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Protein

Pyruvate kinase

Gene

pkma

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gapdhs), Glyceraldehyde-3-phosphate dehydrogenase 2 (gapdh-2), Glyceraldehyde-3-phosphate dehydrogenase (gapdh)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Enolase (eno1a), Enolase (eno2), Enolase (eno3)
  5. Pyruvate kinase, Pyruvate kinase (pkma), Pyruvate kinase (CABZ01066502.1), Pyruvate kinase (pkma), Pyruvate kinase (pkmb), Pyruvate kinase (pkma), Pyruvate kinase (pklr), Pyruvate kinase (pkmb), Pyruvate kinase (pkmb), Pyruvate kinase (pklr), Pyruvate kinase (pkmb), Pyruvate kinase (pkma)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pkmaImported
Synonyms:pkm2aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-031201-4. pkma.

PTM / Processingi

Proteomic databases

PRIDEiQ6NXD1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110339.

Structurei

3D structure databases

ProteinModelPortaliQ6NXD1.
SMRiQ6NXD1. Positions 14-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKAQDMG SAFIQTQQLN AAMADTFLEH MCLLDIDSEP TIARNTGIIC
60 70 80 90 100
TIGPASRSVD TLKEMIKSGM NIARMNFSHG SHEYHGETIK NVREACASFK
110 120 130 140 150
PGSIQYRPVG IALDTKGPEI RTGLIKGSGT AEVELKKGNK IKVTLDDSFM
160 170 180 190 200
ENCDEDTLWL DYKNITKVVE VGSKVYIDDG LISLQVLQIG SDYLICEIEN
210 220 230 240 250
GGSLGSKKGV NLPGAAVDLP AVSEKDIKDL QFGVEMGVDM IFASFIRKAA
260 270 280 290 300
DVQAVRKVLG EKGKNIKIIS KLENHEGVRR FDEIMEASDG IMVARGDLGI
310 320 330 340 350
EIPTEKVFLA QKMMIGRCNK AGKPIICATQ MLESMIKKPR PTRAEGSDVA
360 370 380 390 400
NAVLDGADCI MLSGETAKGD YPLEAVRTQH MIAREAEAAM FHRQVFEDLR
410 420 430 440 450
RCLPLSTDPA EAIAIGAVEA SFKILSSAFI VLTGSGRSAH LISRYRPRAP
460 470 480 490 500
ILAVTRNEQT ARQAHLYRGI FPIYYNSPSN DVWAEDVDLR VNFAMDVGKA
510 520 530
RGFFKAGDVV IVLTGWRPGS GYTNTMRVVP VP
Length:532
Mass (Da):58,113
Last modified:July 5, 2004 - v1
Checksum:iE598BCC73721D43D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067143 mRNA. Translation: AAH67143.1.
UniGeneiDr.79861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067143 mRNA. Translation: AAH67143.1.
UniGeneiDr.79861.

3D structure databases

ProteinModelPortaliQ6NXD1.
SMRiQ6NXD1. Positions 14-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110339.

Proteomic databases

PRIDEiQ6NXD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-031201-4. pkma.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ6NXD1_DANRE
AccessioniPrimary (citable) accession number: Q6NXD1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.