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Q6NWZ9

- CDO1_DANRE

UniProt

Q6NWZ9 - CDO1_DANRE

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Protein

Cysteine dioxygenase type 1

Gene

cdo1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalyticBy similarity
Metal bindingi88 – 881Iron; catalyticBy similarity
Metal bindingi141 – 1411Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:cdo1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1704. cdo1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Cysteine dioxygenase type 1PRO_0000206610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1583'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063177.

Structurei

3D structure databases

ProteinModelPortaliQ6NWZ9.
SMRiQ6NWZ9. Positions 5-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiNOG126313.
HOVERGENiHBG004469.
InParanoidiQ6NWZ9.
KOiK00456.
PhylomeDBiQ6NWZ9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NWZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF
60 70 80 90 100
AKFDQYRYTR NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG
110 120 130 140 150
QLKETLFDWP DRKLQSGMKP RGQSVLQENQ CAYINDSLGL HRVENVSHTE
160 170 180 190 200
PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM TFWSKYGERT PYELSVSQEN

N
Length:201
Mass (Da):23,474
Last modified:July 5, 2004 - v1
Checksum:i443CF9938F2752A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059531 mRNA. Translation: AAH59531.1.
BC067344 mRNA. Translation: AAH67344.1.
RefSeqiNP_957035.2. NM_200741.1.
UniGeneiDr.79566.

Genome annotation databases

GeneIDi393714.
KEGGidre:393714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059531 mRNA. Translation: AAH59531.1 .
BC067344 mRNA. Translation: AAH67344.1 .
RefSeqi NP_957035.2. NM_200741.1.
UniGenei Dr.79566.

3D structure databases

ProteinModelPortali Q6NWZ9.
SMRi Q6NWZ9. Positions 5-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000063177.

Protocols and materials databases

DNASUi 393714.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393714.
KEGGi dre:393714.

Organism-specific databases

CTDi 1036.
ZFINi ZDB-GENE-040426-1704. cdo1.

Phylogenomic databases

eggNOGi NOG126313.
HOVERGENi HBG004469.
InParanoidi Q6NWZ9.
KOi K00456.
PhylomeDBi Q6NWZ9.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Miscellaneous databases

NextBioi 20814716.
PROi Q6NWZ9.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCDO1_DANRE
AccessioniPrimary (citable) accession number: Q6NWZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3