Q6NXP6 (NXRD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADP-dependent oxidoreductase domain-containing protein 1
EC=1.-.-.-

Alternative name(s):
Pyrroline-5-carboxylate reductase-like protein C14orf148

Gene names

Name:	NOXRED1
Synonyms:	C14orf148

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable oxidoreductase By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NXP6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NXP6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     229-359: GIILNIKWLE...PVISTGFPSQ → HGSTYFWHSFENYFPVGPLLSY

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	NADP-dependent oxidoreductase domain-containing protein 1		PRO_0000280279
Natural variations
	Alternative sequence	229 – 359	131	GIILN…GFPSQ → HGSTYFWHSFENYFPVGPLL SY in isoform 2.		VSP_038392
Experimental info
	Sequence conflict	166	1	V → A in AAH66965. Ref.4
	Sequence conflict	183	1	N → D in AAH66965. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: B0FA3F74289B3A92	FASTA	359	39,880
	10 20 30 40 50 60 MDMLQDLESL QFEYGVPEED RIWLYLQGRS RGLMIEACAH ATFFCKLLYN LRASLNKNQS 70 80 90 100 110 120 SRHLSIGSLN SATPEEFKVG IIGGGHLGKQ LAGTLLQLGP IPAESLRIST RRPETLGELQ 130 140 150 160 170 180 KLGIKCFYHN ADLVSWADVI FLCCLPSQLP NICVEIYTSL EKASIVYSFV AAIPLPRLKL 190 200 210 220 230 240 LLNHTNILRP QYQYDEDSVS VWGANKGVIA ALQDPTILQA TCPYSPAGGI ILNIKWLEGV 250 260 270 280 290 300 FYAALNICTA RNMAHSQVLQ LLSELFLSVH FEDCGKDTAS CPKLQLTDFV SKAYGKNLSQ 310 320 330 340 350 ERPFPWFDLT AVQLKETPFS QHLSSSPVLQ DHLTHLYCAS FGISLTKEQP VISTGFPSQ
	Isoform 2 [UniParc]. Checksum: 70D0F6CC03127414	FASTA	250	27,897
	10 20 30 40 50 60 MDMLQDLESL QFEYGVPEED RIWLYLQGRS RGLMIEACAH ATFFCKLLYN LRASLNKNQS 70 80 90 100 110 120 SRHLSIGSLN SATPEEFKVG IIGGGHLGKQ LAGTLLQLGP IPAESLRIST RRPETLGELQ 130 140 150 160 170 180 KLGIKCFYHN ADLVSWADVI FLCCLPSQLP NICVEIYTSL EKASIVYSFV AAIPLPRLKL 190 200 210 220 230 240 LLNHTNILRP QYQYDEDSVS VWGANKGVIA ALQDPTILQA TCPYSPAGHG STYFWHSFEN 250 YFPVGPLLSY

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057371 mRNA. Translation: BAG51909.1. AF111168 Genomic DNA. Translation: AAD09625.1. AC007954 Genomic DNA. Translation: AAF62562.1. CH471061 Genomic DNA. Translation: EAW81285.1. BC066965 mRNA. Translation: AAH66965.1.
IPI	IPI00743780. IPI00829746.
RefSeq	NP_001106946.1. NM_001113475.2.
UniGene	Hs.97556.
3D structure databases
ProteinModelPortal	Q6NXP6.
SMR	Q6NXP6. Positions 77-182.
ModBase	Search...
Polymorphism databases
DMDM	134034048.
Proteomic databases
PRIDE	Q6NXP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380835; ENSP00000370215; ENSG00000165555.
GeneID	122945.
KEGG	hsa:122945.
UCSC	uc001xtr.2. human.
Organism-specific databases
CTD	122945.
GeneCards	GC14M077860.
HGNC	HGNC:20487. NOXRED1.
neXtProt	NX_Q6NXP6.
PharmGKB	PA134935429.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12008.
GeneTree	ENSGT00390000007632.
HOGENOM	HBG444679.
HOVERGEN	HBG081280.
InParanoid	Q6NXP6.
OMA	ACAHATF.
OrthoDB	EOG4VQ9PQ.
PhylomeDB	Q6NXP6.
Gene expression databases
ArrayExpress	Q6NXP6.
Bgee	Q6NXP6.
CleanEx	HS_C14orf148.
Genevestigator	Q6NXP6.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PROSITE	PS00521. P5CR. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	81032.

Entry information

Entry name

NXRD1_HUMAN

Accession

Primary (citable) accession number: Q6NXP6
Secondary accession number(s): B3KQ47, O95435

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.