Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q6NWZ9 (CDO1_DANRE)

Last modified January 19, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cysteine dioxygenase type 1
    EC=1.13.11.20
Alternative name(s):
    Cysteine dioxygenase type I
      Short name=CDO-I
      Short name=CDO
Gene names
Name: cdo1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Cysteine dioxygenase type 1
PRO_0000206610

Sites

Metal binding861Iron; catalytic By similarity
Metal binding881Iron; catalytic By similarity
Metal binding1411Iron; catalytic By similarity

Amino acid modifications

Cross-link93 ↔ 1583'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NWZ9-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 443CF9938F2752A7

FASTA20123,474
        10         20         30         40         50         60 
MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF AKFDQYRYTR 

        70         80         90        100        110        120 
NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG QLKETLFDWP DRKLQSGMKP 

       130        140        150        160        170        180 
RGQSVLQENQ CAYINDSLGL HRVENVSHTE PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM 

       190        200 
TFWSKYGERT PYELSVSQEN N 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC059531 mRNA. Translation: AAH59531.1.
BC067344 mRNA. Translation: AAH67344.1.
IPIIPI00508833.
RefSeqNP_957035.1.
UniGeneDr.79566

3D structure databases

SMRQ6NWZ9. Positions 5-191.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6NWZ9.

Genome annotation databases

EnsemblENSDART00000063178; ENSDARP00000063177; ENSDARG00000043036; Danio rerio. [Genome view]
GeneID393714.
KEGGdre:393714.

Organism-specific databases

CTD393714.
ZFINZDB-GENE-040426-1704. cdo1.

Phylogenomic databases

eggNOGfiNOG04158.
HOVERGENQ6NWZ9.

Enzyme and pathway databases

BRENDA1.13.11.20. 96826.

Gene expression databases

BgeeQ6NWZ9.

Family and domain databases

InterProIPR011051. Cupin_RmlC_type.
IPR010300. Cys_dOase_I.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDO1_DANRE
AccessionPrimary (citable) accession number: Q6NWZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents