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Q6NWW5

- KIF24_MOUSE

UniProt

Q6NWW5 - KIF24_MOUSE

Protein

Kinesin-like protein KIF24

Gene

Kif24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi308 – 3158ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: UniProtKB

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. metabolic process Source: GOC
    3. microtubule-based movement Source: InterPro
    4. microtubule depolymerization Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF24
    Gene namesi
    Name:Kif24
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1918345. Kif24.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
    Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. kinesin complex Source: InterPro
    3. microtubule Source: UniProtKB-KW
    4. protein complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13561356Kinesin-like protein KIF24PRO_0000278249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphoserineBy similarity
    Modified residuei473 – 4731PhosphoserineBy similarity
    Modified residuei640 – 6401PhosphoserineBy similarity
    Modified residuei1008 – 10081PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6NWW5.

    PTM databases

    PhosphoSiteiQ6NWW5.

    Expressioni

    Tissue specificityi

    Expressed in brain, spinal cord, and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ6NWW5.
    BgeeiQ6NWW5.
    CleanExiMM_KIF24.
    GenevestigatoriQ6NWW5.

    Interactioni

    Subunit structurei

    Interacts with CCP110 and CEP97.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NWW5.
    SMRiQ6NWW5. Positions 2-63, 218-538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6464SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 541324Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00740000114912.
    HOGENOMiHOG000232152.
    HOVERGENiHBG080392.
    InParanoidiQ6NWW5.
    KOiK10393.
    OMAiQKLKYQP.
    OrthoDBiEOG7TJ3H2.
    PhylomeDBiQ6NWW5.
    TreeFamiTF336001.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NWW5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND     50
    RKRLFQLIKI IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF 100
    DSPSASKDKM ANNETGSLSN FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA 150
    PDASAADASM QTETNAPLFS SNYFSPQLGN CDIPVIQRVS HVSGYNYGIP 200
    HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV ITVEDKETLL 250
    VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG 300
    SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV 350
    WISFYEIYCG QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ 400
    VILKGSKERS TGATGVNADS SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS 450
    ERAADARDSD RQTKMEGAEI NQSLLALKEC IRALDQEHTH TPFRQSKLTQ 500
    VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE LKKGVKCCAS 550
    ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV 600
    KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH 650
    SIKKGAESAP LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ 700
    PVQPVQKQLL SRPRLLANSH HLEATQDSKV GTPAGLAPEA WTNPILQQKE 750
    REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL LCQHRPSEGR LQSETGFPLH 800
    SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL ERSGSSFFLH 850
    QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL 900
    SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA 950
    QVSDIRLEAF TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV 1000
    CTPLREVSEN RVTHTPGRVN SSTPFQEDSG EQIQMCSANA SGLMAPLTMS 1050
    LLETPCHEDL SSLEQIAQDG AGYGFMAEIV GGPAAGHTVP SYDQEAALPV 1100
    SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG REAYQTRRPI 1150
    LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT 1200
    GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR 1250
    CLDSDSPVVP SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE 1300
    ETLMTQMDSN DFEDFVTQLD EIMALKSRCI QSLRSQLQLY LTSHRPAAAP 1350
    ERTVVS 1356
    Length:1,356
    Mass (Da):150,207
    Last modified:February 20, 2007 - v2
    Checksum:iCA1009620C23BF43
    GO
    Isoform 2 (identifier: Q6NWW5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         265-398: Missing.

    Show »
    Length:1,222
    Mass (Da):134,855
    Checksum:i7CBCEDE7C7BBDA72
    GO

    Sequence cautioni

    The sequence AAH67395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC39323.1 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti413 – 4131A → T in BAC39323. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei265 – 398134Missing in isoform 2. 1 PublicationVSP_023214Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084967 mRNA. Translation: BAC39323.1. Sequence problems.
    AL807823, BX470237 Genomic DNA. Translation: CAM20982.1.
    BX470237, AL807823 Genomic DNA. Translation: CAM23927.1.
    BC067395 mRNA. Translation: AAH67395.1. Different initiation.
    AB054028 Genomic DNA. Translation: BAB32492.1.
    CCDSiCCDS18060.2. [Q6NWW5-1]
    RefSeqiNP_077203.2. NM_024241.2. [Q6NWW5-1]
    XP_006537612.1. XM_006537549.1. [Q6NWW5-1]
    XP_006537613.1. XM_006537550.1. [Q6NWW5-1]
    UniGeneiMm.370288.

    Genome annotation databases

    EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. [Q6NWW5-2]
    ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438. [Q6NWW5-1]
    GeneIDi109242.
    KEGGimmu:109242.
    UCSCiuc008sio.1. mouse. [Q6NWW5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084967 mRNA. Translation: BAC39323.1 . Sequence problems.
    AL807823 , BX470237 Genomic DNA. Translation: CAM20982.1 .
    BX470237 , AL807823 Genomic DNA. Translation: CAM23927.1 .
    BC067395 mRNA. Translation: AAH67395.1 . Different initiation.
    AB054028 Genomic DNA. Translation: BAB32492.1 .
    CCDSi CCDS18060.2. [Q6NWW5-1 ]
    RefSeqi NP_077203.2. NM_024241.2. [Q6NWW5-1 ]
    XP_006537612.1. XM_006537549.1. [Q6NWW5-1 ]
    XP_006537613.1. XM_006537550.1. [Q6NWW5-1 ]
    UniGenei Mm.370288.

    3D structure databases

    ProteinModelPortali Q6NWW5.
    SMRi Q6NWW5. Positions 2-63, 218-538.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6NWW5.

    Proteomic databases

    PRIDEi Q6NWW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030148 ; ENSMUSP00000030148 ; ENSMUSG00000028438 . [Q6NWW5-2 ]
    ENSMUST00000108055 ; ENSMUSP00000103690 ; ENSMUSG00000028438 . [Q6NWW5-1 ]
    GeneIDi 109242.
    KEGGi mmu:109242.
    UCSCi uc008sio.1. mouse. [Q6NWW5-1 ]

    Organism-specific databases

    CTDi 347240.
    MGIi MGI:1918345. Kif24.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00740000114912.
    HOGENOMi HOG000232152.
    HOVERGENi HBG080392.
    InParanoidi Q6NWW5.
    KOi K10393.
    OMAi QKLKYQP.
    OrthoDBi EOG7TJ3H2.
    PhylomeDBi Q6NWW5.
    TreeFami TF336001.

    Miscellaneous databases

    ChiTaRSi KIF24. mouse.
    NextBioi 361817.
    PROi Q6NWW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6NWW5.
    Bgeei Q6NWW5.
    CleanExi MM_KIF24.
    Genevestigatori Q6NWW5.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryonic germ cell.
    4. "All kinesin superfamily protein, KIF, genes in mouse and human."
      Miki H., Setou M., Kaneshiro K.
      Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-450, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKIF24_MOUSE
    AccessioniPrimary (citable) accession number: Q6NWW5
    Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3