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Q6NVV3

- NIPA3_HUMAN

UniProt

Q6NVV3 - NIPA3_HUMAN

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Protein
Magnesium transporter NIPA3
Gene
NIPAL1, NIPA3, NPAL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+, Cu2+ and Co2+ but to a much less extent than Mg2+ By similarity.

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter NIPA3
Alternative name(s):
NIPA-like protein 1
Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
Gene namesi
Name:NIPAL1
Synonyms:NIPA3, NPAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:27194. NIPAL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767Extracellular Reviewed prediction
Add
BLAST
Transmembranei68 – 8821Helical; Reviewed prediction
Add
BLAST
Topological domaini89 – 11426Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Topological domaini136 – 1361Extracellular Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 1658Cytoplasmic Reviewed prediction
Transmembranei166 – 18621Helical; Reviewed prediction
Add
BLAST
Topological domaini187 – 20721Extracellular Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Topological domaini229 – 2335Cytoplasmic Reviewed prediction
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 27319Extracellular Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Topological domaini295 – 30511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Topological domaini327 – 33610Extracellular Reviewed prediction
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Topological domaini358 – 41053Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Magnesium transporter NIPA3
PRO_0000242146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NVV3.
PRIDEiQ6NVV3.

Expressioni

Gene expression databases

ArrayExpressiQ6NVV3.
BgeeiQ6NVV3.
CleanExiHS_NPAL1.
GenevestigatoriQ6NVV3.

Organism-specific databases

HPAiHPA036765.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295461.

Structurei

3D structure databases

ProteinModelPortaliQ6NVV3.

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298616.
HOGENOMiHOG000203962.
InParanoidiQ6NVV3.
OMAiEPCQEGY.
OrthoDBiEOG73BVD7.
PhylomeDBiQ6NVV3.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVV3-1 [UniParc]FASTAAdd to Basket

« Hide

MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN    50
YSINNLSISA NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG 100
FTRAGQGGHS YLKEWLWWVG LLSMGAGEAA NFAAYAFAPA TLVTPLGALS 150
VLISAILSSY FLNEHLNIHG KIGCILSILG STVMVIHAPQ EEEVTSLHEM 200
EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI SICSLIGAFS 250
VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT 300
FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG 350
IFLLHAFKNT DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND 400
DVTLFSRTDD 410
Length:410
Mass (Da):44,638
Last modified:July 5, 2004 - v1
Checksum:i4690E95C87D43EB8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241I → V.
Corresponds to variant rs13116684 [ dbSNP | Ensembl ].
VAR_026843

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011E → G in CAH18311. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095299 mRNA. Translation: BAG53022.1.
CR749484 mRNA. Translation: CAH18311.1.
BC067881 mRNA. Translation: AAH67881.1.
CCDSiCCDS3479.1.
RefSeqiNP_997213.1. NM_207330.1.
UniGeneiHs.134190.

Genome annotation databases

EnsembliENST00000295461; ENSP00000295461; ENSG00000163293.
GeneIDi152519.
KEGGihsa:152519.
UCSCiuc003gxw.3. human.

Polymorphism databases

DMDMi74736867.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095299 mRNA. Translation: BAG53022.1 .
CR749484 mRNA. Translation: CAH18311.1 .
BC067881 mRNA. Translation: AAH67881.1 .
CCDSi CCDS3479.1.
RefSeqi NP_997213.1. NM_207330.1.
UniGenei Hs.134190.

3D structure databases

ProteinModelPortali Q6NVV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000295461.

Polymorphism databases

DMDMi 74736867.

Proteomic databases

PaxDbi Q6NVV3.
PRIDEi Q6NVV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295461 ; ENSP00000295461 ; ENSG00000163293 .
GeneIDi 152519.
KEGGi hsa:152519.
UCSCi uc003gxw.3. human.

Organism-specific databases

CTDi 152519.
GeneCardsi GC04P047917.
HGNCi HGNC:27194. NIPAL1.
HPAi HPA036765.
neXtProti NX_Q6NVV3.
PharmGKBi PA164723925.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298616.
HOGENOMi HOG000203962.
InParanoidi Q6NVV3.
OMAi EPCQEGY.
OrthoDBi EOG73BVD7.
PhylomeDBi Q6NVV3.
TreeFami TF313214.

Miscellaneous databases

GenomeRNAii 152519.
NextBioi 86972.
PROi Q6NVV3.

Gene expression databases

ArrayExpressi Q6NVV3.
Bgeei Q6NVV3.
CleanExi HS_NPAL1.
Genevestigatori Q6NVV3.

Family and domain databases

InterProi IPR008521. Mg_trans_NIPA.
[Graphical view ]
PANTHERi PTHR12570. PTHR12570. 1 hit.
Pfami PF05653. Mg_trans_NIPA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiNIPA3_HUMAN
AccessioniPrimary (citable) accession number: Q6NVV3
Secondary accession number(s): B3KTB0, Q68DA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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