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Protein

RCC1 and BTB domain-containing protein 1

Gene

Rcbtb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell cycle regulation by chromatin remodeling.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 1
Alternative name(s):
Regulator of chromosome condensation and BTB domain-containing protein 1
Gene namesi
Name:Rcbtb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918580. Rcbtb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531RCC1 and BTB domain-containing protein 1PRO_0000206643Add
BLAST

Proteomic databases

EPDiQ6NXM2.
MaxQBiQ6NXM2.
PaxDbiQ6NXM2.
PRIDEiQ6NXM2.

PTM databases

iPTMnetiQ6NXM2.
PhosphoSiteiQ6NXM2.

Expressioni

Gene expression databases

BgeeiQ6NXM2.

Interactioni

Protein-protein interaction databases

BioGridi214641. 1 interaction.
IntActiQ6NXM2. 1 interaction.
STRINGi10090.ENSMUSP00000022551.

Structurei

3D structure databases

ProteinModelPortaliQ6NXM2.
SMRiQ6NXM2. Positions 37-314, 356-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati40 – 9152RCC1 1Add
BLAST
Repeati93 – 14553RCC1 2Add
BLAST
Repeati147 – 19852RCC1 3Add
BLAST
Repeati199 – 25052RCC1 4Add
BLAST
Repeati252 – 30251RCC1 5Add
BLAST
Repeati304 – 35653RCC1 6Add
BLAST
Domaini370 – 43768BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini470 – 49930BTB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
Contains 6 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
HOGENOMiHOG000065752.
HOVERGENiHBG053261.
InParanoidiQ6NXM2.
KOiK11494.
PhylomeDBiQ6NXM2.
TreeFamiTF329478.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVGKWPIF TLLSPQEAGS IRKACVFGTS ANEAIYVTDN DEVFVFGLNY
60 70 80 90 100
SNCLGTGDNQ STLVPKKLEA LCGKKIKSLS YGSGPHVLLT TEDGVVYAWG
110 120 130 140 150
HNGYSQLGNG TTNQGIAPVQ VCTNLLIKQV IEVACGSHHS MALAADGELF
160 170 180 190 200
AWGYNNCGQV GSGSTANQPT PRKVTNCLHT KRVVNIACGQ TSSMAVLDSG
210 220 230 240 250
EVYGWGYNGN GQLGLGNNGN QLTPVRVAAL HGMCVNQIVC GYAHTLALTD
260 270 280 290 300
EGLLYAWGAN TYGQLGTGSK NNLLSPTQIM VEKERVIEIA ACHSTHTSAA
310 320 330 340 350
KTQGGHVYMW GQCRGQSVIL PHLTHFCCTD DVFACFGTPA VSWRLLSVEH
360 370 380 390 400
EDFLTVAESL KKEFDSPEIA DLKFRIDGKY IHVHKAVLKI RCEHFRSMFQ
410 420 430 440 450
SYWNEDMKEV IEIDQFSYPV YRAFLQYLYT DTVDLPPEDA IGLLDLATSY
460 470 480 490 500
CENRLKRLCQ HIIKRGITVE NAFSLFSAAV RYDAEDLEEF CFKFCINHLT
510 520 530
EVTQTAAFWQ MDGPLLKEFI AKASKCGAFK N
Length:531
Mass (Da):58,379
Last modified:July 5, 2004 - v1
Checksum:iAF542D25AB504024
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741V → I in BAC40268 (PubMed:16141072).Curated
Sequence conflicti369 – 3691I → T in BAC28324 (PubMed:16141072).Curated
Sequence conflicti369 – 3691I → T in BAC40268 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033501 mRNA. Translation: BAC28324.1.
AK088299 mRNA. Translation: BAC40268.1.
BC067005 mRNA. Translation: AAH67005.1.
CCDSiCCDS27168.1.
RefSeqiNP_082040.2. NM_027764.2.
XP_006519629.1. XM_006519566.2.
XP_006519630.1. XM_006519567.2.
XP_006519631.1. XM_006519568.2.
XP_006519632.1. XM_006519569.2.
UniGeneiMm.234195.

Genome annotation databases

GeneIDi71330.
KEGGimmu:71330.
UCSCiuc007ueb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033501 mRNA. Translation: BAC28324.1.
AK088299 mRNA. Translation: BAC40268.1.
BC067005 mRNA. Translation: AAH67005.1.
CCDSiCCDS27168.1.
RefSeqiNP_082040.2. NM_027764.2.
XP_006519629.1. XM_006519566.2.
XP_006519630.1. XM_006519567.2.
XP_006519631.1. XM_006519568.2.
XP_006519632.1. XM_006519569.2.
UniGeneiMm.234195.

3D structure databases

ProteinModelPortaliQ6NXM2.
SMRiQ6NXM2. Positions 37-314, 356-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214641. 1 interaction.
IntActiQ6NXM2. 1 interaction.
STRINGi10090.ENSMUSP00000022551.

PTM databases

iPTMnetiQ6NXM2.
PhosphoSiteiQ6NXM2.

Proteomic databases

EPDiQ6NXM2.
MaxQBiQ6NXM2.
PaxDbiQ6NXM2.
PRIDEiQ6NXM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71330.
KEGGimmu:71330.
UCSCiuc007ueb.2. mouse.

Organism-specific databases

CTDi55213.
MGIiMGI:1918580. Rcbtb1.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
HOGENOMiHOG000065752.
HOVERGENiHBG053261.
InParanoidiQ6NXM2.
KOiK11494.
PhylomeDBiQ6NXM2.
TreeFamiTF329478.

Miscellaneous databases

NextBioi333557.
PROiQ6NXM2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NXM2.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Colon and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiRCBT1_MOUSE
AccessioniPrimary (citable) accession number: Q6NXM2
Secondary accession number(s): Q8BTZ6, Q8BZV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.