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Q6NWZ9

- CDO1_DANRE

UniProt

Q6NWZ9 - CDO1_DANRE

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Protein
Cysteine dioxygenase type 1
Gene
cdo1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalytic By similarity
Metal bindingi88 – 881Iron; catalytic By similarity
Metal bindingi141 – 1411Iron; catalytic By similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:cdo1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1704. cdo1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Cysteine dioxygenase type 1
PRO_0000206610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1583'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Keywords - PTMi

Thioether bond

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063177.

Structurei

3D structure databases

ProteinModelPortaliQ6NWZ9.
SMRiQ6NWZ9. Positions 5-191.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG126313.
HOVERGENiHBG004469.
KOiK00456.
PhylomeDBiQ6NWZ9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NWZ9-1 [UniParc]FASTAAdd to Basket

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MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF    50
AKFDQYRYTR NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG 100
QLKETLFDWP DRKLQSGMKP RGQSVLQENQ CAYINDSLGL HRVENVSHTE 150
PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM TFWSKYGERT PYELSVSQEN 200
N 201
Length:201
Mass (Da):23,474
Last modified:July 5, 2004 - v1
Checksum:i443CF9938F2752A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059531 mRNA. Translation: AAH59531.1.
BC067344 mRNA. Translation: AAH67344.1.
RefSeqiNP_957035.2. NM_200741.1.
UniGeneiDr.79566.

Genome annotation databases

GeneIDi393714.
KEGGidre:393714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059531 mRNA. Translation: AAH59531.1 .
BC067344 mRNA. Translation: AAH67344.1 .
RefSeqi NP_957035.2. NM_200741.1.
UniGenei Dr.79566.

3D structure databases

ProteinModelPortali Q6NWZ9.
SMRi Q6NWZ9. Positions 5-191.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000063177.

Protocols and materials databases

DNASUi 393714.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393714.
KEGGi dre:393714.

Organism-specific databases

CTDi 1036.
ZFINi ZDB-GENE-040426-1704. cdo1.

Phylogenomic databases

eggNOGi NOG126313.
HOVERGENi HBG004469.
KOi K00456.
PhylomeDBi Q6NWZ9.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Miscellaneous databases

NextBioi 20814716.
PROi Q6NWZ9.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCDO1_DANRE
AccessioniPrimary (citable) accession number: Q6NWZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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