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Protein
Submitted name:

Atm protein

Gene

Atm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. DNA-dependent protein kinase activity Source: MGI
  4. histone serine kinase activity Source: Ensembl
  5. protein complex binding Source: MGI
  6. protein dimerization activity Source: MGI
  7. protein kinase activity Source: MGI
  8. protein N-terminus binding Source: MGI
  9. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. cell cycle arrest Source: MGI
  3. cellular response to DNA damage stimulus Source: MGI
  4. cellular response to gamma radiation Source: MGI
  5. determination of adult lifespan Source: MGI
  6. DNA damage checkpoint Source: MGI
  7. DNA damage induced protein phosphorylation Source: MGI
  8. DNA repair Source: MGI
  9. double-strand break repair via homologous recombination Source: MGI
  10. female gamete generation Source: MGI
  11. heart development Source: MGI
  12. histone mRNA catabolic process Source: MGI
  13. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  14. lipoprotein catabolic process Source: MGI
  15. mitotic spindle assembly checkpoint Source: MGI
  16. negative regulation of B cell proliferation Source: MGI
  17. neuron apoptotic process Source: MGI
  18. oocyte development Source: MGI
  19. peptidyl-serine phosphorylation Source: MGI
  20. phosphatidylinositol-3-phosphate biosynthetic process Source: MGI
  21. positive regulation of apoptotic process Source: MGI
  22. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  23. positive regulation of neuron apoptotic process Source: MGI
  24. protein autophosphorylation Source: MGI
  25. protein phosphorylation Source: MGI
  26. replicative senescence Source: MGI
  27. response to hypoxia Source: Ensembl
  28. response to ionizing radiation Source: MGI
  29. signal transduction involved in mitotic G2 DNA damage checkpoint Source: MGI
  30. somitogenesis Source: MGI
  31. telomere maintenance Source: InterPro
  32. V(D)J recombination Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Atm proteinImported
Gene namesi
Name:AtmImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107202. Atm.

Subcellular locationi

GO - Cellular componenti

  1. chromosome, telomeric region Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: MGI
  4. spindle Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6NX74.

Expressioni

Gene expression databases

BgeeiQ6NX74.
ExpressionAtlasiQ6NX74. baseline and differential.
GenevestigatoriQ6NX74.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113388.

Structurei

3D structure databases

ProteinModelPortaliQ6NX74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FAT domain.SAAS annotation
Contains FATC domain.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG103270.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR015519. ATM.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PANTHERiPTHR11139:SF66. PTHR11139:SF66. 1 hit.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6NX74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TQLPERAIFK IKQYNSAICG ISEWHLEEAQ VFWAKKEQSL ALSILKQMIK
60 70 80 90 100
KLDSSFKDKE NDAGLKVIYA ECLRVCGSWL AETCLENPAV IMQTYLEKAV
110 120 130 140 150
KVAGSYDGNS RELRNGQMKA FLSLARFSDT QYQRIENYMK SSEFENKQTL
160 170 180 190 200
LKRAKEEVGL LREHKIQTNR YTVKVQRELE LDECALRALR EDRKRFLCKA
210 220 230 240 250
VENYINCLLS GEEHDLWVFR LCSLWLENSG VSEVNGMMKK DGMKISSYKF
260 270 280 290 300
LPLMYQLAAR MGTKMTGGLG FHEVLNNLIS RISLDHPHHT LFIILALANA
310 320 330 340 350
NKDEFLSKPE TTRRSRITKS TSKENSHLDE DRTEAATRII HSIRSKRCKM
360 370 380 390 400
VKDMEALCDA YIILANMDAS QWRAQRKGIN IPANQPITKL KNLEDVVVPT
410 420 430 440 450
MEIKVDPTGE YENLVTIKSF KTEFRLAGGL NLPKIIDCVG SDGKERRQLV
460 470 480 490 500
KGRDDLRQDA VMQQVFQMCN TLLQRNTETR KRKLTICTYK VVPLSQRSGV
510 520 530 540 550
LEWCTGTVPI GEYLVNSEDG AHRRYRPNDF SANQCQKKMM EVQKKSFEEK
560 570 580 590 600
YDTFMTICQN FEPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL
610 620 630 640 650
GLGDRHVQNI LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLSRDIVD
660 670 680 690 700
GMGITGVEGV FRRCCEKTME VMRSSQETLL TIVEVLLYDP LFDWTMNPLK
710 720 730 740 750
ALYLQQRPED ESDLHSTPNA DDQECKQSLS DTDQSFNKVA ERVLMRLQEK
760 770 780 790
LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS RLFPGWKAWV
Length:790
Mass (Da):90,686
Last modified:July 5, 2004 - v1
Checksum:i7A03FF59D0B8C189
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067212 mRNA. Translation: AAH67212.1.
UniGeneiMm.5088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067212 mRNA. Translation: AAH67212.1.
UniGeneiMm.5088.

3D structure databases

ProteinModelPortaliQ6NX74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113388.

Proteomic databases

PRIDEiQ6NX74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107202. Atm.

Phylogenomic databases

HOVERGENiHBG103270.

Miscellaneous databases

ChiTaRSiAtm. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NX74.
ExpressionAtlasiQ6NX74. baseline and differential.
GenevestigatoriQ6NX74.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR015519. ATM.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PANTHERiPTHR11139:SF66. PTHR11139:SF66. 1 hit.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ6NX74_MOUSE
AccessioniPrimary (citable) accession number: Q6NX74
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.