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Reviewed, UniProtKB/Swiss-Prot Q6NW40 (RGMB_HUMAN)

Last modified March 2, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
RGM domain family member B
Alternative name(s):
DRG11-responsive axonal guidance and outgrowth of neurite
Short name=DRAGON
Gene names
Name:RGMB
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system By similarity. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling By similarity. Promotes neuronal adhesion By similarity. May inhibit neurite outgrowth. Ref.3

Subunit structure

Homooligomer By similarity. Interacts with DRGX By similarity. Interacts with BMP2 and BMP4 By similarity. Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B By similarity.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor By similarity. Membrane raft By similarity.

Post-translational modification

GPI-anchored By similarity.

Sequence similarities

Belongs to the repulsive guidance molecule (RGM) family.

Sequence caution

The sequence BAC11268.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4545 Potential
Chain46 – 413368RGM domain family member B
PRO_0000030394
Propeptide414 – 43724Removed in mature form Potential
PRO_0000030395

Amino acid modifications

Lipidation4131GPI-anchor amidated asparagine Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6NW40-1 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: B81604080FFBF0C5

FASTA43747,544
        10         20         30         40         50         60 
MGLRAAPSSA AAAAAEVEQR RRPGLCPPPL ELLLLLLFSL GLLHAGDCQQ PAQCRIQKCT 

        70         80         90        100        110        120 
TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN 

       130        140        150        160        170        180 
CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT 

       190        200        210        220        230        240 
CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHGCTDQK VYQAVTDDLP 

       250        260        270        280        290        300 
AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA 

       310        320        330        340        350        360 
MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE 

       370        380        390        400        410        420 
KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGNGTPRGGS 

       430 
DLSVSLGLTC LILIVFL

« Hide

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References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury."
Liu X., Hashimoto M., Horii H., Yamaguchi A., Naito K., Yamashita T.
Biochem. Biophys. Res. Commun. 382:795-800(2009) [PubMed: 19324014] [Abstract]
Cited for: FUNCTION.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK074887 mRNA. Translation: BAC11268.1. Sequence problems.
BC067736 mRNA. Translation: AAH67736.1. Different initiation.
IPIIPI00168358.
IPI00456736.
RefSeqNP_001012779.2.
UniGeneHs.526902

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6NW40.

Proteomic databases

PRIDEQ6NW40.

Genome annotation databases

EnsemblENST00000308234; ENSP00000308219; ENSG00000174136; Homo sapiens. [Genome view]
GeneID285704.
KEGGhsa:285704.
UCSCuc003knb.1. human.
uc003knc.1. human.

Organism-specific databases

CTD285704.
GeneCardsGC05P098132.
HGNCHGNC:26896. RGMB.
MIM612687. gene.
PharmGKBPA134868641.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG15941.
HOGENOMHBG505677.
HOVERGENHBG057627.
InParanoidQ6NW40.

Enzyme and pathway databases

Pathway_Interaction_DBbmppathway. BMP receptor signaling.

Gene expression databases

ArrayExpressQ6NW40.
BgeeQ6NW40.
CleanExHS_RGMB.
GenevestigatorQ6NW40.
GermOnlineENSG00000174136. Homo sapiens.

Family and domain databases

InterProIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio95719.
SOURCESearch...

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Entry information

Entry nameRGMB_HUMAN
AccessionPrimary (citable) accession number: Q6NW40
Secondary accession number(s): Q8NC92
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 2, 2010
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents