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Protein

Protein WWC2

Gene

Wwc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WWC2
Alternative name(s):
WW domain-containing protein 2
Gene namesi
Name:Wwc2
Synonyms:D8Ertd594e
ORF Names:MNCb-4173
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1261872. Wwc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11871187Protein WWC2PRO_0000309491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861PhosphoserineCombined sources
Modified residuei999 – 9991PhosphothreonineCombined sources
Modified residuei1017 – 10171PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6NXJ0.
PaxDbiQ6NXJ0.
PRIDEiQ6NXJ0.

PTM databases

iPTMnetiQ6NXJ0.
PhosphoSiteiQ6NXJ0.

Expressioni

Gene expression databases

BgeeiQ6NXJ0.
CleanExiMM_WWC2.
GenevisibleiQ6NXJ0. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056121.

Structurei

3D structure databases

ProteinModelPortaliQ6NXJ0.
SMRiQ6NXJ0. Positions 11-90, 700-823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 4334WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 9034WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini714 – 80390C2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili121 – 19474Sequence analysisAdd
BLAST
Coiled coili224 – 25633Sequence analysisAdd
BLAST
Coiled coili302 – 423122Sequence analysisAdd
BLAST
Coiled coili859 – 88527Sequence analysisAdd
BLAST
Coiled coili1063 – 114381Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WWC family.Curated
Contains 1 C2 domain.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ6NXJ0.
OMAiESREPLN.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ6NXJ0.
TreeFamiTF324040.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRAGSGQL PLPRGWEEAR DYDGKVFYID HNTRRTSWID PRDRLTKPLS
60 70 80 90 100
FADCVGDELP WGWEAGFDPQ IGAYYIDHIN KTTQIEDPRK QWRGEQEKML
110 120 130 140 150
KDYLSVAQDA LRTQKELYHV KEQRLALALD EYVRLNDAYK EKSSSHTSLF
160 170 180 190 200
SGSSSSTKYD PDILKAEIST TQLRVKKLKR ELSHMKQELL YKQQGFETLQ
210 220 230 240 250
QIDEKMSGGQ SGYELNEAKA ILTELKSIRK AISSGEKEKQ DLMQSLAKLQ
260 270 280 290 300
ERFHLDQNMG SSEPDLRSSP VNSHLSLSRQ TLDAGSQTSI SGDIGVRSRS
310 320 330 340 350
NLAEKVRLSL QYEEAKRSMA NLKIELSKLD GEAWPGALDI EKEKLMLINE
360 370 380 390 400
KEELLKELQF ITPQKRSQEE LERLEAERQH LEEELMAARG SPSRALTERL
410 420 430 440 450
KLEEKRKELL QKLEETTKLT TSLYSQLQSL SSSTLSMSSG SSLGSLASSR
460 470 480 490 500
GSLNTSSRGS LNSLSSSELY YSSQGDQMDT DYQYKLDFLL QEKGGYIPSG
510 520 530 540 550
PITTIHENEV VKSPSQPGQS GLCGVGVTAS SHTTPLTEAS KSVASLSSRS
560 570 580 590 600
SLSSLSPPGS PLVLDSVFPG SSHDTSPHQF PTDFEDCELS RRFADVGLGE
610 620 630 640 650
NQALLDSDSG GASQPLLEDK GLSDCPGELL CEGATDVEKS LPKRRGLHLR
660 670 680 690 700
GDKTTRVSAA ASDESVAGDS GVYEASMKQP GEMEDVPYSE EDVTIVETAQ
710 720 730 740 750
VQIGLRYDTK SSSFMVIIAQ LRNLHAFSIP HSSKVYFRVA LLPSSADVSC
760 770 780 790 800
LFRTKVHPPT ESVLYNDVFR VAVSQAALQQ KTLRVDLCSA SKHRREECLA
810 820 830 840 850
GTQISLADLP FSNEIFMLWY NLLPSKQMPC KKNEDGNEEP GARSQQPMLD
860 870 880 890 900
PIDLDAVSAL LARTSAELLA VEQELAQEEE EEELRPERRG PGRDCLTMLR
910 920 930 940 950
EASDEPAALR ESGVPLAEGS RCTEDPKPCP RGPETSQCRK EPAEDPGQLP
960 970 980 990 1000
SGLPTLVDKE TNTDEVVDSN MAVRPKDRSS LSSRQHPFVR NSVIVRSQTF
1010 1020 1030 1040 1050
SPGERSQYIC RLNRSDSDSS TLAKKSLFVR NSTERRSLRV KRAVCQPTLR
1060 1070 1080 1090 1100
RTAQECPVRT SLDLELDLQA SLTRQSRLND ELQALRGLRQ KLEELKAQGE
1110 1120 1130 1140 1150
TDLPPGVLED ERFQKLLKQA EKQAEQTKEE QKQDLNAERL MRQVSKDVCR
1160 1170 1180
LREQSQKEPR QVQSFREKIA YFTRAKISIP SLPADDV
Length:1,187
Mass (Da):132,620
Last modified:July 5, 2004 - v1
Checksum:i40FB67C9D1D3B296
GO

Sequence cautioni

The sequence BAA97983.1 differs from that shown. Reason: Frameshift at positions 59, 61, 424, 578 and 580. Curated
The sequence BAE28244.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti352 – 3521E → G in BAE28244 (PubMed:16141072).Curated
Sequence conflicti361 – 3611I → V in BAE28047 (PubMed:16141072).Curated
Sequence conflicti572 – 5721S → F in BAA97983 (Ref. 1) Curated
Sequence conflicti576 – 5772SP → FS in BAA97983 (Ref. 1) Curated
Sequence conflicti683 – 6831M → V in BAA97983 (Ref. 1) Curated
Sequence conflicti699 – 6991A → T in BAE28047 (PubMed:16141072).Curated
Sequence conflicti773 – 7731V → A in BAA97983 (Ref. 1) Curated
Sequence conflicti864 – 8641T → I in BAA97983 (Ref. 1) Curated
Sequence conflicti1174 – 11741R → I in BAA97983 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045323 mRNA. Translation: BAA97983.1. Frameshift.
AK028956 mRNA. Translation: BAC26212.1.
AK147648 mRNA. Translation: BAE28047.1.
AK147944 mRNA. Translation: BAE28244.1. Different initiation.
BC054434 mRNA. Translation: AAH54434.1.
BC067050 mRNA. Translation: AAH67050.1.
CCDSiCCDS22301.1.
RefSeqiNP_598552.2. NM_133791.4.
UniGeneiMm.235074.
Mm.390033.

Genome annotation databases

EnsembliENSMUST00000057561; ENSMUSP00000056121; ENSMUSG00000031563.
GeneIDi52357.
KEGGimmu:52357.
UCSCiuc009lrm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045323 mRNA. Translation: BAA97983.1. Frameshift.
AK028956 mRNA. Translation: BAC26212.1.
AK147648 mRNA. Translation: BAE28047.1.
AK147944 mRNA. Translation: BAE28244.1. Different initiation.
BC054434 mRNA. Translation: AAH54434.1.
BC067050 mRNA. Translation: AAH67050.1.
CCDSiCCDS22301.1.
RefSeqiNP_598552.2. NM_133791.4.
UniGeneiMm.235074.
Mm.390033.

3D structure databases

ProteinModelPortaliQ6NXJ0.
SMRiQ6NXJ0. Positions 11-90, 700-823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056121.

PTM databases

iPTMnetiQ6NXJ0.
PhosphoSiteiQ6NXJ0.

Proteomic databases

MaxQBiQ6NXJ0.
PaxDbiQ6NXJ0.
PRIDEiQ6NXJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057561; ENSMUSP00000056121; ENSMUSG00000031563.
GeneIDi52357.
KEGGimmu:52357.
UCSCiuc009lrm.2. mouse.

Organism-specific databases

CTDi80014.
MGIiMGI:1261872. Wwc2.

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ6NXJ0.
OMAiESREPLN.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ6NXJ0.
TreeFamiTF324040.

Miscellaneous databases

ChiTaRSiWwc2. mouse.
NextBioi308834.
PROiQ6NXJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NXJ0.
CleanExiMM_WWC2.
GenevisibleiQ6NXJ0. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N-3.
    Tissue: Brain and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-999, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Lung and Testis.

Entry informationi

Entry nameiWWC2_MOUSE
AccessioniPrimary (citable) accession number: Q6NXJ0
Secondary accession number(s): Q3UGG4
, Q3UH10, Q7TMY1, Q8CE61, Q9JJ63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.