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Protein
Submitted name:

Interleukin 1 receptor, type I

Gene

IL1R1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 1 receptor, type IImported
Gene namesi
Name:IL1R1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei338 – 359HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500427761821 – 569Sequence analysisAdd BLAST549

Proteomic databases

PaxDbiQ6NWP6.
PeptideAtlasiQ6NWP6.
PRIDEiQ6NWP6.

Structurei

3D structure databases

ProteinModelPortaliQ6NWP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 110Ig-likeInterPro annotationAdd BLAST67
Domaini226 – 328Ig-likeInterPro annotationAdd BLAST103
Domaini383 – 541TIRInterPro annotationAdd BLAST159

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
HOVERGENiHBG052103.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
IPR035897. Toll_tir_struct_dom_sf.
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NWP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE
60 70 80 90 100
HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN
110 120 130 140 150
SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN
160 170 180 190 200
ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTRHASY
210 220 230 240 250
TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV
260 270 280 290 300
TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE
310 320 330 340 350
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV
360 370 380 390 400
CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST
410 420 430 440 450
SDCDIFVFKV LPGVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL
460 470 480 490 500
IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP
510 520 530 540 550
ESIKFIKQKH GTIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ
560
LLSPATKEKL QREAHVPLG
Length:569
Mass (Da):65,413
Last modified:July 5, 2004 - v1
Checksum:iCEDB80A174225AB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067507 mRNA. Translation: AAH67507.1.
UniGeneiHs.701982.

Similar proteinsi

Entry informationi

Entry nameiQ6NWP6_HUMAN
AccessioniPrimary (citable) accession number: Q6NWP6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.