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Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiC78.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive Ufm1-specific protease 1
Short name:
UfSP1
Gene namesi
Name:UFSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33821. UFSP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi402682.
OpenTargetsiENSG00000176125.
PharmGKBiPA162408522.

Polymorphism and mutation databases

BioMutaiUFSP1.
DMDMi296452856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803601 – 142Inactive Ufm1-specific protease 1Add BLAST142

Proteomic databases

EPDiQ6NVU6.
MaxQBiQ6NVU6.
PaxDbiQ6NVU6.
PeptideAtlasiQ6NVU6.
PRIDEiQ6NVU6.

PTM databases

iPTMnetiQ6NVU6.
PhosphoSitePlusiQ6NVU6.

Expressioni

Gene expression databases

BgeeiENSG00000176125.
CleanExiHS_UFSP1.
GenevisibleiQ6NVU6. HS.

Organism-specific databases

HPAiHPA024132.
HPA027099.

Interactioni

Protein-protein interaction databases

IntActiQ6NVU6. 3 interactors.
STRINGi9606.ENSP00000373413.

Structurei

3D structure databases

ProteinModelPortaliQ6NVU6.
SMRiQ6NVU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

eggNOGiKOG2433. Eukaryota.
ENOG410XTJE. LUCA.
GeneTreeiENSGT00520000055644.
HOGENOMiHOG000169159.
HOVERGENiHBG094130.
InParanoidiQ6NVU6.
OMAiCIGSGTE.
OrthoDBiEOG091G04IB.
PhylomeDBiQ6NVU6.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR033502. UfSP1.
[Graphical view]
PANTHERiPTHR24375:SF136. PTHR24375:SF136. 1 hit.
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL
60 70 80 90 100
YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS
110 120 130 140
PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD
Length:142
Mass (Da):15,060
Last modified:May 18, 2010 - v2
Checksum:i9D42E879A1D3315A
GO

Sequence cautioni

The sequence EAL23814 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03112547L → V.2 PublicationsCorresponds to variant rs12666989dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1.
AK292467 mRNA. Translation: BAF85156.1.
CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1.
CCDSiCCDS34710.1.
RefSeqiNP_001015072.2. NM_001015072.3.
UniGeneiHs.534845.

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
GeneIDi402682.
KEGGihsa:402682.
UCSCiuc003uxc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1.
AK292467 mRNA. Translation: BAF85156.1.
CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1.
CCDSiCCDS34710.1.
RefSeqiNP_001015072.2. NM_001015072.3.
UniGeneiHs.534845.

3D structure databases

ProteinModelPortaliQ6NVU6.
SMRiQ6NVU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NVU6. 3 interactors.
STRINGi9606.ENSP00000373413.

Protein family/group databases

MEROPSiC78.001.

PTM databases

iPTMnetiQ6NVU6.
PhosphoSitePlusiQ6NVU6.

Polymorphism and mutation databases

BioMutaiUFSP1.
DMDMi296452856.

Proteomic databases

EPDiQ6NVU6.
MaxQBiQ6NVU6.
PaxDbiQ6NVU6.
PeptideAtlasiQ6NVU6.
PRIDEiQ6NVU6.

Protocols and materials databases

DNASUi402682.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
GeneIDi402682.
KEGGihsa:402682.
UCSCiuc003uxc.4. human.

Organism-specific databases

CTDi402682.
DisGeNETi402682.
GeneCardsiUFSP1.
H-InvDBHIX0201190.
HGNCiHGNC:33821. UFSP1.
HPAiHPA024132.
HPA027099.
MIMi611481. gene.
neXtProtiNX_Q6NVU6.
OpenTargetsiENSG00000176125.
PharmGKBiPA162408522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2433. Eukaryota.
ENOG410XTJE. LUCA.
GeneTreeiENSGT00520000055644.
HOGENOMiHOG000169159.
HOVERGENiHBG094130.
InParanoidiQ6NVU6.
OMAiCIGSGTE.
OrthoDBiEOG091G04IB.
PhylomeDBiQ6NVU6.

Miscellaneous databases

GenomeRNAii402682.
PROiQ6NVU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176125.
CleanExiHS_UFSP1.
GenevisibleiQ6NVU6. HS.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR033502. UfSP1.
[Graphical view]
PANTHERiPTHR24375:SF136. PTHR24375:SF136. 1 hit.
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUFSP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVU6
Secondary accession number(s): A4D2E4
, A8K8V2, B6ZDG6, Q9BXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.