Reviewed, UniProtKB/Swiss-Prot Q6NWZ9 (CDO1_DANRE)

Names and origin

Protein names

Recommended name:
    Cysteine dioxygenase type 1
    EC=1.13.11.20
Alternative name(s):
    Cysteine dioxygenase type I
      Short name=CDO-I
      Short name=CDO

Gene names

Name:

cdo1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Gene Ontology (GO)
Biological process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Cysteine dioxygenase type 1		PRO_0000206610
Sites
	Metal binding	86	1	Iron; catalytic By similarity
	Metal binding	88	1	Iron; catalytic By similarity
	Metal binding	141	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	93 ↔ 158		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6NWZ9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 443CF9938F2752A7	FASTA	201	23,474
	10 20 30 40 50 60 MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF AKFDQYRYTR 70 80 90 100 110 120 NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG QLKETLFDWP DRKLQSGMKP 130 140 150 160 170 180 RGQSVLQENQ CAYINDSLGL HRVENVSHTE PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM 190 200 TFWSKYGERT PYELSVSQEN N

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059531 mRNA. Translation: AAH59531.1. BC067344 mRNA. Translation: AAH67344.1.
IPI	IPI00508833.
RefSeq	NP_957035.1.
UniGene	Dr.79566
3D structure databases
SMR	Q6NWZ9. Positions 5-191.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6NWZ9.
Genome annotation databases
Ensembl	ENSDART00000063178; ENSDARP00000063177; ENSDARG00000043036; Danio rerio. [Genome view]
GeneID	393714.
KEGG	dre:393714.
Organism-specific databases
CTD	393714.
ZFIN	ZDB-GENE-040426-1704. cdo1.
Phylogenomic databases
eggNOG	fiNOG04158.
HOVERGEN	Q6NWZ9.
Enzyme and pathway databases
BRENDA	1.13.11.20. 96826.
Gene expression databases
Bgee	Q6NWZ9.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR010300. Cys_dOase_I. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDO1_DANRE

Accession

Primary (citable) accession number: Q6NWZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project