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Protein
Submitted name:

FLNA protein

Gene

FLNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
FLNA proteinImported
Gene namesi
Name:FLNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28172.

PTM / Processingi

Proteomic databases

PaxDbiQ6NXF2.
PRIDEiQ6NXF2.

Expressioni

Gene expression databases

BgeeiQ6NXF2.
GenevisibleiQ6NXF2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358866.

Structurei

3D structure databases

ProteinModelPortaliQ6NXF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG074524.
KOiK04437.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00630. Filamin. 9 hits.
[Graphical view]
SMARTiSM00557. IG_FLMN. 10 hits.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 10 hits.
PROSITEiPS50194. FILAMIN_REPEAT. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6NXF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QIGEETVITV DTKAAGKGKV TCTVCTPDGS EVDVDVVENE DGTFDIFYTA
60 70 80 90 100
PQPGKYVICV RFGGEHVPNS PFQVTALAGD QPSVQPPLRS QQLAPQYTYA
110 120 130 140 150
QGGQQTWAPE RPLVGVNGLD VTSLRPFDLV IPFTIKKGEI TGEVRMPSGK
160 170 180 190 200
VAQPTITDNK DGTVTVRYAP SEAGLHEMDI RYDNMHIPGS PLQFYVDYVN
210 220 230 240 250
CGHVTAYGPG LTHGVVNKPA TFTVNTKDAG EGGLSLAIEG PSKAEISCTD
260 270 280 290 300
NQDGTCSVSY LPVLPGDYSI LVKYNEQHVP GSPFTARVTG DDSMRMSHLK
310 320 330 340 350
VGSAADIPIN ISETDLSLLT ATVVPPSGRE EPCLLKRLRN GHVGISFVPK
360 370 380 390 400
ETGEHLVHVK KNGQHVASSP IPVVISQSEI GDASRVRVSG QGLHEGHTFE
410 420 430 440 450
PAEFIIDTRD AGYGGLSLSI EGPSKVDINT EDLEDGTCRV TYCPTEPGNY
460 470 480 490 500
IINIKFADQH VPGSPFSVKV TGEGRVKESI TRRRRAPSVA NVGSHCDLSL
510 520 530 540 550
KIPEISIQDM TAQVTSPSGK THEAEIVEGE NHTYCIRFVP AEMGTHTVSV
560 570 580 590 600
KYKGQHVPGS PFQFTVGPLG EGGAHKVRAG GPGLERAEAG VPAEFSIWTR
610 620 630 640 650
EAGAGGLAIA VEGPSKAEIS FEDRKDGSCG VAYVVQEPGD YEVSVKFNEE
660 670 680 690 700
HIPDSPFVVP VASPSGDARR LTVSSLQESG LKVNQPASFA VSLNGAKGAI
710 720 730 740 750
DAKVHSPSGA LEECYVTEID QDKYAVRFIP RENGVYLIDV KFNGTHIPGS
760 770 780 790 800
PFKIRVGEPG HGGDPGLVSA YGAGLEGGVT GNPAEFVVNT SNAGAGALSV
810 820 830 840 850
TIDGPSKVKM DCQECPEGYR VTYTPMAPGS YLISIKYGGP YHIGGSPFKA
860 870 880 890 900
KVTGPRLVSN HSLHETSSVF VDSLTKATCA PQHGAPGPGP ADASKVVAKG
910 920 930 940 950
LGLSKAYVGQ KSSFTVDCSK AGNNMLLVGV HGPRTPCEEI LVKHVGSRLY
960 970 980
SVSYLLKDKG EYTLVVKWGD EHIPGSPYRV VVP
Length:983
Mass (Da):104,164
Last modified:July 5, 2004 - v1
Checksum:i8B944332B1AC27F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067111 mRNA. Translation: AAH67111.1.
RefSeqiNP_001104026.1. NM_001110556.1.
NP_001447.2. NM_001456.3.
UniGeneiHs.195464.

Genome annotation databases

GeneIDi2316.
KEGGihsa:2316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067111 mRNA. Translation: AAH67111.1.
RefSeqiNP_001104026.1. NM_001110556.1.
NP_001447.2. NM_001456.3.
UniGeneiHs.195464.

3D structure databases

ProteinModelPortaliQ6NXF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358866.

Proteomic databases

PaxDbiQ6NXF2.
PRIDEiQ6NXF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2316.
KEGGihsa:2316.

Organism-specific databases

CTDi2316.
PharmGKBiPA28172.

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG074524.
KOiK04437.

Miscellaneous databases

ChiTaRSiFLNA. human.
GenomeRNAii2316.
NextBioi9405.

Gene expression databases

BgeeiQ6NXF2.
GenevisibleiQ6NXF2. HS.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00630. Filamin. 9 hits.
[Graphical view]
SMARTiSM00557. IG_FLMN. 10 hits.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 10 hits.
PROSITEiPS50194. FILAMIN_REPEAT. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SkinImported.

Entry informationi

Entry nameiQ6NXF2_HUMAN
AccessioniPrimary (citable) accession number: Q6NXF2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.