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Protein

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Gene

ppp1cc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi248 – 2481Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_275252. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
REACT_276199. Separation of Sister Chromatids.
REACT_296114. Downregulation of TGF-beta receptor signaling.
REACT_304215. Circadian Clock.
REACT_331668. Mitotic Prometaphase.
REACT_349176. Resolution of Sister Chromatid Cohesion.
REACT_360417. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitBy similarity (EC:3.1.3.16)
Short name:
PP-1GBy similarity
Gene namesi
Name:ppp1ccImported
ORF Names:TEgg061c20.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-967934. ppp1cc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Serine/threonine-protein phosphatase PP1-gamma catalytic subunitPRO_0000365636Add
BLAST

Proteomic databases

PRIDEiQ6NVU2.

Expressioni

Gene expression databases

BgeeiQ6NVU2.

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000052896.

Structurei

3D structure databases

ProteinModelPortaliQ6NVU2.
SMRiQ6NVU2. Positions 6-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Sequence Analysis

Phylogenomic databases

GeneTreeiENSGT00530000062911.
HOVERGENiHBG000216.
InParanoidiQ6NVU2.
KOiK06269.
OMAiISSRICP.
OrthoDBiEOG7TJ3K3.
TreeFamiTF354243.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE
310 320
KKKPNASRPV TPPRGMITKQ AKK
Length:323
Mass (Da):36,956
Last modified:July 5, 2004 - v1
Checksum:i8CD4C5DE036A8C2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761289 mRNA. Translation: CAJ81429.1.
BC067911 mRNA. Translation: AAH67911.1.
RefSeqiNP_998835.1. NM_213670.2.
UniGeneiStr.5048.

Genome annotation databases

EnsembliENSXETT00000052896; ENSXETP00000052896; ENSXETG00000024480.
GeneIDi407879.
KEGGixtr:407879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761289 mRNA. Translation: CAJ81429.1.
BC067911 mRNA. Translation: AAH67911.1.
RefSeqiNP_998835.1. NM_213670.2.
UniGeneiStr.5048.

3D structure databases

ProteinModelPortaliQ6NVU2.
SMRiQ6NVU2. Positions 6-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000052896.

Proteomic databases

PRIDEiQ6NVU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000052896; ENSXETP00000052896; ENSXETG00000024480.
GeneIDi407879.
KEGGixtr:407879.

Organism-specific databases

CTDi5501.
XenbaseiXB-GENE-967934. ppp1cc.

Phylogenomic databases

GeneTreeiENSGT00530000062911.
HOVERGENiHBG000216.
InParanoidiQ6NVU2.
KOiK06269.
OMAiISSRICP.
OrthoDBiEOG7TJ3K3.
TreeFamiTF354243.

Enzyme and pathway databases

ReactomeiREACT_275252. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
REACT_276199. Separation of Sister Chromatids.
REACT_296114. Downregulation of TGF-beta receptor signaling.
REACT_304215. Circadian Clock.
REACT_331668. Mitotic Prometaphase.
REACT_349176. Resolution of Sister Chromatid Cohesion.
REACT_360417. RHO GTPases Activate Formins.

Gene expression databases

BgeeiQ6NVU2.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EggImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiPPIG_XENTR
AccessioniPrimary (citable) accession number: Q6NVU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.