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Protein
Submitted name:

Rapgef2 protein

Gene

Rapgef2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rapgef2 proteinImported
Gene namesi
Name:Rapgef2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2659071 Rapgef2

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6NXI4
PRIDEiQ6NXI4

Expressioni

Gene expression databases

GenevisibleiQ6NXI4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6NXI4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6NXI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 250Cyclic nucleotide-bindingInterPro annotationAdd BLAST101
Domaini282 – 395N-terminal Ras-GEFInterPro annotationAdd BLAST114
Domaini400 – 470PDZInterPro annotationAdd BLAST71
Domaini621 – 707Ras-associatingInterPro annotationAdd BLAST87
Domaini732 – 959Ras-GEFInterPro annotationAdd BLAST228

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili243 – 263Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
HOGENOMiHOG000247009
HOVERGENiHBG056658
KOiK08018

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR030739 RapGEF2
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23113:SF217 PTHR23113:SF217, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Fragment.

Q6NXI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LRGIFFYLEK EAFSTQEMAF LVRCYANCLQ PWSSKLPADF TKLHLTDSLH
60 70 80 90 100
PQVTHVSSSH SGCSITSDSG SSSLSDIYQA TESEAGDMDL SGLPETAVDS
110 120 130 140 150
EDDDDEEDIE RASDPLMSRD IVRDCLEKDP IDRTDDDIEQ LLEFMHQLPA
160 170 180 190 200
FANMTMSVRR ELCAVMVFAV VERAGTIVLN DGEELDSWSV ILNGSVEVTY
210 220 230 240 250
PDGKAEILCM GNSFGVSPTM DKEYMKGVMR TKVDDCQFVC IAQQDYCRIL
260 270 280 290 300
NQVEKNMQKV EEEGEIVMVK EHRELDRTGT RKGHIVIKGT SERLTMHLVE
310 320 330 340 350
EHSVVDPTFI EDFLLTYRTF LSSPMEVGKK LLEWFNDPSL RDKVTRVVLL
360 370 380 390 400
WVNNHFNDFE GDPAMTRFLE EFENNLEREK MGGHLRLLNI ACAAKAKRRL
410 420 430 440 450
MTLTKPSREA PLPFILLGGS EKGFGIFVDS VDSCSKATEA GLKRGDQILE
460 470 480 490 500
VNGQNFENIQ LSKAMEILRN NTHLSITVKT NLFVFKELLT RLSEEKRNGA
510 520 530 540 550
PHLPKIGDIK KASRYSIPDL AVDVEQVIGL EKVNKKSKAN TVGGRNKLKK
560 570 580 590 600
ILDKTRISIL PQKPYNDIGI GQSQDDSIVG LRQTKHIPAA LPVSGTLSSS
610 620 630 640 650
NPDLLQSHHR ILDFSTTPDL PDQVLRVFKA DQQSRYIMIS KDTTAKEVVI
660 670 680 690 700
QAIREFAVTA TPEQYSLCEV SVTPEGVIKQ RRLPDQLSKL ADRIQLSGRY
710 720 730 740 750
YLKNNMETET LCSDEDAQEL LRESQISLLQ LSTVEVATQL SMRNFELFRN
760 770 780 790 800
IEPTEYIDDL FKLKSKTSCA NLKKFEEVIN QETFWVASEI LRETNQLKRM
810 820 830 840 850
KIIKHFIKIA LHCRECKNFN SMFAIISGLN LAPVARLRTT WEKLPNKYEK
860 870 880 890 900
LFQDLQDLFD PSRNMAKYRN VLSGQNLQPP VIPLFPVIKK DLTFLHEGND
910 920 930 940 950
SKVDGLVNFE KLRMIAKEIR HVGRMASVNM DPALMFRTRK KKWRSLGSLS
960 970 980 990 1000
QGSANATVLD VAQTGGHKKR VRRSSFLNAK KLYEDAQMAR KVKQYLSNLE
1010 1020 1030 1040 1050
LEMDEESLQT LSLQCEPATS TLPKNPGDKK PVKSETSPVA PRAGPQQKVQ
1060 1070 1080 1090 1100
PQQPLAQPQP PHKVSQGLQV PAVSLYPSRK KVPVKDLPPF GINSPQALKK
1110 1120 1130 1140 1150
ILSLSEEGSL ERHRKQAEDT ISNASSQLSS PPTSPQSSPR KGYALALSGT
1160 1170 1180 1190 1200
VDNFSDSGHS EISSRSSIVS NSSFDSVPVS LHDERRQRHS VSIVESNLGV
1210 1220 1230 1240 1250
GRMERRTLME PDQYSLGSYA PVSESRGLYA AATVISSPST EELSHDQGDR
1260 1270 1280 1290 1300
ASLDAADSGR GSWTSCSSGS HDNIQTIQHQ RSWETLPFGH THFDYSGDAA
1310 1320 1330 1340 1350
SIWASGGHMD QMMFSDHSTK YNRQNQSRES LEQAQSRASW ASSTGYWGED
1360 1370 1380 1390 1400
SEGDTGTIKR RGGKDVSAEA ESSSMVPVTT EEAKPVPMPA HIAVTPSTTK
1410 1420 1430 1440 1450
GLIARKEGRY REPPPTPPGY VGIPIADFPE GPCHPARKPP DYNVALQRSR
1460 1470 1480 1490 1500
MVARPTEAPA PGRTPPAAAA SRPGSKPQWH KPSDADPRLA PFQPQGFAGA
1510
EEDEDEQVSA V
Length:1,511
Mass (Da):168,517
Last modified:July 5, 2004 - v1
Checksum:iFC65F1077673A757
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067056 mRNA Translation: AAH67056.1
RefSeqiNP_001093094.2, NM_001099624.3
NP_001297465.1, NM_001310536.1
UniGeneiMm.31220
Mm.462396

Genome annotation databases

GeneIDi76089
KEGGimmu:76089

Similar proteinsi

Entry informationi

Entry nameiQ6NXI4_MOUSE
AccessioniPrimary (citable) accession number: Q6NXI4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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