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Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC78.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive Ufm1-specific protease 1
Short name:
UfSP1
Gene namesi
Name:UFSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33821. UFSP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408522.

Polymorphism and mutation databases

BioMutaiUFSP1.
DMDMi296452856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Inactive Ufm1-specific protease 1PRO_0000280360Add
BLAST

Proteomic databases

MaxQBiQ6NVU6.
PRIDEiQ6NVU6.

Expressioni

Gene expression databases

BgeeiQ6NVU6.
CleanExiHS_UFSP1.
GenevisibleiQ6NVU6. HS.

Organism-specific databases

HPAiHPA024132.
HPA027099.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373413.

Structurei

3D structure databases

ProteinModelPortaliQ6NVU6.
SMRiQ6NVU6. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

eggNOGiNOG305716.
GeneTreeiENSGT00520000055644.
HOGENOMiHOG000169159.
HOVERGENiHBG094130.
InParanoidiQ6NVU6.
OMAiCIGSGTE.
OrthoDBiEOG7D59PC.
PhylomeDBiQ6NVU6.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL
60 70 80 90 100
YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS
110 120 130 140
PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD
Length:142
Mass (Da):15,060
Last modified:May 18, 2010 - v2
Checksum:i9D42E879A1D3315A
GO

Sequence cautioni

The sequence EAL23814.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471L → V.2 Publications
Corresponds to variant rs12666989 [ dbSNP | Ensembl ].
VAR_031125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1.
AK292467 mRNA. Translation: BAF85156.1.
CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1.
CCDSiCCDS34710.1.
RefSeqiNP_001015072.2. NM_001015072.3.
UniGeneiHs.534845.

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
GeneIDi402682.
KEGGihsa:402682.
UCSCiuc003uxc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA. Translation: AAK21004.1.
AK292467 mRNA. Translation: BAF85156.1.
CH236956 Genomic DNA. Translation: EAL23814.1. Sequence problems.
AC011895 Genomic DNA. No translation available.
BC067904 mRNA. Translation: AAH67904.1.
CCDSiCCDS34710.1.
RefSeqiNP_001015072.2. NM_001015072.3.
UniGeneiHs.534845.

3D structure databases

ProteinModelPortaliQ6NVU6.
SMRiQ6NVU6. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000373413.

Protein family/group databases

MEROPSiC78.001.

Polymorphism and mutation databases

BioMutaiUFSP1.
DMDMi296452856.

Proteomic databases

MaxQBiQ6NVU6.
PRIDEiQ6NVU6.

Protocols and materials databases

DNASUi402682.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125.
GeneIDi402682.
KEGGihsa:402682.
UCSCiuc003uxc.4. human.

Organism-specific databases

CTDi402682.
GeneCardsiGC07M100486.
H-InvDBHIX0201190.
HGNCiHGNC:33821. UFSP1.
HPAiHPA024132.
HPA027099.
MIMi611481. gene.
neXtProtiNX_Q6NVU6.
PharmGKBiPA162408522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305716.
GeneTreeiENSGT00520000055644.
HOGENOMiHOG000169159.
HOVERGENiHBG094130.
InParanoidiQ6NVU6.
OMAiCIGSGTE.
OrthoDBiEOG7D59PC.
PhylomeDBiQ6NVU6.

Miscellaneous databases

GenomeRNAii402682.
NextBioi107581.
PROiQ6NVU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NVU6.
CleanExiHS_UFSP1.
GenevisibleiQ6NVU6. HS.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-47.
    Tissue: Testis.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-47.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiUFSP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVU6
Secondary accession number(s): A4D2E4
, A8K8V2, B6ZDG6, Q9BXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.