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Q6NVV3 (NIPA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium transporter NIPA3
Alternative name(s):
NIPA-like protein 1
Non-imprinted in Prader-Willi/Angelman syndrome region protein 3
Gene names
Name:NIPAL1
Synonyms:NIPA3, NPAL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a Mg2+ transporter. Can also transport other divalent cations such as Fe2+, Sr2+, Ba2+, Mn2+, Cu2+ and Co2+ but to a much less extent than Mg2+ By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the NIPA family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmagnesium ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Magnesium transporter NIPA3
PRO_0000242146

Regions

Topological domain1 – 6767Extracellular Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 11426Cytoplasmic Potential
Transmembrane115 – 13521Helical; Potential
Topological domain1361Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1658Cytoplasmic Potential
Transmembrane166 – 18621Helical; Potential
Topological domain187 – 20721Extracellular Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 2335Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 27319Extracellular Potential
Transmembrane274 – 29421Helical; Potential
Topological domain295 – 30511Cytoplasmic Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 33610Extracellular Potential
Transmembrane337 – 35721Helical; Potential
Topological domain358 – 41053Cytoplasmic Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation551N-linked (GlcNAc...) Potential

Natural variations

Natural variant3241I → V.
Corresponds to variant rs13116684 [ dbSNP | Ensembl ].
VAR_026843

Experimental info

Sequence conflict2011E → G in CAH18311. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6NVV3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4690E95C87D43EB8

FASTA41044,638
        10         20         30         40         50         60 
MGAQVRLPPG EPCREGYVLS LVCPNSSQAW CEITNVSQLL ASPVLYTDLN YSINNLSISA 

        70         80         90        100        110        120 
NVENKYSLYV GLVLAVSSSI FIGSSFILKK KGLLQLASKG FTRAGQGGHS YLKEWLWWVG 

       130        140        150        160        170        180 
LLSMGAGEAA NFAAYAFAPA TLVTPLGALS VLISAILSSY FLNEHLNIHG KIGCILSILG 

       190        200        210        220        230        240 
STVMVIHAPQ EEEVTSLHEM EMKLRDPGFI SFAVIITVIS LVLILIVAPK KGQTNILVYI 

       250        260        270        280        290        300 
SICSLIGAFS VSSVKGLGIA IKELIEWKPV YKHPLVFVLL AVLVLSVTTQ INYLNKALDT 

       310        320        330        340        350        360 
FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMTAGDIIGT LSGFFTIIIG IFLLHAFKNT 

       370        380        390        400        410 
DITWSELTST AKKEAVSLNV NENNYVLLEN LECSAPGYND DVTLFSRTDD 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095299 mRNA. Translation: BAG53022.1.
CR749484 mRNA. Translation: CAH18311.1.
BC067881 mRNA. Translation: AAH67881.1.
RefSeqNP_997213.1. NM_207330.1.
UniGeneHs.134190.

3D structure databases

ProteinModelPortalQ6NVV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000295461.

Polymorphism databases

DMDM74736867.

Proteomic databases

PaxDbQ6NVV3.
PRIDEQ6NVV3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295461; ENSP00000295461; ENSG00000163293.
GeneID152519.
KEGGhsa:152519.
UCSCuc003gxw.3. human.

Organism-specific databases

CTD152519.
GeneCardsGC04P047917.
HGNCHGNC:27194. NIPAL1.
HPAHPA036765.
neXtProtNX_Q6NVV3.
PharmGKBPA164723925.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG298616.
HOGENOMHOG000203962.
InParanoidQ6NVV3.
OMASPVLYRD.
OrthoDBEOG73BVD7.
PhylomeDBQ6NVV3.
TreeFamTF313214.

Gene expression databases

ArrayExpressQ6NVV3.
BgeeQ6NVV3.
CleanExHS_NPAL1.
GenevestigatorQ6NVV3.

Family and domain databases

InterProIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERPTHR12570. PTHR12570. 1 hit.
PfamPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi152519.
NextBio86972.
PROQ6NVV3.

Entry information

Entry nameNIPA3_HUMAN
AccessionPrimary (citable) accession number: Q6NVV3
Secondary accession number(s): B3KTB0, Q68DA9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM