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Protein

Vasculin

Gene

Gpbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GC-rich promoter-specific transactivating transcription factor.1 Publication

GO - Molecular functioni

  • DNA binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin
Alternative name(s):
GC-rich promoter-binding protein 1
Short name:
mGPBP
Gene namesi
Name:Gpbp1
Synonyms:Gpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920524. Gpbp1.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241111 – 473VasculinAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei87Omega-N-methylarginineBy similarity1
Modified residuei274PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei322PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ6NXH3.
PaxDbiQ6NXH3.
PeptideAtlasiQ6NXH3.
PRIDEiQ6NXH3.

PTM databases

iPTMnetiQ6NXH3.
PhosphoSitePlusiQ6NXH3.

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000032745.
CleanExiMM_GPBP1.
ExpressionAtlasiQ6NXH3. baseline and differential.
GenevisibleiQ6NXH3. MM.

Interactioni

Subunit structurei

Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.1 Publication

Protein-protein interaction databases

BioGridi215884. 5 interactors.
IntActiQ6NXH3. 1 interactor.
MINTiMINT-1563310.
STRINGi10090.ENSMUSP00000048240.

Structurei

3D structure databases

ProteinModelPortaliQ6NXH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IJH3. Eukaryota.
ENOG410Y09K. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ6NXH3.
OMAiTSVKECN.
OrthoDBiEOG091G05VV.
PhylomeDBiQ6NXH3.
TreeFamiTF332220.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFSWTENRY DVSRRRHNSS
60 70 80 90 100
DGFDSGIGRP NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGNSRSRSS
110 120 130 140 150
IFHSGKSQGL HENSIPDNET GRKEDKRERR QFEAEDFPSL NPEYEREPNQ
160 170 180 190 200
NKSLAAGVWD YPPNPKSRTP RMLVIKKGNT KDLQLSGFPV AGNLQSQPVK
210 220 230 240 250
NGTGPSVYKG LVPKPAVPPT KPTQWKSQTK ENKVGTSFSH ESTYGVGNFN
260 270 280 290 300
TFKSTAKNIS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRSDKKSE
310 320 330 340 350
FLKALKRDRV EEEHEDESHA GSEKDDDSFN LHNSNTTHQE RDINRNFDEN
360 370 380 390 400
EIPQENGNAS MISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN
410 420 430 440 450
DETCAPLTED EMREFQVISE QLQKNGLRKN GILKNGLICD FKFGPWKNST
460 470
FKPTIENDDT ETSSSDTSDD DDV
Length:473
Mass (Da):53,423
Last modified:July 5, 2004 - v1
Checksum:iADE2CF4F36D81E1C
GO
Isoform 2 (identifier: Q6NXH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-159: W → WGLHAQTHTYPTKKISQAPLL

Show »
Length:493
Mass (Da):55,610
Checksum:iEF20E34A87463EEE
GO
Isoform 3 (identifier: Q6NXH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-137: QHDFAPAWLN...ERRQFEAEDF → LILVLDVLME
     159-159: W → WGLHAQTHTYPTKKISQAPLL

Show »
Length:368
Mass (Da):41,308
Checksum:i63E9BBA1CE3FBB26
GO

Sequence cautioni

The sequence AAH16083 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204G → S in AAQ88446 (PubMed:14612417).Curated1
Sequence conflicti361M → I in AAQ88446 (PubMed:14612417).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321383 – 137QHDFA…EAEDF → LILVLDVLME in isoform 3. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_032139159W → WGLHAQTHTYPTKKISQAPL L in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382529 mRNA. Translation: AAQ88446.1.
AK082704 mRNA. Translation: BAC38578.1.
AK135728 mRNA. Translation: BAE22631.1.
AK145318 mRNA. Translation: BAE26364.1.
AK161928 mRNA. Translation: BAE36638.1.
AK163370 mRNA. Translation: BAE37320.1.
AK163390 mRNA. Translation: BAE37330.1.
AK169406 mRNA. Translation: BAE41152.1.
BC016083 mRNA. Translation: AAH16083.1. Different initiation.
BC067075 mRNA. Translation: AAH67075.1.
BC094888 mRNA. Translation: AAH94888.1.
CCDSiCCDS26769.1. [Q6NXH3-2]
CCDS49362.1. [Q6NXH3-1]
RefSeqiNP_001116435.1. NM_001122963.1. [Q6NXH3-1]
NP_082763.3. NM_028487.4. [Q6NXH3-2]
XP_006517835.1. XM_006517772.1. [Q6NXH3-2]
XP_006517836.1. XM_006517773.3. [Q6NXH3-3]
XP_017171102.1. XM_017315613.1.
XP_017171103.1. XM_017315614.1.
UniGeneiMm.441830.
Mm.57286.

Genome annotation databases

EnsembliENSMUST00000047627; ENSMUSP00000048240; ENSMUSG00000032745. [Q6NXH3-2]
ENSMUST00000091236; ENSMUSP00000088777; ENSMUSG00000032745. [Q6NXH3-1]
GeneIDi73274.
KEGGimmu:73274.
UCSCiuc007rvv.2. mouse. [Q6NXH3-3]
uc007rvw.2. mouse. [Q6NXH3-2]
uc007rvx.2. mouse. [Q6NXH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382529 mRNA. Translation: AAQ88446.1.
AK082704 mRNA. Translation: BAC38578.1.
AK135728 mRNA. Translation: BAE22631.1.
AK145318 mRNA. Translation: BAE26364.1.
AK161928 mRNA. Translation: BAE36638.1.
AK163370 mRNA. Translation: BAE37320.1.
AK163390 mRNA. Translation: BAE37330.1.
AK169406 mRNA. Translation: BAE41152.1.
BC016083 mRNA. Translation: AAH16083.1. Different initiation.
BC067075 mRNA. Translation: AAH67075.1.
BC094888 mRNA. Translation: AAH94888.1.
CCDSiCCDS26769.1. [Q6NXH3-2]
CCDS49362.1. [Q6NXH3-1]
RefSeqiNP_001116435.1. NM_001122963.1. [Q6NXH3-1]
NP_082763.3. NM_028487.4. [Q6NXH3-2]
XP_006517835.1. XM_006517772.1. [Q6NXH3-2]
XP_006517836.1. XM_006517773.3. [Q6NXH3-3]
XP_017171102.1. XM_017315613.1.
XP_017171103.1. XM_017315614.1.
UniGeneiMm.441830.
Mm.57286.

3D structure databases

ProteinModelPortaliQ6NXH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215884. 5 interactors.
IntActiQ6NXH3. 1 interactor.
MINTiMINT-1563310.
STRINGi10090.ENSMUSP00000048240.

PTM databases

iPTMnetiQ6NXH3.
PhosphoSitePlusiQ6NXH3.

Proteomic databases

EPDiQ6NXH3.
PaxDbiQ6NXH3.
PeptideAtlasiQ6NXH3.
PRIDEiQ6NXH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047627; ENSMUSP00000048240; ENSMUSG00000032745. [Q6NXH3-2]
ENSMUST00000091236; ENSMUSP00000088777; ENSMUSG00000032745. [Q6NXH3-1]
GeneIDi73274.
KEGGimmu:73274.
UCSCiuc007rvv.2. mouse. [Q6NXH3-3]
uc007rvw.2. mouse. [Q6NXH3-2]
uc007rvx.2. mouse. [Q6NXH3-1]

Organism-specific databases

CTDi65056.
MGIiMGI:1920524. Gpbp1.

Phylogenomic databases

eggNOGiENOG410IJH3. Eukaryota.
ENOG410Y09K. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ6NXH3.
OMAiTSVKECN.
OrthoDBiEOG091G05VV.
PhylomeDBiQ6NXH3.
TreeFamiTF332220.

Miscellaneous databases

PROiQ6NXH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032745.
CleanExiMM_GPBP1.
ExpressionAtlasiQ6NXH3. baseline and differential.
GenevisibleiQ6NXH3. MM.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPBP1_MOUSE
AccessioniPrimary (citable) accession number: Q6NXH3
Secondary accession number(s): Q3TQR2
, Q3TSN7, Q6TYE7, Q8C498, Q8R252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.