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Protein

Magnesium transporter NIPA3

Gene

NIPAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+, Cu2+ and Co2+ but to a much less extent than Mg2+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter NIPA3
Alternative name(s):
NIPA-like protein 1
Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
Gene namesi
Name:NIPAL1
Synonyms:NIPA3, NPAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27194. NIPAL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67ExtracellularSequence analysisAdd BLAST67
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 114CytoplasmicSequence analysisAdd BLAST26
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136ExtracellularSequence analysis1
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 165CytoplasmicSequence analysis8
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 207ExtracellularSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 233CytoplasmicSequence analysis5
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 273ExtracellularSequence analysisAdd BLAST19
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305CytoplasmicSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336ExtracellularSequence analysis10
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 410CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163293.
PharmGKBiPA164723925.

Polymorphism and mutation databases

BioMutaiNIPAL1.
DMDMi74736867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421461 – 410Magnesium transporter NIPA3Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NVV3.
PaxDbiQ6NVV3.
PeptideAtlasiQ6NVV3.
PRIDEiQ6NVV3.

PTM databases

iPTMnetiQ6NVV3.
PhosphoSitePlusiQ6NVV3.

Expressioni

Gene expression databases

BgeeiENSG00000163293.
CleanExiHS_NPAL1.
ExpressionAtlasiQ6NVV3. baseline and differential.
GenevisibleiQ6NVV3. HS.

Organism-specific databases

HPAiHPA036765.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295461.

Structurei

3D structure databases

ProteinModelPortaliQ6NVV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2922. Eukaryota.
ENOG410XNR8. LUCA.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
InParanoidiQ6NVV3.
OMAiEPCQEGY.
OrthoDBiEOG091G0M8A.
PhylomeDBiQ6NVV3.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN
60 70 80 90 100
YSINNLSISA NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG
110 120 130 140 150
FTRAGQGGHS YLKEWLWWVG LLSMGAGEAA NFAAYAFAPA TLVTPLGALS
160 170 180 190 200
VLISAILSSY FLNEHLNIHG KIGCILSILG STVMVIHAPQ EEEVTSLHEM
210 220 230 240 250
EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI SICSLIGAFS
260 270 280 290 300
VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT
310 320 330 340 350
FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG
360 370 380 390 400
IFLLHAFKNT DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND
410
DVTLFSRTDD
Length:410
Mass (Da):44,638
Last modified:July 5, 2004 - v1
Checksum:i4690E95C87D43EB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201E → G in CAH18311 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026843324I → V.Corresponds to variant rs13116684dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095299 mRNA. Translation: BAG53022.1.
CR749484 mRNA. Translation: CAH18311.1.
BC067881 mRNA. Translation: AAH67881.1.
CCDSiCCDS3479.1.
RefSeqiNP_997213.1. NM_207330.2.
UniGeneiHs.134190.

Genome annotation databases

EnsembliENST00000295461; ENSP00000295461; ENSG00000163293.
GeneIDi152519.
KEGGihsa:152519.
UCSCiuc003gxw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095299 mRNA. Translation: BAG53022.1.
CR749484 mRNA. Translation: CAH18311.1.
BC067881 mRNA. Translation: AAH67881.1.
CCDSiCCDS3479.1.
RefSeqiNP_997213.1. NM_207330.2.
UniGeneiHs.134190.

3D structure databases

ProteinModelPortaliQ6NVV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295461.

PTM databases

iPTMnetiQ6NVV3.
PhosphoSitePlusiQ6NVV3.

Polymorphism and mutation databases

BioMutaiNIPAL1.
DMDMi74736867.

Proteomic databases

MaxQBiQ6NVV3.
PaxDbiQ6NVV3.
PeptideAtlasiQ6NVV3.
PRIDEiQ6NVV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295461; ENSP00000295461; ENSG00000163293.
GeneIDi152519.
KEGGihsa:152519.
UCSCiuc003gxw.4. human.

Organism-specific databases

CTDi152519.
GeneCardsiNIPAL1.
HGNCiHGNC:27194. NIPAL1.
HPAiHPA036765.
neXtProtiNX_Q6NVV3.
OpenTargetsiENSG00000163293.
PharmGKBiPA164723925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2922. Eukaryota.
ENOG410XNR8. LUCA.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
InParanoidiQ6NVV3.
OMAiEPCQEGY.
OrthoDBiEOG091G0M8A.
PhylomeDBiQ6NVV3.
TreeFamiTF313214.

Enzyme and pathway databases

ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiNIPAL1. human.
GenomeRNAii152519.
PROiQ6NVV3.

Gene expression databases

BgeeiENSG00000163293.
CleanExiHS_NPAL1.
ExpressionAtlasiQ6NVV3. baseline and differential.
GenevisibleiQ6NVV3. HS.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIPA3_HUMAN
AccessioniPrimary (citable) accession number: Q6NVV3
Secondary accession number(s): B3KTB0, Q68DA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.