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Protein

Protein phosphatase inhibitor 2-like protein 3

Gene

PPP1R2P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciZFISH:G66-32219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2-like protein 3
Alternative name(s):
Protein phosphatase 1, regulatory subunit 2 pseudogene 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16318. PPP1R2P3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74736994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861381 – 205Protein phosphatase inhibitor 2-like protein 3Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXS1.
MaxQBiQ6NXS1.
PaxDbiQ6NXS1.
PeptideAtlasiQ6NXS1.
PRIDEiQ6NXS1.
TopDownProteomicsiQ6NXS1.

PTM databases

iPTMnetiQ6NXS1.
PhosphoSitePlusiQ6NXS1.

Expressioni

Tissue specificityi

Only detected in spermatozoa, both heads and tails.1 Publication

Organism-specific databases

HPAiHPA043729.
HPA059420.

Interactioni

Subunit structurei

Interacts with PPP1C.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621365EBI-10251630,EBI-357253
PPP1CBP621405EBI-10251630,EBI-352350

Protein-protein interaction databases

IntActiQ6NXS1. 3 interactors.
STRINGi9606.ENSP00000328178.

Structurei

3D structure databases

ProteinModelPortaliQ6NXS1.
SMRiQ6NXS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiQ6NXS1.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRRSVDEEL SKKSQKWDEI
60 70 80 90 100
NILATYHPAD KGYGLMKIDE PSPPYHSMMG DDEDACRDTE TTEAMAPGIL
110 120 130 140 150
AKKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMRRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,048
Last modified:July 5, 2004 - v1
Checksum:i4F766617932F54E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066922 mRNA. No translation available.
UniGeneiHs.567727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066922 mRNA. No translation available.
UniGeneiHs.567727.

3D structure databases

ProteinModelPortaliQ6NXS1.
SMRiQ6NXS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NXS1. 3 interactors.
STRINGi9606.ENSP00000328178.

PTM databases

iPTMnetiQ6NXS1.
PhosphoSitePlusiQ6NXS1.

Polymorphism and mutation databases

DMDMi74736994.

Proteomic databases

EPDiQ6NXS1.
MaxQBiQ6NXS1.
PaxDbiQ6NXS1.
PeptideAtlasiQ6NXS1.
PRIDEiQ6NXS1.
TopDownProteomicsiQ6NXS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPPP1R2P3.
HGNCiHGNC:16318. PPP1R2P3.
HPAiHPA043729.
HPA059420.
neXtProtiNX_Q6NXS1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiQ6NXS1.

Enzyme and pathway databases

BioCyciZFISH:G66-32219-MONOMER.

Miscellaneous databases

PROiQ6NXS1.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPP2M_HUMAN
AccessioniPrimary (citable) accession number: Q6NXS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.