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Q6NVV3

- NIPA3_HUMAN

UniProt

Q6NVV3 - NIPA3_HUMAN

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Protein

Magnesium transporter NIPA3

Gene

NIPAL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+, Cu2+ and Co2+ but to a much less extent than Mg2+ (By similarity).By similarity

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter NIPA3
Alternative name(s):
NIPA-like protein 1
Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
Gene namesi
Name:NIPAL1
Synonyms:NIPA3, NPAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:27194. NIPAL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767ExtracellularSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Topological domaini89 – 11426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 1361ExtracellularSequence Analysis
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 1658CytoplasmicSequence Analysis
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 20721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Topological domaini229 – 2335CytoplasmicSequence Analysis
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 27319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Topological domaini295 – 30511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Topological domaini327 – 33610ExtracellularSequence Analysis
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Topological domaini358 – 41053CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Magnesium transporter NIPA3PRO_0000242146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NVV3.
PRIDEiQ6NVV3.

Expressioni

Gene expression databases

BgeeiQ6NVV3.
CleanExiHS_NPAL1.
ExpressionAtlasiQ6NVV3. baseline and differential.
GenevestigatoriQ6NVV3.

Organism-specific databases

HPAiHPA036765.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295461.

Structurei

3D structure databases

ProteinModelPortaliQ6NVV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298616.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
InParanoidiQ6NVV3.
OMAiEPCQEGY.
OrthoDBiEOG73BVD7.
PhylomeDBiQ6NVV3.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN
60 70 80 90 100
YSINNLSISA NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG
110 120 130 140 150
FTRAGQGGHS YLKEWLWWVG LLSMGAGEAA NFAAYAFAPA TLVTPLGALS
160 170 180 190 200
VLISAILSSY FLNEHLNIHG KIGCILSILG STVMVIHAPQ EEEVTSLHEM
210 220 230 240 250
EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI SICSLIGAFS
260 270 280 290 300
VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT
310 320 330 340 350
FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG
360 370 380 390 400
IFLLHAFKNT DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND
410
DVTLFSRTDD
Length:410
Mass (Da):44,638
Last modified:July 5, 2004 - v1
Checksum:i4690E95C87D43EB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011E → G in CAH18311. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241I → V.
Corresponds to variant rs13116684 [ dbSNP | Ensembl ].
VAR_026843

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095299 mRNA. Translation: BAG53022.1.
CR749484 mRNA. Translation: CAH18311.1.
BC067881 mRNA. Translation: AAH67881.1.
CCDSiCCDS3479.1.
RefSeqiNP_997213.1. NM_207330.1.
UniGeneiHs.134190.

Genome annotation databases

EnsembliENST00000295461; ENSP00000295461; ENSG00000163293.
GeneIDi152519.
KEGGihsa:152519.
UCSCiuc003gxw.3. human.

Polymorphism databases

DMDMi74736867.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095299 mRNA. Translation: BAG53022.1 .
CR749484 mRNA. Translation: CAH18311.1 .
BC067881 mRNA. Translation: AAH67881.1 .
CCDSi CCDS3479.1.
RefSeqi NP_997213.1. NM_207330.1.
UniGenei Hs.134190.

3D structure databases

ProteinModelPortali Q6NVV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000295461.

Polymorphism databases

DMDMi 74736867.

Proteomic databases

PaxDbi Q6NVV3.
PRIDEi Q6NVV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295461 ; ENSP00000295461 ; ENSG00000163293 .
GeneIDi 152519.
KEGGi hsa:152519.
UCSCi uc003gxw.3. human.

Organism-specific databases

CTDi 152519.
GeneCardsi GC04P047917.
HGNCi HGNC:27194. NIPAL1.
HPAi HPA036765.
neXtProti NX_Q6NVV3.
PharmGKBi PA164723925.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298616.
GeneTreei ENSGT00550000074395.
HOGENOMi HOG000203962.
InParanoidi Q6NVV3.
OMAi EPCQEGY.
OrthoDBi EOG73BVD7.
PhylomeDBi Q6NVV3.
TreeFami TF313214.

Miscellaneous databases

ChiTaRSi NIPAL1. human.
GenomeRNAii 152519.
NextBioi 86972.
PROi Q6NVV3.

Gene expression databases

Bgeei Q6NVV3.
CleanExi HS_NPAL1.
ExpressionAtlasi Q6NVV3. baseline and differential.
Genevestigatori Q6NVV3.

Family and domain databases

InterProi IPR008521. Mg_trans_NIPA.
[Graphical view ]
PANTHERi PTHR12570. PTHR12570. 1 hit.
Pfami PF05653. Mg_trans_NIPA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiNIPA3_HUMAN
AccessioniPrimary (citable) accession number: Q6NVV3
Secondary accession number(s): B3KTB0, Q68DA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3