Reviewed, UniProtKB/Swiss-Prot Q6NXI8 (CXXC4_MOUSE)

Names and origin

Protein names

Recommended name:
    CXXC-type zinc finger protein 4
Alternative name(s):
    Inhibition of the Dvl and axin complex protein

Gene names

Name:	Cxxc4
Synonyms:	Idax

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. Ref.2
Subunit structure	Interacts with the PDZ domain of DVL1 By similarity.
Subcellular location	Cytoplasm By similarity.
Developmental stage	Highest expression at embryonic day 11. Ref.2
Sequence similarities	Contains 1 CXXC-type zinc finger.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Ref.2 Inferred from physical interaction. Source: MGI
Cellular component	cytoplasmic membrane-bounded vesicle Ref.2 Inferred from direct assay. Source: MGI
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	CXXC-type zinc finger protein 4		PRO_0000317543
Regions
	Zinc finger	132 – 173	42	CXXC-type
	Region	161 – 166	6	Interaction with DVL1 By similarity
	Compositional bias	116 – 123	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q6NXI8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9D9F7FAD11A9B759	FASTA	198	20,978
	10 20 30 40 50 60 MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL 70 80 90 100 110 120 PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS 130 140 150 160 170 180 SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG 190 TSLERTPVPS AEAFRWFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein." Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. Mol. Cell. Biol. 21:330-342(2001) [PubMed: 11113207] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC067052 mRNA. Translation: AAH67052.1. BC082332 mRNA. Translation: AAH82332.1.
IPI	IPI00128988.
RefSeq	NP_001004367.1.
UniGene	Mm.442744 Mm.457442
3D structure databases
SMR	Q6NXI8. Positions 127-181.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6NXI8.
Proteomic databases
PRIDE	Q6NXI8.
Genome annotation databases
Ensembl	ENSMUST00000053048; ENSMUSP00000061614; ENSMUSG00000044365; Mus musculus. [Genome view]
GeneID	319478.
KEGG	mmu:319478.
UCSC	uc008rkx.1. mouse.
Organism-specific databases
CTD	319478.
MGI	MGI:2442112. Cxxc4.
Phylogenomic databases
eggNOG	maNOG14675.
HOGENOM	HBG445020.
HOVERGEN	Q6NXI8.
InParanoid	Q6NXI8.
OMA	MANTNSP.
OrthoDB	EOG9P5NW3.
PhylomeDB	Q6NXI8.
Gene expression databases
ArrayExpress	Q6NXI8.
Bgee	Q6NXI8.
CleanEx	MM_CXXC4.
Genevestigator	Q6NXI8.
Family and domain databases
InterPro	IPR002857. Znf_CXXC. [Graphical view]
Pfam	PF02008. zf-CXXC. 1 hit. [Graphical view]
PROSITE	PS51058. ZF_CXXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	394812.
SOURCE	Search...

Entry information

Entry name

CXXC4_MOUSE

Accession

Primary (citable) accession number: Q6NXI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)