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Q6NX74 (Q6NX74_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Atm EMBL AAH67212.1 MGI 107202
OrganismMus musculus (Mouse) EMBL AAH67212.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length790 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains FAT domain. SAAS SAAS018936

Contains FATC domain. SAAS SAAS018936

Contains PI3K/PI4K domain. SAAS SAAS018936

Ontologies

Keywords
   LigandATP-binding SAAS SAAS003152
Nucleotide-binding
   Molecular functionKinase SAAS SAAS018936
Transferase
Gene Ontology (GO)
   Biological_processDNA damage checkpoint

Inferred from mutant phenotype PubMed 12937170. Source: MGI

DNA damage induced protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

DNA repair

Inferred from direct assay PubMed 15364958. Source: MGI

brain development

Inferred from genetic interaction PubMed 16687486. Source: MGI

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to DNA damage stimulus

Traceable author statement PubMed 11040211. Source: MGI

cellular response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

female gamete generation

Inferred from mutant phenotype PubMed 15640358. Source: MGI

heart development

Inferred from genetic interaction PubMed 16687486. Source: MGI

histone mRNA catabolic process

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from mutant phenotype PubMed 11040211PubMed 16777961. Source: MGI

lipoprotein catabolic process

Inferred from genetic interaction PubMed 15863839. Source: MGI

mitotic spindle assembly checkpoint

Inferred from electronic annotation. Source: Ensembl

negative regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from genetic interaction PubMed 11248063. Source: MGI

oocyte development

Inferred from mutant phenotype PubMed 11536012. Source: MGI

positive regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron apoptotic process

Inferred from genetic interaction PubMed 10639175PubMed 16777961. Source: MGI

protein autophosphorylation

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Inferred from direct assay PubMed 15364958. Source: MGI

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to ionizing radiation

Inferred from genetic interaction PubMed 10639175. Source: MGI

signal transduction involved in mitotic G2 DNA damage checkpoint

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from genetic interaction PubMed 16687486. Source: MGI

   Cellular_componentchromosome, telomeric region

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement PubMed 15604234. Source: MGI

spindle

Inferred from direct assay PubMed 15509711. Source: MGI

   Molecular_function1-phosphatidylinositol-3-kinase activity

Inferred from electronic annotation. Source: Ensembl

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA-dependent protein kinase activity

Inferred from electronic annotation. Source: Ensembl

histone serine kinase activity

Inferred from electronic annotation. Source: Ensembl

protein kinase activity

Inferred from direct assay PubMed 15364958. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAH67212.1

Sequences

Sequence LengthMass (Da)Tools
Q6NX74 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7A03FF59D0B8C189

FASTA79090,686
        10         20         30         40         50         60 
TQLPERAIFK IKQYNSAICG ISEWHLEEAQ VFWAKKEQSL ALSILKQMIK KLDSSFKDKE 

        70         80         90        100        110        120 
NDAGLKVIYA ECLRVCGSWL AETCLENPAV IMQTYLEKAV KVAGSYDGNS RELRNGQMKA 

       130        140        150        160        170        180 
FLSLARFSDT QYQRIENYMK SSEFENKQTL LKRAKEEVGL LREHKIQTNR YTVKVQRELE 

       190        200        210        220        230        240 
LDECALRALR EDRKRFLCKA VENYINCLLS GEEHDLWVFR LCSLWLENSG VSEVNGMMKK 

       250        260        270        280        290        300 
DGMKISSYKF LPLMYQLAAR MGTKMTGGLG FHEVLNNLIS RISLDHPHHT LFIILALANA 

       310        320        330        340        350        360 
NKDEFLSKPE TTRRSRITKS TSKENSHLDE DRTEAATRII HSIRSKRCKM VKDMEALCDA 

       370        380        390        400        410        420 
YIILANMDAS QWRAQRKGIN IPANQPITKL KNLEDVVVPT MEIKVDPTGE YENLVTIKSF 

       430        440        450        460        470        480 
KTEFRLAGGL NLPKIIDCVG SDGKERRQLV KGRDDLRQDA VMQQVFQMCN TLLQRNTETR 

       490        500        510        520        530        540 
KRKLTICTYK VVPLSQRSGV LEWCTGTVPI GEYLVNSEDG AHRRYRPNDF SANQCQKKMM 

       550        560        570        580        590        600 
EVQKKSFEEK YDTFMTICQN FEPVFRYFCM EKFLDPAVWF EKRLAYTRSV ATSSIVGYIL 

       610        620        630        640        650        660 
GLGDRHVQNI LINEQSAELV HIDLGVAFEQ GKILPTPETV PFRLSRDIVD GMGITGVEGV 

       670        680        690        700        710        720 
FRRCCEKTME VMRSSQETLL TIVEVLLYDP LFDWTMNPLK ALYLQQRPED ESDLHSTPNA 

       730        740        750        760        770        780 
DDQECKQSLS DTDQSFNKVA ERVLMRLQEK LKGVEEGTVL SVGGQVNLLI QQAMDPKNLS 

       790 
RLFPGWKAWV 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH67212.1.
Tissue: Mammary tumor. C3 EMBL AAH67212.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC067212 mRNA. Translation: AAH67212.1.
UniGeneMm.5088.

3D structure databases

ProteinModelPortalQ6NX74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000113388.

Proteomic databases

PRIDEQ6NX74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:107202. Atm.

Phylogenomic databases

HOVERGENHBG103270.
InParanoidQ6NX74.

Gene expression databases

BgeeQ6NX74.
GenevestigatorQ6NX74.

Family and domain databases

Gene3D1.10.1070.11. 3 hits.
InterProIPR015519. ATM.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PANTHERPTHR11139:SF66. PTHR11139:SF66. 1 hit.
PfamPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATM. mouse.
SOURCESearch...

Entry information

Entry nameQ6NX74_MOUSE
AccessionPrimary (citable) accession number: Q6NX74
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)