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Protein

Inactive dipeptidyl peptidase 10

Gene

Dpp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (Probable).By similarityCurated1 Publication

GO - Molecular functioni

  • potassium channel regulator activity Source: UniProtKB
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERimouse-dpp10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase X
Short name:
DPP X
Gene namesi
Name:Dpp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442409. Dpp10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence analysisAdd
BLAST
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini56 – 797742ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 797797Inactive dipeptidyl peptidase 10PRO_0000122418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Modified residuei139 – 1391PhosphotyrosineBy similarity
Modified residuei144 – 1441PhosphotyrosineBy similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence analysis
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence analysis
Glycosylationi749 – 7491N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-258, which is crucial.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6NXK7.
PaxDbiQ6NXK7.
PRIDEiQ6NXK7.

PTM databases

iPTMnetiQ6NXK7.
PhosphoSiteiQ6NXK7.

Expressioni

Tissue specificityi

Detected in brain cortex (at protein level) (PubMed:22311982). Expressed in the brain, predominantly by neurons and not by glia.2 Publications

Gene expression databases

BgeeiENSMUSG00000036815.
CleanExiMM_DPP10.

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 and KCND2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6NXK7. 1 interaction.
MINTiMINT-4117001.
STRINGi10090.ENSMUSP00000108225.

Structurei

3D structure databases

ProteinModelPortaliQ6NXK7.
SMRiQ6NXK7. Positions 66-784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ6NXK7.
PhylomeDBiQ6NXK7.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NXK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEQQPTPG ARATQSQPAD QELGSNSPPQ RNWKGIAIAL LVILVVCSLI
60 70 80 90 100
TMSVILLTPD ELTNSSETRL SLEELLGKGF GLHNPEPRWI NDTVVVYKTN
110 120 130 140 150
NGHVMKLNTE SNASTLLLDN STFVTFKASR HSLSPDLKYV LLAYDVKQIF
160 170 180 190 200
HYSFTASYLI YNIHTGEVWE LNPPEVEDSV LQYAAWGVQG QQLIYIFENN
210 220 230 240 250
IYYQPDIKSS SLRLTSSGKE GIIFNGIADW LYEEELLHSH IAHWWSPDGE
260 270 280 290 300
RLAFLMINDS LVPNMIIPRF TGALYPKAKQ YPYPKAGQAN PSVKLYVVNL
310 320 330 340 350
YGPTHTLELM PPDIFKSREY YITMVKWVSN TRTVVRWLNR PQNISILTLC
360 370 380 390 400
ESTTGACSRK YEMTSDTWLS KQNEEPVFSR DGSKFFMTVP VKQGGRGEFH
410 420 430 440 450
HIAMFLVQSK SEQITVRHLT SGNWEVIRIL AYDETTQKIY FLSTESSPQG
460 470 480 490 500
RQLYSASTEG LLNRDCISCN FMKEDCTYFD ASFSPMNQHF LLFCEGPKVP
510 520 530 540 550
VVSLHITDNP SRYFLLENNS VMKETIQKKK LAKRETRILH IDDYELPLQL
560 570 580 590 600
SFPKDFMEKN QYALLLIMDE EPGGQMVTDK FHVDWDSVLI DTDNVIVARF
610 620 630 640 650
DGRGSGFQGL KVLQEIHRRI GSVEAKDQVA AVKYLLKQPY IDSKRLSIFG
660 670 680 690 700
KGYGGYIASM ILKSDEKFFK CGAVVAPISD MKLYASAFSE RYLGMPSKEE
710 720 730 740 750
STYQASSVLH NIHGLKEENL LIIHGTADTK VHFQHSAELI KHLIKAGVNY
760 770 780 790
TLQVYPDEGY HISDKSKHHF YSTILRFFSD CLKEEVSVLP QEPEEDE
Length:797
Mass (Da):90,827
Last modified:July 5, 2004 - v1
Checksum:i46808DCF364763DE
GO

Sequence cautioni

The sequence AAH63074 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029696 mRNA. Translation: AAH29696.1.
BC063074 mRNA. Translation: AAH63074.1. Different initiation.
BC067026 mRNA. Translation: AAH67026.1.
RefSeqiNP_950186.3. NM_199021.3.
UniGeneiMm.417716.
Mm.483255.

Genome annotation databases

GeneIDi269109.
KEGGimmu:269109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029696 mRNA. Translation: AAH29696.1.
BC063074 mRNA. Translation: AAH63074.1. Different initiation.
BC067026 mRNA. Translation: AAH67026.1.
RefSeqiNP_950186.3. NM_199021.3.
UniGeneiMm.417716.
Mm.483255.

3D structure databases

ProteinModelPortaliQ6NXK7.
SMRiQ6NXK7. Positions 66-784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NXK7. 1 interaction.
MINTiMINT-4117001.
STRINGi10090.ENSMUSP00000108225.

Protein family/group databases

ESTHERimouse-dpp10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

PTM databases

iPTMnetiQ6NXK7.
PhosphoSiteiQ6NXK7.

Proteomic databases

MaxQBiQ6NXK7.
PaxDbiQ6NXK7.
PRIDEiQ6NXK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi269109.
KEGGimmu:269109.

Organism-specific databases

CTDi57628.
MGIiMGI:2442409. Dpp10.

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ6NXK7.
PhylomeDBiQ6NXK7.

Miscellaneous databases

PROiQ6NXK7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036815.
CleanExiMM_DPP10.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPP10_MOUSE
AccessioniPrimary (citable) accession number: Q6NXK7
Secondary accession number(s): Q6P554, Q8K1H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Gly-652 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.