SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NXI4

- Q6NXI4_MOUSE

UniProt

Q6NXI4 - Q6NXI4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Rapgef2 protein
Gene
Rapgef2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Rapgef2 proteinImported
Gene namesi
Name:Rapgef2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2659071. Rapgef2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6NXI4.

PTM databases

PhosphoSiteiQ6NXI4.

Expressioni

Gene expression databases

GenevestigatoriQ6NXI4.

Interactioni

Protein-protein interaction databases

IntActiQ6NXI4. 1 interaction.
STRINGi10090.ENSMUSP00000043884.

Structurei

3D structure databases

ProteinModelPortaliQ6NXI4.

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains N-terminal Ras-GEF domain.SAAS annotations
Contains Ras-GEF domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000247009.
HOVERGENiHBG056658.
InParanoidiQ6NXI4.
KOiK08018.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6NXI4-1 [UniParc]FASTAAdd to Basket

« Hide

LRGIFFYLEK EAFSTQEMAF LVRCYANCLQ PWSSKLPADF TKLHLTDSLH     50
PQVTHVSSSH SGCSITSDSG SSSLSDIYQA TESEAGDMDL SGLPETAVDS 100
EDDDDEEDIE RASDPLMSRD IVRDCLEKDP IDRTDDDIEQ LLEFMHQLPA 150
FANMTMSVRR ELCAVMVFAV VERAGTIVLN DGEELDSWSV ILNGSVEVTY 200
PDGKAEILCM GNSFGVSPTM DKEYMKGVMR TKVDDCQFVC IAQQDYCRIL 250
NQVEKNMQKV EEEGEIVMVK EHRELDRTGT RKGHIVIKGT SERLTMHLVE 300
EHSVVDPTFI EDFLLTYRTF LSSPMEVGKK LLEWFNDPSL RDKVTRVVLL 350
WVNNHFNDFE GDPAMTRFLE EFENNLEREK MGGHLRLLNI ACAAKAKRRL 400
MTLTKPSREA PLPFILLGGS EKGFGIFVDS VDSCSKATEA GLKRGDQILE 450
VNGQNFENIQ LSKAMEILRN NTHLSITVKT NLFVFKELLT RLSEEKRNGA 500
PHLPKIGDIK KASRYSIPDL AVDVEQVIGL EKVNKKSKAN TVGGRNKLKK 550
ILDKTRISIL PQKPYNDIGI GQSQDDSIVG LRQTKHIPAA LPVSGTLSSS 600
NPDLLQSHHR ILDFSTTPDL PDQVLRVFKA DQQSRYIMIS KDTTAKEVVI 650
QAIREFAVTA TPEQYSLCEV SVTPEGVIKQ RRLPDQLSKL ADRIQLSGRY 700
YLKNNMETET LCSDEDAQEL LRESQISLLQ LSTVEVATQL SMRNFELFRN 750
IEPTEYIDDL FKLKSKTSCA NLKKFEEVIN QETFWVASEI LRETNQLKRM 800
KIIKHFIKIA LHCRECKNFN SMFAIISGLN LAPVARLRTT WEKLPNKYEK 850
LFQDLQDLFD PSRNMAKYRN VLSGQNLQPP VIPLFPVIKK DLTFLHEGND 900
SKVDGLVNFE KLRMIAKEIR HVGRMASVNM DPALMFRTRK KKWRSLGSLS 950
QGSANATVLD VAQTGGHKKR VRRSSFLNAK KLYEDAQMAR KVKQYLSNLE 1000
LEMDEESLQT LSLQCEPATS TLPKNPGDKK PVKSETSPVA PRAGPQQKVQ 1050
PQQPLAQPQP PHKVSQGLQV PAVSLYPSRK KVPVKDLPPF GINSPQALKK 1100
ILSLSEEGSL ERHRKQAEDT ISNASSQLSS PPTSPQSSPR KGYALALSGT 1150
VDNFSDSGHS EISSRSSIVS NSSFDSVPVS LHDERRQRHS VSIVESNLGV 1200
GRMERRTLME PDQYSLGSYA PVSESRGLYA AATVISSPST EELSHDQGDR 1250
ASLDAADSGR GSWTSCSSGS HDNIQTIQHQ RSWETLPFGH THFDYSGDAA 1300
SIWASGGHMD QMMFSDHSTK YNRQNQSRES LEQAQSRASW ASSTGYWGED 1350
SEGDTGTIKR RGGKDVSAEA ESSSMVPVTT EEAKPVPMPA HIAVTPSTTK 1400
GLIARKEGRY REPPPTPPGY VGIPIADFPE GPCHPARKPP DYNVALQRSR 1450
MVARPTEAPA PGRTPPAAAA SRPGSKPQWH KPSDADPRLA PFQPQGFAGA 1500
EEDEDEQVSA V 1511
Length:1,511
Mass (Da):168,517
Last modified:July 5, 2004 - v1
Checksum:iFC65F1077673A757
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067056 mRNA. Translation: AAH67056.1.
RefSeqiNP_001093094.2. NM_001099624.2.
UniGeneiMm.31220.
Mm.462396.

Genome annotation databases

GeneIDi76089.
KEGGimmu:76089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067056 mRNA. Translation: AAH67056.1 .
RefSeqi NP_001093094.2. NM_001099624.2.
UniGenei Mm.31220.
Mm.462396.

3D structure databases

ProteinModelPortali Q6NXI4.
ModBasei Search...

Protein-protein interaction databases

IntActi Q6NXI4. 1 interaction.
STRINGi 10090.ENSMUSP00000043884.

PTM databases

PhosphoSitei Q6NXI4.

Proteomic databases

PRIDEi Q6NXI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 76089.
KEGGi mmu:76089.

Organism-specific databases

CTDi 9693.
MGIi MGI:2659071. Rapgef2.

Phylogenomic databases

HOGENOMi HOG000247009.
HOVERGENi HBG056658.
InParanoidi Q6NXI4.
KOi K08018.

Miscellaneous databases

NextBioi 344577.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6NXI4.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ6NXI4_MOUSE
AccessioniPrimary (citable) accession number: Q6NXI4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi