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Protein

Keratin, type II cytoskeletal 73

Gene

Krt73

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei382Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 73
Alternative name(s):
Cytokeratin-73
Short name:
CK-73
Keratin-73
Short name:
K73
Type II inner root sheath-specific keratin-K6irs3
Type-II keratin Kb36
Gene namesi
Name:Krt73
Synonyms:Kb36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3607712 Krt73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148821 – 539Keratin, type II cytoskeletal 73Add BLAST539

Proteomic databases

PaxDbiQ6NXH9
PeptideAtlasiQ6NXH9
PRIDEiQ6NXH9

PTM databases

iPTMnetiQ6NXH9
PhosphoSitePlusiQ6NXH9

Expressioni

Gene expression databases

BgeeiENSMUSG00000063661
CleanExiMM_KRT73
GenevisibleiQ6NXH9 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi230210, 7 interactors
IntActiQ6NXH9, 1 interactor
MINTiQ6NXH9
STRINGi10090.ENSMUSP00000065349

Structurei

3D structure databases

ProteinModelPortaliQ6NXH9
SMRiQ6NXH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 444IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 130HeadAdd BLAST130
Regioni131 – 166Coil 1AAdd BLAST36
Regioni167 – 185Linker 1Add BLAST19
Regioni186 – 277Coil 1BAdd BLAST92
Regioni278 – 301Linker 12Add BLAST24
Regioni302 – 440Coil 2Add BLAST139
Regioni441 – 539TailAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 102Gly-richAdd BLAST93

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6NXH9
KOiK07605
OMAiGTYGYWP
OrthoDBiEOG091G09KR
PhylomeDBiQ6NXH9
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NXH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQFTCKPG VANRGFSGCS AVLSGGSSSS YRAAGKGLSG GFSSRSLYSL
60 70 80 90 100
RSPRSISFNV ASSSGRTGGY GFGRNRASGF AGSMFGSGAL GPSNPSLCLP
110 120 130 140 150
GGIHQVTVNK SLLAPLNVEL DPEIQKVRAQ EREQIKALNN KFASFIDKVR
160 170 180 190 200
FLEQQNQVLQ TKWELLQQLD LSNCRRNLEP VYEAHISSLQ KQLDSLSGDR
210 220 230 240 250
VRLDSELRGM RDAVEDCKKR YEEEINKRTT AENEFVVLKK DVDAAYMSKV
260 270 280 290 300
ELQAKVDALD GEIKFLKCLY EGEITQMQSH ISDTSVVLSM DNNRNLDLDS
310 320 330 340 350
IIAEVRAQYE DIALKSKAEA EMVYQTKFQE LQLAAGRHGD DLKHTRNEIS
360 370 380 390 400
ELTRLIQRLR SEIESVKKQC SNLETAIADA EQRGDCALKD ARAKLDELER
410 420 430 440 450
ALHQAKEELA RMLREHQELM SMKLALDIEI ATYRKLLEGE ECRMSGEHTS
460 470 480 490 500
AVSISVISSS APGTVGAGTS FGFSSAGTYG YRQSSVAGGY GILSGGCVTG
510 520 530
SGNCSPRGDT KNRLGSASEF KEVSGKTLAL GSPSKKTMR
Length:539
Mass (Da):58,911
Last modified:July 5, 2004 - v1
Checksum:iBFE03280203C0A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067067 mRNA Translation: AAH67067.1
BK003988 mRNA Translation: DAA02233.1
CCDSiCCDS27864.1
RefSeqiNP_997650.1, NM_212485.2
UniGeneiMm.291498

Genome annotation databases

EnsembliENSMUST00000063292; ENSMUSP00000065349; ENSMUSG00000063661
GeneIDi223915
KEGGimmu:223915
UCSCiuc007xua.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK2C73_MOUSE
AccessioniPrimary (citable) accession number: Q6NXH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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