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Protein

Alpha-(1,6)-fucosyltransferase

Gene

fut8

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.By similarity

Catalytic activityi

GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-XTR-975578. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT23. Glycosyltransferase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferase (EC:2.4.1.68)
Short name:
Alpha1-6FucT
Alternative name(s):
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
Glycoprotein 6-alpha-L-fucosyltransferase
Gene namesi
Name:fut8
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-954943. fut8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini31 – 578548LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Alpha-(1,6)-fucosyltransferasePRO_0000357043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi207 ↔ 269By similarity
Disulfide bondi215 ↔ 233By similarity
Disulfide bondi221 ↔ 225By similarity
Disulfide bondi468 ↔ 475By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6NVP8.

Expressioni

Gene expression databases

BgeeiENSXETG00000007644.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000016641.

Structurei

3D structure databases

ProteinModelPortaliQ6NVP8.
SMRiQ6NVP8. Positions 111-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 496288GT23PROSITE-ProRule annotationAdd
BLAST
Domaini505 – 56662SH3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3692Important for donor substrate binding

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi302 – 3087SH3-bindingSequence analysis

Sequence similaritiesi

Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation
Contains 1 GT23 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain, SH3-binding, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3705. Eukaryota.
ENOG410YHM8. LUCA.
GeneTreeiENSGT00530000063737.
HOGENOMiHOG000007175.
HOVERGENiHBG028260.
InParanoidiQ6NVP8.
KOiK00717.
OMAiSHPPAFF.
OrthoDBiEOG091G05GD.
TreeFamiTF106108.

Family and domain databases

InterProiIPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51659. GT23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNENPDHSS RELSKILAKL
60 70 80 90 100
ERLKQQNEDL RRMAESLRIP EGPIEQGAAA GRIRALEEQL LKAKEQIEMY
110 120 130 140 150
KQQSSNAVSG LGKDHEILRR AIENGAKEFW YFVQSEVKKL KHLDRNELQR
160 170 180 190 200
HVDEIIIDMG HQQRSVMTDL YYLSQTDGAG DWREREAKDL TDLVQRRITY
210 220 230 240 250
LQNPKDCSKA KKLVCNINKG CGYGCQLHHV VYCFMIAYGT QRTLILESQS
260 270 280 290 300
WRYATGGWET VFKPVSETCT DRSGSSTGHW SGEANDKNVQ VVELPIVDSL
310 320 330 340 350
HPRPPYLPLG VPEDLADRLI RLHGDPAVWW VSQFVKYLIR PQPWLEKEIE
360 370 380 390 400
ESTKKLGFKH PVIGVHVRRT DKVGTEAAFH PIEEYMVHVE EHFQLLARRM
410 420 430 440 450
QIDKKRVYLA TDDPTLLQEA KAKYPQYEFI SDNSISWSAG LHNRYTENSL
460 470 480 490 500
RGVILDIHFL SQADFLVCTF SSQVCRVAYE IMQTLHPDAS AHFHSLDDIY
510 520 530 540 550
YFGGQNAHNQ LAIYPHQPRN AEEIPLEPGD IIGVAGNHWD GYSKGINRKL
560 570
GRTGLYPSYK VKEKIETVKY PTYQEAEK
Length:578
Mass (Da):66,685
Last modified:July 5, 2004 - v1
Checksum:iC161502A464C38EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067957 mRNA. Translation: AAH67957.1.
RefSeqiNP_001001232.1. NM_001001232.2.
XP_012825727.1. XM_012970273.1.
UniGeneiStr.230.

Genome annotation databases

EnsembliENSXETT00000016641; ENSXETP00000016641; ENSXETG00000007644.
GeneIDi407913.
KEGGixtr:407913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067957 mRNA. Translation: AAH67957.1.
RefSeqiNP_001001232.1. NM_001001232.2.
XP_012825727.1. XM_012970273.1.
UniGeneiStr.230.

3D structure databases

ProteinModelPortaliQ6NVP8.
SMRiQ6NVP8. Positions 111-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000016641.

Protein family/group databases

CAZyiGT23. Glycosyltransferase Family 23.

Proteomic databases

PaxDbiQ6NVP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000016641; ENSXETP00000016641; ENSXETG00000007644.
GeneIDi407913.
KEGGixtr:407913.

Organism-specific databases

CTDi2530.
XenbaseiXB-GENE-954943. fut8.

Phylogenomic databases

eggNOGiKOG3705. Eukaryota.
ENOG410YHM8. LUCA.
GeneTreeiENSGT00530000063737.
HOGENOMiHOG000007175.
HOVERGENiHBG028260.
InParanoidiQ6NVP8.
KOiK00717.
OMAiSHPPAFF.
OrthoDBiEOG091G05GD.
TreeFamiTF106108.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-XTR-975578. Reactions specific to the complex N-glycan synthesis pathway.

Gene expression databases

BgeeiENSXETG00000007644.

Family and domain databases

InterProiIPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51659. GT23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUT8_XENTR
AccessioniPrimary (citable) accession number: Q6NVP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.