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Protein

Regulation of nuclear pre-mRNA domain-containing protein 2

Gene

Rprd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 2
Gene namesi
Name:Rprd2
Synonyms:Kiaa0460
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922387. Rprd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14691469Regulation of nuclear pre-mRNA domain-containing protein 2PRO_0000244356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei374 – 3741PhosphoserineBy similarity
Modified residuei376 – 3761PhosphothreonineBy similarity
Modified residuei392 – 3921PhosphoserineCombined sources
Modified residuei492 – 4921PhosphoserineBy similarity
Modified residuei495 – 4951PhosphoserineBy similarity
Modified residuei498 – 4981PhosphoserineBy similarity
Modified residuei504 – 5041PhosphoserineBy similarity
Modified residuei536 – 5361PhosphothreonineBy similarity
Modified residuei583 – 5831PhosphoserineBy similarity
Modified residuei612 – 6121PhosphoserineCombined sources
Modified residuei617 – 6171PhosphothreonineBy similarity
Modified residuei633 – 6331PhosphoserineCombined sources
Modified residuei684 – 6841PhosphoserineBy similarity
Modified residuei738 – 7381PhosphoserineCombined sources
Modified residuei742 – 7421PhosphothreonineCombined sources
Modified residuei749 – 7491PhosphoserineCombined sources
Modified residuei751 – 7511PhosphothreonineCombined sources
Modified residuei777 – 7771PhosphoserineCombined sources
Modified residuei781 – 7811PhosphoserineBy similarity
Modified residuei845 – 8451PhosphoserineBy similarity
Modified residuei919 – 9191PhosphoserineBy similarity
Modified residuei947 – 9471PhosphoserineBy similarity
Modified residuei1086 – 10861PhosphoserineCombined sources
Modified residuei1117 – 11171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXI6.
MaxQBiQ6NXI6.
PaxDbiQ6NXI6.
PRIDEiQ6NXI6.

PTM databases

iPTMnetiQ6NXI6.
PhosphoSiteiQ6NXI6.

Expressioni

Gene expression databases

BgeeiQ6NXI6.
ExpressionAtlasiQ6NXI6. baseline and differential.
GenevisibleiQ6NXI6. MM.

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088297.

Structurei

3D structure databases

ProteinModelPortaliQ6NXI6.
SMRiQ6NXI6. Positions 19-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 149131CIDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 1916Gly/Ser-richAdd
BLAST
Compositional biasi476 – 836361Ser-richAdd
BLAST
Compositional biasi1170 – 11767Poly-Gly
Compositional biasi1213 – 1330118Pro-richAdd
BLAST
Compositional biasi1393 – 13986Poly-Gly

Sequence similaritiesi

Contains 1 CID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
GeneTreeiENSGT00400000022016.
HOGENOMiHOG000154192.
HOVERGENiHBG104176.
InParanoidiQ6NXI6.
OMAiGKGNRGH.
OrthoDBiEOG779NWZ.
PhylomeDBiQ6NXI6.
TreeFamiTF320926.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE
60 70 80 90 100
NKKHHSTIVY HWMKWLRRST YPHRLNLFYL ANDVIQNCKR KNAIIFRESF
110 120 130 140 150
ADVLPEAAAL VKDPSVSKSI ERIFKIWEDR NVYPEDMIVA LREALMDRAA
160 170 180 190 200
SHNARLQKLQ CFPGTTFKTQ KQLKENLNKQ PNKQWKKSQT STNPKAALKS
210 220 230 240 250
KIVAEFRSQA LIEELLMYKR SEDQIELKEK QLSTMRVDVC STETLKCLKD
260 270 280 290 300
KTGGKKFSKE FEEASSKLEE FVNGLDKQVK NGPSLTEALE NAGIFYEAQY
310 320 330 340 350
KEVKVVANAY KTFANRVNNL KKKLDQLKST LPDPEESPVP SPSMDAPSPT
360 370 380 390 400
GSESPFQGMG GEEPQSPAME SDKSATPEPV TDNRDVEDME LSDVEDDGSK
410 420 430 440 450
IIVEDRKEKP VEKPAVSTGV PTKSTESVSK ASPCAPPSVP TTAAPPLPKP
460 470 480 490 500
LSTALLSPSP TLVLPNLANV DLAKISSILS SLTSVMKNTG VSSASRPSPG
510 520 530 540 550
IPTSPSNLSS GLKTPAPATT PSHNPLANIL SKVEITPESI LSALSKTQTQ
560 570 580 590 600
SAPALQGLSS LLQSVTANPV PASEVTSQST TASPASTTGS AVKGRNLLSS
610 620 630 640 650
TQSFIPKSFN YSPSSSTSEV SSTSASKASV GQSPVLPSTT FKLPSSSLGF
660 670 680 690 700
TGTHNPSPAA PPTEVAVCQS SEVSKPKPES ESTSPSLEMK IHNFLKGNPG
710 720 730 740 750
FSGLNLNIPI LSSLGSSAPS EGHASDFQRG PTSTSVDSID GTPVRDERSG
760 770 780 790 800
TPTQDEMMDK PTSSSVDTMS LLSKIISPGS STPSSTRSPP PGRDESYPQE
810 820 830 840 850
LPNSVSTYRP FGLGSDSPYK QPSGGVERPS SLMDSSQEKL FPDTSFQEDE
860 870 880 890 900
DYRDFEYSGP PPSAMMNLEK KPAKSILKSS KLSDATEYQP ILSSYNHRAQ
910 920 930 940 950
EFGVKSAFPP SVRALLDSSE NCDRLSSPPG LFGAFNIRGN EPGSERSPSP
960 970 980 990 1000
SKNDAFFTPD SNHSGLSQST AGHLTLPQTQ YPDSPHSVPH RSIFSSQSTL
1010 1020 1030 1040 1050
AAPAGHPPTS GVEKVLASTI STTSTIEFKN MLKNASRKPS DDKHFGQTPN
1060 1070 1080 1090 1100
KGTSSDGVSL SNLTQPSLPT TDQQQEEHYR IETRVSSSCL DLPDSTEEKG
1110 1120 1130 1140 1150
APIETLGYHN AANRRMSGEP IKTVESIRVP GKGNRGHGRE VSRVGWFDLS
1160 1170 1180 1190 1200
TPGSSFDNGP SSASELASLG GGGSGGLTGF KTTPYKERAP QFQESVTSFR
1210 1220 1230 1240 1250
SNSFNSTFEH HLPPSPLEHG APFQREPVGP SSAPPAPPKD HGGIFSREAP
1260 1270 1280 1290 1300
THLPSVDLSN PFTKEASLAH AGPPPPPGEH SGVPFPPPPP PPPPGELSSG
1310 1320 1330 1340 1350
GTGVPFATPA PPPPPVDHSG VVPFPTPPLP EHGVTGAVSV FPKDHSSLLQ
1360 1370 1380 1390 1400
GTMAEHFGVL TGPRDLNGPG LNRSRESLSL PSHPLEHLGP ALGGGGGGNT
1410 1420 1430 1440 1450
SSSGLPLSPA HRDAIGRSGM ILRSPRPDFR PREAFLGRDP FHSLKRPRPP
1460
FVRGPPFFAP KRPFFPPRY
Length:1,469
Mass (Da):156,586
Last modified:July 5, 2004 - v1
Checksum:i1EF4A65F32873748
GO
Isoform 2 (identifier: Q6NXI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-189: Missing.

Show »
Length:1,425
Mass (Da):151,404
Checksum:iC9FFDF3423D8F111
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti491 – 4911V → K in BAC97960 (PubMed:16141072).Curated
Sequence conflicti646 – 6461S → N in BAE32767 (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 18944Missing in isoform 2. 2 PublicationsVSP_019548Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067054 mRNA. Translation: AAH67054.1.
AK129150 mRNA. Translation: BAC97960.1.
AK154692 mRNA. Translation: BAE32767.1.
CCDSiCCDS38549.1. [Q6NXI6-1]
RefSeqiNP_001074762.1. NM_001081293.1. [Q6NXI6-1]
XP_006502291.1. XM_006502228.2. [Q6NXI6-2]
UniGeneiMm.196275.

Genome annotation databases

EnsembliENSMUST00000090791; ENSMUSP00000088297; ENSMUSG00000028106. [Q6NXI6-1]
GeneIDi75137.
KEGGimmu:75137.
UCSCiuc008qkx.1. mouse. [Q6NXI6-1]
uc008qky.1. mouse. [Q6NXI6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067054 mRNA. Translation: AAH67054.1.
AK129150 mRNA. Translation: BAC97960.1.
AK154692 mRNA. Translation: BAE32767.1.
CCDSiCCDS38549.1. [Q6NXI6-1]
RefSeqiNP_001074762.1. NM_001081293.1. [Q6NXI6-1]
XP_006502291.1. XM_006502228.2. [Q6NXI6-2]
UniGeneiMm.196275.

3D structure databases

ProteinModelPortaliQ6NXI6.
SMRiQ6NXI6. Positions 19-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088297.

PTM databases

iPTMnetiQ6NXI6.
PhosphoSiteiQ6NXI6.

Proteomic databases

EPDiQ6NXI6.
MaxQBiQ6NXI6.
PaxDbiQ6NXI6.
PRIDEiQ6NXI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090791; ENSMUSP00000088297; ENSMUSG00000028106. [Q6NXI6-1]
GeneIDi75137.
KEGGimmu:75137.
UCSCiuc008qkx.1. mouse. [Q6NXI6-1]
uc008qky.1. mouse. [Q6NXI6-2]

Organism-specific databases

CTDi23248.
MGIiMGI:1922387. Rprd2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
GeneTreeiENSGT00400000022016.
HOGENOMiHOG000154192.
HOVERGENiHBG104176.
InParanoidiQ6NXI6.
OMAiGKGNRGH.
OrthoDBiEOG779NWZ.
PhylomeDBiQ6NXI6.
TreeFamiTF320926.

Miscellaneous databases

ChiTaRSiRprd2. mouse.
NextBioi342303.
PROiQ6NXI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NXI6.
ExpressionAtlasiQ6NXI6. baseline and differential.
GenevisibleiQ6NXI6. MM.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-491 (ISOFORM 2).
    Strain: NOD.
    Tissue: Dendritic cell.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-1469 (ISOFORM 2).
    Tissue: Embryonic tail.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-738 AND THR-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-633; SER-738; SER-777 AND SER-1086, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-612; SER-738; THR-742; SER-749 AND THR-751, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRPRD2_MOUSE
AccessioniPrimary (citable) accession number: Q6NXI6
Secondary accession number(s): Q3U3L8, Q6ZQA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.