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Protein
Submitted name:

Rapgef2 protein

Gene

Rapgef2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-1 adrenergic receptor binding Source: MGI
  2. PDZ domain binding Source: MGI
  3. Rap GTPase activator activity Source: MGI
  4. Rap guanyl-nucleotide exchange factor activity Source: MGI
  5. Ras guanyl-nucleotide exchange factor activity Source: MGI
  6. WW domain binding Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating adrenergic receptor signaling pathway Source: MGI
  2. cAMP-mediated signaling Source: MGI
  3. cellular response to cAMP Source: MGI
  4. cellular response to cGMP Source: MGI
  5. establishment of endothelial barrier Source: MGI
  6. G-protein coupled receptor signaling pathway Source: MGI
  7. negative regulation of cell proliferation Source: MGI
  8. negative regulation of dendrite morphogenesis Source: MGI
  9. neuron projection development Source: MGI
  10. neuropeptide signaling pathway Source: MGI
  11. positive regulation of cAMP-dependent protein kinase activity Source: MGI
  12. positive regulation of cAMP-mediated signaling Source: MGI
  13. positive regulation of dendritic cell apoptotic process Source: MGI
  14. positive regulation of ERK1 and ERK2 cascade Source: MGI
  15. positive regulation of protein kinase activity Source: MGI
  16. positive regulation of Rap GTPase activity Source: MGI
  17. positive regulation of Ras GTPase activity Source: MGI
  18. Rap protein signal transduction Source: MGI
  19. regulation of cell junction assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Rapgef2 proteinImported
Gene namesi
Name:Rapgef2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2659071. Rapgef2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. late endosome Source: MGI
  3. membrane Source: MGI
  4. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6NXI4.

PTM databases

PhosphoSiteiQ6NXI4.

Expressioni

Gene expression databases

GenevestigatoriQ6NXI4.

Interactioni

Protein-protein interaction databases

IntActiQ6NXI4. 1 interaction.
STRINGi10090.ENSMUSP00000043884.

Structurei

3D structure databases

ProteinModelPortaliQ6NXI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000247009.
HOVERGENiHBG056658.
KOiK08018.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6NXI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LRGIFFYLEK EAFSTQEMAF LVRCYANCLQ PWSSKLPADF TKLHLTDSLH
60 70 80 90 100
PQVTHVSSSH SGCSITSDSG SSSLSDIYQA TESEAGDMDL SGLPETAVDS
110 120 130 140 150
EDDDDEEDIE RASDPLMSRD IVRDCLEKDP IDRTDDDIEQ LLEFMHQLPA
160 170 180 190 200
FANMTMSVRR ELCAVMVFAV VERAGTIVLN DGEELDSWSV ILNGSVEVTY
210 220 230 240 250
PDGKAEILCM GNSFGVSPTM DKEYMKGVMR TKVDDCQFVC IAQQDYCRIL
260 270 280 290 300
NQVEKNMQKV EEEGEIVMVK EHRELDRTGT RKGHIVIKGT SERLTMHLVE
310 320 330 340 350
EHSVVDPTFI EDFLLTYRTF LSSPMEVGKK LLEWFNDPSL RDKVTRVVLL
360 370 380 390 400
WVNNHFNDFE GDPAMTRFLE EFENNLEREK MGGHLRLLNI ACAAKAKRRL
410 420 430 440 450
MTLTKPSREA PLPFILLGGS EKGFGIFVDS VDSCSKATEA GLKRGDQILE
460 470 480 490 500
VNGQNFENIQ LSKAMEILRN NTHLSITVKT NLFVFKELLT RLSEEKRNGA
510 520 530 540 550
PHLPKIGDIK KASRYSIPDL AVDVEQVIGL EKVNKKSKAN TVGGRNKLKK
560 570 580 590 600
ILDKTRISIL PQKPYNDIGI GQSQDDSIVG LRQTKHIPAA LPVSGTLSSS
610 620 630 640 650
NPDLLQSHHR ILDFSTTPDL PDQVLRVFKA DQQSRYIMIS KDTTAKEVVI
660 670 680 690 700
QAIREFAVTA TPEQYSLCEV SVTPEGVIKQ RRLPDQLSKL ADRIQLSGRY
710 720 730 740 750
YLKNNMETET LCSDEDAQEL LRESQISLLQ LSTVEVATQL SMRNFELFRN
760 770 780 790 800
IEPTEYIDDL FKLKSKTSCA NLKKFEEVIN QETFWVASEI LRETNQLKRM
810 820 830 840 850
KIIKHFIKIA LHCRECKNFN SMFAIISGLN LAPVARLRTT WEKLPNKYEK
860 870 880 890 900
LFQDLQDLFD PSRNMAKYRN VLSGQNLQPP VIPLFPVIKK DLTFLHEGND
910 920 930 940 950
SKVDGLVNFE KLRMIAKEIR HVGRMASVNM DPALMFRTRK KKWRSLGSLS
960 970 980 990 1000
QGSANATVLD VAQTGGHKKR VRRSSFLNAK KLYEDAQMAR KVKQYLSNLE
1010 1020 1030 1040 1050
LEMDEESLQT LSLQCEPATS TLPKNPGDKK PVKSETSPVA PRAGPQQKVQ
1060 1070 1080 1090 1100
PQQPLAQPQP PHKVSQGLQV PAVSLYPSRK KVPVKDLPPF GINSPQALKK
1110 1120 1130 1140 1150
ILSLSEEGSL ERHRKQAEDT ISNASSQLSS PPTSPQSSPR KGYALALSGT
1160 1170 1180 1190 1200
VDNFSDSGHS EISSRSSIVS NSSFDSVPVS LHDERRQRHS VSIVESNLGV
1210 1220 1230 1240 1250
GRMERRTLME PDQYSLGSYA PVSESRGLYA AATVISSPST EELSHDQGDR
1260 1270 1280 1290 1300
ASLDAADSGR GSWTSCSSGS HDNIQTIQHQ RSWETLPFGH THFDYSGDAA
1310 1320 1330 1340 1350
SIWASGGHMD QMMFSDHSTK YNRQNQSRES LEQAQSRASW ASSTGYWGED
1360 1370 1380 1390 1400
SEGDTGTIKR RGGKDVSAEA ESSSMVPVTT EEAKPVPMPA HIAVTPSTTK
1410 1420 1430 1440 1450
GLIARKEGRY REPPPTPPGY VGIPIADFPE GPCHPARKPP DYNVALQRSR
1460 1470 1480 1490 1500
MVARPTEAPA PGRTPPAAAA SRPGSKPQWH KPSDADPRLA PFQPQGFAGA
1510
EEDEDEQVSA V
Length:1,511
Mass (Da):168,517
Last modified:July 5, 2004 - v1
Checksum:iFC65F1077673A757
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067056 mRNA. Translation: AAH67056.1.
RefSeqiNP_001093094.2. NM_001099624.2.
UniGeneiMm.31220.
Mm.462396.

Genome annotation databases

GeneIDi76089.
KEGGimmu:76089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067056 mRNA. Translation: AAH67056.1.
RefSeqiNP_001093094.2. NM_001099624.2.
UniGeneiMm.31220.
Mm.462396.

3D structure databases

ProteinModelPortaliQ6NXI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NXI4. 1 interaction.
STRINGi10090.ENSMUSP00000043884.

PTM databases

PhosphoSiteiQ6NXI4.

Proteomic databases

PRIDEiQ6NXI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76089.
KEGGimmu:76089.

Organism-specific databases

CTDi9693.
MGIiMGI:2659071. Rapgef2.

Phylogenomic databases

HOGENOMiHOG000247009.
HOVERGENiHBG056658.
KOiK08018.

Miscellaneous databases

ChiTaRSiRapgef2. mouse.
NextBioi344577.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ6NXI4.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.30.42.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 3 hits.
SSF50156. SSF50156. 1 hit.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ6NXI4_MOUSE
AccessioniPrimary (citable) accession number: Q6NXI4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.