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Q6NWW5

- KIF24_MOUSE

UniProt

Q6NWW5 - KIF24_MOUSE

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Protein
Kinesin-like protein KIF24
Gene
Kif24
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi308 – 3158ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule depolymerization Source: UniProtKB
  4. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:Kif24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1918345. Kif24.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole By similarity.

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13561356Kinesin-like protein KIF24
PRO_0000278249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021Phosphoserine By similarity
Modified residuei473 – 4731Phosphoserine By similarity
Modified residuei640 – 6401Phosphoserine By similarity
Modified residuei1008 – 10081Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6NWW5.

PTM databases

PhosphoSiteiQ6NWW5.

Expressioni

Tissue specificityi

Expressed in brain, spinal cord, and small intestine.1 Publication

Gene expression databases

ArrayExpressiQ6NWW5.
BgeeiQ6NWW5.
CleanExiMM_KIF24.
GenevestigatoriQ6NWW5.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6NWW5.
SMRiQ6NWW5. Positions 2-63, 218-538.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464SAM
Add
BLAST
Domaini218 – 541324Kinesin motor
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00740000114912.
HOGENOMiHOG000232152.
HOVERGENiHBG080392.
InParanoidiQ6NWW5.
KOiK10393.
OMAiQKLKYQP.
OrthoDBiEOG7TJ3H2.
PhylomeDBiQ6NWW5.
TreeFamiTF336001.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NWW5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND     50
RKRLFQLIKI IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF 100
DSPSASKDKM ANNETGSLSN FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA 150
PDASAADASM QTETNAPLFS SNYFSPQLGN CDIPVIQRVS HVSGYNYGIP 200
HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV ITVEDKETLL 250
VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG 300
SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV 350
WISFYEIYCG QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ 400
VILKGSKERS TGATGVNADS SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS 450
ERAADARDSD RQTKMEGAEI NQSLLALKEC IRALDQEHTH TPFRQSKLTQ 500
VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE LKKGVKCCAS 550
ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV 600
KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH 650
SIKKGAESAP LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ 700
PVQPVQKQLL SRPRLLANSH HLEATQDSKV GTPAGLAPEA WTNPILQQKE 750
REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL LCQHRPSEGR LQSETGFPLH 800
SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL ERSGSSFFLH 850
QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL 900
SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA 950
QVSDIRLEAF TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV 1000
CTPLREVSEN RVTHTPGRVN SSTPFQEDSG EQIQMCSANA SGLMAPLTMS 1050
LLETPCHEDL SSLEQIAQDG AGYGFMAEIV GGPAAGHTVP SYDQEAALPV 1100
SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG REAYQTRRPI 1150
LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT 1200
GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR 1250
CLDSDSPVVP SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE 1300
ETLMTQMDSN DFEDFVTQLD EIMALKSRCI QSLRSQLQLY LTSHRPAAAP 1350
ERTVVS 1356
Length:1,356
Mass (Da):150,207
Last modified:February 20, 2007 - v2
Checksum:iCA1009620C23BF43
GO
Isoform 2 (identifier: Q6NWW5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-398: Missing.

Show »
Length:1,222
Mass (Da):134,855
Checksum:i7CBCEDE7C7BBDA72
GO

Sequence cautioni

The sequence AAH67395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC39323.1 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei265 – 398134Missing in isoform 2.
VSP_023214Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 4131A → T in BAC39323. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK084967 mRNA. Translation: BAC39323.1. Sequence problems.
AL807823, BX470237 Genomic DNA. Translation: CAM20982.1.
BX470237, AL807823 Genomic DNA. Translation: CAM23927.1.
BC067395 mRNA. Translation: AAH67395.1. Different initiation.
AB054028 Genomic DNA. Translation: BAB32492.1.
CCDSiCCDS18060.2. [Q6NWW5-1]
RefSeqiNP_077203.2. NM_024241.2. [Q6NWW5-1]
XP_006537612.1. XM_006537549.1. [Q6NWW5-1]
XP_006537613.1. XM_006537550.1. [Q6NWW5-1]
UniGeneiMm.370288.

Genome annotation databases

EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438. [Q6NWW5-1]
GeneIDi109242.
KEGGimmu:109242.
UCSCiuc008sio.1. mouse. [Q6NWW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK084967 mRNA. Translation: BAC39323.1 . Sequence problems.
AL807823 , BX470237 Genomic DNA. Translation: CAM20982.1 .
BX470237 , AL807823 Genomic DNA. Translation: CAM23927.1 .
BC067395 mRNA. Translation: AAH67395.1 . Different initiation.
AB054028 Genomic DNA. Translation: BAB32492.1 .
CCDSi CCDS18060.2. [Q6NWW5-1 ]
RefSeqi NP_077203.2. NM_024241.2. [Q6NWW5-1 ]
XP_006537612.1. XM_006537549.1. [Q6NWW5-1 ]
XP_006537613.1. XM_006537550.1. [Q6NWW5-1 ]
UniGenei Mm.370288.

3D structure databases

ProteinModelPortali Q6NWW5.
SMRi Q6NWW5. Positions 2-63, 218-538.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6NWW5.

Proteomic databases

PRIDEi Q6NWW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030148 ; ENSMUSP00000030148 ; ENSMUSG00000028438 . [Q6NWW5-2 ]
ENSMUST00000108055 ; ENSMUSP00000103690 ; ENSMUSG00000028438 . [Q6NWW5-1 ]
GeneIDi 109242.
KEGGi mmu:109242.
UCSCi uc008sio.1. mouse. [Q6NWW5-1 ]

Organism-specific databases

CTDi 347240.
MGIi MGI:1918345. Kif24.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00740000114912.
HOGENOMi HOG000232152.
HOVERGENi HBG080392.
InParanoidi Q6NWW5.
KOi K10393.
OMAi QKLKYQP.
OrthoDBi EOG7TJ3H2.
PhylomeDBi Q6NWW5.
TreeFami TF336001.

Miscellaneous databases

ChiTaRSi KIF24. mouse.
NextBioi 361817.
PROi Q6NWW5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6NWW5.
Bgeei Q6NWW5.
CleanExi MM_KIF24.
Genevestigatori Q6NWW5.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic germ cell.
  4. "All kinesin superfamily protein, KIF, genes in mouse and human."
    Miki H., Setou M., Kaneshiro K.
    Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-450, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKIF24_MOUSE
AccessioniPrimary (citable) accession number: Q6NWW5
Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi