Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NVU2

- PPIG_XENTR

UniProt

Q6NVU2 - PPIG_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Gene

ppp1cc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi248 – 2481Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. glycogen metabolic process Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
  4. mitotic nuclear envelope reassembly Source: UniProtKB
  5. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_207635. Separation of Sister Chromatids.
REACT_214596. Resolution of Sister Chromatid Cohesion.
REACT_227588. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitBy similarity (EC:3.1.3.16)
Short name:
PP-1GBy similarity
Gene namesi
Name:ppp1ccImported
ORF Names:TEgg061c20.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-967934. ppp1cc.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cleavage furrow By similarity. Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity. Midbody By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. kinetochore Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Serine/threonine-protein phosphatase PP1-gamma catalytic subunitPRO_0000365636Add
BLAST

Proteomic databases

PRIDEiQ6NVU2.

Expressioni

Gene expression databases

BgeeiQ6NVU2.

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NVU2.
SMRiQ6NVU2. Positions 6-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Sequence Analysis

Phylogenomic databases

GeneTreeiENSGT00530000062911.
HOVERGENiHBG000216.
InParanoidiQ6NVU2.
KOiK06269.
OMAiLWNDPSD.
OrthoDBiEOG7TJ3K3.
TreeFamiTF354243.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE
310 320
KKKPNASRPV TPPRGMITKQ AKK
Length:323
Mass (Da):36,956
Last modified:July 5, 2004 - v1
Checksum:i8CD4C5DE036A8C2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761289 mRNA. Translation: CAJ81429.1.
BC067911 mRNA. Translation: AAH67911.1.
RefSeqiNP_998835.1. NM_213670.2.
UniGeneiStr.5048.

Genome annotation databases

EnsembliENSXETT00000052896; ENSXETP00000052896; ENSXETG00000024480.
GeneIDi407879.
KEGGixtr:407879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761289 mRNA. Translation: CAJ81429.1 .
BC067911 mRNA. Translation: AAH67911.1 .
RefSeqi NP_998835.1. NM_213670.2.
UniGenei Str.5048.

3D structure databases

ProteinModelPortali Q6NVU2.
SMRi Q6NVU2. Positions 6-300.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6NVU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000052896 ; ENSXETP00000052896 ; ENSXETG00000024480 .
GeneIDi 407879.
KEGGi xtr:407879.

Organism-specific databases

CTDi 5501.
Xenbasei XB-GENE-967934. ppp1cc.

Phylogenomic databases

GeneTreei ENSGT00530000062911.
HOVERGENi HBG000216.
InParanoidi Q6NVU2.
KOi K06269.
OMAi LWNDPSD.
OrthoDBi EOG7TJ3K3.
TreeFami TF354243.

Enzyme and pathway databases

Reactomei REACT_207635. Separation of Sister Chromatids.
REACT_214596. Resolution of Sister Chromatid Cohesion.
REACT_227588. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Gene expression databases

Bgeei Q6NVU2.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EggImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiPPIG_XENTR
AccessioniPrimary (citable) accession number: Q6NVU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3