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Q6NVV3

- NIPA3_HUMAN

UniProt

Q6NVV3 - NIPA3_HUMAN

Protein

Magnesium transporter NIPA3

Gene

NIPAL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+, Cu2+ and Co2+ but to a much less extent than Mg2+ By similarity.By similarity

    GO - Molecular functioni

    1. magnesium ion transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magnesium transporter NIPA3
    Alternative name(s):
    NIPA-like protein 1
    Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
    Gene namesi
    Name:NIPAL1
    Synonyms:NIPA3, NPAL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:27194. NIPAL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164723925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Magnesium transporter NIPA3PRO_0000242146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6NVV3.
    PRIDEiQ6NVV3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NVV3.
    BgeeiQ6NVV3.
    CleanExiHS_NPAL1.
    GenevestigatoriQ6NVV3.

    Organism-specific databases

    HPAiHPA036765.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295461.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NVV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini89 – 11426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini136 – 1361ExtracellularSequence Analysis
    Topological domaini158 – 1658CytoplasmicSequence Analysis
    Topological domaini187 – 20721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 2335CytoplasmicSequence Analysis
    Topological domaini255 – 27319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 30511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 33610ExtracellularSequence Analysis
    Topological domaini358 – 41053CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG298616.
    HOGENOMiHOG000203962.
    InParanoidiQ6NVV3.
    OMAiEPCQEGY.
    OrthoDBiEOG73BVD7.
    PhylomeDBiQ6NVV3.
    TreeFamiTF313214.

    Family and domain databases

    InterProiIPR008521. Mg_trans_NIPA.
    [Graphical view]
    PANTHERiPTHR12570. PTHR12570. 1 hit.
    PfamiPF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NVV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN    50
    YSINNLSISA NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG 100
    FTRAGQGGHS YLKEWLWWVG LLSMGAGEAA NFAAYAFAPA TLVTPLGALS 150
    VLISAILSSY FLNEHLNIHG KIGCILSILG STVMVIHAPQ EEEVTSLHEM 200
    EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI SICSLIGAFS 250
    VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT 300
    FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG 350
    IFLLHAFKNT DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND 400
    DVTLFSRTDD 410
    Length:410
    Mass (Da):44,638
    Last modified:July 5, 2004 - v1
    Checksum:i4690E95C87D43EB8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti201 – 2011E → G in CAH18311. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti324 – 3241I → V.
    Corresponds to variant rs13116684 [ dbSNP | Ensembl ].
    VAR_026843

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095299 mRNA. Translation: BAG53022.1.
    CR749484 mRNA. Translation: CAH18311.1.
    BC067881 mRNA. Translation: AAH67881.1.
    CCDSiCCDS3479.1.
    RefSeqiNP_997213.1. NM_207330.1.
    UniGeneiHs.134190.

    Genome annotation databases

    EnsembliENST00000295461; ENSP00000295461; ENSG00000163293.
    GeneIDi152519.
    KEGGihsa:152519.
    UCSCiuc003gxw.3. human.

    Polymorphism databases

    DMDMi74736867.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095299 mRNA. Translation: BAG53022.1 .
    CR749484 mRNA. Translation: CAH18311.1 .
    BC067881 mRNA. Translation: AAH67881.1 .
    CCDSi CCDS3479.1.
    RefSeqi NP_997213.1. NM_207330.1.
    UniGenei Hs.134190.

    3D structure databases

    ProteinModelPortali Q6NVV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295461.

    Polymorphism databases

    DMDMi 74736867.

    Proteomic databases

    PaxDbi Q6NVV3.
    PRIDEi Q6NVV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295461 ; ENSP00000295461 ; ENSG00000163293 .
    GeneIDi 152519.
    KEGGi hsa:152519.
    UCSCi uc003gxw.3. human.

    Organism-specific databases

    CTDi 152519.
    GeneCardsi GC04P047917.
    HGNCi HGNC:27194. NIPAL1.
    HPAi HPA036765.
    neXtProti NX_Q6NVV3.
    PharmGKBi PA164723925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298616.
    HOGENOMi HOG000203962.
    InParanoidi Q6NVV3.
    OMAi EPCQEGY.
    OrthoDBi EOG73BVD7.
    PhylomeDBi Q6NVV3.
    TreeFami TF313214.

    Miscellaneous databases

    GenomeRNAii 152519.
    NextBioi 86972.
    PROi Q6NVV3.

    Gene expression databases

    ArrayExpressi Q6NVV3.
    Bgeei Q6NVV3.
    CleanExi HS_NPAL1.
    Genevestigatori Q6NVV3.

    Family and domain databases

    InterProi IPR008521. Mg_trans_NIPA.
    [Graphical view ]
    PANTHERi PTHR12570. PTHR12570. 1 hit.
    Pfami PF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiNIPA3_HUMAN
    AccessioniPrimary (citable) accession number: Q6NVV3
    Secondary accession number(s): B3KTB0, Q68DA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3