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Protein

Zinc finger protein 544

Gene

ZNF544

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri354 – 37421C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 544
Gene namesi
Name:ZNF544
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16759. ZNF544.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871299.

Polymorphism and mutation databases

BioMutaiZNF544.
DMDMi74762345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Zinc finger protein 544PRO_0000047643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki534 – 534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6NX49.
MaxQBiQ6NX49.
PaxDbiQ6NX49.
PeptideAtlasiQ6NX49.
PRIDEiQ6NX49.

PTM databases

iPTMnetiQ6NX49.
PhosphoSiteiQ6NX49.

Expressioni

Gene expression databases

BgeeiQ6NX49.
CleanExiHS_ZNF544.
ExpressionAtlasiQ6NX49. baseline and differential.
GenevisibleiQ6NX49. HS.

Organism-specific databases

HPAiHPA002732.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760033EBI-2841978,EBI-374781
NDEL1Q9GZM83EBI-2841978,EBI-928842
TRAF2Q129333EBI-2841978,EBI-355744
TSGA10Q9BZW73EBI-2841978,EBI-744794

Protein-protein interaction databases

BioGridi118123. 11 interactions.
IntActiQ6NX49. 7 interactions.
STRINGi9606.ENSP00000269829.

Structurei

3D structure databases

ProteinModelPortaliQ6NX49.
SMRiQ6NX49. Positions 12-54, 241-715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri354 – 37421C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129791.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6NX49.
KOiK09228.
OMAiDDCKDYG.
PhylomeDBiQ6NX49.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NX49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARSMLVPP QASVCFEDVA MAFTQEEWEQ LDLAQRTLYR EVTLETWEHI
60 70 80 90 100
VSLGLFLSKS DVISQLEQEE DLCRAEQEAP RDWKATLEEN RLNSEKDRAR
110 120 130 140 150
EELSHHVEVY RSGPEEPPSL VLGKVQDQSN QLREHQENSL RFMVLTSERL
160 170 180 190 200
FAQREHCELE LGGGYSLPST LSLLPTTLPT STGFPKPNSQ VKELKQNSAF
210 220 230 240 250
INHEKNGADG KHCESHQCAR AFCQSIYLSK LGNVETGKKN PYEYIVSGDS
260 270 280 290 300
LNYGSSLCFH GRTFSVKKSD DCKDYGNLFS HSVSLNEQKP VHFGKSQYEC
310 320 330 340 350
DECRETCSES LCLVQTERSG PGETPFRCEE RCAAFPMASS FSDCNIIQTT
360 370 380 390 400
EKPSVCNQCG KSFSCCKLIH QRTHTGEKPF ECTQCGKSFS QSYDLVIHQR
410 420 430 440 450
THTGEKPYEC DLCGKSFTQR SKLITHQRIH TGEKPYQCIE CRKSFRWNSN
460 470 480 490 500
LIVHQRIHTG EKPYECTHCG KSFSQSYELV THKRTHTGEK PFKCTQCGKS
510 520 530 540 550
FSQKYDLVVH QRTHTGEKPY ECNLCGKSFS QSSKLITHQR IHTGEKPYQC
560 570 580 590 600
IECGKSFRWN SNLVIHQRIH TGEKPYDCTH CGKSFSQSYQ LVAHKRTHTG
610 620 630 640 650
EKPYECNECG KAFNRSTQLI RHLQIHTGEK PYKCNQCNKA FARSSYLVMH
660 670 680 690 700
QRTHTGEKPF ECSQCGKAFS GSSNLLSHHR IHSGEKPYEC SDCGKSFRQQ
710
SQLVVHRRTH TGEKP
Length:715
Mass (Da):81,742
Last modified:July 5, 2004 - v1
Checksum:iD0F6F775D9741E03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861T → P in AAC01956 (Ref. 1) Curated
Sequence conflicti91 – 911R → G in AAC01956 (Ref. 1) Curated
Sequence conflicti348 – 3481Q → L in AAC01956 (Ref. 1) Curated
Sequence conflicti446 – 4461R → T in AAC01956 (Ref. 1) Curated
Sequence conflicti590 – 5901Q → R in AAC01956 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031H → D.
Corresponds to variant rs6510130 [ dbSNP | Ensembl ].
VAR_052859
Natural varianti700 – 7001Q → R.3 Publications
Corresponds to variant rs260462 [ dbSNP | Ensembl ].
VAR_052860

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020591 mRNA. Translation: AAC01956.1.
AK291656 mRNA. Translation: BAF84345.1.
CH471135 Genomic DNA. Translation: EAW72568.1.
BC067271 mRNA. Translation: AAH67271.1.
CCDSiCCDS12973.1.
RefSeqiNP_001307696.1. NM_001320767.1.
NP_001307698.1. NM_001320769.1.
NP_001307699.1. NM_001320770.1.
NP_001307700.1. NM_001320771.1.
NP_001307702.1. NM_001320773.1.
NP_001307705.1. NM_001320776.1.
NP_001307706.1. NM_001320777.1.
NP_001307709.1. NM_001320780.1.
NP_001307712.1. NM_001320783.1.
NP_001307714.1. NM_001320785.1.
NP_001307715.1. NM_001320786.1.
NP_001307720.1. NM_001320791.1.
NP_055295.2. NM_014480.3.
XP_011525045.1. XM_011526743.1.
UniGeneiHs.438994.
Hs.677532.
Hs.710049.

Genome annotation databases

EnsembliENST00000269829; ENSP00000269829; ENSG00000198131.
ENST00000596652; ENSP00000469635; ENSG00000198131.
GeneIDi27300.
KEGGihsa:27300.
UCSCiuc061dqq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020591 mRNA. Translation: AAC01956.1.
AK291656 mRNA. Translation: BAF84345.1.
CH471135 Genomic DNA. Translation: EAW72568.1.
BC067271 mRNA. Translation: AAH67271.1.
CCDSiCCDS12973.1.
RefSeqiNP_001307696.1. NM_001320767.1.
NP_001307698.1. NM_001320769.1.
NP_001307699.1. NM_001320770.1.
NP_001307700.1. NM_001320771.1.
NP_001307702.1. NM_001320773.1.
NP_001307705.1. NM_001320776.1.
NP_001307706.1. NM_001320777.1.
NP_001307709.1. NM_001320780.1.
NP_001307712.1. NM_001320783.1.
NP_001307714.1. NM_001320785.1.
NP_001307715.1. NM_001320786.1.
NP_001307720.1. NM_001320791.1.
NP_055295.2. NM_014480.3.
XP_011525045.1. XM_011526743.1.
UniGeneiHs.438994.
Hs.677532.
Hs.710049.

3D structure databases

ProteinModelPortaliQ6NX49.
SMRiQ6NX49. Positions 12-54, 241-715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118123. 11 interactions.
IntActiQ6NX49. 7 interactions.
STRINGi9606.ENSP00000269829.

PTM databases

iPTMnetiQ6NX49.
PhosphoSiteiQ6NX49.

Polymorphism and mutation databases

BioMutaiZNF544.
DMDMi74762345.

Proteomic databases

EPDiQ6NX49.
MaxQBiQ6NX49.
PaxDbiQ6NX49.
PeptideAtlasiQ6NX49.
PRIDEiQ6NX49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269829; ENSP00000269829; ENSG00000198131.
ENST00000596652; ENSP00000469635; ENSG00000198131.
GeneIDi27300.
KEGGihsa:27300.
UCSCiuc061dqq.1. human.

Organism-specific databases

CTDi27300.
GeneCardsiZNF544.
HGNCiHGNC:16759. ZNF544.
HPAiHPA002732.
neXtProtiNX_Q6NX49.
PharmGKBiPA134871299.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129791.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6NX49.
KOiK09228.
OMAiDDCKDYG.
PhylomeDBiQ6NX49.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF544. human.
GenomeRNAii27300.
PROiQ6NX49.

Gene expression databases

BgeeiQ6NX49.
CleanExiHS_ZNF544.
ExpressionAtlasiQ6NX49. baseline and differential.
GenevisibleiQ6NX49. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human gene coding a zinc finger protein."
    Hu P., Yu L., Zhang M.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-700.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-700.
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-700.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  5. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN544_HUMAN
AccessioniPrimary (citable) accession number: Q6NX49
Secondary accession number(s): A8K6J1, Q9UEX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.