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Protein

RWD domain-containing protein 4

Gene

RWDD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 4
Alternative name(s):
Protein FAM28A
Gene namesi
Name:RWDD4
Synonyms:FAM28A, RWDD4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23750. RWDD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670965.

Polymorphism and mutation databases

BioMutaiRWDD4.
DMDMi116242778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 188187RWD domain-containing protein 4PRO_0000076307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6NW29.
MaxQBiQ6NW29.
PaxDbiQ6NW29.
PRIDEiQ6NW29.

PTM databases

iPTMnetiQ6NW29.
PhosphoSiteiQ6NW29.

Expressioni

Gene expression databases

BgeeiQ6NW29.
CleanExiHS_RWDD4A.
ExpressionAtlasiQ6NW29. baseline and differential.
GenevisibleiQ6NW29. HS.

Organism-specific databases

HPAiHPA036501.
HPA036502.

Interactioni

Protein-protein interaction databases

BioGridi128409. 8 interactions.
IntActiQ6NW29. 2 interactions.
MINTiMINT-1452836.
STRINGi9606.ENSP00000388920.

Structurei

3D structure databases

ProteinModelPortaliQ6NW29.
SMRiQ6NW29. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 111103RWDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000015545.
HOGENOMiHOG000006780.
HOVERGENiHBG054504.
InParanoidiQ6NW29.
OMAiQYKYGEE.
OrthoDBiEOG72NRRS.
PhylomeDBiQ6NW29.
TreeFamiTF326409.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NW29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSANEDQEME LEALRSIYEG DESFRELSPV SFQYRIGENG DPKAFLIEIS
60 70 80 90 100
WTETYPQTPP ILSMNAFFNN TISSAVKQSI LAKLQEAVEA NLGTAMTYTL
110 120 130 140 150
FEYAKDNKEQ FMENHNPINS ATSISNIISI ETPNTAPSSK KKDKKEQLSK
160 170 180
AQKRKLADKT DHKGELPRGW NWVDVVKHLS KTGSKDDE
Length:188
Mass (Da):21,251
Last modified:October 17, 2006 - v3
Checksum:i2A100A29E526F8D6
GO
Isoform 2 (identifier: Q6NW29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:93
Mass (Da):10,648
Checksum:iF9DE01D44CF87718
GO

Sequence cautioni

The sequence AAQ96848.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191E → G (PubMed:15815621).Curated
Sequence conflicti34 – 341Y → H (PubMed:15815621).Curated
Sequence conflicti88 – 881V → A in AAQ96848 (PubMed:15815621).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241I → L.1 Publication
Corresponds to variant rs10015804 [ dbSNP | Ensembl ].
VAR_024928

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595Missing in isoform 2. 1 PublicationVSP_056650Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293274 mRNA. Translation: BAG56803.1.
AK315515 mRNA. Translation: BAG37896.1.
AC093081 Genomic DNA. Translation: AAQ96848.1. Sequence problems.
BC017472 mRNA. Translation: AAH17472.1.
BC067752 mRNA. Translation: AAH67752.1.
BC107432 mRNA. Translation: AAI07433.1.
CCDSiCCDS34111.1. [Q6NW29-1]
RefSeqiNP_001294851.1. NM_001307922.1.
NP_689895.2. NM_152682.3. [Q6NW29-1]
UniGeneiHs.133337.

Genome annotation databases

EnsembliENST00000326397; ENSP00000388920; ENSG00000182552. [Q6NW29-1]
ENST00000510968; ENSP00000426329; ENSG00000182552. [Q6NW29-2]
GeneIDi201965.
KEGGihsa:201965.
UCSCiuc063bgm.1. human. [Q6NW29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293274 mRNA. Translation: BAG56803.1.
AK315515 mRNA. Translation: BAG37896.1.
AC093081 Genomic DNA. Translation: AAQ96848.1. Sequence problems.
BC017472 mRNA. Translation: AAH17472.1.
BC067752 mRNA. Translation: AAH67752.1.
BC107432 mRNA. Translation: AAI07433.1.
CCDSiCCDS34111.1. [Q6NW29-1]
RefSeqiNP_001294851.1. NM_001307922.1.
NP_689895.2. NM_152682.3. [Q6NW29-1]
UniGeneiHs.133337.

3D structure databases

ProteinModelPortaliQ6NW29.
SMRiQ6NW29. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128409. 8 interactions.
IntActiQ6NW29. 2 interactions.
MINTiMINT-1452836.
STRINGi9606.ENSP00000388920.

PTM databases

iPTMnetiQ6NW29.
PhosphoSiteiQ6NW29.

Polymorphism and mutation databases

BioMutaiRWDD4.
DMDMi116242778.

Proteomic databases

EPDiQ6NW29.
MaxQBiQ6NW29.
PaxDbiQ6NW29.
PRIDEiQ6NW29.

Protocols and materials databases

DNASUi201965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326397; ENSP00000388920; ENSG00000182552. [Q6NW29-1]
ENST00000510968; ENSP00000426329; ENSG00000182552. [Q6NW29-2]
GeneIDi201965.
KEGGihsa:201965.
UCSCiuc063bgm.1. human. [Q6NW29-1]

Organism-specific databases

CTDi201965.
GeneCardsiRWDD4.
H-InvDBHIX0033677.
HGNCiHGNC:23750. RWDD4.
HPAiHPA036501.
HPA036502.
neXtProtiNX_Q6NW29.
PharmGKBiPA142670965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000015545.
HOGENOMiHOG000006780.
HOVERGENiHBG054504.
InParanoidiQ6NW29.
OMAiQYKYGEE.
OrthoDBiEOG72NRRS.
PhylomeDBiQ6NW29.
TreeFamiTF326409.

Miscellaneous databases

GenomeRNAii201965.
PROiQ6NW29.

Gene expression databases

BgeeiQ6NW29.
CleanExiHS_RWDD4A.
ExpressionAtlasiQ6NW29. baseline and differential.
GenevisibleiQ6NW29. HS.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-124.
    Tissue: Testis and Uterus.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRWDD4_HUMAN
AccessioniPrimary (citable) accession number: Q6NW29
Secondary accession number(s): B2RDE9
, B4DDP2, Q75LA9, Q8WVW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.