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Q6NVU2

- PPIG_XENTR

UniProt

Q6NVU2 - PPIG_XENTR

Protein

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Gene

ppp1cc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Manganese 1By similarity
    Metal bindingi66 – 661Manganese 1By similarity
    Metal bindingi92 – 921Manganese 1By similarity
    Metal bindingi92 – 921Manganese 2By similarity
    Metal bindingi124 – 1241Manganese 2By similarity
    Active sitei125 – 1251Proton donorBy similarity
    Metal bindingi173 – 1731Manganese 2By similarity
    Metal bindingi248 – 2481Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. glycogen metabolic process Source: UniProtKB-KW
    3. mitotic nuclear division Source: UniProtKB-KW
    4. mitotic nuclear envelope reassembly Source: UniProtKB
    5. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Mitosis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_207635. Separation of Sister Chromatids.
    REACT_214596. Resolution of Sister Chromatid Cohesion.
    REACT_227588. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunitBy similarity (EC:3.1.3.16)
    Short name:
    PP-1GBy similarity
    Gene namesi
    Name:ppp1ccImported
    ORF Names:TEgg061c20.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-967934. ppp1cc.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cleavage furrow By similarity. Nucleusnucleolus By similarity. Nucleusnucleoplasm By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity. Midbody By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB-SubCell
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. midbody Source: UniProtKB-SubCell
    4. mitochondrion Source: UniProtKB
    5. nuclear speck Source: UniProtKB-SubCell
    6. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Kinetochore, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Serine/threonine-protein phosphatase PP1-gamma catalytic subunitPRO_0000365636Add
    BLAST

    Proteomic databases

    PRIDEiQ6NVU2.

    Expressioni

    Gene expression databases

    BgeeiQ6NVU2.

    Interactioni

    Subunit structurei

    PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NVU2.
    SMRiQ6NVU2. Positions 6-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Sequence Analysis

    Phylogenomic databases

    GeneTreeiENSGT00530000062911.
    HOVERGENiHBG000216.
    InParanoidiQ6NVU2.
    KOiK06269.
    OMAiLWNDPSD.
    OrthoDBiEOG7TJ3K3.
    TreeFamiTF354243.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NVU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP    50
    ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 100
    LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 150
    TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 200
    LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 250
    VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 300
    KKKPNASRPV TPPRGMITKQ AKK 323
    Length:323
    Mass (Da):36,956
    Last modified:July 5, 2004 - v1
    Checksum:i8CD4C5DE036A8C2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761289 mRNA. Translation: CAJ81429.1.
    BC067911 mRNA. Translation: AAH67911.1.
    RefSeqiNP_998835.1. NM_213670.2.
    UniGeneiStr.5048.

    Genome annotation databases

    EnsembliENSXETT00000052896; ENSXETP00000052896; ENSXETG00000024480.
    GeneIDi407879.
    KEGGixtr:407879.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761289 mRNA. Translation: CAJ81429.1 .
    BC067911 mRNA. Translation: AAH67911.1 .
    RefSeqi NP_998835.1. NM_213670.2.
    UniGenei Str.5048.

    3D structure databases

    ProteinModelPortali Q6NVU2.
    SMRi Q6NVU2. Positions 6-300.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6NVU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000052896 ; ENSXETP00000052896 ; ENSXETG00000024480 .
    GeneIDi 407879.
    KEGGi xtr:407879.

    Organism-specific databases

    CTDi 5501.
    Xenbasei XB-GENE-967934. ppp1cc.

    Phylogenomic databases

    GeneTreei ENSGT00530000062911.
    HOVERGENi HBG000216.
    InParanoidi Q6NVU2.
    KOi K06269.
    OMAi LWNDPSD.
    OrthoDBi EOG7TJ3K3.
    TreeFami TF354243.

    Enzyme and pathway databases

    Reactomei REACT_207635. Separation of Sister Chromatids.
    REACT_214596. Resolution of Sister Chromatid Cohesion.
    REACT_227588. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

    Gene expression databases

    Bgeei Q6NVU2.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EggImported.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiPPIG_XENTR
    AccessioniPrimary (citable) accession number: Q6NVU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3