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Protein
Submitted name:

EPHB2 protein

Gene

EPHB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
EPHB2 proteinImported
Submitted name:
Ephrin type-B receptor 2Imported
Gene namesi
Name:EPHB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000133216.16
HGNCiHGNC:3393 EPHB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501431056519 – 482Sequence analysisAdd BLAST464

Expressioni

Gene expression databases

BgeeiENSG00000133216

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 202Eph LBDInterPro annotationAdd BLAST183
Domaini324 – 434Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini435 – 482Fibronectin type-IIIInterPro annotationAdd BLAST48

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233856
HOVERGENiHBG062180
KOiK05111

Family and domain databases

CDDicd10477 EphR_LBD_B2, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR034238 EphB2_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NVW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD
60 70 80 90 100
ENMNTIRTYQ VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI
110 120 130 140 150
PSVPGSCKET FNLYYYEADF DSATKTFPNW MENPWVKVDT IAADESFSQV
160 170 180 190 200
DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD YGGCMSLIAV RVFYRKCPRI
210 220 230 240 250
IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY CNGDGEWLVP
260 270 280 290 300
IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
310 320 330 340 350
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS
360 370 380 390 400
GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA
410 420 430 440 450
HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD
460 470 480
SITLSWSQPD QPNGVILDYE LQYYEKMKTQ RS
Length:482
Mass (Da):53,252
Last modified:July 5, 2004 - v1
Checksum:i29086541708507B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035704 Genomic DNA No translation available.
AL158086 Genomic DNA No translation available.
AL512444 Genomic DNA No translation available.
AL611946 Genomic DNA No translation available.
BC067861 mRNA Translation: AAH67861.1
RefSeqiNP_001296121.1, NM_001309192.1
NP_001296122.1, NM_001309193.1
NP_004433.2, NM_004442.7
NP_059145.2, NM_017449.4
UniGeneiHs.380705
Hs.523329

Genome annotation databases

EnsembliENST00000544305; ENSP00000444174; ENSG00000133216
GeneIDi2048
KEGGihsa:2048
UCSCiuc057dec.1 human

Similar proteinsi

Entry informationi

Entry nameiQ6NVW1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health