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Protein

Putative disintegrin and metalloproteinase domain-containing protein 5

Gene

ADAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

This is a non catalytic metalloprotease-like protein.By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative disintegrin and metalloproteinase domain-containing protein 5
Alternative name(s):
Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
Short name:
tMDC II
Gene namesi
Name:ADAM5
Synonyms:ADAM5P, TMDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:212. ADAM5.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi121946258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Putative disintegrin and metalloproteinase domain-containing protein 5PRO_0000349304Add
BLAST

Proteomic databases

PRIDEiQ6NVV9.
TopDownProteomicsiQ6NVV9-7. [Q6NVV9-7]

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6NVV9.
SMRiQ6NVV9. Positions 163-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 19989DisintegrinAdd
BLAST
Domaini351 – 38535EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain

Phylogenomic databases

InParanoidiQ6NVV9.
PhylomeDBiQ6NVV9.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view]
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NVV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH
60 70 80 90 100
SKPLLVQMDC NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA
110 120 130 140 150
VSGFIHKIYE EKYADTNILL EENDTYTWFN SEYQVRKSSE KTDFIKLFPR
160 170 180 190 200
YIEMHIVVDK NLFKPANMIC RKSVGKECDF TEYCNGDLPY CLPDTYVRDG
210 220 230 240 250
EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE INTRGDNFGN
260 270 280 290 300
CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR
310 320 330 340 350
RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMYCFE MHCKHVRFLM
360 370 380 390 400
NLKLCDASNH CDRHGVCNNF NHCHCEKGYN PPYCQPKQGA FGSIDDGHLV
410
PPTERSYMEE GR
Length:412
Mass (Da):47,181
Last modified:August 30, 2005 - v2
Checksum:i8F1E8FC241CFD471
GO
Isoform 2 (identifier: Q6NVV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     163-170: FKPANMIC → VLWWCKGF
     171-412: Missing.

Show »
Length:113
Mass (Da):13,164
Checksum:i3153CCF56C99D7E6
GO
Isoform 3 (identifier: Q6NVV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     85-162: TMQLKNISYG...EMHIVVDKNL → MTLILGLIQS...SEECDCGTKD

Show »
Length:326
Mass (Da):36,728
Checksum:i12505ECA149898DF
GO
Isoform 4 (identifier: Q6NVV9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:355
Mass (Da):40,477
Checksum:i0FDB5181861987F0
GO
Isoform 5 (identifier: Q6NVV9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     141-162: Missing.

Show »
Length:333
Mass (Da):37,774
Checksum:iF35EAAEF44935268
GO
Isoform 6 (identifier: Q6NVV9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-365: Missing.

Show »
Length:383
Mass (Da):43,690
Checksum:i9E2C1404CE71DC9B
GO
Isoform 7 (identifier: Q6NVV9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-412: ERSYMEEGR → APVS

Show »
Length:407
Mass (Da):46,398
Checksum:i813302DC72F86221
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 3. 1 PublicationVSP_035339Add
BLAST
Alternative sequencei1 – 5757Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_035340Add
BLAST
Alternative sequencei85 – 16278TMQLK…VDKNL → MTLILGLIQSIKSEKVQKYS GGVKDFNICSLDDFKYISSH NGLTCLQTNPLEMPHRRICG NGLLEGSEECDCGTKD in isoform 3. 1 PublicationVSP_035341Add
BLAST
Alternative sequencei141 – 16222Missing in isoform 5. 1 PublicationVSP_035342Add
BLAST
Alternative sequencei163 – 1708FKPANMIC → VLWWCKGF in isoform 2. 2 PublicationsVSP_035343
Alternative sequencei171 – 412242Missing in isoform 2. 2 PublicationsVSP_035344Add
BLAST
Alternative sequencei337 – 36529Missing in isoform 6. 1 PublicationVSP_035345Add
BLAST
Alternative sequencei404 – 4129ERSYMEEGR → APVS in isoform 7. 1 PublicationVSP_035346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132820 mRNA. No translation available.
AJ132821 mRNA. No translation available.
AJ132822 mRNA. No translation available.
AJ132823 mRNA. No translation available.
AJ132824 mRNA. No translation available.
AJ132825 mRNA. No translation available.
AJ132826 mRNA. No translation available.
AJ132827 mRNA. No translation available.
AC105185 Genomic DNA. No translation available.
BC026083 mRNA. No translation available.
BC067864 mRNA. No translation available.
UniGeneiHs.369765.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132820 mRNA. No translation available.
AJ132821 mRNA. No translation available.
AJ132822 mRNA. No translation available.
AJ132823 mRNA. No translation available.
AJ132824 mRNA. No translation available.
AJ132825 mRNA. No translation available.
AJ132826 mRNA. No translation available.
AJ132827 mRNA. No translation available.
AC105185 Genomic DNA. No translation available.
BC026083 mRNA. No translation available.
BC067864 mRNA. No translation available.
UniGeneiHs.369765.

3D structure databases

ProteinModelPortaliQ6NVV9.
SMRiQ6NVV9. Positions 163-379.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi121946258.

Proteomic databases

PRIDEiQ6NVV9.
TopDownProteomicsiQ6NVV9-7. [Q6NVV9-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiADAM5.
HGNCiHGNC:212. ADAM5.
neXtProtiNX_Q6NVV9.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ6NVV9.
PhylomeDBiQ6NVV9.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view]
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADAM5_HUMAN
AccessioniPrimary (citable) accession number: Q6NVV9
Secondary accession number(s): A8MW71, Q4G196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 30, 2005
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Not expected to have protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.