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Q6NWE1 (PHF10_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
PHD finger protein 10
Gene names
Name:phf10
ORF Names:si:dkey-66m17.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors By similarity.

Subunit structure

Component of neural progenitors-specific chromatin remodeling complex (npBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin remodeling complexes By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SAYP family.

Contains 2 PHD-type zinc fingers.

Caution

It is uncertain whether Met-1 or Met-83 is the initiator.

Sequence caution

The sequence AAH67626.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAQ97830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processNeurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490PHD finger protein 10
PRO_0000059299

Regions

Zinc finger371 – 42858PHD-type 1; degenerate
Zinc finger430 – 47344PHD-type 2; degenerate
Region83 – 292210SAY
Compositional bias293 – 32937Asp-rich

Experimental info

Sequence conflict3391K → N in AAQ97830. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6NWE1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: D0EECA31A26800EE

FASTA49055,184
        10         20         30         40         50         60 
MAAVLSPRPC DSNPATPGTQ SIKDDIEENS SDGSQAPKRR RMGSGDSSRS CDTSTHELGP 

        70         80         90        100        110        120 
TYFPAENLTE YKWPPDDTGE YYMLQEQVSE YLGVTSFKRK YPEMERRDLS HKEKLYLREQ 

       130        140        150        160        170        180 
NVITETQCTL GLTALRSDEV IDLMIKEYPA KHAEYSVILQ ERERQRITKE YNVSTLSVQM 

       190        200        210        220        230        240 
QQQNPQKVEA SKVPEYIKKA AKKAAEFNSN FNRERMEERR AYFDLQTHII QVPQGKYKIL 

       250        260        270        280        290        300 
PPERTKTGPF PVALIPGQFQ EYYKRYSPNE LRYLPLNTAL FEPPLDPELP ALDSDGDSDD 

       310        320        330        340        350        360 
GDDGKEDGKK NKGSSDSSSG NTSDGDSQDS GIHSKVKSKD RPGAQGKDGT PRSIQHKSVP 

       370        380        390        400        410        420 
GYKPKVIPNA ICGICQKGKE ANKRGKPEAL IHCSQCQNSG HPSCLDMSVD LVAKIKMYPW 

       430        440        450        460        470        480 
QCMECKTCTV CQQPHHEEEM MFCDKCDRGF HTFCVGMDSI PMGCWVCDLC SKDISTPQKK 

       490 
GQTKTPKKAK

« Hide

References

[1]"Hematopoietic gene expression profile in zebrafish kidney marrow."
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney marrow.
[2]The Danio rerio sequencing project at the Sanger Institute
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-490.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY398397 mRNA. Translation: AAQ97830.1. Different initiation.
BX629343 Genomic DNA. Translation: CAN88748.1.
BC067626 mRNA. Translation: AAH67626.1. Different initiation.
IPIIPI00635065.
RefSeqNP_956949.3. NM_200655.3.
UniGeneDr.78790.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000093339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000102563; ENSDARP00000093339; ENSDARG00000070084.
GeneID393628.
KEGGdre:393628.

Organism-specific databases

CTD55274.
ZFINZDB-GENE-040426-1573. phf10.

Phylogenomic databases

eggNOGNOG279558.
GeneTreeENSGT00530000063194.
HOGENOMHOG000286026.
HOVERGENHBG053581.
InParanoidQ6NWE1.
OrthoDBEOG4BCDNG.

Gene expression databases

ArrayExpressQ6NWE1.
BgeeQ6NWE1.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
InterProIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 2 hits.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20814637.

Entry information

Entry namePHF10_DANRE
AccessionPrimary (citable) accession number: Q6NWE1
Secondary accession number(s): A5PMM9, Q6TGV9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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