Reviewed, UniProtKB/Swiss-Prot Q6NVV9 (ADAM5_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative disintegrin and metalloproteinase domain-containing protein 5
Alternative name(s):
    Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
      Short name=tMDC II

Gene names

Name:	ADAM5P
Synonyms:	ADAM5, TMDC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Function	This is a non catalytic metalloprotease-like protein By similarity.
Tissue specificity	Highly expressed in testis. Ref.1
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain.
Caution	Could be the product of a pseudogene. Not expected to have protease activity.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6NVV9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6NVV9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     163-170: FKPANMIC → VLWWCKGF
     171-412: Missing.

Isoform 3 (identifier: Q6NVV9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     85-162: TMQLKNISYG...EMHIVVDKNL → MTLILGLIQS...SEECDCGTKD

Isoform 4 (identifier: Q6NVV9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Isoform 5 (identifier: Q6NVV9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     141-162: Missing.

Isoform 6 (identifier: Q6NVV9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     337-365: Missing.

Isoform 7 (identifier: Q6NVV9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     404-412: ERSYMEEGR → APVS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Putative disintegrin and metalloproteinase domain-containing protein 5		PRO_0000349304
Regions
	Domain	111 – 199	89	Disintegrin
	Domain	351 – 385	35	EGF-like
Natural variations
	Alternative sequence	1 – 84	84	Missing in isoform 3.		VSP_035339
	Alternative sequence	1 – 57	57	Missing in isoform 2, isoform 4 and isoform 5.		VSP_035340
	Alternative sequence	85 – 162	78	TMQLK…VDKNL → MTLILGLIQSIKSEKVQKYS GGVKDFNICSLDDFKYISSH NGLTCLQTNPLEMPHRRICG NGLLEGSEECDCGTKD in isoform 3.		VSP_035341
	Alternative sequence	141 – 162	22	Missing in isoform 5.		VSP_035342
	Alternative sequence	163 – 170	8	FKPANMIC → VLWWCKGF in isoform 2.		VSP_035343
	Alternative sequence	171 – 412	242	Missing in isoform 2.		VSP_035344
	Alternative sequence	337 – 365	29	Missing in isoform 6.		VSP_035345
	Alternative sequence	404 – 412	9	ERSYMEEGR → APVS in isoform 7.		VSP_035346

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 8F1E8FC241CFD471	FASTA	412	47,181
	10 20 30 40 50 60 MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH SKPLLVQMDC 70 80 90 100 110 120 NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA VSGFIHKIYE EKYADTNILL 130 140 150 160 170 180 EENDTYTWFN SEYQVRKSSE KTDFIKLFPR YIEMHIVVDK NLFKPANMIC RKSVGKECDF 190 200 210 220 230 240 TEYCNGDLPY CLPDTYVRDG EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE 250 260 270 280 290 300 INTRGDNFGN CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR 310 320 330 340 350 360 RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMYCFE MHCKHVRFLM NLKLCDASNH 370 380 390 400 410 CDRHGVCNNF NHCHCEKGYN PPYCQPKQGA FGSIDDGHLV PPTERSYMEE GR
	Isoform 2. Checksum: 3153CCF56C99D7E6	FASTA	113	13,164
	10 20 30 40 50 60 MDCNYNGYVA GIPNSLVTLS VCSGLRGTMQ LKNISYGIEP MEAVSGFIHK IYEEKYADTN 70 80 90 100 110 ILLEENDTYT WFNSEYQVRK SSEKTDFIKL FPRYIEMHIV VDKNLVLWWC KGF
	Isoform 3. Checksum: 12505ECA149898DF	FASTA	326	36,728
	10 20 30 40 50 60 MTLILGLIQS IKSEKVQKYS GGVKDFNICS LDDFKYISSH NGLTCLQTNP LEMPHRRICG 70 80 90 100 110 120 NGLLEGSEEC DCGTKDFKPA NMICRKSVGK ECDFTEYCNG DLPYCLPDTY VRDGEYCDSG 130 140 150 160 170 180 GAFCFQGKCR TFDKQCDDLI GRGSRGAPVF CYDEINTRGD NFGNCGTAHC LFQHILCGKL 190 200 210 220 230 240 VCTWEHRDLI SRPNLSVIYA HVRDQTCVST YLPRRTPPPV NSPISITSYY SAEDRDETFV 250 260 270 280 290 300 QDGSMCGPDM YCFEMHCKHV RFLMNLKLCD ASNHCDRHGV CNNFNHCHCE KGYNPPYCQP 310 320 KQGAFGSIDD GHLVPPTERS YMEEGR
	Isoform 4. Checksum: 0FDB5181861987F0	FASTA	355	40,477
	10 20 30 40 50 60 MDCNYNGYVA GIPNSLVTLS VCSGLRGTMQ LKNISYGIEP MEAVSGFIHK IYEEKYADTN 70 80 90 100 110 120 ILLEENDTYT WFNSEYQVRK SSEKTDFIKL FPRYIEMHIV VDKNLFKPAN MICRKSVGKE 130 140 150 160 170 180 CDFTEYCNGD LPYCLPDTYV RDGEYCDSGG AFCFQGKCRT FDKQCDDLIG RGSRGAPVFC 190 200 210 220 230 240 YDEINTRGDN FGNCGTAHCL FQHILCGKLV CTWEHRDLIS RPNLSVIYAH VRDQTCVSTY 250 260 270 280 290 300 LPRRTPPPVN SPISITSYYS AEDRDETFVQ DGSMCGPDMY CFEMHCKHVR FLMNLKLCDA 310 320 330 340 350 SNHCDRHGVC NNFNHCHCEK GYNPPYCQPK QGAFGSIDDG HLVPPTERSY MEEGR
	Isoform 5. Checksum: F35EAAEF44935268	FASTA	333	37,774
	10 20 30 40 50 60 MDCNYNGYVA GIPNSLVTLS VCSGLRGTMQ LKNISYGIEP MEAVSGFIHK IYEEKYADTN 70 80 90 100 110 120 ILLEENDTYT WFNSEYQVRK SSEFKPANMI CRKSVGKECD FTEYCNGDLP YCLPDTYVRD 130 140 150 160 170 180 GEYCDSGGAF CFQGKCRTFD KQCDDLIGRG SRGAPVFCYD EINTRGDNFG NCGTAHCLFQ 190 200 210 220 230 240 HILCGKLVCT WEHRDLISRP NLSVIYAHVR DQTCVSTYLP RRTPPPVNSP ISITSYYSAE 250 260 270 280 290 300 DRDETFVQDG SMCGPDMYCF EMHCKHVRFL MNLKLCDASN HCDRHGVCNN FNHCHCEKGY 310 320 330 NPPYCQPKQG AFGSIDDGHL VPPTERSYME EGR
	Isoform 6. Checksum: 9E2C1404CE71DC9B	FASTA	383	43,690
	10 20 30 40 50 60 MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH SKPLLVQMDC 70 80 90 100 110 120 NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA VSGFIHKIYE EKYADTNILL 130 140 150 160 170 180 EENDTYTWFN SEYQVRKSSE KTDFIKLFPR YIEMHIVVDK NLFKPANMIC RKSVGKECDF 190 200 210 220 230 240 TEYCNGDLPY CLPDTYVRDG EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE 250 260 270 280 290 300 INTRGDNFGN CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR 310 320 330 340 350 360 RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMVCNN FNHCHCEKGY NPPYCQPKQG 370 380 AFGSIDDGHL VPPTERSYME EGR
	Isoform 7. Checksum: 813302DC72F86221	FASTA	407	46,398
	10 20 30 40 50 60 MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH SKPLLVQMDC 70 80 90 100 110 120 NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA VSGFIHKIYE EKYADTNILL 130 140 150 160 170 180 EENDTYTWFN SEYQVRKSSE KTDFIKLFPR YIEMHIVVDK NLFKPANMIC RKSVGKECDF 190 200 210 220 230 240 TEYCNGDLPY CLPDTYVRDG EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE 250 260 270 280 290 300 INTRGDNFGN CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR 310 320 330 340 350 360 RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMYCFE MHCKHVRFLM NLKLCDASNH 370 380 390 400 CDRHGVCNNF NHCHCEKGYN PPYCQPKQGA FGSIDDGHLV PPTAPVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcripts encoding the sperm surface protein tMDC II are non-functional in the human." Frayne J., Dimsey E.A., Jury J.A., Hall L. Biochem. J. 341:771-775(1999) [PubMed: 10417343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6 AND 7), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ132820 mRNA. No translation available. AJ132821 mRNA. No translation available. AJ132822 mRNA. No translation available. AJ132823 mRNA. No translation available. AJ132824 mRNA. No translation available. AJ132825 mRNA. No translation available. AJ132826 mRNA. No translation available. AJ132827 mRNA. No translation available. AC105185 Genomic DNA. No translation available. BC026083 mRNA. No translation available. BC067864 mRNA. No translation available.
IPI	IPI00432868. IPI00647668. IPI00794747. IPI00902430. IPI00902484. IPI00902507. IPI00902823.
UniGene	Hs.369765
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000359790; ENSP00000352838; ENSG00000196115; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC08P039293.
HGNC	HGNC:212. ADAM5P.
GenAtlas	Search...
Phylogenomic databases
OMA	RYIEMHI
OrthoDB	EOG9JDKSG
Gene expression databases
ArrayExpress	Q6NVV9.
Bgee	Q6NVV9.
Genevestigator	Q6NVV9.
Family and domain databases
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. [Graphical view]
SMART	SM00608. ACR. 1 hit. [Graphical view]
PROSITE	PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS00022. EGF_1. False negative. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADAM5_HUMAN

Accession

Primary (citable) accession number: Q6NVV9
Secondary accession number(s): A8MW71, Q4G196

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	August 30, 2005
Last modified:	November 24, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.