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Protein

Protein phosphatase inhibitor 2 family member B

Gene

PPP1R2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2 family member BCurated
Alternative name(s):
PPP1R2 family member B
Protein phosphatase 1, regulatory subunit 2 pseudogene 3
Protein phosphatase inhibitor 2-like protein 3
Gene namesi
Name:PPP1R2BImported
Synonyms:PPP1R2P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16318 PPP1R2B
neXtProtiNX_Q6NXS1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231989

Polymorphism and mutation databases

DMDMi74736994

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002861382 – 205Protein phosphatase inhibitor 2 family member BAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei89PhosphothreonineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NXS1
MaxQBiQ6NXS1
PeptideAtlasiQ6NXS1
PRIDEiQ6NXS1
TopDownProteomicsiQ6NXS1

PTM databases

iPTMnetiQ6NXS1
PhosphoSitePlusiQ6NXS1

Expressioni

Tissue specificityi

Only detected in spermatozoa, both heads and tails.1 Publication

Organism-specific databases

HPAiHPA043729
HPA059420

Interactioni

Subunit structurei

Interacts with PPP1CC.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6NXS1, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6NXS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041 Eukaryota
ENOG4111SYV LUCA
GeneTreeiENSGT00390000004757
HOGENOMiHOG000017696
HOVERGENiHBG006170
InParanoidiQ6NXS1
OMAiRAHYNEG

Family and domain databases

InterProiView protein in InterPro
IPR007062 PPI-2
PANTHERiPTHR12398 PTHR12398, 1 hit
PfamiView protein in Pfam
PF04979 IPP-2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRRSVDEEL SKKSQKWDEI
60 70 80 90 100
NILATYHPAD KGYGLMKIDE PSPPYHSMMG DDEDACRDTE TTEAMAPDIL
110 120 130 140 150
AKKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMRRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,106
Last modified:March 28, 2018 - v2
Checksum:i69AF42846313A728
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98D → G in BC066922 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF438008 mRNA Translation: AEB77711.1
AC011414 Genomic DNA No translation available.
BC066922 mRNA No translation available.
UniGeneiHs.567727

Genome annotation databases

EnsembliENST00000522232; ENSP00000490297; ENSG00000231989

Similar proteinsi

Entry informationi

Entry nameiIPP2B_HUMAN
AccessioniPrimary (citable) accession number: Q6NXS1
Secondary accession number(s): G1AUC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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