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Protein

RNA/RNP complex-1-interacting phosphatase

Gene

Dusp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei151 – 1511Phosphocysteine intermediatePROSITE-ProRule annotation
Active sitei157 – 1571Proton donor/acceptorSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
Gene namesi
Name:Dusp11
Synonyms:Pir1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919352. Dusp11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321RNA/RNP complex-1-interacting phosphatasePRO_0000094817Add
BLAST

Proteomic databases

EPDiQ6NXK5.
MaxQBiQ6NXK5.
PaxDbiQ6NXK5.
PRIDEiQ6NXK5.

PTM databases

iPTMnetiQ6NXK5.
PhosphoSiteiQ6NXK5.

Expressioni

Gene expression databases

BgeeiQ6NXK5.
ExpressionAtlasiQ6NXK5. baseline and differential.
GenevisibleiQ6NXK5. MM.

Interactioni

Subunit structurei

May interact with SFRS7 and SFRS9/SRP30C.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032071.

Structurei

3D structure databases

ProteinModelPortaliQ6NXK5.
SMRiQ6NXK5. Positions 28-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 19670Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1576Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000112295.
HOVERGENiHBG051420.
InParanoidiQ6NXK5.
KOiK14165.
OMAiGPPGEDY.
OrthoDBiEOG72VH64.
PhylomeDBiQ6NXK5.
TreeFamiTF105124.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQHYGRHGR GRGRDFAACA PPKKKGRNHI PERWKDYLPV GQRMPGTRFI
60 70 80 90 100
AFKVPLQKKF EAKLMPEECF SPLDLFNKIQ EQNEELGLII DLTYTQRYYK
110 120 130 140 150
VEDLPETISY IKIFTVGHQI PDNDTIFQFK CAVKEFLKKN KNNDKLIGVH
160 170 180 190 200
CTHGLNRTGY LICRYLIDVE GMRPDDAIEL FNSCRGHCIE RQNYIENLQK
210 220 230 240 250
RHVRKNRNVS APRTDGLEDS ADPTEQVYTN NKPVKKKPRK NRRGGHLAPS
260 270 280 290 300
QHFQHQTQSS PYSLRKWSQN QSVYQRGLVP PPGPAGEDYS QRRFFWSARP
310 320
NKWTAESYQR PFYPYYWEWN L
Length:321
Mass (Da):37,851
Last modified:July 5, 2004 - v1
Checksum:i5C757545FBA235E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591G → A in BAC40665 (PubMed:16141072).Curated
Sequence conflicti173 – 1731R → T in BAC40665 (PubMed:16141072).Curated
Sequence conflicti178 – 1781I → N in BAC40665 (PubMed:16141072).Curated
Sequence conflicti193 – 1931N → D in BAC40665 (PubMed:16141072).Curated
Sequence conflicti237 – 2371K → E in BAC40665 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040232 mRNA. Translation: BAC30546.1.
AK088941 mRNA. Translation: BAC40665.1.
BC067028 mRNA. Translation: AAH67028.1.
CCDSiCCDS20306.1.
RefSeqiNP_082375.4. NM_028099.4.
UniGeneiMm.24007.

Genome annotation databases

EnsembliENSMUST00000032071; ENSMUSP00000032071; ENSMUSG00000030002.
GeneIDi72102.
KEGGimmu:72102.
UCSCiuc009cqp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040232 mRNA. Translation: BAC30546.1.
AK088941 mRNA. Translation: BAC40665.1.
BC067028 mRNA. Translation: AAH67028.1.
CCDSiCCDS20306.1.
RefSeqiNP_082375.4. NM_028099.4.
UniGeneiMm.24007.

3D structure databases

ProteinModelPortaliQ6NXK5.
SMRiQ6NXK5. Positions 28-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032071.

PTM databases

iPTMnetiQ6NXK5.
PhosphoSiteiQ6NXK5.

Proteomic databases

EPDiQ6NXK5.
MaxQBiQ6NXK5.
PaxDbiQ6NXK5.
PRIDEiQ6NXK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032071; ENSMUSP00000032071; ENSMUSG00000030002.
GeneIDi72102.
KEGGimmu:72102.
UCSCiuc009cqp.1. mouse.

Organism-specific databases

CTDi8446.
MGIiMGI:1919352. Dusp11.

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000112295.
HOVERGENiHBG051420.
InParanoidiQ6NXK5.
KOiK14165.
OMAiGPPGEDY.
OrthoDBiEOG72VH64.
PhylomeDBiQ6NXK5.
TreeFamiTF105124.

Miscellaneous databases

ChiTaRSiDusp11. mouse.
NextBioi335440.
PROiQ6NXK5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NXK5.
ExpressionAtlasiQ6NXK5. baseline and differential.
GenevisibleiQ6NXK5. MM.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiDUS11_MOUSE
AccessioniPrimary (citable) accession number: Q6NXK5
Secondary accession number(s): Q8BTR4, Q8BYE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.