Q6NWW5 (KIF24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF24

Gene names

Name:

Kif24

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1356 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress abberrant cilia formation By similarity.
Subunit structure	Interacts with CCP110 and CEP97 By similarity.
Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole By similarity. Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole By similarity.
Tissue specificity	Expressed in brain, spinal cord, and small intestine. Ref.4
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Contains 1 SAM (sterile alpha motif) domain.
Sequence caution	The sequence AAH67395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC39323.1 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB microtubule depolymerization Inferred from sequence or structural similarity. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	centriole Inferred from sequence or structural similarity. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NWW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NWW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     265-398: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1356	1356	Kinesin-like protein KIF24		PRO_0000278249
Regions
	Domain	1 – 64	64	SAM
	Domain	215 – 472	258	Kinesin-motor
	Nucleotide binding	308 – 315	8	ATP Potential
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity
	Modified residue	473	1	Phosphoserine By similarity
	Modified residue	640	1	Phosphoserine By similarity
	Modified residue	1008	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	265 – 398	134	Missing in isoform 2.		VSP_023214
Experimental info
	Sequence conflict	413	1	A → T in BAC39323. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: CA1009620C23BF43	FASTA	1,356	150,207
	10 20 30 40 50 60 MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF DSPSASKDKM ANNETGSLSN 130 140 150 160 170 180 FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA PDASAADASM QTETNAPLFS SNYFSPQLGN 190 200 210 220 230 240 CDIPVIQRVS HVSGYNYGIP HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV 250 260 270 280 290 300 ITVEDKETLL VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG 310 320 330 340 350 360 SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV WISFYEIYCG 370 380 390 400 410 420 QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ VILKGSKERS TGATGVNADS 430 440 450 460 470 480 SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS ERAADARDSD RQTKMEGAEI NQSLLALKEC 490 500 510 520 530 540 IRALDQEHTH TPFRQSKLTQ VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE 550 560 570 580 590 600 LKKGVKCCAS ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV 610 620 630 640 650 660 KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH SIKKGAESAP 670 680 690 700 710 720 LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ PVQPVQKQLL SRPRLLANSH 730 740 750 760 770 780 HLEATQDSKV GTPAGLAPEA WTNPILQQKE REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL 790 800 810 820 830 840 LCQHRPSEGR LQSETGFPLH SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL 850 860 870 880 890 900 ERSGSSFFLH QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL 910 920 930 940 950 960 SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA QVSDIRLEAF 970 980 990 1000 1010 1020 TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV CTPLREVSEN RVTHTPGRVN 1030 1040 1050 1060 1070 1080 SSTPFQEDSG EQIQMCSANA SGLMAPLTMS LLETPCHEDL SSLEQIAQDG AGYGFMAEIV 1090 1100 1110 1120 1130 1140 GGPAAGHTVP SYDQEAALPV SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG 1150 1160 1170 1180 1190 1200 REAYQTRRPI LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT 1210 1220 1230 1240 1250 1260 GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR CLDSDSPVVP 1270 1280 1290 1300 1310 1320 SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE ETLMTQMDSN DFEDFVTQLD 1330 1340 1350 EIMALKSRCI QSLRSQLQLY LTSHRPAAAP ERTVVS
	Isoform 2 [UniParc]. Checksum: 7CBCEDE7C7BBDA72	FASTA	1,222	134,855
	10 20 30 40 50 60 MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF DSPSASKDKM ANNETGSLSN 130 140 150 160 170 180 FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA PDASAADASM QTETNAPLFS SNYFSPQLGN 190 200 210 220 230 240 CDIPVIQRVS HVSGYNYGIP HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV 250 260 270 280 290 300 ITVEDKETLL VHEKKEAVDL TQYILQVILK GSKERSTGAT GVNADSSRSH AIIQIQIKDS 310 320 330 340 350 360 AKRTFGRISF IDLAGSERAA DARDSDRQTK MEGAEINQSL LALKECIRAL DQEHTHTPFR 370 380 390 400 410 420 QSKLTQVLKD SFIGNAKTCM IANISPSHIA TEHTLNTLRY ADRVKELKKG VKCCASATSQ 430 440 450 460 470 480 NQTSANASPK RIQSSPVTLP GDKCSPKKVK LGLQQSLTVA PGPTKVKAHP LASHVPNVPF 490 500 510 520 530 540 TSGPKTPGKK SSSRGSPTPE WDMKASPRKG TTRSGHSIKK GAESAPLCSE KSQIGSKIAV 550 560 570 580 590 600 GWEGRASDPG EGLLRVRLPT RGKKVQPVQP VQKQLLSRPR LLANSHHLEA TQDSKVGTPA 610 620 630 640 650 660 GLAPEAWTNP ILQQKEREEH LRFYHQQFQQ PPLLKQKLNY QPLQRLLCQH RPSEGRLQSE 670 680 690 700 710 720 TGFPLHSNPE NRDGAQAEDL DDSDFSEDSF SHGSSQPAMK QGSTALERSG SSFFLHQDRE 730 740 750 760 770 780 HSPEEQAAER QQCLLFSSET DGSKKRPADS WVYSRDPIIS HRRGALSQSH SPSMVCPDWS 790 800 810 820 830 840 KEEDSASSGP SPKDNRAQKP SSSQVDFVHH QKPGEAQVSD IRLEAFTSEV PEQAEGSLSS 850 860 870 880 890 900 PSPENGLSFP LSHVAVSGSP DQRDRVCTPL REVSENRVTH TPGRVNSSTP FQEDSGEQIQ 910 920 930 940 950 960 MCSANASGLM APLTMSLLET PCHEDLSSLE QIAQDGAGYG FMAEIVGGPA AGHTVPSYDQ 970 980 990 1000 1010 1020 EAALPVSSAT ECLWLSSSPP DNRPSGDLPA LSPSPIHQHS PDKLPGREAY QTRRPILLPE 1030 1040 1050 1060 1070 1080 NHMGSKLYDD RAEETELGGS LTFPRKPSSN IHAGVPYSTP FLTSCTGSSN GVGRPWAQER 1090 1100 1110 1120 1130 1140 KHPTGVSCQE LVSSTDSNKP HYNEDIAWLR HRPISRCLDS DSPVVPSCSS KALRTYCPLT 1150 1160 1170 1180 1190 1200 PEQAQQVIIR AHKEQLDEMA ELDLKEETLM TQMDSNDFED FVTQLDEIMA LKSRCIQSLR 1210 1220 SQLQLYLTSH RPAAAPERTV VS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Lung.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryonic germ cell.
[4]	"All kinesin superfamily protein, KIF, genes in mouse and human." Miki H., Setou M., Kaneshiro K. Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-450, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK084967 mRNA. Translation: BAC39323.1. Sequence problems. AL807823, BX470237 Genomic DNA. Translation: CAM20982.1. BX470237, AL807823 Genomic DNA. Translation: CAM23927.1. BC067395 mRNA. Translation: AAH67395.1. Different initiation. AB054028 Genomic DNA. Translation: BAB32492.1.
IPI	IPI00121506. IPI00607944.
RefSeq	NP_077203.2. NM_024241.2.
UniGene	Mm.370288.
3D structure databases
HSSP	HSSP built from PDB template 1V8J based on UniProtKB Q922S8.
ProteinModelPortal	Q6NWW5.
SMR	Q6NWW5. Positions 3-63, 217-567.
ModBase	Search...
PTM databases
PhosphoSite	Q6NWW5.
Proteomic databases
PRIDE	Q6NWW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438.
GeneID	109242.
KEGG	mmu:109242.
Organism-specific databases
CTD	347240.
MGI	MGI:1918345. Kif24.
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00680000099804.
HOGENOM	HOG000232152.
HOVERGEN	HBG080392.
InParanoid	Q6NWW5.
KO	K10393.
OMA	QKLKYQP.
OrthoDB	EOG4SJ5CZ.
Gene expression databases
ArrayExpress	Q6NWW5.
Bgee	Q6NWW5.
CleanEx	MM_KIF24.
Genevestigator	Q6NWW5.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR001660. SAM. IPR013761. SAM/pointed. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KIF24. mouse.
NextBio	361817.
SOURCE	Search...

Entry information

Entry name

KIF24_MOUSE

Accession

Primary (citable) accession number: Q6NWW5
Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program