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Protein

Kinesin-like protein KIF24

Gene

Kif24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi308 – 3158ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cilium assembly Source: UniProtKB
  3. metabolic process Source: MGI
  4. microtubule-based movement Source: GO_Central
  5. microtubule depolymerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:Kif24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1918345. Kif24.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. kinesin complex Source: GO_Central
  3. microtubule Source: UniProtKB-KW
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13561356Kinesin-like protein KIF24PRO_0000278249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei473 – 4731PhosphoserineBy similarity
Modified residuei640 – 6401PhosphoserineBy similarity
Modified residuei1008 – 10081PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6NWW5.

PTM databases

PhosphoSiteiQ6NWW5.

Expressioni

Tissue specificityi

Expressed in brain, spinal cord, and small intestine.1 Publication

Gene expression databases

BgeeiQ6NWW5.
CleanExiMM_KIF24.
ExpressionAtlasiQ6NWW5. baseline and differential.
GenevestigatoriQ6NWW5.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NWW5.
SMRiQ6NWW5. Positions 3-63, 217-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464SAMPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 541324Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00780000121914.
HOGENOMiHOG000232152.
HOVERGENiHBG080392.
InParanoidiQ6NWW5.
KOiK10393.
OMAiQKLKYQP.
OrthoDBiEOG7TJ3H2.
PhylomeDBiQ6NWW5.
TreeFamiTF336001.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NWW5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND
60 70 80 90 100
RKRLFQLIKI IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF
110 120 130 140 150
DSPSASKDKM ANNETGSLSN FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA
160 170 180 190 200
PDASAADASM QTETNAPLFS SNYFSPQLGN CDIPVIQRVS HVSGYNYGIP
210 220 230 240 250
HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV ITVEDKETLL
260 270 280 290 300
VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG
310 320 330 340 350
SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV
360 370 380 390 400
WISFYEIYCG QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ
410 420 430 440 450
VILKGSKERS TGATGVNADS SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS
460 470 480 490 500
ERAADARDSD RQTKMEGAEI NQSLLALKEC IRALDQEHTH TPFRQSKLTQ
510 520 530 540 550
VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE LKKGVKCCAS
560 570 580 590 600
ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV
610 620 630 640 650
KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH
660 670 680 690 700
SIKKGAESAP LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ
710 720 730 740 750
PVQPVQKQLL SRPRLLANSH HLEATQDSKV GTPAGLAPEA WTNPILQQKE
760 770 780 790 800
REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL LCQHRPSEGR LQSETGFPLH
810 820 830 840 850
SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL ERSGSSFFLH
860 870 880 890 900
QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL
910 920 930 940 950
SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA
960 970 980 990 1000
QVSDIRLEAF TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV
1010 1020 1030 1040 1050
CTPLREVSEN RVTHTPGRVN SSTPFQEDSG EQIQMCSANA SGLMAPLTMS
1060 1070 1080 1090 1100
LLETPCHEDL SSLEQIAQDG AGYGFMAEIV GGPAAGHTVP SYDQEAALPV
1110 1120 1130 1140 1150
SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG REAYQTRRPI
1160 1170 1180 1190 1200
LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT
1210 1220 1230 1240 1250
GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR
1260 1270 1280 1290 1300
CLDSDSPVVP SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE
1310 1320 1330 1340 1350
ETLMTQMDSN DFEDFVTQLD EIMALKSRCI QSLRSQLQLY LTSHRPAAAP

ERTVVS
Length:1,356
Mass (Da):150,207
Last modified:February 20, 2007 - v2
Checksum:iCA1009620C23BF43
GO
Isoform 2 (identifier: Q6NWW5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-398: Missing.

Show »
Length:1,222
Mass (Da):134,855
Checksum:i7CBCEDE7C7BBDA72
GO

Sequence cautioni

The sequence AAH67395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC39323.1 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 4131A → T in BAC39323. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei265 – 398134Missing in isoform 2. 1 PublicationVSP_023214Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084967 mRNA. Translation: BAC39323.1. Sequence problems.
AL807823, BX470237 Genomic DNA. Translation: CAM20982.1.
BX470237, AL807823 Genomic DNA. Translation: CAM23927.1.
BC067395 mRNA. Translation: AAH67395.1. Different initiation.
AB054028 Genomic DNA. Translation: BAB32492.1.
CCDSiCCDS18060.2. [Q6NWW5-1]
RefSeqiNP_077203.2. NM_024241.2. [Q6NWW5-1]
XP_006537612.1. XM_006537549.1. [Q6NWW5-1]
XP_006537613.1. XM_006537550.1. [Q6NWW5-1]
UniGeneiMm.370288.

Genome annotation databases

EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438. [Q6NWW5-1]
GeneIDi109242.
KEGGimmu:109242.
UCSCiuc008sio.1. mouse. [Q6NWW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084967 mRNA. Translation: BAC39323.1. Sequence problems.
AL807823, BX470237 Genomic DNA. Translation: CAM20982.1.
BX470237, AL807823 Genomic DNA. Translation: CAM23927.1.
BC067395 mRNA. Translation: AAH67395.1. Different initiation.
AB054028 Genomic DNA. Translation: BAB32492.1.
CCDSiCCDS18060.2. [Q6NWW5-1]
RefSeqiNP_077203.2. NM_024241.2. [Q6NWW5-1]
XP_006537612.1. XM_006537549.1. [Q6NWW5-1]
XP_006537613.1. XM_006537550.1. [Q6NWW5-1]
UniGeneiMm.370288.

3D structure databases

ProteinModelPortaliQ6NWW5.
SMRiQ6NWW5. Positions 3-63, 217-567.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6NWW5.

Proteomic databases

PRIDEiQ6NWW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438. [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438. [Q6NWW5-1]
GeneIDi109242.
KEGGimmu:109242.
UCSCiuc008sio.1. mouse. [Q6NWW5-1]

Organism-specific databases

CTDi347240.
MGIiMGI:1918345. Kif24.

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00780000121914.
HOGENOMiHOG000232152.
HOVERGENiHBG080392.
InParanoidiQ6NWW5.
KOiK10393.
OMAiQKLKYQP.
OrthoDBiEOG7TJ3H2.
PhylomeDBiQ6NWW5.
TreeFamiTF336001.

Miscellaneous databases

ChiTaRSiKif24. mouse.
NextBioi361817.
PROiQ6NWW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NWW5.
CleanExiMM_KIF24.
ExpressionAtlasiQ6NWW5. baseline and differential.
GenevestigatoriQ6NWW5.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic germ cell.
  4. "All kinesin superfamily protein, KIF, genes in mouse and human."
    Miki H., Setou M., Kaneshiro K.
    Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-450, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKIF24_MOUSE
AccessioniPrimary (citable) accession number: Q6NWW5
Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 4, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.