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Q6NWW5 (KIF24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF24
Gene names
Name:Kif24
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation By similarity.

Subunit structure

Interacts with CCP110 and CEP97 By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole By similarity.

Tissue specificity

Expressed in brain, spinal cord, and small intestine. Ref.4

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Contains 1 kinesin motor domain.

Contains 1 SAM (sterile alpha motif) domain.

Sequence caution

The sequence AAH67395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC39323.1 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NWW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NWW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     265-398: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13561356Kinesin-like protein KIF24
PRO_0000278249

Regions

Domain1 – 6464SAM
Domain218 – 541324Kinesin motor
Nucleotide binding308 – 3158ATP By similarity

Amino acid modifications

Modified residue1021Phosphoserine By similarity
Modified residue4731Phosphoserine By similarity
Modified residue6401Phosphoserine By similarity
Modified residue10081Phosphoserine By similarity

Natural variations

Alternative sequence265 – 398134Missing in isoform 2.
VSP_023214

Experimental info

Sequence conflict4131A → T in BAC39323. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: CA1009620C23BF43

FASTA1,356150,207
        10         20         30         40         50         60 
MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND RKRLFQLIKI 

        70         80         90        100        110        120 
IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF DSPSASKDKM ANNETGSLSN 

       130        140        150        160        170        180 
FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA PDASAADASM QTETNAPLFS SNYFSPQLGN 

       190        200        210        220        230        240 
CDIPVIQRVS HVSGYNYGIP HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV 

       250        260        270        280        290        300 
ITVEDKETLL VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG 

       310        320        330        340        350        360 
SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV WISFYEIYCG 

       370        380        390        400        410        420 
QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ VILKGSKERS TGATGVNADS 

       430        440        450        460        470        480 
SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS ERAADARDSD RQTKMEGAEI NQSLLALKEC 

       490        500        510        520        530        540 
IRALDQEHTH TPFRQSKLTQ VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE 

       550        560        570        580        590        600 
LKKGVKCCAS ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV 

       610        620        630        640        650        660 
KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH SIKKGAESAP 

       670        680        690        700        710        720 
LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ PVQPVQKQLL SRPRLLANSH 

       730        740        750        760        770        780 
HLEATQDSKV GTPAGLAPEA WTNPILQQKE REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL 

       790        800        810        820        830        840 
LCQHRPSEGR LQSETGFPLH SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL 

       850        860        870        880        890        900 
ERSGSSFFLH QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL 

       910        920        930        940        950        960 
SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA QVSDIRLEAF 

       970        980        990       1000       1010       1020 
TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV CTPLREVSEN RVTHTPGRVN 

      1030       1040       1050       1060       1070       1080 
SSTPFQEDSG EQIQMCSANA SGLMAPLTMS LLETPCHEDL SSLEQIAQDG AGYGFMAEIV 

      1090       1100       1110       1120       1130       1140 
GGPAAGHTVP SYDQEAALPV SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG 

      1150       1160       1170       1180       1190       1200 
REAYQTRRPI LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT 

      1210       1220       1230       1240       1250       1260 
GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR CLDSDSPVVP 

      1270       1280       1290       1300       1310       1320 
SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE ETLMTQMDSN DFEDFVTQLD 

      1330       1340       1350 
EIMALKSRCI QSLRSQLQLY LTSHRPAAAP ERTVVS 

« Hide

Isoform 2 [UniParc].

Checksum: 7CBCEDE7C7BBDA72
Show »

FASTA1,222134,855

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Lung.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Embryonic germ cell.
[4]"All kinesin superfamily protein, KIF, genes in mouse and human."
Miki H., Setou M., Kaneshiro K.
Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-450, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK084967 mRNA. Translation: BAC39323.1. Sequence problems.
AL807823, BX470237 Genomic DNA. Translation: CAM20982.1.
BX470237, AL807823 Genomic DNA. Translation: CAM23927.1.
BC067395 mRNA. Translation: AAH67395.1. Different initiation.
AB054028 Genomic DNA. Translation: BAB32492.1.
CCDSCCDS18060.2. [Q6NWW5-1]
RefSeqNP_077203.2. NM_024241.2. [Q6NWW5-1]
XP_006537612.1. XM_006537549.1. [Q6NWW5-1]
XP_006537613.1. XM_006537550.1. [Q6NWW5-1]
UniGeneMm.370288.

3D structure databases

ProteinModelPortalQ6NWW5.
SMRQ6NWW5. Positions 2-63, 218-538.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6NWW5.

Proteomic databases

PRIDEQ6NWW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438. [Q6NWW5-1]
GeneID109242.
KEGGmmu:109242.
UCSCuc008sio.1. mouse. [Q6NWW5-1]

Organism-specific databases

CTD347240.
MGIMGI:1918345. Kif24.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00740000114912.
HOGENOMHOG000232152.
HOVERGENHBG080392.
InParanoidQ6NWW5.
KOK10393.
OMAQKLKYQP.
OrthoDBEOG7TJ3H2.
PhylomeDBQ6NWW5.
TreeFamTF336001.

Gene expression databases

ArrayExpressQ6NWW5.
BgeeQ6NWW5.
CleanExMM_KIF24.
GenevestigatorQ6NWW5.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIF24. mouse.
NextBio361817.
PROQ6NWW5.
SOURCESearch...

Entry information

Entry nameKIF24_MOUSE
AccessionPrimary (citable) accession number: Q6NWW5
Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot