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Protein

Zinc finger protein 774

Gene

ZNF774

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 774
Gene namesi
Name:ZNF774
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:33108. ZNF774.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410358.

Polymorphism and mutation databases

BioMutaiZNF774.
DMDMi313104065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Zinc finger protein 774PRO_0000263653Add
BLAST

Proteomic databases

MaxQBiQ6NX45.
PaxDbiQ6NX45.
PeptideAtlasiQ6NX45.
PRIDEiQ6NX45.

PTM databases

iPTMnetiQ6NX45.
PhosphoSiteiQ6NX45.

Expressioni

Gene expression databases

BgeeiQ6NX45.
CleanExiHS_ZNF774.
ExpressionAtlasiQ6NX45. baseline and differential.

Organism-specific databases

HPAiHPA030840.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEGAINQ9BUH83EBI-10251462,EBI-742722
GOLGA2Q083793EBI-10251462,EBI-618309
LDOC1O957513EBI-10251462,EBI-740738
RBM11P570523EBI-10251462,EBI-741332

Protein-protein interaction databases

BioGridi131165. 5 interactions.
IntActiQ6NX45. 4 interactions.
STRINGi9606.ENSP00000346348.

Structurei

3D structure databases

ProteinModelPortaliQ6NX45.
SMRiQ6NX45. Positions 125-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464KRABAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6NX45.
OMAiGNWERGL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6NX45.
TreeFamiTF336942.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NX45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLGTSGKSG LPGHCLENPL QECHPAQLEE WALKGISRPS VISQPEQKEE
60 70 80 90 100
PWVLPLQNFE ARKIPRESHT DCEHQVAKLN QDNSETAEQC GTSSERTNKD
110 120 130 140 150
LSHTLSWGGN WEQGLELEGQ HGTLPGEGQL ESFSQERDLN KLLDGYVGEK
160 170 180 190 200
PMCAECGKSF NQSSYLIRHL RTHTGERPYT CIECGKGFKQ SSDLVTHRRT
210 220 230 240 250
HTGEKPYQCK GCEKKFSDSS TLIKHQRTHT GERPYECPEC GKTFGRKPHL
260 270 280 290 300
IMHQRTHTGE KPYACLECHK SFSRSSNFIT HQRTHTGVKP YRCNDCGESF
310 320 330 340 350
SQSSDLIKHQ RTHTGERPFK CPECGKGFRD SSHFVAHMST HSGERPFSCP
360 370 380 390 400
DCHKSFSQSS HLVTHQRTHT GERPFKCENC GKGFADSSAL IKHQRIHTGE
410 420 430 440 450
RPYKCGECGK SFNQSSHFIT HQRIHLGDRP YRCPECGKTF NQRSHFLTHQ
460 470 480
RTHTGEKPFH CSKCNKSFRQ KAHLLCHQNT HLI
Length:483
Mass (Da):55,068
Last modified:November 30, 2010 - v2
Checksum:i88C98561DA99E7A5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651P → L.
Corresponds to variant rs16944267 [ dbSNP | Ensembl ].
VAR_029596
Natural varianti83 – 831N → S.1 Publication
Corresponds to variant rs2589957 [ dbSNP | Ensembl ].
VAR_029597
Natural varianti147 – 1471V → I.
Corresponds to variant rs11854320 [ dbSNP | Ensembl ].
VAR_029598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289385 mRNA. Translation: BAF82074.1.
AC018946 Genomic DNA. No translation available.
BC067279 mRNA. Translation: AAH67279.1.
CCDSiCCDS32330.1.
RefSeqiNP_001004309.2. NM_001004309.2.
UniGeneiHs.55307.

Genome annotation databases

EnsembliENST00000354377; ENSP00000346348; ENSG00000196391.
GeneIDi342132.
KEGGihsa:342132.
UCSCiuc002bpk.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289385 mRNA. Translation: BAF82074.1.
AC018946 Genomic DNA. No translation available.
BC067279 mRNA. Translation: AAH67279.1.
CCDSiCCDS32330.1.
RefSeqiNP_001004309.2. NM_001004309.2.
UniGeneiHs.55307.

3D structure databases

ProteinModelPortaliQ6NX45.
SMRiQ6NX45. Positions 125-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131165. 5 interactions.
IntActiQ6NX45. 4 interactions.
STRINGi9606.ENSP00000346348.

PTM databases

iPTMnetiQ6NX45.
PhosphoSiteiQ6NX45.

Polymorphism and mutation databases

BioMutaiZNF774.
DMDMi313104065.

Proteomic databases

MaxQBiQ6NX45.
PaxDbiQ6NX45.
PeptideAtlasiQ6NX45.
PRIDEiQ6NX45.

Protocols and materials databases

DNASUi342132.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354377; ENSP00000346348; ENSG00000196391.
GeneIDi342132.
KEGGihsa:342132.
UCSCiuc002bpk.5. human.

Organism-specific databases

CTDi342132.
GeneCardsiZNF774.
HGNCiHGNC:33108. ZNF774.
HPAiHPA030840.
neXtProtiNX_Q6NX45.
PharmGKBiPA162410358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6NX45.
OMAiGNWERGL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6NX45.
TreeFamiTF336942.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii342132.
PROiQ6NX45.

Gene expression databases

BgeeiQ6NX45.
CleanExiHS_ZNF774.
ExpressionAtlasiQ6NX45. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-83.
    Tissue: PNS.

Entry informationi

Entry nameiZN774_HUMAN
AccessioniPrimary (citable) accession number: Q6NX45
Secondary accession number(s): A8K020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.