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Q6NVL5

- ELP3_XENTR

UniProt

Q6NVL5 - ELP3_XENTR

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Protein

Elongator complex protein 3

Gene

elp3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi114 – 1141Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. regulation of protein kinase activity Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-957348. elp3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Elongator complex protein 3PRO_0000283991Add
BLAST

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000045738.

Structurei

3D structure databases

ProteinModelPortaliQ6NVL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 549152N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
HOVERGENiHBG107845.
InParanoidiQ6NVL5.
KOiK07739.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NVL5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPDRGPRGK QSQAELMMMT VADVIKQLVE AHEQGKDVNL NKLKTKTSAK
60 70 80 90 100
YGLSAQPRLV DIIAAVPPQY RKILVPKLKA KPIRTASGIA VVAVMCKPHR
110 120 130 140 150
CPHINFTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYDPYLQT
160 170 180 190 200
RHRVEQLKQL GHSVDKVEFI VMGGTFMALS EDYRDFFIRN LHDALSGHTS
210 220 230 240 250
NSVSEAVRYS ERSNTKCVGI TIETRPDYCL KRHLSDMLSY GCTRLEIGVQ
260 270 280 290 300
SVYEDVARDT NRGHTVKAVC ESFHMAKDAG FKVVSHMMPD LPNVGLERDT
310 320 330 340 350
EQFIEFFENP AFRPDGMKLY PTLVIRGTGL YELWKTGRYR SYSPSTLVDL
360 370 380 390 400
VARILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTEC
410 420 430 440 450
RDVRTREVGI QEIHHKVRPY QVELIRRDYV ANGGWETFLS YEDPEQDILI
460 470 480 490 500
GLLRLRKCSE QSFRPELKGG VSIVRELHVY GSVVPISSRD PSKFQHQGFG
510 520 530 540
MLLMEEAERI AREEHGSCKI AVISGVGTRN YYRKLGYELE GPYMVKKLD
Length:549
Mass (Da):62,361
Last modified:July 5, 2004 - v1
Checksum:i12C36414D58E6C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067990 mRNA. Translation: AAH67990.1.
RefSeqiNP_001001215.1. NM_001001215.1.
UniGeneiStr.4002.

Genome annotation databases

GeneIDi407885.
KEGGixtr:407885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC067990 mRNA. Translation: AAH67990.1 .
RefSeqi NP_001001215.1. NM_001001215.1.
UniGenei Str.4002.

3D structure databases

ProteinModelPortali Q6NVL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000045738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 407885.
KEGGi xtr:407885.

Organism-specific databases

CTDi 55140.
Xenbasei XB-GENE-957348. elp3.

Phylogenomic databases

eggNOGi COG1243.
HOGENOMi HOG000227514.
HOVERGENi HBG107845.
InParanoidi Q6NVL5.
KOi K07739.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiELP3_XENTR
AccessioniPrimary (citable) accession number: Q6NVL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3