Q6NWU0 (Q6NWU0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytochrome P450 2D6 EMBL ABB77898.1

Submitted name:
Cytochrome P450, family 2, subfamily D, polypeptide 6 EMBL AAH67432.1

Gene names

Name:	CYP2D6 EMBL AAH67432.1
ORF Names:	RP4-669P10.17-001 EMBL CAP58856.1

Organism

Homo sapiens (Human) EMBL AAH67432.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU003700 Oxidoreductase
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6NWU0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 484E013AE3E6D1C9	FASTA	497	55,730
	10 20 30 40 50 60 MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 70 80 90 100 110 120 LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF 130 140 150 160 170 180 LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK 190 200 210 220 230 240 AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV 250 260 270 280 290 300 LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLCIVVA 310 320 330 340 350 360 DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI 370 380 390 400 410 420 HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF 430 440 450 460 470 480 LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV 490 FAFLVTPSPY ELCAVPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAH67432.1.
[2]	Lloyd D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Evolution of Detoxifying Systems: The Role of Environment and Population History in Shaping Genetic Diversity at Human CYP2D6 Locus." Fuselli S., de Filippo C., Mona S., Sistonen J., Fariselli P., Destro-Bisol G., Barbujani G., Bertorelle G., Sajantila A. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"CYP2D6 Evolution and Allele Diversity Among Human Races." Koch W.H., Nikoloff D.M., Lu W., Pan R.M., deLeon J., Wedlund P.J. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC067432 mRNA. Translation: AAH67432.1. BC126858 mRNA. Translation: AAI26859.1. DQ282147 Genomic DNA. Translation: ABB77898.1. DQ282156 Genomic DNA. Translation: ABB77904.1. DQ282160 Genomic DNA. Translation: ABB77908.1. GU586995 Genomic DNA. Translation: ADF36226.1. GU587005 Genomic DNA. Translation: ADF36236.1. GU587008 Genomic DNA. Translation: ADF36239.1. GU587009 Genomic DNA. Translation: ADF36240.1. GU587010 Genomic DNA. Translation: ADF36241.1. GU587011 Genomic DNA. Translation: ADF36242.1. GU587012 Genomic DNA. Translation: ADF36243.1. GU587013 Genomic DNA. Translation: ADF36244.1. GU587018 Genomic DNA. Translation: ADF36249.1. GU587021 Genomic DNA. Translation: ADF36252.1. GU587022 Genomic DNA. Translation: ADF36253.1. GU587028 Genomic DNA. Translation: ADF36259.1. GU587029 Genomic DNA. Translation: ADF36260.1. GU587030 Genomic DNA. Translation: ADF36261.1. GU587031 Genomic DNA. Translation: ADF36262.1. GU587036 Genomic DNA. Translation: ADF36267.1. GU587037 Genomic DNA. Translation: ADF36268.1. GU587050 Genomic DNA. Translation: ADF36281.1. GU587052 Genomic DNA. Translation: ADF36283.1. GU587059 Genomic DNA. Translation: ADF36290.1. GU587062 Genomic DNA. Translation: ADF36293.1. GU587064 Genomic DNA. Translation: ADF36295.1. GU587066 Genomic DNA. Translation: ADF36297.1. GU587069 Genomic DNA. Translation: ADF36299.1. GU587075 Genomic DNA. Translation: ADF36304.1. GU587079 Genomic DNA. Translation: ADF36308.1. GU587081 Genomic DNA. Translation: ADF36310.1. GU587093 Genomic DNA. Translation: ADF36322.1. GU587094 Genomic DNA. Translation: ADF36323.1. GU587104 Genomic DNA. Translation: ADF36332.1. GU587114 Genomic DNA. Translation: ADF36342.1. GU587115 Genomic DNA. Translation: ADF36343.1. GU587118 Genomic DNA. Translation: ADF36346.1. GU587129 Genomic DNA. Translation: ADF36356.1. GU587132 Genomic DNA. Translation: ADF36359.1. GU587133 Genomic DNA. Translation: ADF36360.1. GU587135 Genomic DNA. Translation: ADF36362.1. GU587136 Genomic DNA. Translation: ADF36363.1. GU587138 Genomic DNA. Translation: ADF36364.1. GU587139 Genomic DNA. Translation: ADF36365.1. GU587141 Genomic DNA. Translation: ADF36367.1. GU587144 Genomic DNA. Translation: ADF36370.1. GU587148 Genomic DNA. Translation: ADF36374.1. GU587152 Genomic DNA. Translation: ADF36378.1. GU587154 Genomic DNA. Translation: ADF36380.1. GU587173 Genomic DNA. Translation: ADF36399.1. GU587178 Genomic DNA. Translation: ADF36404.1. GU587180 Genomic DNA. Translation: ADF36406.1. GU587183 Genomic DNA. Translation: ADF36409.1. GU587184 Genomic DNA. Translation: ADF36410.1. GU587195 Genomic DNA. Translation: ADF36421.1. GU587198 Genomic DNA. Translation: ADF36424.1. GU587199 Genomic DNA. Translation: ADF36425.1. GU587201 Genomic DNA. Translation: ADF36427.1. GU587206 Genomic DNA. Translation: ADF36432.1. GU587207 Genomic DNA. Translation: ADF36433.1. GU587208 Genomic DNA. Translation: ADF36434.1. GU587212 Genomic DNA. Translation: ADF36438.1. GU587213 Genomic DNA. Translation: ADF36439.1. GU587216 Genomic DNA. Translation: ADF36442.1. GU587218 Genomic DNA. Translation: ADF36444.1. GU587219 Genomic DNA. Translation: ADF36445.1. GU587220 Genomic DNA. Translation: ADF36446.1. GU587221 Genomic DNA. Translation: ADF36447.1. GU587225 Genomic DNA. Translation: ADF36451.1. GU587231 Genomic DNA. Translation: ADF36457.1. GU587240 Genomic DNA. Translation: ADF36466.1. GU587241 Genomic DNA. Translation: ADF36467.1. GU587243 Genomic DNA. Translation: ADF36469.1. GU587247 Genomic DNA. Translation: ADF36473.1. GU587249 Genomic DNA. Translation: ADF36475.1. GU587253 Genomic DNA. Translation: ADF36479.1. GU587254 Genomic DNA. Translation: ADF36480.1. BX247885 Genomic DNA. Translation: CAP58856.1.
IPI	IPI00456699.
RefSeq	NP_000097.2. NM_000106.4.
UniGene	Hs.648256.
3D structure databases
ProteinModelPortal	Q6NWU0.
SMR	Q6NWU0. Positions 34-497.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6NWU0.
Proteomic databases
PRIDE	Q6NWU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1565.
KEGG	hsa:1565.
UCSC	uc003bce.1. human.
Organism-specific databases
CTD	1565.
PharmGKB	PA128.
Phylogenomic databases
GeneTree	ENSGT00560000076621.
HOVERGEN	HBG015789.
OMA	DEANWEK.
PhylomeDB	Q6NWU0.
Gene expression databases
ArrayExpress	Q6NWU0.
Bgee	Q6NWU0.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008069. Cyt_P450_E_grp-I_CYP2D-like. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K07414.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01686. EP450ICYP2D. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	6449.

Entry information

Entry name

Q6NWU0_HUMAN

Accession

Primary (citable) accession number: Q6NWU0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.