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Protein

Keratin, type II cytoskeletal 73

Gene

Krt73

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei382Stutter1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 73
Alternative name(s):
Cytokeratin-73
Short name:
CK-73
Keratin-73
Short name:
K73
Type II inner root sheath-specific keratin-K6irs3
Type-II keratin Kb36
Gene namesi
Name:Krt73
Synonyms:Kb36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3607712. Krt73.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148821 – 539Keratin, type II cytoskeletal 73Add BLAST539

Proteomic databases

PaxDbiQ6NXH9.
PeptideAtlasiQ6NXH9.
PRIDEiQ6NXH9.

PTM databases

iPTMnetiQ6NXH9.
PhosphoSitePlusiQ6NXH9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063661.
CleanExiMM_KRT73.
GenevisibleiQ6NXH9. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi230210. 7 interactors.
IntActiQ6NXH9. 1 interactor.
MINTiMINT-1859473.
STRINGi10090.ENSMUSP00000065349.

Structurei

3D structure databases

ProteinModelPortaliQ6NXH9.
SMRiQ6NXH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 130HeadAdd BLAST130
Regioni131 – 440RodAdd BLAST310
Regioni131 – 166Coil 1AAdd BLAST36
Regioni167 – 185Linker 1Add BLAST19
Regioni186 – 277Coil 1BAdd BLAST92
Regioni278 – 301Linker 12Add BLAST24
Regioni302 – 440Coil 2Add BLAST139
Regioni441 – 539TailAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 102Gly-richAdd BLAST93

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6NXH9.
KOiK07605.
OMAiGTYGYWP.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6NXH9.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQFTCKPG VANRGFSGCS AVLSGGSSSS YRAAGKGLSG GFSSRSLYSL
60 70 80 90 100
RSPRSISFNV ASSSGRTGGY GFGRNRASGF AGSMFGSGAL GPSNPSLCLP
110 120 130 140 150
GGIHQVTVNK SLLAPLNVEL DPEIQKVRAQ EREQIKALNN KFASFIDKVR
160 170 180 190 200
FLEQQNQVLQ TKWELLQQLD LSNCRRNLEP VYEAHISSLQ KQLDSLSGDR
210 220 230 240 250
VRLDSELRGM RDAVEDCKKR YEEEINKRTT AENEFVVLKK DVDAAYMSKV
260 270 280 290 300
ELQAKVDALD GEIKFLKCLY EGEITQMQSH ISDTSVVLSM DNNRNLDLDS
310 320 330 340 350
IIAEVRAQYE DIALKSKAEA EMVYQTKFQE LQLAAGRHGD DLKHTRNEIS
360 370 380 390 400
ELTRLIQRLR SEIESVKKQC SNLETAIADA EQRGDCALKD ARAKLDELER
410 420 430 440 450
ALHQAKEELA RMLREHQELM SMKLALDIEI ATYRKLLEGE ECRMSGEHTS
460 470 480 490 500
AVSISVISSS APGTVGAGTS FGFSSAGTYG YRQSSVAGGY GILSGGCVTG
510 520 530
SGNCSPRGDT KNRLGSASEF KEVSGKTLAL GSPSKKTMR
Length:539
Mass (Da):58,911
Last modified:July 5, 2004 - v1
Checksum:iBFE03280203C0A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067067 mRNA. Translation: AAH67067.1.
BK003988 mRNA. Translation: DAA02233.1.
CCDSiCCDS27864.1.
RefSeqiNP_997650.1. NM_212485.2.
UniGeneiMm.291498.

Genome annotation databases

EnsembliENSMUST00000063292; ENSMUSP00000065349; ENSMUSG00000063661.
GeneIDi223915.
KEGGimmu:223915.
UCSCiuc007xua.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067067 mRNA. Translation: AAH67067.1.
BK003988 mRNA. Translation: DAA02233.1.
CCDSiCCDS27864.1.
RefSeqiNP_997650.1. NM_212485.2.
UniGeneiMm.291498.

3D structure databases

ProteinModelPortaliQ6NXH9.
SMRiQ6NXH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230210. 7 interactors.
IntActiQ6NXH9. 1 interactor.
MINTiMINT-1859473.
STRINGi10090.ENSMUSP00000065349.

PTM databases

iPTMnetiQ6NXH9.
PhosphoSitePlusiQ6NXH9.

Proteomic databases

PaxDbiQ6NXH9.
PeptideAtlasiQ6NXH9.
PRIDEiQ6NXH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063292; ENSMUSP00000065349; ENSMUSG00000063661.
GeneIDi223915.
KEGGimmu:223915.
UCSCiuc007xua.1. mouse.

Organism-specific databases

CTDi319101.
MGIiMGI:3607712. Krt73.

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6NXH9.
KOiK07605.
OMAiGTYGYWP.
OrthoDBiEOG091G09KR.
PhylomeDBiQ6NXH9.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6NXH9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063661.
CleanExiMM_KRT73.
GenevisibleiQ6NXH9. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C73_MOUSE
AccessioniPrimary (citable) accession number: Q6NXH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.