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Q6NXI4

- Q6NXI4_MOUSE

UniProt

Q6NXI4 - Q6NXI4_MOUSE

Protein
Submitted name:

Rapgef2 protein

Gene

Rapgef2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Rapgef2 proteinImported
    Gene namesi
    Name:Rapgef2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2659071. Rapgef2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6NXI4.

    PTM databases

    PhosphoSiteiQ6NXI4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6NXI4.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6NXI4. 1 interaction.
    STRINGi10090.ENSMUSP00000043884.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NXI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.UniRule annotation
    Contains Ras-GEF domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000247009.
    HOVERGENiHBG056658.
    InParanoidiQ6NXI4.
    KOiK08018.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6NXI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    LRGIFFYLEK EAFSTQEMAF LVRCYANCLQ PWSSKLPADF TKLHLTDSLH     50
    PQVTHVSSSH SGCSITSDSG SSSLSDIYQA TESEAGDMDL SGLPETAVDS 100
    EDDDDEEDIE RASDPLMSRD IVRDCLEKDP IDRTDDDIEQ LLEFMHQLPA 150
    FANMTMSVRR ELCAVMVFAV VERAGTIVLN DGEELDSWSV ILNGSVEVTY 200
    PDGKAEILCM GNSFGVSPTM DKEYMKGVMR TKVDDCQFVC IAQQDYCRIL 250
    NQVEKNMQKV EEEGEIVMVK EHRELDRTGT RKGHIVIKGT SERLTMHLVE 300
    EHSVVDPTFI EDFLLTYRTF LSSPMEVGKK LLEWFNDPSL RDKVTRVVLL 350
    WVNNHFNDFE GDPAMTRFLE EFENNLEREK MGGHLRLLNI ACAAKAKRRL 400
    MTLTKPSREA PLPFILLGGS EKGFGIFVDS VDSCSKATEA GLKRGDQILE 450
    VNGQNFENIQ LSKAMEILRN NTHLSITVKT NLFVFKELLT RLSEEKRNGA 500
    PHLPKIGDIK KASRYSIPDL AVDVEQVIGL EKVNKKSKAN TVGGRNKLKK 550
    ILDKTRISIL PQKPYNDIGI GQSQDDSIVG LRQTKHIPAA LPVSGTLSSS 600
    NPDLLQSHHR ILDFSTTPDL PDQVLRVFKA DQQSRYIMIS KDTTAKEVVI 650
    QAIREFAVTA TPEQYSLCEV SVTPEGVIKQ RRLPDQLSKL ADRIQLSGRY 700
    YLKNNMETET LCSDEDAQEL LRESQISLLQ LSTVEVATQL SMRNFELFRN 750
    IEPTEYIDDL FKLKSKTSCA NLKKFEEVIN QETFWVASEI LRETNQLKRM 800
    KIIKHFIKIA LHCRECKNFN SMFAIISGLN LAPVARLRTT WEKLPNKYEK 850
    LFQDLQDLFD PSRNMAKYRN VLSGQNLQPP VIPLFPVIKK DLTFLHEGND 900
    SKVDGLVNFE KLRMIAKEIR HVGRMASVNM DPALMFRTRK KKWRSLGSLS 950
    QGSANATVLD VAQTGGHKKR VRRSSFLNAK KLYEDAQMAR KVKQYLSNLE 1000
    LEMDEESLQT LSLQCEPATS TLPKNPGDKK PVKSETSPVA PRAGPQQKVQ 1050
    PQQPLAQPQP PHKVSQGLQV PAVSLYPSRK KVPVKDLPPF GINSPQALKK 1100
    ILSLSEEGSL ERHRKQAEDT ISNASSQLSS PPTSPQSSPR KGYALALSGT 1150
    VDNFSDSGHS EISSRSSIVS NSSFDSVPVS LHDERRQRHS VSIVESNLGV 1200
    GRMERRTLME PDQYSLGSYA PVSESRGLYA AATVISSPST EELSHDQGDR 1250
    ASLDAADSGR GSWTSCSSGS HDNIQTIQHQ RSWETLPFGH THFDYSGDAA 1300
    SIWASGGHMD QMMFSDHSTK YNRQNQSRES LEQAQSRASW ASSTGYWGED 1350
    SEGDTGTIKR RGGKDVSAEA ESSSMVPVTT EEAKPVPMPA HIAVTPSTTK 1400
    GLIARKEGRY REPPPTPPGY VGIPIADFPE GPCHPARKPP DYNVALQRSR 1450
    MVARPTEAPA PGRTPPAAAA SRPGSKPQWH KPSDADPRLA PFQPQGFAGA 1500
    EEDEDEQVSA V 1511
    Length:1,511
    Mass (Da):168,517
    Last modified:July 5, 2004 - v1
    Checksum:iFC65F1077673A757
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC067056 mRNA. Translation: AAH67056.1.
    RefSeqiNP_001093094.2. NM_001099624.2.
    UniGeneiMm.31220.
    Mm.462396.

    Genome annotation databases

    GeneIDi76089.
    KEGGimmu:76089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC067056 mRNA. Translation: AAH67056.1 .
    RefSeqi NP_001093094.2. NM_001099624.2.
    UniGenei Mm.31220.
    Mm.462396.

    3D structure databases

    ProteinModelPortali Q6NXI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6NXI4. 1 interaction.
    STRINGi 10090.ENSMUSP00000043884.

    PTM databases

    PhosphoSitei Q6NXI4.

    Proteomic databases

    PRIDEi Q6NXI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 76089.
    KEGGi mmu:76089.

    Organism-specific databases

    CTDi 9693.
    MGIi MGI:2659071. Rapgef2.

    Phylogenomic databases

    HOGENOMi HOG000247009.
    HOVERGENi HBG056658.
    InParanoidi Q6NXI4.
    KOi K08018.

    Miscellaneous databases

    NextBioi 344577.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6NXI4.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ6NXI4_MOUSE
    AccessioniPrimary (citable) accession number: Q6NXI4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)