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Q6NWZ9

- CDO1_DANRE

UniProt

Q6NWZ9 - CDO1_DANRE

Protein

Cysteine dioxygenase type 1

Gene

cdo1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Iron; catalyticBy similarity
    Metal bindingi88 – 881Iron; catalyticBy similarity
    Metal bindingi141 – 1411Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro
    2. taurine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase type 1 (EC:1.13.11.20)
    Alternative name(s):
    Cysteine dioxygenase type I
    Short name:
    CDO
    Short name:
    CDO-I
    Gene namesi
    Name:cdo1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-1704. cdo1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Cysteine dioxygenase type 1PRO_0000206610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki93 ↔ 1583'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

    Post-translational modificationi

    The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

    Keywords - PTMi

    Thioether bond

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000063177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NWZ9.
    SMRiQ6NWZ9. Positions 5-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG126313.
    HOVERGENiHBG004469.
    KOiK00456.
    PhylomeDBiQ6NWZ9.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NWZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF    50
    AKFDQYRYTR NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG 100
    QLKETLFDWP DRKLQSGMKP RGQSVLQENQ CAYINDSLGL HRVENVSHTE 150
    PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM TFWSKYGERT PYELSVSQEN 200
    N 201
    Length:201
    Mass (Da):23,474
    Last modified:July 5, 2004 - v1
    Checksum:i443CF9938F2752A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC059531 mRNA. Translation: AAH59531.1.
    BC067344 mRNA. Translation: AAH67344.1.
    RefSeqiNP_957035.2. NM_200741.1.
    UniGeneiDr.79566.

    Genome annotation databases

    GeneIDi393714.
    KEGGidre:393714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC059531 mRNA. Translation: AAH59531.1 .
    BC067344 mRNA. Translation: AAH67344.1 .
    RefSeqi NP_957035.2. NM_200741.1.
    UniGenei Dr.79566.

    3D structure databases

    ProteinModelPortali Q6NWZ9.
    SMRi Q6NWZ9. Positions 5-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000063177.

    Protocols and materials databases

    DNASUi 393714.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 393714.
    KEGGi dre:393714.

    Organism-specific databases

    CTDi 1036.
    ZFINi ZDB-GENE-040426-1704. cdo1.

    Phylogenomic databases

    eggNOGi NOG126313.
    HOVERGENi HBG004469.
    KOi K00456.
    PhylomeDBi Q6NWZ9.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .

    Miscellaneous databases

    NextBioi 20814716.
    PROi Q6NWZ9.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiCDO1_DANRE
    AccessioniPrimary (citable) accession number: Q6NWZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3