Q6NX74 (Q6NX74_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Atm protein EMBL AAH67212.1

Gene names

Name:

Atm MGI 107202

Organism

Mus musculus (Mouse) EMBL AAH67212.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	790 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FAT domain. SAAS SAAS018936 Contains 1 FATC domain. SAAS SAAS018936 Contains 1 PI3K/PI4K domain. SAAS SAAS018936

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS018936 Nucleotide-binding
Molecular function	Kinase SAAS SAAS018936 Transferase
Gene Ontology (GO)
Biological_process	DNA damage checkpoint Inferred from mutant phenotype PubMed 12937170. Source: MGI DNA damage induced protein phosphorylation Inferred from electronic annotation. Source: Compara DNA repair Inferred from direct assay PubMed 15364958. Source: MGI G2 DNA damage checkpoint Inferred from electronic annotation. Source: Compara brain development Inferred from genetic interaction PubMed 16687486. Source: MGI cell cycle arrest Inferred from electronic annotation. Source: Compara cellular response to gamma radiation Inferred from electronic annotation. Source: Compara female gamete generation Inferred from mutant phenotype PubMed 15640358. Source: MGI heart development Inferred from genetic interaction PubMed 16687486. Source: MGI histone mRNA catabolic process Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to DNA damage Inferred from mutant phenotype PubMed 11040211PubMed 16777961. Source: MGI lipoprotein catabolic process Inferred from genetic interaction PubMed 15863839. Source: MGI mitotic spindle assembly checkpoint Inferred from electronic annotation. Source: Compara negative regulation of B cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from mutant phenotype PubMed 11536012. Source: MGI neuron apoptotic process Inferred from genetic interaction PubMed 11248063. Source: MGI positive regulation of DNA damage response, signal transduction by p53 class mediator Inferred from electronic annotation. Source: Compara positive regulation of neuron apoptotic process Inferred from genetic interaction PubMed 10639175PubMed 16777961. Source: MGI protein autophosphorylation Inferred from electronic annotation. Source: Compara replicative senescence Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to ionizing radiation Inferred from genetic interaction PubMed 10639175. Source: MGI somitogenesis Inferred from genetic interaction PubMed 16687486. Source: MGI telomere maintenance Inferred from electronic annotation. Source: InterPro
Cellular_component	chromosome, telomeric region Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara nucleus Traceable author statement PubMed 15604234. Source: MGI spindle Inferred from direct assay PubMed 15509711. Source: MGI
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: Compara ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-dependent protein kinase activity Inferred from electronic annotation. Source: Compara histone serine kinase activity Inferred from electronic annotation. Source: Compara protein kinase activity Inferred from direct assay PubMed 15364958. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH67212.1

Sequences

	Sequence		Length	Mass (Da)
	Q6NX74 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7A03FF59D0B8C189	FASTA	790	90,686
	10 20 30 40 50 60 TQLPERAIFK IKQYNSAICG ISEWHLEEAQ VFWAKKEQSL ALSILKQMIK KLDSSFKDKE 70 80 90 100 110 120 NDAGLKVIYA ECLRVCGSWL AETCLENPAV IMQTYLEKAV KVAGSYDGNS RELRNGQMKA 130 140 150 160 170 180 FLSLARFSDT QYQRIENYMK SSEFENKQTL LKRAKEEVGL LREHKIQTNR YTVKVQRELE 190 200 210 220 230 240 LDECALRALR EDRKRFLCKA VENYINCLLS GEEHDLWVFR LCSLWLENSG VSEVNGMMKK 250 260 270 280 290 300 DGMKISSYKF LPLMYQLAAR MGTKMTGGLG FHEVLNNLIS RISLDHPHHT LFIILALANA 310 320 330 340 350 360 NKDEFLSKPE TTRRSRITKS TSKENSHLDE DRTEAATRII HSIRSKRCKM VKDMEALCDA 370 380 390 400 410 420 YIILANMDAS QWRAQRKGIN IPANQPITKL KNLEDVVVPT MEIKVDPTGE YENLVTIKSF 430 440 450 460 470 480 KTEFRLAGGL NLPKIIDCVG SDGKERRQLV KGRDDLRQDA VMQQVFQMCN TLLQRNTETR 490 500 510 520 530 540 KRKLTICTYK VVPLSQRSGV LEWCTGTVPI GEYLVNSEDG AHRRYRPNDF SANQCQKKMM 550 560 570 580 590 600 EVQKKSFEEK YDTFMTICQN FEPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL 610 620 630 640 650 660 GLGDRHVQNI LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLSRDIVD GMGITGVEGV 670 680 690 700 710 720 FRRCCEKTME VMRSSQETLL TIVEVLLYDP LFDWTMNPLK ALYLQQRPED ESDLHSTPNA 730 740 750 760 770 780 DDQECKQSLS DTDQSFNKVA ERVLMRLQEK LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS 790 RLFPGWKAWV

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N EMBL AAH67212.1. Tissue: Mammary tumor. C3 EMBL AAH67212.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC067212 mRNA. Translation: AAH67212.1.
IPI	IPI00895163.
UniGene	Mm.5088.
3D structure databases
ProteinModelPortal	Q6NX74.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000113388. Q6NX74.
Proteomic databases
PRIDE	Q6NX74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:107202. Atm.
Phylogenomic databases
HOVERGEN	HBG103270.
InParanoid	Q6NX74.
Gene expression databases
ArrayExpress	Q6NX74.
Bgee	Q6NX74.
Genevestigator	Q6NX74.
Family and domain databases
Gene3D	1.10.1070.11. 3 hits.
InterPro	IPR015519. ATM/Tel1. IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR003151. PIK-rel_kinase_FAT. IPR014009. PIK_FAT. [Graphical view]
PANTHER	PTHR11139:SF3. PTHR11139:SF3. 1 hit.
Pfam	PF02259. FAT. 1 hit. PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATM. mouse.
SOURCE	Search...

Entry information

Entry name

Q6NX74_MOUSE

Accession

Primary (citable) accession number: Q6NX74

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)