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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

slc2a12

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • glucose import in response to insulin stimulus Source: ZFIN
  • heart contraction Source: ZFIN
  • heart development Source: ZFIN
  • heart valve morphogenesis Source: ZFIN
  • hexose transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-428790. Facilitative Na+-independent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:slc2a12
ORF Names:zgc:66027, zgc:85776
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040426-1513. slc2a12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 84ExtracellularSequence analysisAdd BLAST14
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 118CytoplasmicSequence analysisAdd BLAST13
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 141ExtracellularSequence analysis2
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 201ExtracellularSequence analysis4
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 286CytoplasmicSequence analysisAdd BLAST64
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 325ExtracellularSequence analysisAdd BLAST18
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 353CytoplasmicSequence analysis7
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 475ExtracellularSequence analysisAdd BLAST101
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Topological domaini497 – 511CytoplasmicSequence analysisAdd BLAST15
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Topological domaini533 – 542ExtracellularSequence analysis10
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Topological domaini564 – 610CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920171 – 610Solute carrier family 2, facilitated glucose transporter member 12Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NWF1.
PRIDEiQ6NWF1.

Expressioni

Gene expression databases

BgeeiENSDARG00000036865.
ExpressionAtlasiQ6NWF1. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053530.

Structurei

3D structure databases

ProteinModelPortaliQ6NWF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ6NWF1.
KOiK08149.
OMAiVCVYELM.
OrthoDBiEOG091G085H.
PhylomeDBiQ6NWF1.
TreeFamiTF332408.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NWF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPEESIRM TSDPQSKIYV QNPDTHIHLE QGPSAKSGNG RALVLCSVSV
60 70 80 90 100
ACLSGLLMGY EMSLISGALL QLRDVLTLSC PEQEQVVGSL LLGAFLLSLG
110 120 130 140 150
GGTILDHYGR RFTIILTALL CVLGTLLSVC VVSFWALVVG RMLVGMSVAL
160 170 180 190 200
SGTASCLYAA EVAPAAWRGR CVCVYELMVV LGMLLGFGLS WAFAGVPDGW
210 220 230 240 250
RFTFGGALLP ALLQAGVMPL LPDSPRFLLA QQREKEAHAT LLRLRAGIKE
260 270 280 290 300
VEPVEDELRA IRLAMGAERL HGFLDLFQSR DNMLQRLLVG AALVFLQQAT
310 320 330 340 350
GQPNILAYAS TVLSSVGFHG NEAATLASTG FGVVKVGGTI PAIFLVDKVG
360 370 380 390 400
PKALLCVGVV VMMLSTATLG AITMQSRTHV SSLCRGPGNT ANFTLFETGD
410 420 430 440 450
ETDIQTNTPL GLYQPQNKLK TNTFLTSIND TREHWILNHT YNHRTALMET
460 470 480 490 500
AELSKKDSAK IALQSLHEVS PSLKWISLVS LLVYVAGFSI SLGPMVHVVL
510 520 530 540 550
SAIFPTGIRG KAVSVISAFN WATNLLISMT FLTLTERIGL PTVIFSYSAM
560 570 580 590 600
SFLLVVFVIV FVPETKGRSL EQISKELAMK NHLRGTLLCH RRKHKATAQP
610
SQEEKALATV
Length:610
Mass (Da):65,778
Last modified:July 19, 2005 - v2
Checksum:iE5F794C4805E757C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32G → S in AAH56306 (Ref. 1) Curated1
Sequence conflicti423T → A in AAH56306 (Ref. 1) Curated1
Sequence conflicti442N → D in AAH56306 (Ref. 1) Curated1
Sequence conflicti448M → I in AAH56306 (Ref. 1) Curated1
Sequence conflicti597T → I in AAH56306 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056306 mRNA. Translation: AAH56306.1.
BC067616 mRNA. Translation: AAH67616.2.
RefSeqiNP_956832.1. NM_200538.1.
XP_005162361.1. XM_005162304.3.
UniGeneiDr.28449.

Genome annotation databases

EnsembliENSDART00000053531; ENSDARP00000053530; ENSDARG00000036865.
ENSDART00000163820; ENSDARP00000135190; ENSDARG00000036865.
GeneIDi393510.
KEGGidre:393510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056306 mRNA. Translation: AAH56306.1.
BC067616 mRNA. Translation: AAH67616.2.
RefSeqiNP_956832.1. NM_200538.1.
XP_005162361.1. XM_005162304.3.
UniGeneiDr.28449.

3D structure databases

ProteinModelPortaliQ6NWF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053530.

Proteomic databases

PaxDbiQ6NWF1.
PRIDEiQ6NWF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053531; ENSDARP00000053530; ENSDARG00000036865.
ENSDART00000163820; ENSDARP00000135190; ENSDARG00000036865.
GeneIDi393510.
KEGGidre:393510.

Organism-specific databases

CTDi154091.
ZFINiZDB-GENE-040426-1513. slc2a12.

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ6NWF1.
KOiK08149.
OMAiVCVYELM.
OrthoDBiEOG091G085H.
PhylomeDBiQ6NWF1.
TreeFamiTF332408.

Enzyme and pathway databases

ReactomeiR-DRE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

PROiQ6NWF1.

Gene expression databases

BgeeiENSDARG00000036865.
ExpressionAtlasiQ6NWF1. differential.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR12_DANRE
AccessioniPrimary (citable) accession number: Q6NWF1
Secondary accession number(s): Q6PHV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.