Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM71F2

Gene

FAM71F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71F2
Alternative name(s):
Protein FAM137B
Gene namesi
Name:FAM71F2
Synonyms:FAM137B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27998. FAM71F2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387816.

Polymorphism and mutation databases

BioMutaiFAM71F2.
DMDMi296439354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Protein FAM71F2PRO_0000311689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei263 – 2631PhosphoserineBy similarity
Modified residuei267 – 2671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NXP2.
PRIDEiQ6NXP2.

Expressioni

Gene expression databases

BgeeiQ6NXP2.
CleanExiHS_FAM71F2.
ExpressionAtlasiQ6NXP2. baseline and differential.
GenevisibleiQ6NXP2. HS.

Organism-specific databases

HPAiHPA020513.
HPA024248.

Interactioni

Protein-protein interaction databases

BioGridi131394. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6NXP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

eggNOGiENOG410IYAN. Eukaryota.
ENOG4111BI6. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000060269.
HOVERGENiHBG057798.
InParanoidiQ6NXP2.
OMAiHCLVPKM.
OrthoDBiEOG70W3DK.
PhylomeDBiQ6NXP2.
TreeFamiTF336050.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKIRGLPPE VREPGPGVEL GVENGLLCQL IHSPEFNLFS NSVVFESNFI
60 70 80 90 100
QTHVPEADFQ VTKPGNWRDV CEGSATVILG VTSSVPSLPL PNVLLMANVT
110 120 130 140 150
WPQGPFTTWS TPGDAPVINL SRLLPLKYVE LRIYDRLQRI LRVRTVTEKI
160 170 180 190 200
YYLKLHEKHP EIVFQFWVRL VKILQKGLSI TTKDPRIKFT HCLVPKMPTN
210 220 230 240 250
STETTPENSL LSSPQPSEPL VLLAAEQTSG SFSQLSGKPQ LTADRNNDTA
260 270 280 290 300
IEIDNCSSYK IPSPVASPIN LNIPMRAALS HSLWEQEDWN EHLLQVHIAS

YLGEHFLGA
Length:309
Mass (Da):34,516
Last modified:May 18, 2010 - v3
Checksum:i3EDFA2DF5681549D
GO
Isoform 2 (identifier: Q6NXP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-60: Missing.

Show »
Length:300
Mass (Da):33,491
Checksum:i5ABAA851F79CF6F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121P → T.1 Publication
Corresponds to variant rs17169357 [ dbSNP | Ensembl ].
VAR_037267
Natural varianti114 – 1141D → V.2 Publications
Corresponds to variant rs6971819 [ dbSNP | Ensembl ].
VAR_037268
Natural varianti136 – 1361R → W.1 Publication
Corresponds to variant rs6467210 [ dbSNP | Ensembl ].
VAR_037269
Natural varianti251 – 2511I → V.1 Publication
Corresponds to variant rs1109552 [ dbSNP | Ensembl ].
VAR_037270

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 609Missing in isoform 2. 1 PublicationVSP_029581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018638 Genomic DNA. No translation available.
AC093183 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24114.1.
BC047310 mRNA. Translation: AAH47310.2.
BC066973 mRNA. Translation: AAH66973.2.
BC105729 mRNA. Translation: AAI05730.1.
BC105730 mRNA. Translation: AAI05731.1.
BC105731 mRNA. Translation: AAI05732.1.
CCDSiCCDS47701.1. [Q6NXP2-1]
CCDS47702.1. [Q6NXP2-2]
RefSeqiNP_001012457.3. NM_001012454.5. [Q6NXP2-1]
NP_001122398.1. NM_001128926.3. [Q6NXP2-2]
XP_011514430.1. XM_011516128.1. [Q6NXP2-1]
XP_011514431.1. XM_011516129.1. [Q6NXP2-1]
XP_011514432.1. XM_011516130.1. [Q6NXP2-1]
XP_011514433.1. XM_011516131.1. [Q6NXP2-1]
XP_011514434.1. XM_011516132.1. [Q6NXP2-2]
UniGeneiHs.445236.

Genome annotation databases

EnsembliENST00000434001; ENSP00000401654; ENSG00000205085. [Q6NXP2-2]
ENST00000474069; ENSP00000418907; ENSG00000205085. [Q6NXP2-2]
ENST00000480462; ENSP00000420140; ENSG00000205085. [Q6NXP2-1]
GeneIDi346653.
KEGGihsa:346653.
UCSCiuc003vnk.6. human. [Q6NXP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018638 Genomic DNA. No translation available.
AC093183 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24114.1.
BC047310 mRNA. Translation: AAH47310.2.
BC066973 mRNA. Translation: AAH66973.2.
BC105729 mRNA. Translation: AAI05730.1.
BC105730 mRNA. Translation: AAI05731.1.
BC105731 mRNA. Translation: AAI05732.1.
CCDSiCCDS47701.1. [Q6NXP2-1]
CCDS47702.1. [Q6NXP2-2]
RefSeqiNP_001012457.3. NM_001012454.5. [Q6NXP2-1]
NP_001122398.1. NM_001128926.3. [Q6NXP2-2]
XP_011514430.1. XM_011516128.1. [Q6NXP2-1]
XP_011514431.1. XM_011516129.1. [Q6NXP2-1]
XP_011514432.1. XM_011516130.1. [Q6NXP2-1]
XP_011514433.1. XM_011516131.1. [Q6NXP2-1]
XP_011514434.1. XM_011516132.1. [Q6NXP2-2]
UniGeneiHs.445236.

3D structure databases

ProteinModelPortaliQ6NXP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131394. 2 interactions.

Polymorphism and mutation databases

BioMutaiFAM71F2.
DMDMi296439354.

Proteomic databases

PaxDbiQ6NXP2.
PRIDEiQ6NXP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434001; ENSP00000401654; ENSG00000205085. [Q6NXP2-2]
ENST00000474069; ENSP00000418907; ENSG00000205085. [Q6NXP2-2]
ENST00000480462; ENSP00000420140; ENSG00000205085. [Q6NXP2-1]
GeneIDi346653.
KEGGihsa:346653.
UCSCiuc003vnk.6. human. [Q6NXP2-1]

Organism-specific databases

CTDi346653.
GeneCardsiFAM71F2.
HGNCiHGNC:27998. FAM71F2.
HPAiHPA020513.
HPA024248.
neXtProtiNX_Q6NXP2.
PharmGKBiPA162387816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYAN. Eukaryota.
ENOG4111BI6. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000060269.
HOVERGENiHBG057798.
InParanoidiQ6NXP2.
OMAiHCLVPKM.
OrthoDBiEOG70W3DK.
PhylomeDBiQ6NXP2.
TreeFamiTF336050.

Miscellaneous databases

GenomeRNAii346653.
NextBioi98995.
PROiQ6NXP2.

Gene expression databases

BgeeiQ6NXP2.
CleanExiHS_FAM71F2.
ExpressionAtlasiQ6NXP2. baseline and differential.
GenevisibleiQ6NXP2. HS.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-114.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-112; VAL-114; TRP-136 AND VAL-251.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiF71F2_HUMAN
AccessioniPrimary (citable) accession number: Q6NXP2
Secondary accession number(s): Q0VGF6, Q0VGF7, Q86X39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.