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Protein

Interferon-inducible GTPase 5

Gene

IRGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698GTP
Nucleotide bindingi87 – 915GTP
Nucleotide bindingi169 – 1713GTP
Nucleotide bindingi216 – 2183GTP

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-inducible GTPase 5 (EC:3.6.5.-)
Alternative name(s):
Immunity-related GTPase cinema 1
Gene namesi
Name:IRGC
Synonyms:IIGP5, IRGC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28835. IRGC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671651.

Polymorphism and mutation databases

BioMutaiIRGC.
DMDMi74736988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Interferon-inducible GTPase 5PRO_0000285265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471PhosphoserineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NXR0.
PeptideAtlasiQ6NXR0.
PRIDEiQ6NXR0.

PTM databases

iPTMnetiQ6NXR0.
PhosphoSiteiQ6NXR0.

Expressioni

Gene expression databases

BgeeiQ6NXR0.
CleanExiHS_IRGC.
ExpressionAtlasiQ6NXR0. baseline and differential.
GenevisibleiQ6NXR0. HS.

Organism-specific databases

HPAiHPA046769.
HPA060064.

Interactioni

Protein-protein interaction databases

BioGridi121129. 15 interactions.
STRINGi9606.ENSP00000244314.

Structurei

3D structure databases

ProteinModelPortaliQ6NXR0.
SMRiQ6NXR0. Positions 18-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 235183IRG-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IJSM. Eukaryota.
ENOG41125KF. LUCA.
GeneTreeiENSGT00390000014733.
HOGENOMiHOG000220822.
HOVERGENiHBG054304.
InParanoidiQ6NXR0.
OMAiAEPRIFL.
OrthoDBiEOG7GBFWM.
PhylomeDBiQ6NXR0.
TreeFamiTF331897.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030385. G_IRG_dom.
IPR007743. Immunity-related_GTPase-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05049. IIGP. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51716. G_IRG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSKLPVVP GEEENTILMA KERLEALRTA FESGDLPQAA SHLQELLAST
60 70 80 90 100
ESIRLEVGVT GESGAGKSSL INALRGLEAE DPGAALTGVM ETTMQPSPYP
110 120 130 140 150
HPQFPDVTLW DLPGAGSPGC PADKYLKQVD FSRYDFFLLV SPRRCGAVET
160 170 180 190 200
RLAAEILCQG KKFYFVRTKV DEDLAATRTQ RPSGFREAAV LQEIRDHCAE
210 220 230 240 250
RLREAGVADP RIFLVSNLSP ARYDFPTLVS TWEHDLPSHR RHAGLLSLPD
260 270 280 290 300
ISLEALQKKK AMLQEQVLKT ALVLGVIQAL PVPGLAAAYD DALLIHSLRG
310 320 330 340 350
YHRSFGLDDD SLAKLAEQVG KQAGDLRSVI RSPLANEVSP ETVLRLYSQS
360 370 380 390 400
SDGAMRVARA FERGIPVFGT LVAGGISFGA VYTMLQGCLN EMAEDAQRVR
410 420 430 440 450
IKALEDDEPQ PEVSLEVASD NGVEKGGSGE GGGEEAPLST CRKLGLLLKY
460
ILDSWKKHDS EEK
Length:463
Mass (Da):50,288
Last modified:July 5, 2004 - v1
Checksum:i8ED3B06C512212D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351D → N.1 Publication
Corresponds to variant rs11555891 [ dbSNP | Ensembl ].
VAR_032008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005622 Genomic DNA. Translation: AAC34467.1.
BC033853 mRNA. Translation: AAH33853.1.
BC066939 mRNA. Translation: AAH66939.1.
CCDSiCCDS12629.1.
RefSeqiNP_062558.1. NM_019612.3.
XP_006723346.1. XM_006723283.2.
XP_011525420.1. XM_011527118.1.
UniGeneiHs.515444.

Genome annotation databases

EnsembliENST00000244314; ENSP00000244314; ENSG00000124449.
GeneIDi56269.
KEGGihsa:56269.
UCSCiuc002oxh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005622 Genomic DNA. Translation: AAC34467.1.
BC033853 mRNA. Translation: AAH33853.1.
BC066939 mRNA. Translation: AAH66939.1.
CCDSiCCDS12629.1.
RefSeqiNP_062558.1. NM_019612.3.
XP_006723346.1. XM_006723283.2.
XP_011525420.1. XM_011527118.1.
UniGeneiHs.515444.

3D structure databases

ProteinModelPortaliQ6NXR0.
SMRiQ6NXR0. Positions 18-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121129. 15 interactions.
STRINGi9606.ENSP00000244314.

PTM databases

iPTMnetiQ6NXR0.
PhosphoSiteiQ6NXR0.

Polymorphism and mutation databases

BioMutaiIRGC.
DMDMi74736988.

Proteomic databases

PaxDbiQ6NXR0.
PeptideAtlasiQ6NXR0.
PRIDEiQ6NXR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244314; ENSP00000244314; ENSG00000124449.
GeneIDi56269.
KEGGihsa:56269.
UCSCiuc002oxh.4. human.

Organism-specific databases

CTDi56269.
GeneCardsiIRGC.
HGNCiHGNC:28835. IRGC.
HPAiHPA046769.
HPA060064.
neXtProtiNX_Q6NXR0.
PharmGKBiPA142671651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJSM. Eukaryota.
ENOG41125KF. LUCA.
GeneTreeiENSGT00390000014733.
HOGENOMiHOG000220822.
HOVERGENiHBG054304.
InParanoidiQ6NXR0.
OMAiAEPRIFL.
OrthoDBiEOG7GBFWM.
PhylomeDBiQ6NXR0.
TreeFamiTF331897.

Miscellaneous databases

GeneWikiiInterferon-inducible_GTPase_5.
GenomeRNAii56269.
PROiQ6NXR0.

Gene expression databases

BgeeiQ6NXR0.
CleanExiHS_IRGC.
ExpressionAtlasiQ6NXR0. baseline and differential.
GenevisibleiQ6NXR0. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030385. G_IRG_dom.
IPR007743. Immunity-related_GTPase-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05049. IIGP. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51716. G_IRG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-135.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiIIGP5_HUMAN
AccessioniPrimary (citable) accession number: Q6NXR0
Secondary accession number(s): Q05BR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.