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Protein
Submitted name:

EPHB2 protein

Gene

EPHB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
EPHB2 proteinImported
Submitted name:
Ephrin type-B receptor 2Imported
Gene namesi
Name:EPHB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3393. EPHB2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500878264819 – 482Sequence analysisAdd BLAST464

Proteomic databases

MaxQBiQ6NVW1.

Expressioni

Gene expression databases

BgeeiENSG00000133216.
ExpressionAtlasiQ6NVW1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363763.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 202Eph LBD (Eph ligand-binding)InterPro annotationAdd BLAST183
Domaini324 – 434Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini435 – 482Fibronectin type-IIIInterPro annotationAdd BLAST48

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
KOiK05111.

Family and domain databases

CDDicd10477. EphR_LBD_B2. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR034238. EphB2_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 1 hit.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NVW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD
60 70 80 90 100
ENMNTIRTYQ VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI
110 120 130 140 150
PSVPGSCKET FNLYYYEADF DSATKTFPNW MENPWVKVDT IAADESFSQV
160 170 180 190 200
DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD YGGCMSLIAV RVFYRKCPRI
210 220 230 240 250
IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY CNGDGEWLVP
260 270 280 290 300
IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
310 320 330 340 350
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS
360 370 380 390 400
GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA
410 420 430 440 450
HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD
460 470 480
SITLSWSQPD QPNGVILDYE LQYYEKMKTQ RS
Length:482
Mass (Da):53,252
Last modified:July 5, 2004 - v1
Checksum:i29086541708507B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035704 Genomic DNA. No translation available.
AL158086 Genomic DNA. No translation available.
AL512444 Genomic DNA. No translation available.
AL611946 Genomic DNA. No translation available.
BC067861 mRNA. Translation: AAH67861.1.
RefSeqiNP_001296121.1. NM_001309192.1.
NP_001296122.1. NM_001309193.1.
NP_004433.2. NM_004442.7.
NP_059145.2. NM_017449.4.
UniGeneiHs.380705.
Hs.523329.

Genome annotation databases

EnsembliENST00000544305; ENSP00000444174; ENSG00000133216.
GeneIDi2048.
KEGGihsa:2048.
UCSCiuc057dec.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035704 Genomic DNA. No translation available.
AL158086 Genomic DNA. No translation available.
AL512444 Genomic DNA. No translation available.
AL611946 Genomic DNA. No translation available.
BC067861 mRNA. Translation: AAH67861.1.
RefSeqiNP_001296121.1. NM_001309192.1.
NP_001296122.1. NM_001309193.1.
NP_004433.2. NM_004442.7.
NP_059145.2. NM_017449.4.
UniGeneiHs.380705.
Hs.523329.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363763.

Proteomic databases

MaxQBiQ6NVW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000544305; ENSP00000444174; ENSG00000133216.
GeneIDi2048.
KEGGihsa:2048.
UCSCiuc057dec.1. human.

Organism-specific databases

CTDi2048.
HGNCiHGNC:3393. EPHB2.
OpenTargetsiENSG00000133216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
KOiK05111.

Miscellaneous databases

ChiTaRSiEPHB2. human.
GenomeRNAii2048.

Gene expression databases

BgeeiENSG00000133216.
ExpressionAtlasiQ6NVW1. baseline and differential.

Family and domain databases

CDDicd10477. EphR_LBD_B2. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR034238. EphB2_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 1 hit.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6NVW1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.