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Q6NX74

- Q6NX74_MOUSE

UniProt

Q6NX74 - Q6NX74_MOUSE

Protein
Submitted name:

Atm protein

Gene

Atm

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. DNA-dependent protein kinase activity Source: Ensembl
    4. histone serine kinase activity Source: Ensembl
    5. protein kinase activity Source: MGI

    GO - Biological processi

    1. brain development Source: MGI
    2. cell cycle arrest Source: Ensembl
    3. cellular response to DNA damage stimulus Source: MGI
    4. cellular response to gamma radiation Source: Ensembl
    5. DNA damage checkpoint Source: MGI
    6. DNA damage induced protein phosphorylation Source: Ensembl
    7. DNA repair Source: MGI
    8. female gamete generation Source: MGI
    9. heart development Source: MGI
    10. histone mRNA catabolic process Source: Ensembl
    11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    12. lipoprotein catabolic process Source: MGI
    13. mitotic spindle assembly checkpoint Source: Ensembl
    14. negative regulation of B cell proliferation Source: Ensembl
    15. neuron apoptotic process Source: MGI
    16. oocyte development Source: MGI
    17. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    18. positive regulation of neuron apoptotic process Source: MGI
    19. protein autophosphorylation Source: Ensembl
    20. protein phosphorylation Source: MGI
    21. replicative senescence Source: InterPro
    22. response to hypoxia Source: Ensembl
    23. response to ionizing radiation Source: MGI
    24. signal transduction involved in mitotic G2 DNA damage checkpoint Source: Ensembl
    25. somitogenesis Source: MGI
    26. telomere maintenance Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Atm proteinImported
    Gene namesi
    Name:AtmImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:107202. Atm.

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome, telomeric region Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: MGI
    4. spindle Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6NX74.

    Expressioni

    Gene expression databases

    BgeeiQ6NX74.
    GenevestigatoriQ6NX74.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113388.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NX74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FAT domain.SAAS annotation
    Contains FATC domain.SAAS annotation
    Contains PI3K/PI4K domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG103270.
    InParanoidiQ6NX74.

    Family and domain databases

    Gene3Di1.10.1070.11. 3 hits.
    InterProiIPR015519. ATM.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    [Graphical view]
    PANTHERiPTHR11139:SF66. PTHR11139:SF66. 1 hit.
    PfamiPF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view]
    SMARTiSM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6NX74-1 [UniParc]FASTAAdd to Basket

    « Hide

    TQLPERAIFK IKQYNSAICG ISEWHLEEAQ VFWAKKEQSL ALSILKQMIK    50
    KLDSSFKDKE NDAGLKVIYA ECLRVCGSWL AETCLENPAV IMQTYLEKAV 100
    KVAGSYDGNS RELRNGQMKA FLSLARFSDT QYQRIENYMK SSEFENKQTL 150
    LKRAKEEVGL LREHKIQTNR YTVKVQRELE LDECALRALR EDRKRFLCKA 200
    VENYINCLLS GEEHDLWVFR LCSLWLENSG VSEVNGMMKK DGMKISSYKF 250
    LPLMYQLAAR MGTKMTGGLG FHEVLNNLIS RISLDHPHHT LFIILALANA 300
    NKDEFLSKPE TTRRSRITKS TSKENSHLDE DRTEAATRII HSIRSKRCKM 350
    VKDMEALCDA YIILANMDAS QWRAQRKGIN IPANQPITKL KNLEDVVVPT 400
    MEIKVDPTGE YENLVTIKSF KTEFRLAGGL NLPKIIDCVG SDGKERRQLV 450
    KGRDDLRQDA VMQQVFQMCN TLLQRNTETR KRKLTICTYK VVPLSQRSGV 500
    LEWCTGTVPI GEYLVNSEDG AHRRYRPNDF SANQCQKKMM EVQKKSFEEK 550
    YDTFMTICQN FEPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL 600
    GLGDRHVQNI LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLSRDIVD 650
    GMGITGVEGV FRRCCEKTME VMRSSQETLL TIVEVLLYDP LFDWTMNPLK 700
    ALYLQQRPED ESDLHSTPNA DDQECKQSLS DTDQSFNKVA ERVLMRLQEK 750
    LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS RLFPGWKAWV 790
    Length:790
    Mass (Da):90,686
    Last modified:July 5, 2004 - v1
    Checksum:i7A03FF59D0B8C189
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC067212 mRNA. Translation: AAH67212.1.
    UniGeneiMm.5088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC067212 mRNA. Translation: AAH67212.1 .
    UniGenei Mm.5088.

    3D structure databases

    ProteinModelPortali Q6NX74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113388.

    Proteomic databases

    PRIDEi Q6NX74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:107202. Atm.

    Phylogenomic databases

    HOVERGENi HBG103270.
    InParanoidi Q6NX74.

    Miscellaneous databases

    ChiTaRSi ATM. mouse.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NX74.
    Genevestigatori Q6NX74.

    Family and domain databases

    Gene3Di 1.10.1070.11. 3 hits.
    InterProi IPR015519. ATM.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    [Graphical view ]
    PANTHERi PTHR11139:SF66. PTHR11139:SF66. 1 hit.
    Pfami PF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view ]
    SMARTi SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. C3Imported.

    Entry informationi

    Entry nameiQ6NX74_MOUSE
    AccessioniPrimary (citable) accession number: Q6NX74
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)