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Q6NX74

- Q6NX74_MOUSE

UniProt

Q6NX74 - Q6NX74_MOUSE

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Protein
Submitted name:

Atm protein

Gene

Atm

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. DNA-dependent protein kinase activity Source: Ensembl
  4. histone serine kinase activity Source: Ensembl
  5. protein kinase activity Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. cell cycle arrest Source: Ensembl
  3. cellular response to DNA damage stimulus Source: MGI
  4. cellular response to gamma radiation Source: Ensembl
  5. DNA damage checkpoint Source: MGI
  6. DNA damage induced protein phosphorylation Source: Ensembl
  7. DNA repair Source: MGI
  8. female gamete generation Source: MGI
  9. heart development Source: MGI
  10. histone mRNA catabolic process Source: Ensembl
  11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  12. lipoprotein catabolic process Source: MGI
  13. mitotic spindle assembly checkpoint Source: Ensembl
  14. negative regulation of B cell proliferation Source: Ensembl
  15. neuron apoptotic process Source: MGI
  16. oocyte development Source: MGI
  17. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  18. positive regulation of neuron apoptotic process Source: MGI
  19. protein autophosphorylation Source: Ensembl
  20. protein phosphorylation Source: MGI
  21. replicative senescence Source: InterPro
  22. response to hypoxia Source: Ensembl
  23. response to ionizing radiation Source: MGI
  24. signal transduction involved in mitotic G2 DNA damage checkpoint Source: Ensembl
  25. somitogenesis Source: MGI
  26. telomere maintenance Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Atm proteinImported
Gene namesi
Name:AtmImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107202. Atm.

Subcellular locationi

GO - Cellular componenti

  1. chromosome, telomeric region Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: MGI
  4. spindle Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6NX74.

Expressioni

Gene expression databases

BgeeiQ6NX74.
ExpressionAtlasiQ6NX74. baseline and differential.
GenevestigatoriQ6NX74.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113388.

Structurei

3D structure databases

ProteinModelPortaliQ6NX74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FAT domain.SAAS annotation
Contains FATC domain.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG103270.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR015519. ATM.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PANTHERiPTHR11139:SF66. PTHR11139:SF66. 1 hit.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6NX74 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TQLPERAIFK IKQYNSAICG ISEWHLEEAQ VFWAKKEQSL ALSILKQMIK
60 70 80 90 100
KLDSSFKDKE NDAGLKVIYA ECLRVCGSWL AETCLENPAV IMQTYLEKAV
110 120 130 140 150
KVAGSYDGNS RELRNGQMKA FLSLARFSDT QYQRIENYMK SSEFENKQTL
160 170 180 190 200
LKRAKEEVGL LREHKIQTNR YTVKVQRELE LDECALRALR EDRKRFLCKA
210 220 230 240 250
VENYINCLLS GEEHDLWVFR LCSLWLENSG VSEVNGMMKK DGMKISSYKF
260 270 280 290 300
LPLMYQLAAR MGTKMTGGLG FHEVLNNLIS RISLDHPHHT LFIILALANA
310 320 330 340 350
NKDEFLSKPE TTRRSRITKS TSKENSHLDE DRTEAATRII HSIRSKRCKM
360 370 380 390 400
VKDMEALCDA YIILANMDAS QWRAQRKGIN IPANQPITKL KNLEDVVVPT
410 420 430 440 450
MEIKVDPTGE YENLVTIKSF KTEFRLAGGL NLPKIIDCVG SDGKERRQLV
460 470 480 490 500
KGRDDLRQDA VMQQVFQMCN TLLQRNTETR KRKLTICTYK VVPLSQRSGV
510 520 530 540 550
LEWCTGTVPI GEYLVNSEDG AHRRYRPNDF SANQCQKKMM EVQKKSFEEK
560 570 580 590 600
YDTFMTICQN FEPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL
610 620 630 640 650
GLGDRHVQNI LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLSRDIVD
660 670 680 690 700
GMGITGVEGV FRRCCEKTME VMRSSQETLL TIVEVLLYDP LFDWTMNPLK
710 720 730 740 750
ALYLQQRPED ESDLHSTPNA DDQECKQSLS DTDQSFNKVA ERVLMRLQEK
760 770 780 790
LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS RLFPGWKAWV
Length:790
Mass (Da):90,686
Last modified:July 5, 2004 - v1
Checksum:i7A03FF59D0B8C189
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067212 mRNA. Translation: AAH67212.1.
UniGeneiMm.5088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067212 mRNA. Translation: AAH67212.1 .
UniGenei Mm.5088.

3D structure databases

ProteinModelPortali Q6NX74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000113388.

Proteomic databases

PRIDEi Q6NX74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107202. Atm.

Phylogenomic databases

HOVERGENi HBG103270.

Miscellaneous databases

ChiTaRSi ATM. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q6NX74.
ExpressionAtlasi Q6NX74. baseline and differential.
Genevestigatori Q6NX74.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
InterProi IPR015519. ATM.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view ]
PANTHERi PTHR11139:SF66. PTHR11139:SF66. 1 hit.
Pfami PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ6NX74_MOUSE
AccessioniPrimary (citable) accession number: Q6NX74
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)