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Protein

Inactive dipeptidyl peptidase 10

Gene

Dpp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (Probable).By similarityCurated1 Publication

Caution

Gly-652 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHERimouse-dpp10 DPP4N_Peptidase_S9
MEROPSiS09.974

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase X
Short name:
DPP X
Gene namesi
Name:Dpp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442409 Dpp10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 797ExtracellularSequence analysisAdd BLAST742

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224181 – 797Inactive dipeptidyl peptidase 10Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei139PhosphotyrosineBy similarity1
Modified residuei144PhosphotyrosineBy similarity1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-258, which is crucial.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6NXK7
PaxDbiQ6NXK7
PRIDEiQ6NXK7

PTM databases

iPTMnetiQ6NXK7
PhosphoSitePlusiQ6NXK7

Expressioni

Tissue specificityi

Detected in brain cortex (at protein level) (PubMed:22311982). Expressed in the brain, predominantly by neurons and not by glia.2 Publications

Gene expression databases

CleanExiMM_DPP10

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 and KCND2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6NXK7 1 interactor.
MINTiQ6NXK7
STRINGi10090.ENSMUSP00000108225

Structurei

3D structure databases

ProteinModelPortaliQ6NXK7
SMRiQ6NXK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
HOGENOMiHOG000231875
HOVERGENiHBG105877
InParanoidiQ6NXK7
PhylomeDBiQ6NXK7

Family and domain databases

Gene3Di2.140.10.301 hit
3.40.50.18201 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NXK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEQQPTPG ARATQSQPAD QELGSNSPPQ RNWKGIAIAL LVILVVCSLI
60 70 80 90 100
TMSVILLTPD ELTNSSETRL SLEELLGKGF GLHNPEPRWI NDTVVVYKTN
110 120 130 140 150
NGHVMKLNTE SNASTLLLDN STFVTFKASR HSLSPDLKYV LLAYDVKQIF
160 170 180 190 200
HYSFTASYLI YNIHTGEVWE LNPPEVEDSV LQYAAWGVQG QQLIYIFENN
210 220 230 240 250
IYYQPDIKSS SLRLTSSGKE GIIFNGIADW LYEEELLHSH IAHWWSPDGE
260 270 280 290 300
RLAFLMINDS LVPNMIIPRF TGALYPKAKQ YPYPKAGQAN PSVKLYVVNL
310 320 330 340 350
YGPTHTLELM PPDIFKSREY YITMVKWVSN TRTVVRWLNR PQNISILTLC
360 370 380 390 400
ESTTGACSRK YEMTSDTWLS KQNEEPVFSR DGSKFFMTVP VKQGGRGEFH
410 420 430 440 450
HIAMFLVQSK SEQITVRHLT SGNWEVIRIL AYDETTQKIY FLSTESSPQG
460 470 480 490 500
RQLYSASTEG LLNRDCISCN FMKEDCTYFD ASFSPMNQHF LLFCEGPKVP
510 520 530 540 550
VVSLHITDNP SRYFLLENNS VMKETIQKKK LAKRETRILH IDDYELPLQL
560 570 580 590 600
SFPKDFMEKN QYALLLIMDE EPGGQMVTDK FHVDWDSVLI DTDNVIVARF
610 620 630 640 650
DGRGSGFQGL KVLQEIHRRI GSVEAKDQVA AVKYLLKQPY IDSKRLSIFG
660 670 680 690 700
KGYGGYIASM ILKSDEKFFK CGAVVAPISD MKLYASAFSE RYLGMPSKEE
710 720 730 740 750
STYQASSVLH NIHGLKEENL LIIHGTADTK VHFQHSAELI KHLIKAGVNY
760 770 780 790
TLQVYPDEGY HISDKSKHHF YSTILRFFSD CLKEEVSVLP QEPEEDE
Length:797
Mass (Da):90,827
Last modified:July 5, 2004 - v1
Checksum:i46808DCF364763DE
GO

Sequence cautioni

The sequence AAH63074 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029696 mRNA Translation: AAH29696.1
BC063074 mRNA Translation: AAH63074.1 Different initiation.
BC067026 mRNA Translation: AAH67026.1
RefSeqiNP_950186.3, NM_199021.3
UniGeneiMm.417716
Mm.483255

Genome annotation databases

GeneIDi269109
KEGGimmu:269109

Similar proteinsi

Entry informationi

Entry nameiDPP10_MOUSE
AccessioniPrimary (citable) accession number: Q6NXK7
Secondary accession number(s): Q6P554, Q8K1H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome