Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolus and neural progenitor protein

Gene

NEPRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolus and neural progenitor proteinCurated
Gene namesi
Name:NEPROImported
Synonyms:C3orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163608.14
HGNCiHGNC:24496 NEPRO
neXtProtiNX_Q6NW34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163608
PharmGKBiPA134948355

Polymorphism and mutation databases

BioMutaiC3orf17
DMDMi134047717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002250121 – 567Nucleolus and neural progenitor proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NW34
MaxQBiQ6NW34
PaxDbiQ6NW34
PeptideAtlasiQ6NW34
PRIDEiQ6NW34
ProteomicsDBi66738
66739 [Q6NW34-2]

PTM databases

iPTMnetiQ6NW34
PhosphoSitePlusiQ6NW34

Expressioni

Gene expression databases

BgeeiENSG00000163608
CleanExiHS_C3orf17
ExpressionAtlasiQ6NW34 baseline and differential
GenevisibleiQ6NW34 HS

Organism-specific databases

HPAiHPA069654

Interactioni

Protein-protein interaction databases

BioGridi117387, 45 interactors
IntActiQ6NW34, 12 interactors
STRINGi9606.ENSP00000320251

Structurei

3D structure databases

ProteinModelPortaliQ6NW34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 460Nuclear localization signalBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the nepro family.Curated

Phylogenomic databases

eggNOGiENOG410IFTK Eukaryota
ENOG411118E LUCA
GeneTreeiENSGT00390000007644
HOGENOMiHOG000015316
HOVERGENiHBG056039
InParanoidiQ6NW34
OMAiCCKTFLL
OrthoDBiEOG091G04HM
PhylomeDBiQ6NW34
TreeFamiTF335999

Family and domain databases

InterProiView protein in InterPro
IPR027951 DUF4477
PfamiView protein in Pfam
PF14780 DUF4477, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NW34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAVPPGLE PWNRVRIPKA GNRSAVTVQN PGAALDLCIA AVIKECHLVI
60 70 80 90 100
LSLKSQTLDA ETDVLCAVLY SNHNRMGRHK PHLALKQVEQ CLKRLKNMNL
110 120 130 140 150
EGSIQDLFEL FSSNENQPLT TKVCVVPSQP VVELVLMKVL GACKLLLRLL
160 170 180 190 200
DCCCKTFLLT VKHLGLQEFI ILNLVMVGLV SRLWVLYKGV LKRLILLYEP
210 220 230 240 250
LFGLLQEVAR IQPMPYFKDF TFPSDITEFL GQPYFEAFKK KMPIAFAAKG
260 270 280 290 300
INKLLNKLFL INEQSPRASE ETLLGISKKA KQMKINVQNN VDLGQPVKNK
310 320 330 340 350
RVFKEESSEF DVRAFCNQLK HKATQETSFD FKCSQSRLKT TKYSSQKVIG
360 370 380 390 400
TPHAKSFVQR FREAESFTQL SEEIQMAVVW CRSKKLKAQA IFLGNKLLKS
410 420 430 440 450
NRLKHLEAQG TSLPKKLECI KTSICNHLLR GSGIKTSKHH LRQRRSQNKF
460 470 480 490 500
LRRQRKPQRK LQSTLLREIQ QFSQGTRKSA TDTSAKWRLS HCTVHRTDLY
510 520 530 540 550
PNSKQLLNSG VSMPVIQTKE KMIHENLRGI HENETDSWTV MQINKNSTSG
560
TIKETDDIDD IFALMGV
Length:567
Mass (Da):64,552
Last modified:March 20, 2007 - v3
Checksum:i88CB0CEE2A0CA0A2
GO
Isoform 2 (identifier: Q6NW34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: N → K
     115-184: Missing.

Show »
Length:497
Mass (Da):56,749
Checksum:iC0F35B726819E62F
GO

Sequence cautioni

The sequence CAB55998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → I in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti509S → N in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti520E → G in AAH67743 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025418101E → K. Corresponds to variant dbSNP:rs2291465Ensembl.1
Natural variantiVAR_025419352P → S. Corresponds to variant dbSNP:rs2306858Ensembl.1
Natural variantiVAR_025420357F → I2 PublicationsCorresponds to variant dbSNP:rs2306857Ensembl.1
Natural variantiVAR_025421476T → A. Corresponds to variant dbSNP:rs3732813Ensembl.1
Natural variantiVAR_025422490S → P1 PublicationCorresponds to variant dbSNP:rs7628368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017342114N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_017343115 – 184Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024325 mRNA Translation: BAB14885.1
AL117573 mRNA Translation: CAB55998.1 Different initiation.
CR749341 mRNA Translation: CAH18194.1
CH471052 Genomic DNA Translation: EAW79648.1
CH471052 Genomic DNA Translation: EAW79649.1
BC067743 mRNA Translation: AAH67743.1
CCDSiCCDS33824.1 [Q6NW34-1]
CCDS82820.1 [Q6NW34-2]
PIRiT17308
RefSeqiNP_001306038.1, NM_001319109.1 [Q6NW34-2]
NP_001306039.1, NM_001319110.1
NP_001306040.1, NM_001319111.1
NP_001306041.1, NM_001319112.1
NP_001306043.1, NM_001319114.1
NP_001306044.1, NM_001319115.1
NP_056227.2, NM_015412.3 [Q6NW34-1]
UniGeneiHs.591288

Genome annotation databases

EnsembliENST00000314400; ENSP00000320251; ENSG00000163608 [Q6NW34-1]
ENST00000383675; ENSP00000373173; ENSG00000163608 [Q6NW34-2]
GeneIDi25871
KEGGihsa:25871
UCSCiuc003dzr.4 human [Q6NW34-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiNEPRO_HUMAN
AccessioniPrimary (citable) accession number: Q6NW34
Secondary accession number(s): D3DN69
, Q68DM6, Q9H7U0, Q9UFM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health