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Protein

Nucleolus and neural progenitor protein

Gene

NEPRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolus and neural progenitor proteinCurated
Gene namesi
Name:NEPROImported
Synonyms:C3orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24496. NEPRO.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25871.
OpenTargetsiENSG00000163608.
PharmGKBiPA134948355.

Polymorphism and mutation databases

BioMutaiC3orf17.
DMDMi134047717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002250121 – 567Nucleolus and neural progenitor proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NW34.
MaxQBiQ6NW34.
PaxDbiQ6NW34.
PeptideAtlasiQ6NW34.
PRIDEiQ6NW34.

PTM databases

iPTMnetiQ6NW34.
PhosphoSitePlusiQ6NW34.

Expressioni

Gene expression databases

BgeeiENSG00000163608.
CleanExiHS_C3orf17.
ExpressionAtlasiQ6NW34. baseline and differential.
GenevisibleiQ6NW34. HS.

Organism-specific databases

HPAiHPA031037.

Interactioni

Protein-protein interaction databases

BioGridi117387. 23 interactors.
IntActiQ6NW34. 9 interactors.
MINTiMINT-4540942.
STRINGi9606.ENSP00000320251.

Structurei

3D structure databases

ProteinModelPortaliQ6NW34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 460Nuclear localization signalBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the nepro family.Curated

Phylogenomic databases

eggNOGiENOG410IFTK. Eukaryota.
ENOG411118E. LUCA.
GeneTreeiENSGT00390000007644.
HOGENOMiHOG000015316.
HOVERGENiHBG056039.
InParanoidiQ6NW34.
OMAiFLLTVKH.
OrthoDBiEOG091G04HM.
PhylomeDBiQ6NW34.
TreeFamiTF335999.

Family and domain databases

InterProiIPR027951. DUF4477.
[Graphical view]
PfamiPF14780. DUF4477. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NW34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAVPPGLE PWNRVRIPKA GNRSAVTVQN PGAALDLCIA AVIKECHLVI
60 70 80 90 100
LSLKSQTLDA ETDVLCAVLY SNHNRMGRHK PHLALKQVEQ CLKRLKNMNL
110 120 130 140 150
EGSIQDLFEL FSSNENQPLT TKVCVVPSQP VVELVLMKVL GACKLLLRLL
160 170 180 190 200
DCCCKTFLLT VKHLGLQEFI ILNLVMVGLV SRLWVLYKGV LKRLILLYEP
210 220 230 240 250
LFGLLQEVAR IQPMPYFKDF TFPSDITEFL GQPYFEAFKK KMPIAFAAKG
260 270 280 290 300
INKLLNKLFL INEQSPRASE ETLLGISKKA KQMKINVQNN VDLGQPVKNK
310 320 330 340 350
RVFKEESSEF DVRAFCNQLK HKATQETSFD FKCSQSRLKT TKYSSQKVIG
360 370 380 390 400
TPHAKSFVQR FREAESFTQL SEEIQMAVVW CRSKKLKAQA IFLGNKLLKS
410 420 430 440 450
NRLKHLEAQG TSLPKKLECI KTSICNHLLR GSGIKTSKHH LRQRRSQNKF
460 470 480 490 500
LRRQRKPQRK LQSTLLREIQ QFSQGTRKSA TDTSAKWRLS HCTVHRTDLY
510 520 530 540 550
PNSKQLLNSG VSMPVIQTKE KMIHENLRGI HENETDSWTV MQINKNSTSG
560
TIKETDDIDD IFALMGV
Length:567
Mass (Da):64,552
Last modified:March 20, 2007 - v3
Checksum:i88CB0CEE2A0CA0A2
GO
Isoform 2 (identifier: Q6NW34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: N → K
     115-184: Missing.

Show »
Length:497
Mass (Da):56,749
Checksum:iC0F35B726819E62F
GO

Sequence cautioni

The sequence CAB55998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → I in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti509S → N in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti520E → G in AAH67743 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025418101E → K.Corresponds to variant rs2291465dbSNPEnsembl.1
Natural variantiVAR_025419352P → S.Corresponds to variant rs2306858dbSNPEnsembl.1
Natural variantiVAR_025420357F → I.2 PublicationsCorresponds to variant rs2306857dbSNPEnsembl.1
Natural variantiVAR_025421476T → A.Corresponds to variant rs3732813dbSNPEnsembl.1
Natural variantiVAR_025422490S → P.1 PublicationCorresponds to variant rs7628368dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017342114N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_017343115 – 184Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024325 mRNA. Translation: BAB14885.1.
AL117573 mRNA. Translation: CAB55998.1. Different initiation.
CR749341 mRNA. Translation: CAH18194.1.
CH471052 Genomic DNA. Translation: EAW79648.1.
CH471052 Genomic DNA. Translation: EAW79649.1.
BC067743 mRNA. Translation: AAH67743.1.
CCDSiCCDS33824.1. [Q6NW34-1]
CCDS82820.1. [Q6NW34-2]
PIRiT17308.
RefSeqiNP_001306038.1. NM_001319109.1. [Q6NW34-2]
NP_001306039.1. NM_001319110.1.
NP_001306040.1. NM_001319111.1.
NP_001306041.1. NM_001319112.1.
NP_001306043.1. NM_001319114.1.
NP_001306044.1. NM_001319115.1.
NP_056227.2. NM_015412.3. [Q6NW34-1]
UniGeneiHs.591288.

Genome annotation databases

EnsembliENST00000314400; ENSP00000320251; ENSG00000163608. [Q6NW34-1]
ENST00000383675; ENSP00000373173; ENSG00000163608. [Q6NW34-2]
GeneIDi25871.
KEGGihsa:25871.
UCSCiuc003dzr.4. human. [Q6NW34-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024325 mRNA. Translation: BAB14885.1.
AL117573 mRNA. Translation: CAB55998.1. Different initiation.
CR749341 mRNA. Translation: CAH18194.1.
CH471052 Genomic DNA. Translation: EAW79648.1.
CH471052 Genomic DNA. Translation: EAW79649.1.
BC067743 mRNA. Translation: AAH67743.1.
CCDSiCCDS33824.1. [Q6NW34-1]
CCDS82820.1. [Q6NW34-2]
PIRiT17308.
RefSeqiNP_001306038.1. NM_001319109.1. [Q6NW34-2]
NP_001306039.1. NM_001319110.1.
NP_001306040.1. NM_001319111.1.
NP_001306041.1. NM_001319112.1.
NP_001306043.1. NM_001319114.1.
NP_001306044.1. NM_001319115.1.
NP_056227.2. NM_015412.3. [Q6NW34-1]
UniGeneiHs.591288.

3D structure databases

ProteinModelPortaliQ6NW34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117387. 23 interactors.
IntActiQ6NW34. 9 interactors.
MINTiMINT-4540942.
STRINGi9606.ENSP00000320251.

PTM databases

iPTMnetiQ6NW34.
PhosphoSitePlusiQ6NW34.

Polymorphism and mutation databases

BioMutaiC3orf17.
DMDMi134047717.

Proteomic databases

EPDiQ6NW34.
MaxQBiQ6NW34.
PaxDbiQ6NW34.
PeptideAtlasiQ6NW34.
PRIDEiQ6NW34.

Protocols and materials databases

DNASUi25871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314400; ENSP00000320251; ENSG00000163608. [Q6NW34-1]
ENST00000383675; ENSP00000373173; ENSG00000163608. [Q6NW34-2]
GeneIDi25871.
KEGGihsa:25871.
UCSCiuc003dzr.4. human. [Q6NW34-1]

Organism-specific databases

CTDi25871.
DisGeNETi25871.
GeneCardsiC3orf17.
H-InvDBHIX0003553.
HIX0119163.
HGNCiHGNC:24496. NEPRO.
HPAiHPA031037.
neXtProtiNX_Q6NW34.
OpenTargetsiENSG00000163608.
PharmGKBiPA134948355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTK. Eukaryota.
ENOG411118E. LUCA.
GeneTreeiENSGT00390000007644.
HOGENOMiHOG000015316.
HOVERGENiHBG056039.
InParanoidiQ6NW34.
OMAiFLLTVKH.
OrthoDBiEOG091G04HM.
PhylomeDBiQ6NW34.
TreeFamiTF335999.

Miscellaneous databases

ChiTaRSiC3orf17. human.
GenomeRNAii25871.
PROiQ6NW34.

Gene expression databases

BgeeiENSG00000163608.
CleanExiHS_C3orf17.
ExpressionAtlasiQ6NW34. baseline and differential.
GenevisibleiQ6NW34. HS.

Family and domain databases

InterProiIPR027951. DUF4477.
[Graphical view]
PfamiPF14780. DUF4477. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEPRO_HUMAN
AccessioniPrimary (citable) accession number: Q6NW34
Secondary accession number(s): D3DN69
, Q68DM6, Q9H7U0, Q9UFM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.