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Protein

Armadillo repeat-containing protein 6

Gene

ARMC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6NXE6.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 6
Gene namesi
Name:ARMC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25049. ARMC6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884604.

Polymorphism and mutation databases

BioMutaiARMC6.
DMDMi109940304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Armadillo repeat-containing protein 6PRO_0000242660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXE6.
MaxQBiQ6NXE6.
PaxDbiQ6NXE6.
PRIDEiQ6NXE6.

PTM databases

iPTMnetiQ6NXE6.
PhosphoSiteiQ6NXE6.

Expressioni

Gene expression databases

BgeeiQ6NXE6.
CleanExiHS_ARMC6.
ExpressionAtlasiQ6NXE6. baseline and differential.
GenevisibleiQ6NXE6. HS.

Organism-specific databases

HPAiHPA041420.
HPA041681.

Interactioni

Protein-protein interaction databases

BioGridi125026. 67 interactions.
IntActiQ6NXE6. 40 interactions.
STRINGi9606.ENSP00000376148.

Structurei

3D structure databases

ProteinModelPortaliQ6NXE6.
SMRiQ6NXE6. Positions 145-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati220 – 26445ARM 1Add
BLAST
Repeati274 – 31845ARM 2Add
BLAST
Repeati319 – 36951ARM 3Add
BLAST
Repeati370 – 41243ARM 4Add
BLAST

Sequence similaritiesi

Belongs to the ARMC6 family.Curated
Contains 4 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4199. Eukaryota.
ENOG410XR4D. LUCA.
GeneTreeiENSGT00390000002913.
HOGENOMiHOG000290683.
HOVERGENiHBG057500.
InParanoidiQ6NXE6.
OMAiDCEDVAK.
OrthoDBiEOG7MPRFJ.
PhylomeDBiQ6NXE6.
TreeFamiTF324526.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERCCSRYS SGASIGCTPT STQAKMVSKR IAQETFDAAV RENIEEFAMG
60 70 80 90 100
PEEAVKEAVE QFESQGVDLS NIVKTAPKVS ADGSQEPTHD ILQMLSDLQE
110 120 130 140 150
SVASSRPQEV SAYLTRFCDQ CKQDKACRFL AAQKGAYPII FTAWKLATAG
160 170 180 190 200
DQGLLLQSLN ALSVLTDGQP DLLDAQGLQL LVATLTQNAD EADLTCSGIR
210 220 230 240 250
CVRHACLKHE QNRQDLVKAG VLPLLTGAIT HHGHHTDVVR EACWALRVMT
260 270 280 290 300
FDDDIRVPFG HAHNHAKMIV QENKGLKVLI EATKAFLDNP GILSELCGTL
310 320 330 340 350
SRLAIRNEFC QEVVDLGGLS ILVSLLADCN DHQMRDQSGV QELVKQVLST
360 370 380 390 400
LRAIAGNDDV KDAIVRAGGT ESIVAAMTQH LTSPQVCEQS CAALCFLALR
410 420 430 440 450
KPDNSRIIVE GGGAVAALQA MKAHPQKAGV QKQACMLIRN LVAHGQAFSK
460 470 480 490 500
PILDLGAEAL IMQARSAHRD CEDVAKAALR DLGCHVELRE LWTGQRGNLA

P
Length:501
Mass (Da):54,142
Last modified:June 27, 2006 - v2
Checksum:i13813F0B99AF8AFF
GO
Isoform 2 (identifier: Q6NXE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: Gene prediction based on EST data.
Show »
Length:476
Mass (Da):51,548
Checksum:i213563493D534278
GO

Sequence cautioni

The sequence AAD03162.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAH67125.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525Missing in isoform 2. CuratedVSP_040103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295488 mRNA. Translation: BAG58410.1.
AC003038 Genomic DNA. Translation: AAD03162.1. Sequence problems.
AC004447 Genomic DNA. No translation available.
BC003700 mRNA. Translation: AAH03700.1.
BC067125 mRNA. Translation: AAH67125.1. Different initiation.
CCDSiCCDS32965.1. [Q6NXE6-2]
CCDS56089.1. [Q6NXE6-1]
RefSeqiNP_001186125.1. NM_001199196.1. [Q6NXE6-1]
NP_219483.1. NM_033415.3. [Q6NXE6-2]
XP_005260214.1. XM_005260157.2. [Q6NXE6-2]
XP_005260215.1. XM_005260158.2. [Q6NXE6-2]
UniGeneiHs.77876.

Genome annotation databases

EnsembliENST00000269932; ENSP00000269932; ENSG00000105676. [Q6NXE6-2]
ENST00000392335; ENSP00000376147; ENSG00000105676. [Q6NXE6-2]
ENST00000392336; ENSP00000376148; ENSG00000105676. [Q6NXE6-1]
ENST00000535612; ENSP00000444156; ENSG00000105676. [Q6NXE6-1]
GeneIDi93436.
KEGGihsa:93436.
UCSCiuc002nlc.4. human. [Q6NXE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295488 mRNA. Translation: BAG58410.1.
AC003038 Genomic DNA. Translation: AAD03162.1. Sequence problems.
AC004447 Genomic DNA. No translation available.
BC003700 mRNA. Translation: AAH03700.1.
BC067125 mRNA. Translation: AAH67125.1. Different initiation.
CCDSiCCDS32965.1. [Q6NXE6-2]
CCDS56089.1. [Q6NXE6-1]
RefSeqiNP_001186125.1. NM_001199196.1. [Q6NXE6-1]
NP_219483.1. NM_033415.3. [Q6NXE6-2]
XP_005260214.1. XM_005260157.2. [Q6NXE6-2]
XP_005260215.1. XM_005260158.2. [Q6NXE6-2]
UniGeneiHs.77876.

3D structure databases

ProteinModelPortaliQ6NXE6.
SMRiQ6NXE6. Positions 145-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125026. 67 interactions.
IntActiQ6NXE6. 40 interactions.
STRINGi9606.ENSP00000376148.

PTM databases

iPTMnetiQ6NXE6.
PhosphoSiteiQ6NXE6.

Polymorphism and mutation databases

BioMutaiARMC6.
DMDMi109940304.

Proteomic databases

EPDiQ6NXE6.
MaxQBiQ6NXE6.
PaxDbiQ6NXE6.
PRIDEiQ6NXE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269932; ENSP00000269932; ENSG00000105676. [Q6NXE6-2]
ENST00000392335; ENSP00000376147; ENSG00000105676. [Q6NXE6-2]
ENST00000392336; ENSP00000376148; ENSG00000105676. [Q6NXE6-1]
ENST00000535612; ENSP00000444156; ENSG00000105676. [Q6NXE6-1]
GeneIDi93436.
KEGGihsa:93436.
UCSCiuc002nlc.4. human. [Q6NXE6-1]

Organism-specific databases

CTDi93436.
GeneCardsiARMC6.
HGNCiHGNC:25049. ARMC6.
HPAiHPA041420.
HPA041681.
neXtProtiNX_Q6NXE6.
PharmGKBiPA134884604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4199. Eukaryota.
ENOG410XR4D. LUCA.
GeneTreeiENSGT00390000002913.
HOGENOMiHOG000290683.
HOVERGENiHBG057500.
InParanoidiQ6NXE6.
OMAiDCEDVAK.
OrthoDBiEOG7MPRFJ.
PhylomeDBiQ6NXE6.
TreeFamiTF324526.

Enzyme and pathway databases

SignaLinkiQ6NXE6.

Miscellaneous databases

ChiTaRSiARMC6. human.
GeneWikiiARMC6.
GenomeRNAii93436.
PROiQ6NXE6.

Gene expression databases

BgeeiQ6NXE6.
CleanExiHS_ARMC6.
ExpressionAtlasiQ6NXE6. baseline and differential.
GenevisibleiQ6NXE6. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix and Skin.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiARMC6_HUMAN
AccessioniPrimary (citable) accession number: Q6NXE6
Secondary accession number(s): B4DI98, O94999, Q9BTH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.