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Q6NVU6

- UFSP1_HUMAN

UniProt

Q6NVU6 - UFSP1_HUMAN

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Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. thiolester hydrolase activity Source: Ensembl
  2. UFM1 hydrolase activity Source: Ensembl
Complete GO annotation...

Protein family/group databases

MEROPSiC78.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive Ufm1-specific protease 1
Short name:
UfSP1
Gene namesi
Name:UFSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:33821. UFSP1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Inactive Ufm1-specific protease 1PRO_0000280360Add
BLAST

Proteomic databases

MaxQBiQ6NVU6.
PRIDEiQ6NVU6.

Expressioni

Gene expression databases

BgeeiQ6NVU6.
CleanExiHS_UFSP1.
GenevestigatoriQ6NVU6.

Organism-specific databases

HPAiHPA024132.
HPA027099.

Interactioni

Protein-protein interaction databases

BioGridi135544. 1 interaction.
STRINGi9606.ENSP00000373413.

Structurei

3D structure databases

ProteinModelPortaliQ6NVU6.
SMRiQ6NVU6. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

eggNOGiNOG305716.
GeneTreeiENSGT00520000055644.
HOGENOMiHOG000169159.
HOVERGENiHBG094130.
InParanoidiQ6NVU6.
OMAiCIGSGTE.
OrthoDBiEOG7D59PC.
PhylomeDBiQ6NVU6.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL
60 70 80 90 100
YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS
110 120 130 140
PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD
Length:142
Mass (Da):15,060
Last modified:May 18, 2010 - v2
Checksum:i9D42E879A1D3315A
GO

Sequence cautioni

The sequence EAL23814.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471L → V.2 Publications
Corresponds to variant rs12666989 [ dbSNP | Ensembl ].
VAR_031125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1.
AK292467 mRNA. Translation: BAF85156.1.
CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1.
CCDSiCCDS34710.1.
RefSeqiNP_001015072.2. NM_001015072.3.
UniGeneiHs.534845.

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
GeneIDi402682.
KEGGihsa:402682.
UCSCiuc003uxc.4. human.

Polymorphism databases

DMDMi296452856.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1 .
AK292467 mRNA. Translation: BAF85156.1 .
CH236956 Genomic DNA. Translation: EAL23814.1 . Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1 .
CCDSi CCDS34710.1.
RefSeqi NP_001015072.2. NM_001015072.3.
UniGenei Hs.534845.

3D structure databases

ProteinModelPortali Q6NVU6.
SMRi Q6NVU6. Positions 1-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 135544. 1 interaction.
STRINGi 9606.ENSP00000373413.

Protein family/group databases

MEROPSi C78.001.

Polymorphism databases

DMDMi 296452856.

Proteomic databases

MaxQBi Q6NVU6.
PRIDEi Q6NVU6.

Protocols and materials databases

DNASUi 402682.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388761 ; ENSP00000373413 ; ENSG00000176125 .
GeneIDi 402682.
KEGGi hsa:402682.
UCSCi uc003uxc.4. human.

Organism-specific databases

CTDi 402682.
GeneCardsi GC07M100486.
H-InvDB HIX0201190.
HGNCi HGNC:33821. UFSP1.
HPAi HPA024132.
HPA027099.
MIMi 611481. gene.
neXtProti NX_Q6NVU6.
PharmGKBi PA162408522.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305716.
GeneTreei ENSGT00520000055644.
HOGENOMi HOG000169159.
HOVERGENi HBG094130.
InParanoidi Q6NVU6.
OMAi CIGSGTE.
OrthoDBi EOG7D59PC.
PhylomeDBi Q6NVU6.

Miscellaneous databases

GenomeRNAii 402682.
NextBioi 107581.
PROi Q6NVU6.
SOURCEi Search...

Gene expression databases

Bgeei Q6NVU6.
CleanExi HS_UFSP1.
Genevestigatori Q6NVU6.

Family and domain databases

InterProi IPR012462. Peptidase_C78_UfSP1/2.
[Graphical view ]
Pfami PF07910. Peptidase_C78. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-47.
    Tissue: Testis.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-47.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiUFSP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVU6
Secondary accession number(s): A4D2E4
, A8K8V2, B6ZDG6, Q9BXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3