Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin enhancer-binding factor 3 homolog

Gene

ilf3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 3 homolog
Gene namesi
Name:ilf3
ORF Names:zgc:77030
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-587. ilf3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260731 – 833Interleukin enhancer-binding factor 3 homologAdd BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NXA4.
PRIDEiQ6NXA4.

PTM databases

iPTMnetiQ6NXA4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000019087.

Structurei

3D structure databases

ProteinModelPortaliQ6NXA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 379DZFPROSITE-ProRule annotationAdd BLAST369
Domaini402 – 471DRBM 1PROSITE-ProRule annotationAdd BLAST70
Domaini527 – 593DRBM 2PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi387 – 391Poly-Lys5
Compositional biasi602 – 605Poly-Lys4
Compositional biasi612 – 824Gly-richAdd BLAST213
Compositional biasi758 – 761Poly-Gly4
Compositional biasi765 – 768Poly-Gly4

Sequence similaritiesi

Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation
Contains 1 DZF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
HOGENOMiHOG000232164.
HOVERGENiHBG069915.
InParanoidiQ6NXA4.
KOiK13090.
PhylomeDBiQ6NXA4.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR014720. dsRBD_dom.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF00035. dsrm. 2 hits.
PF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
PS51703. DZF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NXA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPLRHRSM RIFVNDDRHV MAKHSAIYPT QEELEGVQNM VSHTERALKL
60 70 80 90 100
VSDWLDDQEK GNAKVNALDT DGEGDKETEP STGEQATRSL RGVMRVGLVA
110 120 130 140 150
KGLLLKGDLD LELVLLCKEK PTITLLKKVS DNLAVQLKQL VTEEKYDVKP
160 170 180 190 200
CIRDATIVIK NAKEPPLTLT IHLTSPLVRE EVEKQAAGET LSVIDPPDVL
210 220 230 240 250
DRQKCLTALA SLRHAKWFQA RANGLRSCVI VIRILRDLCA RVPTWSPLRG
260 270 280 290 300
WPLELLCEKA IGTGNRPMGA GEALRRVLEC LASGILMADG SGICDPCEKE
310 320 330 340 350
LTDAISHVDR QQREDITQSA QHALRLSAFG QLHKVLGMDP LPSKMPRKPR
360 370 380 390 400
SDTPIDYTVQ IPPSTTYVPP MKRPIEEEST DEKNPNKKKK KLQKKSPDEK
410 420 430 440 450
AEPAQAMNAL MRLNQLKPGL QYKLISQTGP VHVPVFTMSV EVDGKNFEAS
460 470 480 490 500
GPSKRTAKLH VAVKVLQDMG LPTGMDQKTT ELMKVDEPVS TQETLPPVIK
510 520 530 540 550
MEPEPVPITE TPTDENARQQ GPILTKHGKN PVMELNEKRR GLKYELISET
560 570 580 590 600
GGSHDKRFVM EVEIDGQKFQ GTGSNKKVAK AYAALAALEK LFPEGSNSEV
610 620 630 640 650
NKKKKMPPMH TGFGMVSGPP SDMMPNPRGR GRGRGRGRGR GFNNGGGFNQ
660 670 680 690 700
GGYGTYGYGG NNSGYNFYNN GGSNGGSVAS NQGTNQSSGG AAATGGFGSY
710 720 730 740 750
YQSDSSYTSP APTPKPVGKK PPMHQNTKPQ APGVGQGGSY GQYNQGYGQK
760 770 780 790 800
KNFGQTQGGG GAAAGGGGNF NYSTAYPSQV TGGQEYNYEG YSNQSNYNSQ
810 820 830
GGANQNFGGN SAPYNSGQAG YGRGDPNMNY QYR
Length:833
Mass (Da):90,436
Last modified:April 12, 2005 - v2
Checksum:i4E4F44B7DC839347
GO

Sequence cautioni

The sequence AAH47175 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218F → Y in AAH47175 (Ref. 1) Curated1
Sequence conflicti262G → V in AAH47175 (Ref. 1) Curated1
Sequence conflicti491T → A in AAH67172 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047175 mRNA. Translation: AAH47175.1. Sequence problems.
BC067172 mRNA. Translation: AAH67172.1.
RefSeqiNP_997764.1. NM_212599.1.
UniGeneiDr.76843.

Genome annotation databases

GeneIDi321868.
KEGGidre:321868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047175 mRNA. Translation: AAH47175.1. Sequence problems.
BC067172 mRNA. Translation: AAH67172.1.
RefSeqiNP_997764.1. NM_212599.1.
UniGeneiDr.76843.

3D structure databases

ProteinModelPortaliQ6NXA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000019087.

PTM databases

iPTMnetiQ6NXA4.

Proteomic databases

PaxDbiQ6NXA4.
PRIDEiQ6NXA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi321868.
KEGGidre:321868.

Organism-specific databases

CTDi321868.
ZFINiZDB-GENE-030131-587. ilf3b.

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
HOGENOMiHOG000232164.
HOVERGENiHBG069915.
InParanoidiQ6NXA4.
KOiK13090.
PhylomeDBiQ6NXA4.

Miscellaneous databases

PROiQ6NXA4.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR014720. dsRBD_dom.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF00035. dsrm. 2 hits.
PF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
PS51703. DZF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILF3_DANRE
AccessioniPrimary (citable) accession number: Q6NXA4
Secondary accession number(s): Q802W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: October 5, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.