Q6NVU2 (PPIG_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Short name=PP-1G
EC=3.1.3.16

Gene names

Name:	ppp1cc
ORF Names:	TEgg061c20.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin By similarity. UniProtKB P36874 UniProtKB P36873
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. UniProtKB P36874
Cofactor	Binds 1 iron ion per subunit By similarity. UniProtKB P36873 Binds 1 manganese ion per subunit By similarity. UniProtKB P36873
Subunit structure	PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits By similarity. UniProtKB P63088
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Cleavage furrow By similarity. Nucleus › nucleolus By similarity. Nucleus › nucleoplasm By similarity. Chromosome › centromere › kinetochore By similarity. Nucleus speckle By similarity. Midbody By similarity. Mitochondrion By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cell cycle Cell division Glycogen metabolism Mitosis
Cellular component	Centromere Chromosome Cytoplasm Kinetochore Mitochondrion Nucleus
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara cell division Inferred from electronic annotation. Source: UniProtKB-KW glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW mitotic nuclear envelope reassembly Inferred from sequence or structural similarity. Source: UniProtKB protein dephosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cleavage furrow Inferred from electronic annotation. Source: UniProtKB-SubCell condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell midbody Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		PRO_0000365636
Sites
	Active site	125	1	Proton donor By similarity UniProtKB P36873
	Metal binding	64	1	Iron By similarity UniProtKB P36873
	Metal binding	66	1	Iron By similarity UniProtKB P36873
	Metal binding	92	1	Iron By similarity UniProtKB P36873
	Metal binding	92	1	Manganese By similarity UniProtKB P36873
	Metal binding	124	1	Manganese By similarity UniProtKB P36873
	Metal binding	173	1	Manganese By similarity UniProtKB P36873
	Metal binding	248	1	Manganese By similarity UniProtKB P36873

Sequences

	Sequence		Length	Mass (Da)
	Q6NVU2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8CD4C5DE036A8C2B	FASTA	323	36,956
	10 20 30 40 50 60 MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 70 80 90 100 110 120 ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 130 140 150 160 170 180 LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 190 200 210 220 230 240 QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 250 260 270 280 290 300 LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 310 320 KKKPNASRPV TPPRGMITKQ AKK

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR761289 mRNA. Translation: CAJ81429.1. BC067911 mRNA. Translation: AAH67911.1.
RefSeq	NP_998835.1. NM_213670.2.
UniGene	Str.5048.
3D structure databases
HSSP	HSSP built from PDB template 1JK7 based on UniProtKB P36873.
ProteinModelPortal	Q6NVU2.
SMR	Q6NVU2. Positions 6-300.
ModBase	Search...
Proteomic databases
PRIDE	Q6NVU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000052896; ENSXETP00000052896; ENSXETG00000024480.
GeneID	407879.
KEGG	xtr:407879.
Organism-specific databases
CTD	5501.
Xenbase	XB-GENE-967934. ppp1cc.
Phylogenomic databases
GeneTree	ENSGT00530000062911.
HOVERGEN	HBG000216.
InParanoid	Q6NVU2.
KO	K06269.
OMA	GFEFFAN.
OrthoDB	EOG49GKGT.
Gene expression databases
Bgee	Q6NVU2.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPIG_XENTR

Accession

Primary (citable) accession number: Q6NVU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program