ID   Q6NWC1_DANRE            Unreviewed;       283 AA.
AC   Q6NWC1; B1H1L7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 128.
DE   RecName: Full=Voltage-dependent anion-selective channel protein 1 {ECO:0000256|ARBA:ARBA00017554};
GN   Name=vdac1 {ECO:0000313|EMBL:AAI60655.1,
GN   ECO:0000313|Ensembl:ENSDARP00000066372,
GN   ECO:0000313|RefSeq:NP_001001404.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-6514};
GN   Synonyms=VDAC1 {ECO:0000313|EMBL:AAQ97862.1}, wu:fa13f11
GN   {ECO:0000313|RefSeq:NP_001001404.1}, zgc:85830
GN   {ECO:0000313|RefSeq:NP_001001404.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI60655.1};
RN   [1] {ECO:0000313|EMBL:AAQ97862.1, ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney marrow {ECO:0000313|EMBL:AAQ97862.1};
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16978605;
RA   Damodaran S., Dlugos C.A., Wood T.D., Rabin R.A.;
RT   "Effects of chronic ethanol administration on brain protein levels: a
RT   proteomic investigation using 2-D DIGE system.";
RL   Eur. J. Pharmacol. 547:75-82(2006).
RN   [3] {ECO:0000313|EMBL:AAI60655.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH67647.1}, and Kidney
RC   {ECO:0000313|EMBL:AAI60655.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20528263;
RA   Singh S.K., Sundaram C.S., Shanbhag S., Idris M.M.;
RT   "Proteomic profile of zebrafish brain based on two-dimensional gel
RT   electrophoresis matrix-assisted laser desorption/ionization MS/MS
RT   analysis.";
RL   Zebrafish 7:169-177(2010).
RN   [5] {ECO:0000313|Ensembl:ENSDARP00000066372}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000066372};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [6] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23942336;
RA   Prudent J., Popgeorgiev N., Bonneau B., Thibaut J., Gadet R., Lopez J.,
RA   Gonzalo P., Rimokh R., Manon S., Houart C., Herbomel P., Aouacheria A.,
RA   Gillet G.;
RT   "Bcl-wav and the mitochondrial calcium uniporter drive gastrula
RT   morphogenesis in zebrafish.";
RL   Nat. Commun. 4:2330-2330(2013).
RN   [7] {ECO:0000313|Ensembl:ENSDARP00000066372, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000066372};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [8] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24123299;
RA   Gebriel M., Prabhudesai S., Uleberg K.E., Larssen E., Piston D.,
RA   Bjornstad A.H., Moller S.G.;
RT   "Zebrafish brain proteomics reveals central proteins involved in
RT   neurodegeneration.";
RL   J. Neurosci. Res. 92:104-115(2014).
RN   [9] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25726855;
RA   Purushothaman S., Saxena S., Meghah V., Meena Lakshmi M.G., Singh S.K.,
RA   Brahmendra Swamy C.V., Idris M.M.;
RT   "Proteomic and gene expression analysis of zebrafish brain undergoing
RT   continuous light/dark stress.";
RL   J Sleep Res 24:458-465(2015).
RN   [10] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [11] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27859782;
RA   Soman S., Keatinge M., Moein M., Da Costa M., Mortiboys H., Skupin A.,
RA   Sugunan S., Bazala M., Kuznicki J., Bandmann O.;
RT   "Inhibition of the mitochondrial calcium uniporter rescues dopaminergic
RT   neurons in pink1(-/-) zebrafish.";
RL   Eur. J. Neurosci. 45:528-535(2017).
RN   [12] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [13] {ECO:0000313|RefSeq:NP_001001404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29038520;
RA   Gonzalez-Durruthy M., Werhli A.V., Seus V., Machado K.S., Pazos A.,
RA   Munteanu C.R., Gonzalez-Diaz H., Monserrat J.M.;
RT   "Decrypting Strong and Weak Single-Walled Carbon Nanotubes Interactions
RT   with Mitochondrial Voltage-Dependent Anion Channels Using Molecular Docking
RT   and Perturbation Theory.";
RL   Sci. Rep. 7:13271-13271(2017).
RN   [14] {ECO:0000313|RefSeq:NP_001001404.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       raft {ECO:0000256|ARBA:ARBA00004314}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004314}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
CC       {ECO:0000256|ARBA:ARBA00007780}.
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DR   EMBL; CU929234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067647; AAH67647.1; -; mRNA.
DR   EMBL; BC160655; AAI60655.1; -; mRNA.
DR   EMBL; AY398429; AAQ97862.1; -; mRNA.
DR   RefSeq; NP_001001404.1; NM_001001404.1.
DR   STRING; 7955.ENSDARP00000066372; -.
DR   PaxDb; 7955-ENSDARP00000066372; -.
DR   DNASU; 334582; -.
DR   Ensembl; ENSDART00000066373.7; ENSDARP00000066372.6; ENSDARG00000045132.8.
DR   GeneID; 334582; -.
DR   KEGG; dre:334582; -.
DR   AGR; ZFIN:ZDB-GENE-030131-6514; -.
DR   CTD; 7416; -.
DR   ZFIN; ZDB-GENE-030131-6514; vdac1.
DR   eggNOG; KOG3126; Eukaryota.
DR   HOGENOM; CLU_044399_2_0_1; -.
DR   OMA; WSNANNL; -.
DR   OrthoDB; 2897965at2759; -.
DR   TreeFam; TF315091; -.
DR   Reactome; R-DRE-5205685; PINK1-PRKN Mediated Mitophagy.
DR   Reactome; R-DRE-5689880; Ub-specific processing proteases.
DR   Reactome; R-DRE-70268; Pyruvate metabolism.
DR   Proteomes; UP000000437; Chromosome 21.
DR   Bgee; ENSDARG00000045132; Expressed in brain and 28 other cell types or tissues.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated monoatomic anion channel activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd07306; Porin3_VDAC; 1.
DR   Gene3D; 2.40.160.10; Porin; 1.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001925; Porin_Euk.
DR   InterPro; IPR027246; Porin_Euk/Tom40.
DR   PANTHER; PTHR11743; VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL; 1.
DR   PANTHER; PTHR11743:SF13; VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 1; 1.
DR   Pfam; PF01459; Porin_3; 1.
DR   PRINTS; PR00185; EUKARYTPORIN.
DR   PROSITE; PS00558; EUKARYOTIC_PORIN; 1.
PE   1: Evidence at protein level;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023114};
KW   Membrane {ECO:0000256|ARBA:ARBA00022452};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00022787};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Porin {ECO:0000256|ARBA:ARBA00023114};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q6NWC1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022452};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW   Transport {ECO:0000256|ARBA:ARBA00023114}.
SQ   SEQUENCE   283 AA;  30626 MW;  0FBFA923329C4EB3 CRC64;
     MAVPPTYVDL GKSARDIFTK GYGFGLIKLD LKTRSENGLE FKSSGSANTE TSKVAGTLET
     KYKWAEHGLT FTEKWNTDNT LGTEITLEDQ LTKGLKLTFD SSFSPNTGKK SGKIKSSYQR
     EHINLGCDVD YDINGTAVHG ALVLGLDGWL AGYQMTFEAG RNRITQSNFA VGYKTDEFQL
     HTNVNDGTEF GGSIYQKVND NLETAVNLAW TAGNSNTRFG IAAKYQIDSD AAFSAKVNNS
     SLVGLGYTQT LKPGIKLTLS ALLDGKNINA GGHKMGLGLE FEA
//