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Q6NVU6

- UFSP1_HUMAN

UniProt

Q6NVU6 - UFSP1_HUMAN

Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. thiolester hydrolase activity Source: Ensembl
    2. UFM1 hydrolase activity Source: Ensembl

    Protein family/group databases

    MEROPSiC78.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive Ufm1-specific protease 1
    Short name:
    UfSP1
    Gene namesi
    Name:UFSP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:33821. UFSP1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408522.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Inactive Ufm1-specific protease 1PRO_0000280360Add
    BLAST

    Proteomic databases

    MaxQBiQ6NVU6.
    PRIDEiQ6NVU6.

    Expressioni

    Gene expression databases

    BgeeiQ6NVU6.
    CleanExiHS_UFSP1.
    GenevestigatoriQ6NVU6.

    Organism-specific databases

    HPAiHPA024132.
    HPA027099.

    Interactioni

    Protein-protein interaction databases

    BioGridi135544. 1 interaction.
    STRINGi9606.ENSP00000373413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NVU6.
    SMRiQ6NVU6. Positions 1-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C78 family.Curated

    Phylogenomic databases

    eggNOGiNOG305716.
    HOGENOMiHOG000169159.
    HOVERGENiHBG094130.
    OMAiCIGSGTE.
    OrthoDBiEOG7D59PC.
    PhylomeDBiQ6NVU6.

    Family and domain databases

    InterProiIPR012462. Peptidase_C78_UfSP1/2.
    [Graphical view]
    PfamiPF07910. Peptidase_C78. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NVU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL    50
    YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS 100
    PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD 142
    Length:142
    Mass (Da):15,060
    Last modified:May 18, 2010 - v2
    Checksum:i9D42E879A1D3315A
    GO

    Sequence cautioni

    The sequence EAL23814.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471L → V.2 Publications
    Corresponds to variant rs12666989 [ dbSNP | Ensembl ].
    VAR_031125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312032 Genomic DNA. Translation: AAK21004.1.
    AK292467 mRNA. Translation: BAF85156.1.
    CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
    AC011895 Genomic DNA. No translation available.
    BC067904 mRNA. Translation: AAH67904.1.
    CCDSiCCDS34710.1.
    RefSeqiNP_001015072.2. NM_001015072.3.
    UniGeneiHs.534845.

    Genome annotation databases

    EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
    GeneIDi402682.
    KEGGihsa:402682.
    UCSCiuc003uxc.4. human.

    Polymorphism databases

    DMDMi296452856.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312032 Genomic DNA. Translation: AAK21004.1 .
    AK292467 mRNA. Translation: BAF85156.1 .
    CH236956 Genomic DNA. Translation: EAL23814.1 . Sequence problems.
    AC011895 Genomic DNA. No translation available.
    BC067904 mRNA. Translation: AAH67904.1 .
    CCDSi CCDS34710.1.
    RefSeqi NP_001015072.2. NM_001015072.3.
    UniGenei Hs.534845.

    3D structure databases

    ProteinModelPortali Q6NVU6.
    SMRi Q6NVU6. Positions 1-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 135544. 1 interaction.
    STRINGi 9606.ENSP00000373413.

    Protein family/group databases

    MEROPSi C78.001.

    Polymorphism databases

    DMDMi 296452856.

    Proteomic databases

    MaxQBi Q6NVU6.
    PRIDEi Q6NVU6.

    Protocols and materials databases

    DNASUi 402682.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388761 ; ENSP00000373413 ; ENSG00000176125 .
    GeneIDi 402682.
    KEGGi hsa:402682.
    UCSCi uc003uxc.4. human.

    Organism-specific databases

    CTDi 402682.
    GeneCardsi GC07M100486.
    H-InvDB HIX0201190.
    HGNCi HGNC:33821. UFSP1.
    HPAi HPA024132.
    HPA027099.
    MIMi 611481. gene.
    neXtProti NX_Q6NVU6.
    PharmGKBi PA162408522.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305716.
    HOGENOMi HOG000169159.
    HOVERGENi HBG094130.
    OMAi CIGSGTE.
    OrthoDBi EOG7D59PC.
    PhylomeDBi Q6NVU6.

    Miscellaneous databases

    GenomeRNAii 402682.
    NextBioi 107581.
    PROi Q6NVU6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6NVU6.
    CleanExi HS_UFSP1.
    Genevestigatori Q6NVU6.

    Family and domain databases

    InterProi IPR012462. Peptidase_C78_UfSP1/2.
    [Graphical view ]
    Pfami PF07910. Peptidase_C78. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
      Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-47.
      Tissue: Testis.
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-47.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiUFSP1_HUMAN
    AccessioniPrimary (citable) accession number: Q6NVU6
    Secondary accession number(s): A4D2E4
    , A8K8V2, B6ZDG6, Q9BXP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3