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Protein

NADP-dependent oxidoreductase domain-containing protein 1

Gene

NOXRED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable oxidoreductase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent oxidoreductase domain-containing protein 1 (EC:1.-.-.-)
Alternative name(s):
Pyrroline-5-carboxylate reductase-like protein C14orf148
Gene namesi
Name:NOXRED1
Synonyms:C14orf148
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20487. NOXRED1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935429.

Polymorphism and mutation databases

BioMutaiNOXRED1.
DMDMi134034048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359NADP-dependent oxidoreductase domain-containing protein 1PRO_0000280279Add
BLAST

Proteomic databases

PaxDbiQ6NXP6.
PeptideAtlasiQ6NXP6.
PRIDEiQ6NXP6.

PTM databases

iPTMnetiQ6NXP6.
PhosphoSiteiQ6NXP6.

Expressioni

Gene expression databases

BgeeiQ6NXP6.
CleanExiHS_C14orf148.
ExpressionAtlasiQ6NXP6. baseline and differential.
GenevisibleiQ6NXP6. HS.

Organism-specific databases

HPAiHPA055658.

Interactioni

Protein-protein interaction databases

BioGridi125805. 1 interaction.
STRINGi9606.ENSP00000370215.

Structurei

3D structure databases

ProteinModelPortaliQ6NXP6.
SMRiQ6NXP6. Positions 79-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3124. Eukaryota.
COG0345. LUCA.
GeneTreeiENSGT00390000007632.
HOGENOMiHOG000111827.
HOVERGENiHBG081280.
InParanoidiQ6NXP6.
OMAiHATFFCK.
OrthoDBiEOG7HQN9P.
PhylomeDBiQ6NXP6.
TreeFamiTF335538.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMLQDLESL QFEYGVPEED RIWLYLQGRS RGLMIEACAH ATFFCKLLYN
60 70 80 90 100
LRASLNKNQS SRHLSIGSLN SATPEEFKVG IIGGGHLGKQ LAGTLLQLGP
110 120 130 140 150
IPAESLRIST RRPETLGELQ KLGIKCFYHN ADLVSWADVI FLCCLPSQLP
160 170 180 190 200
NICVEIYTSL EKASIVYSFV AAIPLPRLKL LLNHTNILRP QYQYDEDSVS
210 220 230 240 250
VWGANKGVIA ALQDPTILQA TCPYSPAGGI ILNIKWLEGV FYAALNICTA
260 270 280 290 300
RNMAHSQVLQ LLSELFLSVH FEDCGKDTAS CPKLQLTDFV SKAYGKNLSQ
310 320 330 340 350
ERPFPWFDLT AVQLKETPFS QHLSSSPVLQ DHLTHLYCAS FGISLTKEQP

VISTGFPSQ
Length:359
Mass (Da):39,880
Last modified:March 20, 2007 - v2
Checksum:iB0FA3F74289B3A92
GO
Isoform 2 (identifier: Q6NXP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-359: GIILNIKWLE...PVISTGFPSQ → HGSTYFWHSFENYFPVGPLLSY

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:250
Mass (Da):27,897
Checksum:i70D0F6CC03127414
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661V → A in AAH66965 (PubMed:15489334).Curated
Sequence conflicti183 – 1831N → D in AAH66965 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei229 – 359131GIILN…GFPSQ → HGSTYFWHSFENYFPVGPLL SY in isoform 2. 1 PublicationVSP_038392Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057371 mRNA. Translation: BAG51909.1.
AF111168 Genomic DNA. Translation: AAD09625.1.
AC007954 Genomic DNA. Translation: AAF62562.1.
CH471061 Genomic DNA. Translation: EAW81285.1.
BC066965 mRNA. Translation: AAH66965.1.
CCDSiCCDS45142.1. [Q6NXP6-1]
RefSeqiNP_001106946.1. NM_001113475.2. [Q6NXP6-1]
XP_005267387.1. XM_005267330.2. [Q6NXP6-1]
XP_011534729.1. XM_011536427.1. [Q6NXP6-1]
XP_011534730.1. XM_011536428.1. [Q6NXP6-1]
UniGeneiHs.97556.

Genome annotation databases

EnsembliENST00000380835; ENSP00000370215; ENSG00000165555. [Q6NXP6-1]
GeneIDi122945.
KEGGihsa:122945.
UCSCiuc001xtr.4. human. [Q6NXP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057371 mRNA. Translation: BAG51909.1.
AF111168 Genomic DNA. Translation: AAD09625.1.
AC007954 Genomic DNA. Translation: AAF62562.1.
CH471061 Genomic DNA. Translation: EAW81285.1.
BC066965 mRNA. Translation: AAH66965.1.
CCDSiCCDS45142.1. [Q6NXP6-1]
RefSeqiNP_001106946.1. NM_001113475.2. [Q6NXP6-1]
XP_005267387.1. XM_005267330.2. [Q6NXP6-1]
XP_011534729.1. XM_011536427.1. [Q6NXP6-1]
XP_011534730.1. XM_011536428.1. [Q6NXP6-1]
UniGeneiHs.97556.

3D structure databases

ProteinModelPortaliQ6NXP6.
SMRiQ6NXP6. Positions 79-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125805. 1 interaction.
STRINGi9606.ENSP00000370215.

PTM databases

iPTMnetiQ6NXP6.
PhosphoSiteiQ6NXP6.

Polymorphism and mutation databases

BioMutaiNOXRED1.
DMDMi134034048.

Proteomic databases

PaxDbiQ6NXP6.
PeptideAtlasiQ6NXP6.
PRIDEiQ6NXP6.

Protocols and materials databases

DNASUi122945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380835; ENSP00000370215; ENSG00000165555. [Q6NXP6-1]
GeneIDi122945.
KEGGihsa:122945.
UCSCiuc001xtr.4. human. [Q6NXP6-1]

Organism-specific databases

CTDi122945.
GeneCardsiNOXRED1.
HGNCiHGNC:20487. NOXRED1.
HPAiHPA055658.
neXtProtiNX_Q6NXP6.
PharmGKBiPA134935429.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3124. Eukaryota.
COG0345. LUCA.
GeneTreeiENSGT00390000007632.
HOGENOMiHOG000111827.
HOVERGENiHBG081280.
InParanoidiQ6NXP6.
OMAiHATFFCK.
OrthoDBiEOG7HQN9P.
PhylomeDBiQ6NXP6.
TreeFamiTF335538.

Miscellaneous databases

GenomeRNAii122945.
PROiQ6NXP6.

Gene expression databases

BgeeiQ6NXP6.
CleanExiHS_C14orf148.
ExpressionAtlasiQ6NXP6. baseline and differential.
GenevisibleiQ6NXP6. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiNXRD1_HUMAN
AccessioniPrimary (citable) accession number: Q6NXP6
Secondary accession number(s): B3KQ47, O95435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.