Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase inhibitor 2-like protein 3

Gene

PPP1R2P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2-like protein 3
Alternative name(s):
Protein phosphatase 1, regulatory subunit 2 pseudogene 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16318. PPP1R2P3.

Subcellular locationi

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74736994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002861382 – 205Protein phosphatase inhibitor 2-like protein 3Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei89PhosphothreonineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NXS1.
MaxQBiQ6NXS1.
PaxDbiQ6NXS1.
PeptideAtlasiQ6NXS1.
PRIDEiQ6NXS1.
TopDownProteomicsiQ6NXS1.

PTM databases

iPTMnetiQ6NXS1.
PhosphoSitePlusiQ6NXS1.

Expressioni

Tissue specificityi

Only detected in spermatozoa, both heads and tails.1 Publication

Organism-specific databases

HPAiHPA043729.
HPA059420.

Interactioni

Subunit structurei

Interacts with PPP1C.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6NXS1. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6NXS1.
SMRiQ6NXS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiQ6NXS1.

Family and domain databases

InterProiView protein in InterPro
IPR007062. PPI-2.
PfamiView protein in Pfam
PF04979. IPP-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRRSVDEEL SKKSQKWDEI
60 70 80 90 100
NILATYHPAD KGYGLMKIDE PSPPYHSMMG DDEDACRDTE TTEAMAPGIL
110 120 130 140 150
AKKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMRRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,048
Last modified:July 5, 2004 - v1
Checksum:i4F766617932F54E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066922 mRNA. No translation available.
UniGeneiHs.567727.

Similar proteinsi

Entry informationi

Entry nameiIPP2M_HUMAN
AccessioniPrimary (citable) accession number: Q6NXS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families