ID   RGMB_HUMAN              Reviewed;         437 AA.
AC   Q6NW40; D6R9A0; Q8NC92;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 3.
DT   25-JAN-2012, entry version 63.
DE   RecName: Full=RGM domain family member B;
DE   AltName: Full=DRG11-responsive axonal guidance and outgrowth of neurite;
DE            Short=DRAGON;
DE   Flags: Precursor;
GN   Name=RGMB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=19324014; DOI=10.1016/j.bbrc.2009.03.115;
RA   Liu X., Hashimoto M., Horii H., Yamaguchi A., Naito K., Yamashita T.;
RT   "Repulsive guidance molecule b inhibits neurite growth and is
RT   increased after spinal cord injury.";
RL   Biochem. Biophys. Res. Commun. 382:795-800(2009).
CC   -!- FUNCTION: Member of the repulsive guidance molecule (RGM) family
CC       that contributes to the patterning of the developing nervous
CC       system (By similarity). Acts as a bone morphogenetic protein (BMP)
CC       coreceptor that potentiates BMP signaling (By similarity).
CC       Promotes neuronal adhesion (By similarity). May inhibit neurite
CC       outgrowth.
CC   -!- SUBUNIT: Homooligomer (By similarity). Interacts with DRGX (By
CC       similarity). Interacts with BMP2 and BMP4 (By similarity).
CC       Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B
CC       and with the BMP type II receptor ACVR2B (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By
CC       similarity). Membrane raft (By similarity).
CC   -!- PTM: GPI-anchored (By similarity).
CC   -!- SIMILARITY: Belongs to the repulsive guidance molecule (RGM)
CC       family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67736.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC       Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention;
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DR   EMBL; AK074887; BAC11268.1; ALT_SEQ; mRNA.
DR   EMBL; AC008522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067736; AAH67736.1; ALT_INIT; mRNA.
DR   IPI; IPI00963921; -.
DR   RefSeq; NP_001012779.2; NM_001012761.2.
DR   UniGene; Hs.526902; -.
DR   STRING; Q6NW40; -.
DR   DMDM; 51316243; -.
DR   PRIDE; Q6NW40; -.
DR   Ensembl; ENST00000308234; ENSP00000308219; ENSG00000174136.
DR   Ensembl; ENST00000513185; ENSP00000423256; ENSG00000174136.
DR   GeneID; 285704; -.
DR   KEGG; hsa:285704; -.
DR   UCSC; uc003knb.1; human.
DR   UCSC; uc003knc.1; human.
DR   CTD; 285704; -.
DR   GeneCards; GC05P098132; -.
DR   HGNC; HGNC:26896; RGMB.
DR   HPA; HPA016993; -.
DR   MIM; 612687; gene.
DR   neXtProt; NX_Q6NW40; -.
DR   PharmGKB; PA134868641; -.
DR   eggNOG; prNOG15941; -.
DR   GeneTree; ENSGT00390000008488; -.
DR   HOGENOM; HBG505677; -.
DR   HOVERGEN; HBG057627; -.
DR   InParanoid; Q6NW40; -.
DR   OrthoDB; EOG4GHZNX; -.
DR   Pathway_Interaction_DB; bmppathway; BMP receptor signaling.
DR   Reactome; REACT_111045; Developmental Biology.
DR   NextBio; 95719; -.
DR   ArrayExpress; Q6NW40; -.
DR   Bgee; Q6NW40; -.
DR   CleanEx; HS_RGMB; -.
DR   Genevestigator; Q6NW40; -.
DR   GermOnline; ENSG00000174136; Homo sapiens.
DR   GO; GO:0046658; C:anchored to plasma membrane; ISS:HGNC.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:HGNC.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISS:HGNC.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0030509; P:BMP signaling pathway; ISS:HGNC.
DR   GO; GO:0007155; P:cell adhesion; ISS:HGNC.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:HGNC.
DR   InterPro; IPR009496; RGM_C.
DR   InterPro; IPR010536; RGM_N.
DR   KO; K06847; -.
DR   Pfam; PF06534; RGM_C; 1.
DR   Pfam; PF06535; RGM_N; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Reference proteome; Signal.
FT   SIGNAL        1     45       Potential.
FT   CHAIN        46    413       RGM domain family member B.
FT                                /FTId=PRO_0000030394.
FT   PROPEP      414    437       Removed in mature form (Potential).
FT                                /FTId=PRO_0000030395.
FT   LIPID       413    413       GPI-anchor amidated asparagine
FT                                (Potential).
FT   CARBOHYD    120    120       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    383    383       N-linked (GlcNAc...) (Potential).
FT   CONFLICT     22     22       S -> R (in Ref. 3; AAH67736).
FT   CONFLICT    225    225       E -> G (in Ref. 3; AAH67736).
SQ   SEQUENCE   437 AA;  47547 MW;  48C26166E68DCE5F CRC64;
     MGLRAAPSSA AAAAAEVEQR RSPGLCPPPL ELLLLLLFSL GLLHAGDCQQ PAQCRIQKCT
     TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN
     CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT
     CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHECTDQK VYQAVTDDLP
     AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA
     MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE
     KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGNGTPRGGS
     DLSVSLGLTC LILIVFL
//