Reviewed, UniProtKB/Swiss-Prot Q6NXP6 (CN148_HUMAN)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase-like protein C14orf148
    EC=1.-.-.-

Gene names

Name:

C14orf148

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable oxidoreductase By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.
Sequence caution	The sequence AAD09625.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAF62562.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Pyrroline-5-carboxylate reductase-like protein C14orf148		PRO_0000280279
Experimental info
	Sequence conflict	166	1	V → A in AAH66965. Ref.2
	Sequence conflict	183	1	N → D in AAH66965. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6NXP6-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: B0FA3F74289B3A92	FASTA	359	39,880
	10 20 30 40 50 60 MDMLQDLESL QFEYGVPEED RIWLYLQGRS RGLMIEACAH ATFFCKLLYN LRASLNKNQS 70 80 90 100 110 120 SRHLSIGSLN SATPEEFKVG IIGGGHLGKQ LAGTLLQLGP IPAESLRIST RRPETLGELQ 130 140 150 160 170 180 KLGIKCFYHN ADLVSWADVI FLCCLPSQLP NICVEIYTSL EKASIVYSFV AAIPLPRLKL 190 200 210 220 230 240 LLNHTNILRP QYQYDEDSVS VWGANKGVIA ALQDPTILQA TCPYSPAGGI ILNIKWLEGV 250 260 270 280 290 300 FYAALNICTA RNMAHSQVLQ LLSELFLSVH FEDCGKDTAS CPKLQLTDFV SKAYGKNLSQ 310 320 330 340 350 ERPFPWFDLT AVQLKETPFS QHLSSSPVLQ DHLTHLYCAS FGISLTKEQP VISTGFPSQ

References

[1]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF111168 Genomic DNA. Translation: AAD09625.1. Sequence problems. AC007954 Genomic DNA. Translation: AAF62562.1. Sequence problems. BC066965 mRNA. Translation: AAH66965.1.
IPI	IPI00743780.
RefSeq	NP_001106946.1.
UniGene	Hs.97556
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6NXP6.
Genome annotation databases
Ensembl	ENSG00000165555. Homo sapiens. [Contig view]
GeneID	122945.
KEGG	hsa:122945.
UCSC	uc001xtr.2. human.
Organism-specific databases
GeneCards	GC14M076930.
HGNC	HGNC:20487. C14orf148.
PharmGKB	PA134935429.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6NXP6.
OMA	Q6NXP6. ACAHATF.
Gene expression databases
ArrayExpress	Q6NXP6.
Bgee	Q6NXP6.
CleanEx	HS_C14orf148.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PROSITE	PS00521. P5CR. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	81032.

Entry information

Entry name

CN148_HUMAN

Accession

Primary (citable) accession number: Q6NXP6
Secondary accession number(s): O95435

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	July 7, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)