT6.
PhosphoSiteiQ6NXT6.
SwissPalmiQ6NXT6.

Polymorphism and mutation databases

BioMutaiTAPT1.
DMDMi74737002.

Proteomic databases

EPDiQ6NXT6.
MaxQBiQ6NXT6.
PaxDbiQ6NXT6.
PRIDEiQ6NXT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405303; ENSP00000385347; ENSG00000169762. [Q6NXT6-1]
GeneIDi202018.
KEGGihsa:202018.
UCSCiuc010ied.2. human. [Q6NXT6-1]

Organism-specific databases

CTDi202018.
GeneCardsiTAPT1.
HGNCiHGNC:26887. TAPT1.
HPAiHPA042567.
MIMi612758. gene.
neXtProtiNX_Q6NXT6.
PharmGKBiPA162405167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2490. Eukaryota.
ENOG410XT6F. LUCA.
GeneTreeiENSGT00390000010628.
HOGENOMiHOG000154508.
HOVERGENiHBG108546.
InParanoidiQ6NXT6.
OMAiTCTPGKP.
OrthoDBiEOG7KWSH3.
PhylomeDBiQ6NXT6.
TreeFamiTF105962.

Miscellaneous databases

ChiTaRSiTAPT1. human.
GenomeRNAii202018.
PROiQ6NXT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NXT6.
CleanExiHS_TAPT1.
ExpressionAtlasiQ6NXT6. baseline and differential.
GenevisibleiQ6NXT6. HS.

Family and domain databases

InterProiIPR008010. Tatp1.
[Graphical view]
PANTHERiPTHR13317. PTHR13317. 1 hit.
PfamiPF05346. DUF747. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH."
    Baldwin B.R., Zhang C.-O., Keay S.
    J. Gen. Virol. 81:27-35(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-205, POSSIBLE FUNCTION FOR FUSION WITH HCMV.
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTAPT1_HUMAN
AccessioniPrimary (citable) accession number: Q6NXT6
Secondary accession number(s): Q8N2S3, Q9NZK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.