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Protein

Sentrin-specific protease 5

Gene

Senp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division (By similarity).By similarity

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei640 – 6401By similarity
Active sitei657 – 6571By similarity
Active sitei707 – 7071By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-3065679. SUMO is proteolytically processed.

Protein family/group databases

MEROPSiC48.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 5 (EC:3.4.22.68)
Alternative name(s):
SUMO/Smt3-specific isopeptidase 3
Short name:
Smt3ip3
Sentrin/SUMO-specific protease SENP5
Gene namesi
Name:Senp5
Synonyms:Smt3ip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443596. Senp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Sentrin-specific protease 5PRO_0000267607Add
BLAST

Proteomic databases

MaxQBiQ6NXL6.
PaxDbiQ6NXL6.
PRIDEiQ6NXL6.

PTM databases

iPTMnetiQ6NXL6.
PhosphoSiteiQ6NXL6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022772.
CleanExiMM_SENP5.
ExpressionAtlasiQ6NXL6. baseline and differential.
GenevisibleiQ6NXL6. MM.

Interactioni

Subunit structurei

Interacts with CCAR2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023457.

Structurei

3D structure databases

ProteinModelPortaliQ6NXL6.
SMRiQ6NXL6. Positions 509-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni557 – 718162ProteaseAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0778. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000062941.
HOGENOMiHOG000070166.
HOVERGENiHBG062231.
InParanoidiQ6NXL6.
KOiK08594.
OMAiWRKGIHL.
OrthoDBiEOG091G092N.
PhylomeDBiQ6NXL6.
TreeFamiTF316289.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
IPR033465. SENP5.
[Graphical view]
PANTHERiPTHR12606:SF10. PTHR12606:SF10. 2 hits.
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQKKILWK KGIHLAFSEK WNAGFGSFKK FYFPQNLCFL KAKLGRPVAW
60 70 80 90 100
HRQVKHFQCN KGLHIQKTWI QDVPFCSKTK SGLATQNVST LYPKVKRKDS
110 120 130 140 150
KHFISSSRSL LKLQADKLLS SAKSLDHKYC REKSLLKAAP GLSANTVLGR
160 170 180 190 200
ANGHEPTTDP QASDFPMKFS GESQSPGDSG KTVVLNKHRK RVCHGCYQGL
210 220 230 240 250
EHHRNRRPLI PKQFQLNQHR RVRASLMMYE KLSMIRFRYR IFRSQHFRTK
260 270 280 290 300
SRVCKLRKAQ RSWVQKVTGD HQENLRDNNT EGDNCNPVPS LEPKDPCRCQ
310 320 330 340 350
PYFPDMDSSA VGKGKNCHVP DGHTKENPVL DKEHGLDDTF PDQQNGCVAY
360 370 380 390 400
NWDQSSSCPK WECTEQIHEI PLMEHPSSDK FSPETERALM ALGQESGTSA
410 420 430 440 450
VSDDREKLPV SGADKSVSSV DGPVSEEPAQ NENFQMEEDG SLKQSILSSK
460 470 480 490 500
LLDHPYCKSP LDAPLLCSEP KVENQMSGGK SSQTASPVDD EQLSTCLSGF
510 520 530 540 550
LDEVMKKYGS LVPLSEKDVL GRLKDVFNED FSNRKPFINR EITNYRARHQ
560 570 580 590 600
KCNFRIFYNK HMLDMDDLAT LDGQNWLNDQ VINMYGELIM DAVPDKVHFF
610 620 630 640 650
NSFFHRQLVT KGYNGVKRWT KKVDLFKKSL LLIPIHLEVH WSLITVTLSS
660 670 680 690 700
RIISFYDSQG IHFKFCVENI RKYLLTEARE KNRPEFLQGW QTAVTKCIPQ
710 720 730 740
QKNDSDCGVF VLQYCKCLAL EQPFQFSQED MPRVRKRIYK ELCECRLLD
Length:749
Mass (Da):86,100
Last modified:July 5, 2004 - v1
Checksum:i9356AC4FB3DE590C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511H → P in BAC31483 (PubMed:16141072).Curated
Sequence conflicti288 – 2881V → A in AAT01901 (Ref. 1) Curated
Sequence conflicti323 – 3231H → R in AAT01901 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY522918 mRNA. Translation: AAT01901.1.
AK043171 mRNA. Translation: BAC31483.1.
BC067014 mRNA. Translation: AAH67014.1.
BC080830 mRNA. Translation: AAH80830.1.
CCDSiCCDS28111.1.
RefSeqiNP_796077.2. NM_177103.4.
XP_006522301.1. XM_006522238.2.
XP_006522302.1. XM_006522239.2.
XP_011244235.1. XM_011245933.1.
UniGeneiMm.152890.

Genome annotation databases

EnsembliENSMUST00000023457; ENSMUSP00000023457; ENSMUSG00000022772.
GeneIDi320213.
KEGGimmu:320213.
UCSCiuc007yya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY522918 mRNA. Translation: AAT01901.1.
AK043171 mRNA. Translation: BAC31483.1.
BC067014 mRNA. Translation: AAH67014.1.
BC080830 mRNA. Translation: AAH80830.1.
CCDSiCCDS28111.1.
RefSeqiNP_796077.2. NM_177103.4.
XP_006522301.1. XM_006522238.2.
XP_006522302.1. XM_006522239.2.
XP_011244235.1. XM_011245933.1.
UniGeneiMm.152890.

3D structure databases

ProteinModelPortaliQ6NXL6.
SMRiQ6NXL6. Positions 509-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023457.

Protein family/group databases

MEROPSiC48.008.

PTM databases

iPTMnetiQ6NXL6.
PhosphoSiteiQ6NXL6.

Proteomic databases

MaxQBiQ6NXL6.
PaxDbiQ6NXL6.
PRIDEiQ6NXL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023457; ENSMUSP00000023457; ENSMUSG00000022772.
GeneIDi320213.
KEGGimmu:320213.
UCSCiuc007yya.2. mouse.

Organism-specific databases

CTDi205564.
MGIiMGI:2443596. Senp5.

Phylogenomic databases

eggNOGiKOG0778. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000062941.
HOGENOMiHOG000070166.
HOVERGENiHBG062231.
InParanoidiQ6NXL6.
KOiK08594.
OMAiWRKGIHL.
OrthoDBiEOG091G092N.
PhylomeDBiQ6NXL6.
TreeFamiTF316289.

Enzyme and pathway databases

ReactomeiR-MMU-3065679. SUMO is proteolytically processed.

Miscellaneous databases

PROiQ6NXL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022772.
CleanExiMM_SENP5.
ExpressionAtlasiQ6NXL6. baseline and differential.
GenevisibleiQ6NXL6. MM.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
IPR033465. SENP5.
[Graphical view]
PANTHERiPTHR12606:SF10. PTHR12606:SF10. 2 hits.
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSENP5_MOUSE
AccessioniPrimary (citable) accession number: Q6NXL6
Secondary accession number(s): Q3ZTK4, Q8BXW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.